Colchicine is a potent anti-inflammatory drug that inhibits the NLRP3 inflammasome, a key pathway in age-related chronic inflammation ('inflammaging'). By reducing this low-grade inflammation, it has been shown in large clinical trials to significantly lower the risk of major adverse cardiovascular events like heart attacks and strokes.
Verdict
A proven tool for reducing cardiovascular risk via inflammation modulation.
HEALTHSPAN IMPACT
High Value
RISK LEVEL
Moderate
EVIDENCE GRADE
A
MONTHLY COST
$20 - $60
Protocol
- A typical protocol involves taking a 0.5 mg tablet once daily.
Flags
- Common side effects include diarrhea, nausea, and abdominal cramping.
- Overdose is extremely toxic and can be fatal.
- Contraindicated in patients with severe kidney or liver disease.