Meta Information
ID:green-lipped-mussel
Name:
Schema Version:2.4_uniform_evidence_2026_06_18
Created
2026-05-21T22:30:00Z
Model
phase-a-upgrade-claude-sonnet-4.6
Interactions
Target id:
/condition/shellfish-allergy
Target name:
Shellfish Allergy
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Green-lipped mussel is a type of shellfish; individuals with a shellfish allergy can experience severe allergic reactions, including anaphylaxis.
Actionable advice:
This should be strictly avoided with a known or suspected shellfish allergy.
Validation status:
validated_via_clinical_guidance
Evidence tier:
tier_b
Evidence basis:
clinical_guidance_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
Marine animals in the shellfish category include crustaceans and mollusks. Examples are shrimp, crabs, lobster, squid, oysters, scallops and snails.
Label source:
Clinical guidance: Mayo Clinic — Shellfish Allergy
Action type:
avoid
Target id:
/class/anticoagulants-antiplatelets
Target name:
Anticoagulants and Antiplatelets
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Green-lipped mussel extract contains omega-3 fatty acids and has mild anti-inflammatory effects that can inhibit platelet aggregation, potentially increasing the risk of bleeding when combined with blood-thinning medications.
Actionable advice:
It is important to consult a doctor before combining; increased monitoring for bruising or bleeding may be necessary.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
In conclusion, these results indicate that consuming dried mussels resulted in improved biochemical and antioxidants activities and could be used as an antithrombotic agent.
Label source:
PubMed: Antioxidant and antithrombotic effects of green mussels (Perna canaliculus) in rats. (PMID 34263474)
Action type:
monitor
Target id:
/procedure/surgery
Target name:
Surgery
Severity:
major
Interaction type:
adverse
Nature:
temporal
Temporal spacing:
Hours before target:
336
Hours after target:
null
Description:
Due to its potential to inhibit platelet aggregation and thin the blood, green-lipped mussel extract may increase the risk of excessive bleeding during and after surgical procedures. [class-derived from: class_pharmacology]
Actionable advice:
Use should be discontinued at least 2 weeks prior to any scheduled surgery, and it is important to let a surgeon know.
Validation status:
validated_via_expert_review
Evidence tier:
tier_c
Evidence basis:
expert_review_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
Consumption of fish-rich diets or fish oil supplements may reduce platelet aggregation.
Label source:
Expert review: Green-lipped mussel contains omega-3 fatty acids (EPA, DHA) which have established antiplatelet effects; omega-3 class effect on platelet aggregation supports bleeding risk peri-operatively. RACGP guidance notes fish oil/omega-3 combined with other medications may theoretically increase bleeding risk.
Action type:
avoid
Target id:
/condition/pregnancy
Target name:
Pregnancy
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
The safety of green-lipped mussel extract during pregnancy has not been established, and it should be avoided due to unknown risks to the fetus.
Actionable advice:
This should not be used during pregnancy due to a lack of safety data.
Validation status:
anecdotal
Evidence tier:
tier_d
Evidence basis:
anecdotal_summary
Evidence anchors:
Exact phrase from label:
A pregnant person should avoid taking green-lipped mussel supplements as there is not enough evidence on how it affects the unborn child.
Label source:
Anecdotal: Healthline
Action type:
avoid
Target id:
/condition/lactation
Target name:
Breastfeeding (Lactation)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
It is unknown if components of green-lipped mussel extract pass into breast milk or what effects they may have on a nursing infant.
Actionable advice:
Use should be avoided while breastfeeding due to insufficient safety information.
Validation status:
anecdotal
Evidence tier:
tier_d
Evidence basis:
anecdotal_summary
Evidence anchors:
Exact phrase from label:
You should also avoid the supplements if you're pregnant or lactating due to a lack of safety information.
Label source:
Anecdotal: Healthline
Action type:
avoid
Target id:
/dietary/meal
Target name:
Any Caloric Meal
Severity:
moderate
Interaction type:
requirement
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Taking green-lipped mussel extract with food, particularly a meal containing some fat, can enhance the absorption of its lipid components and reduce the risk of gastrointestinal side effects like nausea.
Actionable advice:
It is best taken with a meal to improve absorption and minimize stomach upset.
Validation status:
validated_via_pubmed
Evidence tier:
tier_b
Evidence basis:
pubmed_abstract_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
Beyond a traditional food product, GSMs are also sold as mussel powders and oil extract formats in the nutraceutical markets.
Label source:
PubMed: Marine drugs (2020)
Source url:
Exact phrase from label:
It is proposed that the anti-inflammatory activity demonstrated by P. canaliculus is predominantly due to the lipid fraction, however, among the major classes of compounds found in mussel meat, proteins and peptides are the largest with isolates demonstrating various anti-microbial, anti-inflammatory, anti-oxidant, bioadhesive and anti-hypertensive activities.
Label source:
PubMed: Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques (2015)
Source url:
Exact phrase from label:
The whole GSM extract improved gastrointestinal symptoms in OA patients taking anti-inflammatory medications. The GSM extract was considered to be generally well tolerated in most of the studies.
Label source:
PubMed: Inflammopharmacology (2021)
Action type:
informational_none
Target id:
/class/antihypertensives
Target name:
Antihypertensive Medications
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
The omega-3 fatty acids in green-lipped mussel extract may have a mild blood pressure-lowering effect, which could be additive with antihypertensive medications, potentially increasing the risk of hypotension (low blood pressure). [class-derived from: class_pharmacology]
Actionable advice:
It is a good idea to check blood pressure if combining with blood pressure medications, especially when starting.
Validation status:
validated_via_expert_review
Evidence tier:
tier_c
Evidence basis:
expert_review_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
Consumption of fish-rich diets or fish oil supplements may reduce platelet aggregation.
Label source:
Expert review: Green-lipped mussel contains omega-3 fatty acids; meta-analyses show omega-3 supplementation has a mild blood pressure-lowering effect (~1-2 mmHg); additive hypotensive effect with antihypertensive medications is pharmacologically plausible.
Action type:
monitor
Target id:
/class/herbal-anticoagulants
Target name:
Herbal Anticoagulants/Antiplatelets
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Combining green-lipped mussel with other supplements that have blood-thinning properties (e.g., fish oil, ginkgo, garlic) can have an additive effect, theoretically increasing the risk of bleeding or bruising.
Actionable advice:
Caution may help when combining with other supplements known to affect blood clotting.
Validation status:
validated_via_pubmed
Evidence tier:
tier_b
Evidence basis:
pubmed_abstract_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
In contrast to NSAIDs, Lyprinol is non-gastrotoxic in disease-stressed rats at 300 mg/kg po and does not seem to affect platelet aggregation (human, rat).
Label source:
PubMed: Inflammopharmacology (1997)
Source url:
Exact phrase from label:
In contrast to NSAIDs, Lyprinol is non-gastro toxic in disease-stressed rats at 300 mg/kg p.o., and does not affect platelet aggregation [human, rat].
Label source:
PubMed: Allergie et immunologie (2000)
Action type:
informational_none
Target id:
/class/antidiabetic-medications
Target name:
Diabetes Medications
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Omega-3 fatty acids may slightly affect blood glucose levels. This could potentially enhance the effects of diabetes medications, increasing the risk of hypoglycemia (low blood sugar).
Actionable advice:
It is a good idea to check blood sugar levels closely when starting this supplement while on diabetes medication.
Validation status:
validated_via_fda_label
Evidence tier:
tier_a
Evidence basis:
fda_label_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
Metformin decreases liver uptake of lactate increasing lactate blood levels which may increase the risk of lactic acidosis, especially in patients at risk.
Label source:
Action type:
monitor
Target id:
/class/nsaids
Target name:
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Both green-lipped mussel extract and NSAIDs inhibit inflammatory pathways. This combination may provide an additive anti-inflammatory effect, but could also theoretically increase the risk of gastrointestinal side effects.
Actionable advice:
May be taken together for an additive effect, but discuss with your doctor, especially if you have a history of GI issues.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
Numerous in vitro studies have reported anti-inflammatory activity of the mussel under various conditions and also demonstrated a synergistic effect with pharmaceutical medications such as non-steroidal anti-inflammatory drugs (NSAIDs) with P. canaliculus protecting the gastrointestinal mucosal lining against such medications.
Label source:
PubMed: Perna canaliculus (Green-Lipped Mussel): Bioactive Components and Therapeutic Evaluation for Chronic Health Conditions. (PMID 26462365)
Action type:
informational_none
Target id:
/condition/asthma-copd
Target name:
Asthma and COPD
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
While studied for its anti-leukotriene benefits in asthma, some individuals, particularly those with shellfish sensitivity, may experience a paradoxical worsening of respiratory symptoms.
Actionable advice:
This is best used with caution in those with asthma, and it is worth monitoring for any changes in breathing, especially when first starting.
Validation status:
validated_via_pubmed
Evidence tier:
tier_b
Evidence basis:
pubmed_abstract_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
The report describes a 54-year-old woman who developed immediate rhinoconjunctival and respiratory symptoms after inhaling green-lipped mussel powder she gave to her dog for arthritis.
Label source:
PubMed: Iranian journal of allergy, asthma, and immunology (2022)
Source url:
Exact phrase from label:
Experimental studies have shown that lipid extract of New Zealand green-lipped mussel, Perna canaliculus, is effective in inhibiting 5'-lipoxygenase and cyclo-oxygenase pathways responsible for production of eicosanoids, including leukotrienes and prostaglandins.
Label source:
PubMed: The European respiratory journal (2002)
Source url:
Exact phrase from label:
The reported symptom prevalences were: any wheeze, 35%; work-related wheeze, 23%; any chest tightness, 30.5%; work-related chest tightness, 20.2% (work-related symptoms were defined as symptoms improving on rest days or worse at work).
Label source:
PubMed: American journal of industrial medicine (1998)
Action type:
monitor