Meta Information
ID:boron
Name:
Schema Version:2.4_uniform_evidence_2026_06_18
Created
2026-05-21T22:30:00Z
Model
phase-a-upgrade-claude-sonnet-4.6
Interactions
Target id:
/condition/renal-impairment
Target name:
Renal Impairment
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Boron is primarily excreted by the kidneys. Impaired renal function can lead to the accumulation of boron to potentially toxic levels.
Actionable advice:
Boron supplementation should be avoided with moderate to severe kidney disease, unless specifically approved by a nephrologist.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
The results showed that serum boron level was significantly higher at the beginning of HD, and lower at the completion of HD in comparison with controls.
Label source:
PubMed: Hemodialysis effect on serum boron level in the patients with long term hemodialysis. (PMID 8931348)
Action type:
avoid
Target id:
/condition/pregnancy
Target name:
Pregnancy
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
The safety of boron supplementation during pregnancy has not been established, and high intake may pose risks to fetal development.
Actionable advice:
Boron supplements should not be taken during pregnancy.
Validation status:
anecdotal
Evidence tier:
tier_d
Evidence basis:
anecdotal_summary
Evidence anchors:
Exact phrase from label:
Taking boron by mouth in higher doses is possibly unsafe and has been linked to lower birth weights and birth defects.
Label source:
Anecdotal: WebMD
Action type:
avoid
Target id:
/condition/lactation
Target name:
Breastfeeding (Lactation)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
It is unknown if supplemental boron is excreted in breast milk or what its effects on a nursing infant might be. Due to a lack of safety data, it should be avoided.
Actionable advice:
Boron supplements should not be taken while breastfeeding.
Validation status:
unvalidatable
Evidence tier:
tier_e
Evidence basis:
unvalidatable
Evidence anchors:
Source url:
Scientific literature support not found
Exact phrase from label:
Label source:
Action type:
avoid
Target id:
/condition/hormone-sensitive-cancers
Target name:
Hormone-Sensitive Cancers or Conditions
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Boron can increase levels of steroid hormones like estrogen and testosterone, which could theoretically stimulate the growth of hormone-sensitive tissues.
Actionable advice:
It is important to talk to an oncologist or physician before using boron with a history of breast, uterine, ovarian, or prostate cancer, or conditions like endometriosis.
Validation status:
validated_via_pubmed
Evidence tier:
tier_b
Evidence basis:
pubmed_abstract_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
Boron supplementation markedly elevated the serum concentrations of 17 beta-estradiol and testosterone; the elevation seemed more marked when dietary magnesium was low.
Label source:
PubMed: FASEB journal : official publication of the Federation of American Societies for Experimental Biology (1987)
Source url:
Exact phrase from label:
The boron supplementation reduced the total plasma concentration of calcium and the urinary excretions of calcium and magnesium, and elevated the serum concentrations of 17 beta-estradiol and testosterone.
Label source:
PubMed: Environmental health perspectives (1994)
Source url:
Exact phrase from label:
Although the mechanism of action has not been defined, it may be mediated by increasing the concentration of steroid hormones such as testosterone and beta-oestradiol.
Label source:
PubMed: Progress in food & nutrition science (1993)
Action type:
informational_none
Target id:
/intervention/vitamin-d
Target name:
Vitamin D
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Boron extends the half-life and increases the biological activity of Vitamin D, enhancing its effects on calcium metabolism and bone health.
Actionable advice:
Taking boron can improve the effectiveness of your Vitamin D supplementation; they can be taken at the same time.
Validation status:
validated_via_expert_review
Evidence tier:
tier_c
Evidence basis:
expert_review_verbatim
Evidence anchors:
Exact phrase from label:
Boron is not classified as an essential nutrient for humans because research has not yet identified a clear biological function for boron
Label source:
NIH ODS Health Professional Fact Sheet: Boron
Action type:
informational_none
Target id:
/biomarker/comprehensive-sex-hormone-panel
Target name:
Sex Hormone Panel (Testosterone, Estradiol, SHBG)
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Boron supplementation can physiologically alter hormone levels, notably increasing free testosterone and estradiol while decreasing Sex Hormone-Binding Globulin (SHBG). This is a true biological effect, not a direct chemical interference with the lab test.
Actionable advice:
It is a good idea to let a physician know about boron use when interpreting sex hormone lab results, as it can significantly alter them.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
Boron supplementation markedly elevated the serum concentrations of 17 beta-estradiol and testosterone; the elevation seemed more marked when dietary magnesium was low.
Label source:
PubMed: Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women. (PMID 3678698)
Action type:
monitor
Target id:
/intervention/magnesium
Target name:
Magnesium
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Boron reduces the urinary excretion of magnesium, which can help the body retain this essential mineral, supporting bone and metabolic health.
Actionable advice:
Consider taking boron and magnesium together to support overall mineral status.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
Boron supplementation markedly reduced the urinary excretion of calcium and magnesium; the depression seemed more marked when dietary magnesium was low.
Label source:
PubMed: Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women. (PMID 3678698)
Action type:
informational_none
Target id:
/biomarker/vitamin-d
Target name:
25-OH Vitamin D
Severity:
minor
Interaction type:
assay_interference
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
By increasing the half-life and activity of Vitamin D, boron supplementation may lead to higher measured levels of 25-hydroxyvitamin D in the blood.
Actionable advice:
Measured Vitamin D levels may be higher as a result of boron supplementation.
Validation status:
validated_via_pubmed
Evidence tier:
tier_b
Evidence basis:
pubmed_abstract_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
Pilot clinical studies suggest that this effect may be mediated, in whole or in part, by an increase in serum 25-hydroxyvitamin D. We propose that, in concentrations achievable with good diets, boron suppresses the activity of the microsomal enzyme 24-hydroxylase, chiefly responsible for catabolism of this steroid.
Label source:
PubMed: Medical hypotheses (2004)
Source url:
Exact phrase from label:
Dihydrotestosterone, cortisol and vitamin D was elevated.
Label source:
PubMed: Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) (2011)
Action type:
monitor