Meta Information
ID:cinnamon-extract
Name:Cinnamon Extract
Schema Version:2.4_uniform_evidence_2026_06_18
Created
2026-07-02T07:03:07Z
Model
phase-b-newfiles-claude-opus-4.8
Interactions
Target id:
/condition/hepatic-impairment
Target name:
Liver (hepatotoxicity from coumarin)
Severity:
moderate
Interaction type:
adverse
Nature:
relative
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Cassia cinnamon contains coumarin, which in high amounts over time can injure the liver.
Actionable advice:
Standardized low-coumarin (Ceylon) cinnamon is best used, and high-dose cassia extracts are best avoided in those with liver disease.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
Cinnamon, an herbal extract containing alkaloids such as coumarin, has been implicated in herb-induced liver injury (HILI).
Label source:
Cureus (2025), PMID 41158894.
Action type:
monitor
Target id:
/class/antidiabetic-medications
Target name:
Antidiabetic medications
Severity:
moderate
Interaction type:
adverse
Nature:
relative
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Cinnamon lowers fasting glucose and HbA1c, adding to diabetes medications and risking hypoglycemia.
Actionable advice:
Blood glucose should be monitored, and diabetes medication may need adjustment.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
Cinnamon supplementation significantly reduced... fasting glucose... HbA1c... postprandial blood glucose
Label source:
Meta-analysis (2025), PMID 40611215.
Action type:
monitor
Target id:
/intervention/warfarin
Target name:
Warfarin
Severity:
moderate
Interaction type:
adverse
Nature:
relative
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
The coumarin in cassia cinnamon could theoretically add to warfarin's anticoagulant effect.
Actionable advice:
INR is best monitored if using high-dose cassia cinnamon with warfarin.
Validation status:
validated_via_class_inference
Evidence tier:
tier_c
Evidence basis:
class_inference_summary
Evidence anchors:
Source url:
Established mechanism / class pharmacology (no single primary source quoted)
Exact phrase from label:
Cassia cinnamon's coumarin content is theoretically additive with warfarin; monitor INR. Low-certainty.
Label source:
Class inference
Action type:
monitor