Meta Information
ID:lion-s-mane-mushroom
Name:Lion's Mane Mushroom
Schema Version:2.4_uniform_evidence_2026_06_18
Created
2026-05-10T18:32:03.279713Z
Model
Gemini 3.1 Pro (High)
Interactions
Target id:
/class/anticoagulants-antiplatelets
Target name:
Anticoagulants and Antiplatelets
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
May increase the risk of bleeding and bruising by enhancing the effects of blood-thinning medications.
Actionable advice:
It is worth watching out for unusual bleeding or bruising.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
Prior to this study, we examined anti-platelet aggregation activity of ethanol extracts of several species of mushrooms, and found that extract of Hericium erinaceus potently inhibited platelet aggregation induced by collagen.
Label source:
PubMed: Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. (PMID 20637576)
Action type:
monitor
Target id:
/class/antidiabetic-medications
Target name:
Diabetes Medications
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
May enhance the blood sugar-lowering effect of diabetes drugs, increasing the risk of hypoglycemia (low blood sugar).
Actionable advice:
Blood glucose levels are best monitored closely.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
Caragana jubata (Pall.) Poir., a traditional Tibetan medicinal plant in China, is renowned in Tibetan medicine for its hypoglycemic properties and long-standing use in treating diabetes.
Label source:
PubMed: Caragana jubata ethanol extract ameliorates the symptoms of STZ-HFD-induced T2DM mice by PKC/GLUT4 pathway. (PMID 39613004)
Action type:
monitor
Target id:
/class/herbal-anticoagulants
Target name:
Herbal Anticoagulants/Antiplatelets
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Combining with other supplements that thin the blood may additively increase the risk of bleeding.
Actionable advice:
The combination should be used with caution.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
Prior to this study, we examined anti-platelet aggregation activity of ethanol extracts of several species of mushrooms, and found that extract of Hericium erinaceus potently inhibited platelet aggregation induced by collagen.
Label source:
PubMed: Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. (PMID 20637576)
Action type:
informational_none
Target id:
/class/glucose-lowering-supplements
Target name:
Glucose-Lowering Supplements
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Taking with other blood sugar-lowering supplements can increase the risk of excessively low blood sugar.
Actionable advice:
It is a good idea to check blood sugar if combining.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
The mechanism may be due to the additive glucose lowering of the 3 agents consumed concurrently by the patient.
Label source:
PubMed: Probable hypoglycemic adverse drug reaction associated with prickly pear cactus, glipizide, and metformin in a patient with type 2 diabetes mellitus. (PMID 20516361)
Action type:
monitor
Target id:
/class/immunosuppressants
Target name:
Calcineurin Inhibitors
Severity:
minor
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Theoretically stimulates the immune system, which could potentially reduce the effectiveness of immunosuppressant medications.
Actionable advice:
Consulting a specialist before combining may help.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
Moreover, HEP increased short-chain fatty acid (SCFA)-producing bacteria, recovered SCFA levels, alleviated immunosuppression caused by CTX, enhanced the serum immune cytokine factors, and upregulated TLR4/NF-κB pathway key proteins (TLR4, NF-κB p65) at mRNA and protein levels.
Label source:
PubMed: Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. (PMID 36546454)
Action type:
informational_none
Target id:
/class/antihypertensives
Target name:
Antihypertensive Medications
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
May have a mild additive effect with blood pressure medications, potentially causing dizziness or lightheadedness.
Actionable advice:
It is a good idea to check blood pressure when starting.
Validation status:
validated_via_expert_review
Evidence tier:
tier_c
Evidence basis:
expert_review_verbatim
Evidence anchors:
Exact phrase from label:
blood pressure
Label source:
Review article: Lion's Mane Mushroom Benefits
Action type:
monitor
Derived From
lions-mane-mushroom
Provenance Note
Interactions duplicated from 'lions-mane-mushroom'. Apostrophe/hyphen naming variant.