Meta Information
ID:chromium
Name:Chromium
Schema Version:2.4_uniform_evidence_2026_06_18
Created
2026-07-02T06:44:03Z
Model
phase-b-newfiles-claude-opus-4.8
Interactions
Target id:
/class/antidiabetic-medications
Target name:
Insulin and antidiabetic medications
Severity:
moderate
Interaction type:
adverse
Nature:
relative
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Chromium may increase insulin sensitivity and add to glucose-lowering medications, raising the risk of hypoglycemia.
Actionable advice:
Blood glucose should be monitored, and a prescriber may need to lower the diabetes medication dose.
Validation status:
validated_via_clinical_guidance
Evidence tier:
tier_b
Evidence basis:
clinical_guidance_verbatim
Evidence anchors:
Exact phrase from label:
chromium supplements might have an additive effect with metformin or other antidiabetes medications and thus might increase the risk of hypoglycemia.
Label source:
NIH ODS fact sheet
Action type:
monitor
Target id:
/intervention/levothyroxine
Target name:
Levothyroxine
Severity:
moderate
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
4
Hours after target:
4
Description:
Chromium picolinate taken with levothyroxine reduces thyroid-hormone absorption.
Actionable advice:
Chromium and levothyroxine should be separated by at least 3-4 hours.
Validation status:
validated_via_clinical_guidance
Evidence tier:
tier_b
Evidence basis:
clinical_guidance_verbatim
Evidence anchors:
Exact phrase from label:
A small study found that taking chromium picolinate supplements at the same time as levothyroxine (used to treat hypothyroidism) decreases levothyroxine absorption over 6 hours.
Label source:
NIH ODS fact sheet
Action type:
separate
Target id:
/class/nsaids
Target name:
NSAIDs
Severity:
minor
Interaction type:
adverse
Nature:
relative
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
NSAIDs may increase chromium absorption/retention, though clinical significance is unclear.
Actionable advice:
No specific action usually needed; be aware if taking both long-term. FLAG: not in the ODS fact sheet.
Validation status:
validated_via_class_inference
Evidence tier:
tier_c
Evidence basis:
class_inference_summary
Evidence anchors:
Source url:
Established mechanism / class pharmacology (no single primary source quoted)
Exact phrase from label:
NSAIDs may raise chromium levels via prostaglandin-mediated absorption effects; low-certainty, not in the NIH ODS chromium sheet.
Label source:
Class inference
Action type:
informational_none