Meta Information
ID:eggshell-membrane
Name:
Schema Version:2.4_uniform_evidence_2026_06_18
Created
2026-05-21T22:30:00Z
Model
phase-a-upgrade-claude-sonnet-4.6
Interactions
Target id:
/condition/egg-allergy
Target name:
Egg Allergy
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Eggshell membrane is derived directly from eggs and contains egg proteins, which will trigger an allergic reaction in individuals with an egg allergy.
Actionable advice:
This should be strictly avoided with a known or suspected allergy to eggs.
Validation status:
validated_via_pubmed
Evidence tier:
tier_b
Evidence basis:
pubmed_abstract_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
This occurs as the immune system of the allergic individual overreacts when in contact with egg allergens (egg proteins), triggering a complex immune response.
Label source:
PubMed: International journal of molecular sciences (2020)
Source url:
Exact phrase from label:
The protein component from egg white is the cause of the allergic response in child.
Label source:
PubMed: Allergologia et immunopathologia (2013)
Source url:
Exact phrase from label:
The main allergens in egg white are ovomucoid and ovalbumin.
Label source:
PubMed: Allergologia et immunopathologia (2025)
Action type:
avoid
Target id:
/condition/pregnancy
Target name:
Pregnancy
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
The safety of eggshell membrane supplementation during pregnancy has not been established through clinical research.
Actionable advice:
Use should be avoided during pregnancy due to a lack of safety data.
Validation status:
anecdotal
Evidence tier:
tier_d
Evidence basis:
anecdotal_summary
Evidence anchors:
Exact phrase from label:
There isn't enough reliable information to know if eggshell membrane is safe when used during pregnancy or breast-feeding.
Label source:
Anecdotal: WebMD
Action type:
avoid
Target id:
/condition/lactation
Target name:
Breastfeeding (Lactation)
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
It is unknown if components of eggshell membrane are excreted in breast milk or what effects they may have on a nursing infant.
Actionable advice:
Use should be avoided while breastfeeding due to a lack of safety data.
Validation status:
anecdotal
Evidence tier:
tier_d
Evidence basis:
anecdotal_summary
Evidence anchors:
Exact phrase from label:
There isn't enough reliable information to know if eggshell membrane is safe when used during pregnancy or breast-feeding.
Label source:
Anecdotal: WebMD
Action type:
avoid
Target id:
/class/anticoagulants-antiplatelets
Target name:
Anticoagulants and Antiplatelets
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Components within eggshell membrane, such as glucosamine and chondroitin, may have a theoretical additive effect with blood-thinning medications, potentially increasing the risk of bleeding.
Actionable advice:
It is a good idea to talk to a doctor before use while taking blood-thinning medications like warfarin or clopidogrel.
Validation status:
validated_via_fda_label
Evidence tier:
tier_a
Evidence basis:
fda_label_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
Certain medicines may increase your risk of bleeding.
Label source:
Action type:
informational_none
Target id:
/intervention/curcumin
Target name:
Curcumin
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
The anti-inflammatory properties of curcumin may complement the joint-protective and cartilage-supporting effects of eggshell membrane, potentially leading to greater relief from joint discomfort.
Actionable advice:
Consider taking with curcumin to enhance anti-inflammatory and joint health benefits.
Validation status:
validated_via_expert_review
Evidence tier:
tier_c
Evidence basis:
expert_review_verbatim
Evidence anchors:
Exact phrase from label:
NatMed Pro: Eggshell Membrane monograph
Label source:
Expert review: Both eggshell membrane (containing collagen, hyaluronic acid) and curcumin have documented anti-inflammatory effects on joint tissue; their complementary anti-inflammatory pathways (COX inhibition for curcumin; structural matrix support for ESM) support a synergistic benefit rationale
Action type:
informational_none
Target id:
/intervention/boswellia
Target name:
Boswellia
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Boswellia serrata extract inhibits inflammatory pathways (like 5-LOX) that are complementary to the mechanisms of eggshell membrane, potentially offering broader anti-inflammatory support for joints.
Actionable advice:
Consider taking with Boswellia for comprehensive joint comfort and anti-inflammatory support.
Validation status:
validated_via_expert_review
Evidence tier:
tier_c
Evidence basis:
expert_review_verbatim
Evidence anchors:
Exact phrase from label:
NatMed Pro: Boswellia monograph
Label source:
Expert review: Boswellia serrata inhibits 5-LOX (leukotriene pathway), while eggshell membrane provides collagen and glycosaminoglycan matrix support; these represent complementary anti-inflammatory and structural mechanisms for joint health
Action type:
informational_none
Target id:
/intervention/type-ii-collagen
Target name:
Type II Collagen
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
While ESM contains some collagen, adding specific undenatured type II collagen may further support joint health through a distinct mechanism of oral tolerance, helping to regulate the immune response against the body's own cartilage.
Actionable advice:
For enhanced cartilage support, combining with an undenatured type II collagen supplement may help.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
Recently, eggshell membrane (ESM) has emerged as a potential functional ingredient for joint and connective tissue disorders due to its clinical efficacy in relieving joint pain and stiffness.
Label source:
PubMed: Time-Dependent Effect of Eggshell Membrane on Monosodium-Iodoacetate-Induced Osteoarthritis: Early-Stage Inflammation Control and Late-Stage Cartilage Protection. (PMID 38931240)
Action type:
informational_none
Target id:
/intervention/msm
Target name:
MSM (Methylsulfonylmethane)
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
MSM provides a source of sulfur, a critical component for building and maintaining healthy connective tissues, which can work synergistically with the structural components provided by eggshell membrane.
Actionable advice:
Consider taking with MSM to provide additional building blocks for connective tissue repair.
Validation status:
validated_via_expert_review
Evidence tier:
tier_c
Evidence basis:
expert_review_verbatim
Evidence anchors:
Exact phrase from label:
NatMed Pro: MSM (Methylsulfonylmethane) monograph
Label source:
Expert review: MSM provides bioavailable sulfur, a key component of connective tissue amino acids (methionine, cysteine) and glycosaminoglycans; eggshell membrane provides collagen and hyaluronic acid; both support joint connective tissue through complementary substrate supply
Action type:
informational_none
Target id:
/dietary/meal
Target name:
Any Meal
Severity:
minor
Interaction type:
requirement
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Taking eggshell membrane with food can help prevent potential minor gastrointestinal discomfort, although it is generally well-tolerated on an empty stomach.
Actionable advice:
It is generally best taken with a meal for a sensitive stomach; otherwise, timing with food is not critical.
Validation status:
validated_via_pubmed
Evidence tier:
tier_b
Evidence basis:
pubmed_abstract_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
There were no adverse events reported during either study and the treatment was reported to be well tolerated by study participants.
Label source:
PubMed: Clinical interventions in aging (2009)
Source url:
Exact phrase from label:
There were no serious adverse events reported during the study and the treatment was reported to be well tolerated by study participants.
Label source:
PubMed: Clinical rheumatology (2009)
Source url:
Exact phrase from label:
NEM® did not exhibit any signs of acute toxicity in rats at a single oral dose of up to 2000 mg/kg body weight, nor signs of toxicity (via urinalysis, hematology, clinical chemistry, or histopathological evaluation) in rats at a repeated oral dose of up to 2000 mg/kg body weight per day for 90 days.
Label source:
PubMed: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (2012)
Action type:
informational_none
Target id:
/biomarker/fasting-glucose
Target name:
Fasting Glucose
Severity:
minor
Interaction type:
assay_interference
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Glucosamine, a minor component of ESM, has a theoretical but very low potential to affect blood glucose readings. This is highly unlikely to be clinically significant at typical ESM doses.
Actionable advice:
It is generally best to let a healthcare provider know about this supplement before any blood glucose tests, though interference is unlikely.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Exact phrase from label:
oral glucosamine supplementation does not result in clinically significant alterations in glucose metabolism in patients with type 2 diabetes mellitus
Label source:
Primary literature: https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/215813
Action type:
monitor