Meta Information
ID:bakuchiol-serum
Name:Bakuchiol Serum
Schema Version:2.4_uniform_evidence_2026_06_18
Created
2026-07-02T07:35:59Z
Model
phase-b-topical-claude-opus-4.8
Interactions
Target id:
/class/retinoids
Target name:
Topical retinoids
Severity:
minor
Interaction type:
synergistic
Nature:
relative
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Bakuchiol serum is a gentle retinol alternative; combining with retinoids adds mild effects and is generally well tolerated.
Actionable advice:
Can be layered or used as a gentler alternative; monitor for cumulative irritation.
Validation status:
validated_via_class_inference
Evidence tier:
tier_c
Evidence basis:
class_inference_summary
Evidence anchors:
Source url:
Established mechanism / dermatologic practice (no single primary source quoted)
Exact phrase from label:
Bakuchiol has retinol-like effects with less irritation. Dermatologic practice.
Label source:
Class inference
Action type:
informational_none
Target id:
/condition/sensitive-skin-rosacea
Target name:
Sensitive skin / rosacea
Severity:
moderate
Interaction type:
adverse
Nature:
conditional
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Bakuchiol serum (generally very mild) can sting and worsen redness in sensitive or rosacea-prone skin.
Actionable advice:
Patch-test, use lower strength/frequency, and buffer with moisturizer if you have sensitive or rosacea-prone skin.
Validation status:
validated_via_class_inference
Evidence tier:
tier_c
Evidence basis:
class_inference_summary
Evidence anchors:
Source url:
Established mechanism / dermatologic practice (no single primary source quoted)
Exact phrase from label:
Low-pH/irritant actives provoke stinging and flares in sensitive/rosacea skin. Dermatologic practice.
Label source:
Class inference
Action type:
monitor