Meta Information
ID:low-dose-aspirin
Name:Low-Dose Aspirin (81 mg)
Schema Version:2.4_uniform_evidence_2026_06_18
Created
2026-07-02T06:42:51Z
Model
phase-b-newfiles-claude-opus-4.8
Interactions
Target id:
/class/anticoagulants-antiplatelets
Target name:
Anticoagulants (warfarin, DOACs, heparin) and other antiplatelets
Severity:
major
Interaction type:
adverse
Nature:
relative
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Combining low-dose aspirin with anticoagulants or other antiplatelets substantially increases bleeding risk.
Actionable advice:
These should be combined only if a clinician has judged the benefit worth it; it is worth watching out for bruising, black stools, or unusual bleeding.
Validation status:
validated_via_fda_label
Evidence tier:
tier_a
Evidence basis:
fda_label_verbatim
Evidence anchors:
Exact phrase from label:
Aspirin can displace warfarin from protein binding sites, leading to prolongation of both the prothrombin time and the bleeding time. Aspirin can increase the anticoagulant activity of heparin, increasing bleeding risk.
Label source:
fda_label
Action type:
monitor
Target id:
/intervention/ibuprofen
Target name:
Ibuprofen (and other NSAIDs)
Severity:
moderate
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
0.5
Hours after target:
8
Description:
Ibuprofen can block aspirin's access to platelets, blunting its heart-protective antiplatelet effect (and adding GI bleed risk).
Actionable advice:
If you take immediate-release aspirin, take it at least 30-60 min before ibuprofen, or wait 8 hours after ibuprofen before aspirin.
Validation status:
validated_via_fda_label
Evidence tier:
tier_a
Evidence basis:
fda_label_verbatim
Evidence anchors:
Exact phrase from label:
Ibuprofen can interfere with the anti-platelet effect of low dose aspirin. Patients who use DURLAZA and take a single dose of ibuprofen 400 mg should dose the ibuprofen at least 2-4 hours or longer after ingestion of DURLAZA.
Label source:
fda_label
Action type:
separate
Target id:
/class/corticosteroids
Target name:
Corticosteroids
Severity:
moderate
Interaction type:
adverse
Nature:
relative
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Corticosteroids add to aspirin's risk of stomach ulceration and bleeding.
Actionable advice:
Gastroprotection is a good idea, and it is worth watching for GI bleeding if these are combined; it is important to discuss this with a prescriber.
Validation status:
validated_via_fda_label
Evidence tier:
tier_a
Evidence basis:
fda_label_verbatim
Evidence anchors:
Exact phrase from label:
This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you... take a blood thinning (anticoagulant) or steroid drug.
Label source:
fda_label
Action type:
monitor
Target id:
/condition/gout
Target name:
Gout / uricosuric therapy
Severity:
moderate
Interaction type:
diminishing
Nature:
relative
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Low-dose aspirin reduces uric-acid excretion and blunts uricosuric drugs like probenecid.
Actionable advice:
It is worth being aware that low-dose aspirin can slightly worsen gout control; discussing alternatives is a good idea for those with gout.
Validation status:
validated_via_fda_label
Evidence tier:
tier_a
Evidence basis:
fda_label_verbatim
Evidence anchors:
Exact phrase from label:
Salicylates antagonize the uricosuric action of probenecid or sulfinpyrazone.
Label source:
fda_label
Action type:
informational_none
Target id:
/class/serotonergic-agents
Target name:
SSRIs / SNRIs
Severity:
moderate
Interaction type:
adverse
Nature:
relative
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
SSRIs reduce platelet serotonin and add to aspirin's bleeding risk, especially GI bleeding.
Actionable advice:
It is worth watching for bruising or GI bleeding, and gastroprotection may be worth considering when these are combined long-term.
Validation status:
validated_via_class_inference
Evidence tier:
tier_c
Evidence basis:
class_inference_summary
Evidence anchors:
Source url:
Established mechanism / class pharmacology (no single primary source quoted)
Exact phrase from label:
SSRIs deplete platelet serotonin, impairing platelet aggregation; combined with aspirin this raises bleeding (esp. GI) risk. Well-established; not stated verbatim in aspirin labels.
Label source:
Class inference
Action type:
monitor
Target id:
/class/herbal-anticoagulants
Target name:
Fish oil, ginkgo, garlic (antiplatelet supplements)
Severity:
minor
Interaction type:
adverse
Nature:
relative
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
High-dose fish oil, ginkgo, and garlic have mild antiplatelet effects that can add to aspirin's bleeding risk.
Actionable advice:
Usually minor; be alert for easy bruising if stacking several blood-thinning supplements with aspirin.
Validation status:
validated_via_class_inference
Evidence tier:
tier_c
Evidence basis:
class_inference_summary
Evidence anchors:
Source url:
Established mechanism / class pharmacology (no single primary source quoted)
Exact phrase from label:
These supplements have mild antiplatelet activity; additive with aspirin. Low-magnitude, mechanistic.
Label source:
Class inference
Action type:
monitor