Meta Information
ID:bitter-melon
Name:Bitter Melon (Momordica charantia)
Schema Version:2.4_uniform_evidence_2026_06_18
Created
2026-07-02T07:03:07Z
Model
phase-b-newfiles-claude-opus-4.8
Interactions
Target id:
/class/antidiabetic-medications
Target name:
Antidiabetic medications (metformin, SGLT2i, insulin, sulfonylureas)
Severity:
moderate
Interaction type:
adverse
Nature:
relative
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Bitter melon lowers HbA1c and fasting glucose, adding to diabetes medications and increasing hypoglycemia risk.
Actionable advice:
Blood glucose should be monitored, and diabetes medication may need a dose reduction.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
The reduction in HbA1c and fasting plasma glucose between 6 and 9 months was significantly greater in patients receiving Momordica charantia compared with controls (p < 0.001).
Label source:
Clinical cohort, Nutrients, PMID 41599921.
Action type:
monitor