Meta Information
ID:dmso
Name:DMSO (Dimethyl Sulfoxide)
Schema Version:2.4_uniform_evidence_2026_06_18
Created
2026-07-02T07:35:59Z
Model
phase-b-topical-claude-opus-4.8
Interactions
Target id:
/class/topical-medications-general
Target name:
Any co-applied topical drug or chemical
Severity:
major
Interaction type:
adverse
Nature:
relative
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
DMSO is a potent penetration enhancer that carries co-applied substances through the skin, greatly increasing their absorption - and potentially the systemic exposure/toxicity of whatever is on the skin.
Actionable advice:
DMSO should not be applied over other topical products or on skin with chemical residues, as it can drive them into the bloodstream. It should be applied only to clean skin.
Validation status:
validated_via_class_inference
Evidence tier:
tier_c
Evidence basis:
class_inference_summary
Evidence anchors:
Source url:
Established mechanism / dermatologic practice (no single primary source quoted)
Exact phrase from label:
DMSO markedly enhances transdermal absorption of co-applied solutes, raising systemic exposure/toxicity risk. Well-established pharmacology.
Label source:
Class inference
Action type:
avoid
Target id:
/condition/pregnancy
Target name:
Pregnancy
Severity:
moderate
Interaction type:
adverse
Nature:
conditional
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
DMSO is systemically absorbed and its safety in pregnancy is not established.
Actionable advice:
DMSO is best avoided during pregnancy.
Validation status:
validated_via_class_inference
Evidence tier:
tier_c
Evidence basis:
class_inference_summary
Evidence anchors:
Source url:
Established mechanism / dermatologic practice (no single primary source quoted)
Exact phrase from label:
DMSO penetrates systemically (local+systemic scope); pregnancy safety unestablished. Precautionary.
Label source:
Class inference
Action type:
avoid
Target id:
/class/anticoagulants-antiplatelets
Target name:
Anticoagulants / antiplatelets
Severity:
minor
Interaction type:
adverse
Nature:
relative
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
DMSO has mild antiplatelet activity that could theoretically add to blood thinners.
Actionable advice:
Minor; be aware if using with anticoagulants/antiplatelets.
Validation status:
validated_via_class_inference
Evidence tier:
tier_c
Evidence basis:
class_inference_summary
Evidence anchors:
Source url:
Established mechanism / dermatologic practice (no single primary source quoted)
Exact phrase from label:
DMSO has mild antiplatelet effects; low-magnitude additive. Low-certainty.
Label source:
Class inference
Action type:
monitor