Meta Information
ID:fenugreek-extract
Name:Fenugreek Extract
Schema Version:2.4_uniform_evidence_2026_06_18
Created
2026-07-02T07:03:07Z
Model
phase-b-newfiles-claude-opus-4.8
Interactions
Target id:
/class/antidiabetic-medications
Target name:
Antidiabetic medications
Severity:
moderate
Interaction type:
adverse
Nature:
relative
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Fenugreek stimulates insulin release and lowers blood glucose, adding to diabetes medications.
Actionable advice:
Blood glucose should be monitored, and diabetes medication may need adjustment.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
specific chemical elements might excite insulin release from the B-cells directly, resulting in a drop in blood glucose levels.
Label source:
Fenugreek review, PMID 40918167.
Action type:
monitor
Target id:
/class/acid-dependent-absorption-drugs
Target name:
Oral medications (absorption)
Severity:
minor
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
2
Description:
Fenugreek's mucilaginous fiber can bind substances in the gut and slow absorption of oral drugs.
Actionable advice:
Other oral medications and fenugreek are best separated by ~2 hours.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
Trigonella foenum-graecum seeds contain mucilaginous fiber, which will tie bile acids and lower fat absorption and cholesterol.
Label source:
Fenugreek review, PMID 40918167.
Action type:
separate
Target id:
/class/anticoagulants-antiplatelets
Target name:
Anticoagulants / antiplatelets
Severity:
minor
Interaction type:
adverse
Nature:
relative
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Fenugreek contains coumarin-like compounds and may have mild antiplatelet activity, theoretically adding to bleeding risk.
Actionable advice:
It is worth watching for bruising or bleeding if this is combined with blood thinners; the effect is usually minor.
Validation status:
validated_via_class_inference
Evidence tier:
tier_c
Evidence basis:
class_inference_summary
Evidence anchors:
Source url:
Established mechanism / class pharmacology (no single primary source quoted)
Exact phrase from label:
Fenugreek has coumarin-like constituents and mild antiplatelet activity; theoretically additive with anticoagulants/antiplatelets. Low-certainty.
Label source:
Class inference
Action type:
monitor