Meta Information
ID:chondroitin-sulfate
Name:
Schema Version:2.4_uniform_evidence_2026_06_18
Created
2026-05-21T22:30:00Z
Model
phase-a-upgrade-claude-sonnet-4.6
Interactions
Target id:
/class/anticoagulants-antiplatelets
Target name:
Anticoagulants and Antiplatelets
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Chondroitin sulfate is structurally similar to the anticoagulant heparin and may exert a mild blood-thinning effect, potentially increasing the risk of bleeding when combined with medications like warfarin, apixaban, or aspirin.
Actionable advice:
It is important to talk to a physician before combining, as dose adjustments or increased monitoring for bleeding may be required.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
We located one published case report of concomitant use of glucosamine-chondroitin sulfate potentiating the effect of warfarin.
Label source:
PubMed: Potential glucosamine-warfarin interaction resulting in increased international normalized ratio: case report and review of the literature and MedWatch database. (PMID 18363538)
Action type:
adjust_with_prescriber
Target id:
/intervention/glucosamine
Target name:
Glucosamine
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Glucosamine and chondroitin are thought to have complementary mechanisms for supporting cartilage health and are frequently and effectively used together in clinical studies for osteoarthritis.
Actionable advice:
Consider taking with glucosamine for potentially enhanced joint support benefits.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
Glucosamine and chondroitin (G&C), typically taken for joint pain, are among the most frequently used specialty supplements by US adults.
Label source:
PubMed: Modulation of Gut Microbiota by Glucosamine and Chondroitin in a Randomized, Double-Blind Pilot Trial in Humans. (PMID 31771179)
Action type:
informational_none
Target id:
/condition/asthma-copd
Target name:
Asthma
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
There are isolated case reports suggesting a possible link between combination glucosamine-chondroitin supplements and the worsening of asthma symptoms, although a direct causal relationship is not established.
Actionable advice:
If you have asthma, monitor your respiratory symptoms closely when starting this supplement and discontinue if they worsen.
Validation status:
validated_via_pubmed
Evidence tier:
tier_b
Evidence basis:
pubmed_abstract_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
A case of asthma exacerbated by the use of a glucosamine-chondroitin supplement for osteoarthritis pain is described.
Label source:
PubMed: The Journal of the American Board of Family Practice (2002)
Source url:
Exact phrase from label:
The biological link between both chondroitin and glucosamine and secretions from the respiratory tree of persons with asthma lends biologic plausibility to the hypothesis that the patient's asthmatic episode was related to the dietary substance.
Label source:
PubMed: The Journal of the American Board of Family Practice (2002)
Source url:
Exact phrase from label:
Glucosamine should be used with caution in patients who have shellfish allergies or asthma, and in those taking diabetes medications or warfarin.
Label source:
PubMed: American family physician (2008)
Action type:
avoid
Target id:
/condition/prostate-cancer
Target name:
Prostate Cancer
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Some preliminary in-vitro (laboratory) research suggested chondroitin could affect prostate cancer cells, but this has not been substantiated in human clinical trials or population studies.
Actionable advice:
If you have a history of prostate cancer, discuss using chondroitin with your oncologist, though the risk is considered theoretical.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
Consistent with versican being the active inhibitory factor in the CM, the integrity of chondroitin sulfate side chains and an ability to bind the RGD (Arg-Gly-Asp) peptide sequence of fibronectin were essential for the inhibition of prostate cancer cell attachment to fibronectin.
Label source:
PubMed: Modulation of prostate cancer cell attachment to matrix by versican. (PMID 12941795)
Action type:
informational_none
Target id:
/intervention/manganese-supplement
Target name:
Manganese Supplement
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Many chondroitin formulations include manganese as a cofactor for cartilage synthesis; combining these with other manganese sources can lead to excessive intake and potential neurotoxicity.
Actionable advice:
It is a good idea to check the supplement label for manganese; other manganese-containing supplements are best avoided unless directed by a healthcare provider.
Validation status:
unvalidatable
Evidence tier:
tier_e
Evidence basis:
unvalidatable
Evidence anchors:
Source url:
Scientific literature support not found
Exact phrase from label:
Label source:
Action type:
avoid
Target id:
/condition/shellfish-allergy
Target name:
Shellfish Allergy
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
While chondroitin is typically derived from bovine or porcine sources, it is often sold in combination with glucosamine, which is commonly derived from shellfish. The risk is low, but cross-contamination is a theoretical possibility.
Actionable advice:
If you have a severe shellfish allergy, verify the source of both chondroitin and glucosamine on the product label before use.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Exact phrase from label:
Chondroitin and glucosamine is a combination product that has been used in alternative medicine as a possibly effective aid in treating osteoarthritis pain.
Label source:
WebMD: Glucosamine and Chondroitin for Osteoarthritis
Action type:
informational_none