Meta Information
ID:bakuchiol
Name:Bakuchiol
Schema Version:2.4_uniform_evidence_2026_06_18
Created
2026-07-02T07:35:59Z
Model
phase-b-topical-claude-opus-4.8
Interactions
Target id:
/class/retinoids
Target name:
Topical retinoids
Severity:
minor
Interaction type:
synergistic
Nature:
relative
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Bakuchiol is a gentler retinol alternative; it can be combined with or substituted for retinoids, with additive (usually mild) effects.
Actionable advice:
Can be layered with retinoids or used as a gentler alternative; monitor for cumulative irritation.
Validation status:
validated_via_class_inference
Evidence tier:
tier_c
Evidence basis:
class_inference_summary
Evidence anchors:
Source url:
Established mechanism / dermatologic practice (no single primary source quoted)
Exact phrase from label:
Bakuchiol has retinol-like effects with less irritation; additive with retinoids. Dermatologic practice.
Label source:
Class inference
Action type:
informational_none
Target id:
/intervention/vitamin-c-topical
Target name:
Topical vitamin C
Severity:
minor
Interaction type:
synergistic
Nature:
relative
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Bakuchiol is stable and compatible with vitamin C, often layered for antioxidant/anti-aging benefit.
Actionable advice:
Compatible; can be layered morning or night.
Validation status:
validated_via_class_inference
Evidence tier:
tier_c
Evidence basis:
class_inference_summary
Evidence anchors:
Source url:
Established mechanism / dermatologic practice (no single primary source quoted)
Exact phrase from label:
Bakuchiol is pH-stable and compatible with vitamin C. Dermatologic practice.
Label source:
Class inference
Action type:
informational_none