Meta Information
ID:glutathione
Name:Glutathione
Schema Version:2.4_uniform_evidence_2026_06_18
Created
2026-07-02T06:44:03Z
Model
phase-b-newfiles-claude-opus-4.8
Interactions
Target id:
/class/chemotherapy-radiation
Target name:
Chemotherapy / radiation (ROS-dependent)
Severity:
moderate
Interaction type:
diminishing
Nature:
relative
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
As an antioxidant, glutathione can mop up the reactive oxygen species that some chemotherapy and radiation rely on, potentially reducing their tumor-killing effect (timing-dependent).
Actionable advice:
Antioxidant glutathione is best avoided during chemo/radiation without the oncologist's approval.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
We investigated whether inhibiting glutathione could enhance the efficacy of 5-fluorouracil (5-FU) in colorectal cancer... increased ROS levels and reduced viability when combined with 5-FU.
Label source:
Europe PMC MED/41724798 (glutathione depletion enhances 5-FU). Supports that high glutathione opposes ROS-dependent chemotherapy.
Action type:
avoid
Target id:
/intervention/nac
Target name:
N-acetylcysteine (NAC)
Severity:
minor
Interaction type:
synergistic
Nature:
relative
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
NAC is a direct precursor to glutathione, so combining them is largely redundant for raising antioxidant levels.
Actionable advice:
No harm, but stacking both mainly overlaps; one is usually sufficient.
Validation status:
validated_via_class_inference
Evidence tier:
tier_c
Evidence basis:
class_inference_summary
Evidence anchors:
Source url:
Established mechanism / class pharmacology (no single primary source quoted)
Exact phrase from label:
NAC replenishes glutathione via cysteine donation; co-use is additive/redundant on antioxidant status.
Label source:
Class inference
Action type:
informational_none
Target id:
/condition/asthma
Target name:
Asthma / reactive airways (inhaled/nebulized)
Severity:
moderate
Interaction type:
adverse
Nature:
conditional
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Inhaled or nebulized thiol antioxidants can trigger bronchospasm in people with reactive airways.
Actionable advice:
Nebulized glutathione is best avoided by those with asthma unless supervised; oral use is not implicated.
Validation status:
validated_via_class_inference
Evidence tier:
tier_c
Evidence basis:
class_inference_summary
Evidence anchors:
Source url:
Established mechanism / class pharmacology (no single primary source quoted)
Exact phrase from label:
Nebulized thiols (e.g., NAC) can provoke bronchospasm in reactive airways; caution with inhaled glutathione. Oral/IV routes not implicated.
Label source:
Class inference
Action type:
avoid