Meta Information
ID:magnesium-liposomal
Name:
Schema Version:2.4_uniform_evidence_2026_06_18
Created
2026-05-21T22:30:00Z
Model
phase-a-upgrade-claude-sonnet-4.6
Interactions
Target id:
/condition/renal-impairment
Target name:
Renal Impairment (Kidney Disease)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Individuals with impaired kidney function cannot effectively clear magnesium from the body, leading to a high risk of toxic accumulation (hypermagnesemia).
Actionable advice:
Magnesium supplements should not be used unless specifically prescribed and monitored by a physician.
Validation status:
validated_via_pubmed
Evidence tier:
tier_b
Evidence basis:
pubmed_abstract_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
Severe symptomatic hypermagnesemia is a rare clinical problem that predominantly results from excess exogenous magnesium intake in patients with renal failure.
Label source:
PubMed: Clinical nephrology (2000)
Source url:
Exact phrase from label:
However, in more advanced CKD (as creatinine clearance falls <30 mL/min), this compensatory mechanism becomes inadequate such that overt hypermagnesaemia develops frequently in patients with creatinine clearances <10 mL/min.
Label source:
PubMed: Clinical kidney journal (2012)
Source url:
Exact phrase from label:
According to the Pharmaceuticals and Medical Devices Agency (PMDA), patients who have been taking magnesium oxide (MgO) for constipation over a prolonged period, especially those with impaired renal function and older individuals, are at high risk of hypermagnesemia.
Label source:
PubMed: Magnesium research (2023)
Action type:
avoid
Target id:
/class/chelating-antibiotics
Target name:
Chelating Antibiotics (Tetracyclines, Quinolones)
Severity:
major
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
6
Description:
Magnesium binds to these antibiotics in the gut, forming a non-absorbable complex, which significantly reduces the effectiveness of the antibiotic.
Actionable advice:
Magnesium should be taken at least 2 hours before or 6 hours after these antibiotics.
Validation status:
validated_via_pubmed
Evidence tier:
tier_b
Evidence basis:
pubmed_abstract_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
magnesium, calcium, and zinc can interfere with the gastrointestinal absorption of tetracycline antibiotics
Label source:
PubMed: International journal of molecular sciences (2019)
Source url:
Exact phrase from label:
when administered orally, reduced absorption and bioavailability can occur due to chelation in the gastrointestinal tract (GIT) with multivalent metal cations acquired from diet, coadministered compounds (sucralfate, didanosine), or drug formulation.
Label source:
PubMed: Pharmaceutics (2021)
Source url:
Exact phrase from label:
Absorption of all quinolones from the stomach and small intestine is greatly reduced by antacids containing magnesium or aluminium salts, including sucralfate, probably as a result of the formation of nonabsorbable chelates.
Label source:
PubMed: Reviews of infectious diseases (1989)
Action type:
separate
Target id:
/intervention/bisphosphonates
Target name:
Bisphosphonates
Severity:
major
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
2
Description:
Magnesium can bind to bisphosphonates in the gastrointestinal tract, significantly reducing their absorption and effectiveness for bone health.
Actionable advice:
Magnesium and bisphosphonate doses should be separated by at least 2 hours.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
It has a strong chelating property to bind or, to some extent, counteract the effects of substances, such as magnesium, calcium citrate, ferrous fumarate, carbonyl iron, as well as the zinc gluconate, sulfate and acetate salts.
Label source:
PubMed: In vivo lung deposition and sub-acute inhalation toxicity studies of nano-sized alendronate sodium as an antidote for inhaled toxic substances in Sprague Dawley rats. (PMID 23851119)
Action type:
separate
Target id:
/condition/myasthenia-gravis
Target name:
Myasthenia Gravis
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Magnesium can inhibit neuromuscular transmission, which may worsen muscle weakness in individuals with myasthenia gravis.
Actionable advice:
Magnesium can worsen muscle weakness in myasthenia gravis. Avoid supplemental magnesium unless your neurologist specifically approves it.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
This case highlights the importance of all members of the team being aware of the drugs that can induce a myasthenic crisis.
Label source:
PubMed: Intravenous magnesium sulfate inducing acute respiratory failure in a patient with myasthenia gravis. (PMID 35738845)
Action type:
avoid
Target id:
/condition/heart-block
Target name:
Heart Block
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
High levels of magnesium can slow electrical conduction in the heart, potentially exacerbating pre-existing heart block.
Actionable advice:
Magnesium supplementation should not be used by those with a heart block, unless directed by a cardiologist.
Validation status:
validated_via_pubmed
Evidence tier:
tier_b
Evidence basis:
pubmed_abstract_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
It has diverse electrophysiological actions on the conduction system of the heart; including prolonging sinus node recovery time, and reducing automaticity, atrioventricular nodal conduction, antegrade and retrograde conduction over an accessory pathway, and His-ventricular conduction.
Label source:
PubMed: Magnesium research (2008)
Source url:
Exact phrase from label:
Magnesium is a crucial mineral involved in various physiological functions, such as neuromuscular conduction, cardiac excitability, vasomotor tone, insulin metabolism, and muscular contraction.
Label source:
PubMed: Medicina (Kaunas, Lithuania) (2023)
Source url:
Exact phrase from label:
Changes in extracellular potassium, calcium, and magnesium levels can change myocyte membrane potential gradients and alter the cardiac action potential.
Label source:
PubMed: The Journal of emergency medicine (2004)
Action type:
avoid
Target id:
/intervention/levothyroxine
Target name:
Levothyroxine
Severity:
moderate
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
4
Hours after target:
4
Description:
Magnesium can reduce the absorption of levothyroxine from the gut, potentially leading to inadequate thyroid hormone levels.
Actionable advice:
Magnesium and levothyroxine doses should be separated by at least 4 hours.
Validation status:
validated_via_fda_label
Evidence tier:
tier_a
Evidence basis:
fda_label_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
Sucralfate, antacids and Antacids proton pump inhibitors may cause hypochlorhydria, affect (e.g., aluminum & magnesium intragastric pH, and reduce levothyroxine absorption.
Label source:
FDA label: Levothyroxine (Synthroid)
Action type:
separate
Target id:
/intervention/calcium-supplements
Target name:
Calcium Supplements
Severity:
moderate
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
2
Description:
High doses of calcium and magnesium compete for the same absorption pathways in the gut, which can reduce the absorption of both minerals.
Actionable advice:
High-dose calcium and magnesium supplements should be separated by at least 2 hours.
Validation status:
validated_via_pubmed
Evidence tier:
tier_b
Evidence basis:
pubmed_abstract_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
CONCLUSION: The increased Mg intake of 826 mg did not affect intestinal Ca absorption determined with tracer doses of 47Ca during Ca intakes of 241 and 812 mg/day.
Label source:
PubMed: Journal of the American College of Nutrition (1994)
Source url:
Exact phrase from label:
Intestinal interactions between Mg and calcium or phosphate have been demonstrated in both humans and animals. The nature of these interactions cannot be readily explained by data currently available.
Label source:
PubMed: The Journal of nutrition (1991)
Source url:
Exact phrase from label:
In the uptake medium (extracellular), magnesium was a noncompetitive inhibitor of saturable calcium transport, consistent with a regulatory role in calcium uptake by binding to the transporter at a locus other than that for calcium.
Label source:
PubMed: The American journal of physiology (1989)
Action type:
separate
Target id:
/class/proton-pump-inhibitors
Target name:
Proton Pump Inhibitors (PPIs)
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Long-term use of PPIs can impair the active transport of magnesium in the intestines, leading to low magnesium levels (hypomagnesemia).
Actionable advice:
If on long-term PPI therapy, regularly monitor magnesium levels.
Validation status:
validated_via_pubmed
Evidence tier:
tier_b
Evidence basis:
pubmed_abstract_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
Clinical reports demonstrate that urinary Mg2+ excretion is low in PPI users with hypomagnesemia, suggesting a compensatory mechanism by the kidney for malabsorption of Mg2+ in the intestines. However, the exact mechanism by which PPIs cause impaired Mg2+ absorption is still unknown.
Label source:
PubMed: Acta physiologica (Oxford, England) (2022)
Source url:
Exact phrase from label:
A large body of observational data has linked chronic PPI use with hypomagnesemia, presumably due to decreased intestinal absorption and consequent magnesium deficiency.
Label source:
PubMed: Journal of clinical pharmacology (2016)
Source url:
Exact phrase from label:
Renal magnesium handling is normal, so implicating impairment of net intestinal absorption as the proximate cause. It is not known whether this is the consequence of defective absorption of magnesium through the active or passive transport processes, or increased losses.
Label source:
PubMed: Current opinion in gastroenterology (2011)
Action type:
monitor
Target id:
/class/loop-diuretics
Target name:
Loop Diuretics (e.g., Furosemide)
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Loop diuretics increase the amount of magnesium lost through urine, which can lead to magnesium deficiency over time.
Actionable advice:
If taking loop diuretics, monitor magnesium levels and consider supplementation as advised by a doctor.
Validation status:
validated_via_pubmed
Evidence tier:
tier_b
Evidence basis:
pubmed_abstract_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
Loop-blocking diuretics, however, cause major urinary losses of Mg. The Mg-wasting effects of loop-blocking diuretics have been demonstrated in large numbers of experimental and clinical studies, and the findings are consistent with micropuncture studies in laboratory animals which indicate the loop of Henle as the major site of Mg reabsorption.
Label source:
PubMed: Magnesium (1986)
Source url:
Exact phrase from label:
Loop diuretics cause hypermagnesiuria mainly through direct blockade of magnesium reabsorption at the loop of Henle.
Label source:
PubMed: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde (1983)
Source url:
Exact phrase from label:
Loop diuretics such as furosemide increase magnesium excretion by virtue of its effects on the transepithelial voltage thereby inhibiting passive magnesium absorption.
Label source:
PubMed: Kidney international (1997)
Action type:
monitor
Target id:
/class/potassium-sparing-diuretics
Target name:
Potassium-Sparing Diuretics
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
These diuretics reduce the excretion of magnesium by the kidneys, increasing the risk of dangerously high magnesium levels (hypermagnesemia) when taking supplements.
Actionable advice:
High-dose magnesium supplements are best avoided, and it is important to talk to a doctor before use.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
Considering the challenges associated with intravenous magnesium use and even with the supplementation of oral forms, there is a need for drugs that effectively reduce urinary magnesium excretion. Amiloride and sodium-glucose cotransporter 2 inhibitors (SGLT2 inhibitors) have emerged as potential candidates.
Label source:
PubMed: The Use of Amiloride and Sodium-Glucose Cotransporter 2 Inhibitors in Cisplatin-Induced Hypomagnesemia: A Case Report and Review of the Literature. (PMID 39022464)
Action type:
avoid
Target id:
/intervention/vitamin-d
Target name:
Vitamin D
Severity:
moderate
Interaction type:
requirement
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Adequate vitamin D levels are necessary for the efficient absorption of magnesium from the intestines and for its function within the body.
Actionable advice:
Sufficient vitamin D status is a good idea for optimal magnesium utilization.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
Magnesium and vitamin D are closely linked-vitamin D aids magnesium absorption, while magnesium is vital for vitamin D synthesis, transport, and activation.
Label source:
PubMed: The Importance of Vitamin D and Magnesium in Athletes. (PMID 40431395)
Action type:
informational_none
Target id:
/circadian/sleep
Target name:
Going to Sleep
Severity:
moderate
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
1
Hours after target:
null
Description:
Magnesium can promote relaxation and may improve sleep quality by regulating neurotransmitters and activating the parasympathetic nervous system.
Actionable advice:
Magnesium is best taken 30-60 minutes before bedtime to support sleep.
Validation status:
validated_via_pubmed
Evidence tier:
tier_b
Evidence basis:
pubmed_abstract_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
Magnesium not only reduces the excitability of the nervous system and alters muscle relaxation but also regulates cellular biological clocks, energy balance, and circadian rhythms, playing a crucial role in sleep regulation.
Label source:
PubMed: Nature and science of sleep (2025)
Source url:
Exact phrase from label:
The natural N-methyl-D-aspartic acid (NMDA) antagonist and GABA agonist, Mg(2+), seems to play a key role in the regulation of sleep.
Label source:
PubMed: Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences (2012)
Source url:
Exact phrase from label:
In the group with daily supplementation of 400 mg of magnesium, HRV parameters clearly increased: pNN50 - an indicator of parasympathetic activity - increased. LF-HF ratio as well as stress index - low values for each represent a good balance of the vegetative nervous system - decreased.
Label source:
PubMed: MMW Fortschritte der Medizin (2016)
Action type:
separate
Target id:
/dietary/meal
Target name:
Any Caloric Meal
Severity:
minor
Interaction type:
informational
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Taking magnesium with food can improve gastrointestinal tolerance and reduce the risk of diarrhea, a common side effect of some forms.
Actionable advice:
Magnesium is generally best taken with a meal to minimize stomach upset.
Validation status:
validated_via_pubmed
Evidence tier:
tier_b
Evidence basis:
pubmed_abstract_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
Our study also showed that, compared to the other Mg sources tested, the Mg-MS microencapsulation technology reduced adverse side effects commonly associated with Mg supplementation, specifically with regard to increased intestinal motility and sensations of gastric heaviness following oral administration.
Label source:
PubMed: Nutrients (2024)
Source url:
Exact phrase from label:
In 1997, the US Institute of Medicine (IOM) dietary reference intakes (DRI) Committee established a magnesium (Mg) tolerable upper intake level (UL) for adults of 350 mg/d from supplemental intake alone. Diarrhea was the limiting factor.
Label source:
PubMed: Advances in nutrition (Bethesda, Md.) (2023)
Source url:
Exact phrase from label:
Magnesium bioavailability from mineral water is enhanced when the water is consumed with a meal, perhaps because of a slower gastrointestinal transit time, the presence of digestion products from the meal, or both.
Label source:
PubMed: The American journal of clinical nutrition (2002)
Action type:
informational_none
Target id:
/intervention/zinc
Target name:
Zinc Supplements (High Dose)
Severity:
minor
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
2
Description:
Very high doses of zinc (over 50 mg elemental) can interfere with magnesium absorption due to competition for transport pathways.
Actionable advice:
High-dose zinc supplements and magnesium are best separated by at least 2 hours.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
OBJECTIVE: Both zinc (Zn) and magnesium (Mg) are widely used as nutritional supplements and the possibility was considered that Zn may interfere with the absorption of Mg, similar to previously reported results [1,2] obtained with the same dose of supplemental Zn on the absorption of calcium (Ca).
Label source:
PubMed: Inhibitory effects of zinc on magnesium balance and magnesium absorption in man. (PMID 7836627)
Action type:
separate
Target id:
/intervention/iron-supplements
Target name:
Iron Supplements
Severity:
minor
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
2
Description:
High doses of supplemental iron and magnesium can compete for intestinal absorption, potentially reducing the uptake of both.
Actionable advice:
Iron and magnesium supplements are best separated by at least 2 hours, especially if treating a deficiency.
Validation status:
anecdotal
Evidence tier:
tier_d
Evidence basis:
anecdotal_summary
Evidence anchors:
Exact phrase from label:
When treating deficiencies with high doses, taking both at the same time could lead to absorption competition, diminishing their effectiveness.
Label source:
Anecdotal: Verywell Health
Action type:
separate
Target id:
/dietary/phytate-rich-foods
Target name:
Phytate-Rich Foods (Grains, Legumes, Nuts)
Severity:
minor
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
1
Hours after target:
1
Description:
Phytic acid, found in plant-based foods like whole grains and legumes, can bind to magnesium in the gut and inhibit its absorption.
Actionable advice:
For maximum absorption, magnesium supplements are best taken at least 1 hour away from very high-phytate meals.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
FA is known as a dietary inhibitor that chelates minerals and trace elements, limiting their bioavailability and reducing their absorption.
Label source:
PubMed: [The role of phytates in human nutrition]. (PMID 37801451)
Action type:
separate
Target id:
/class/viscous-fibers
Target name:
High-Fiber Foods or Supplements
Severity:
minor
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
2
Description:
Extremely high intake of dietary fiber can bind to minerals like magnesium, slightly reducing their absorption from the gut.
Actionable advice:
Magnesium supplements and high-dose fiber supplements are best separated by at least 2 hours.
Validation status:
validated_via_pubmed
Evidence tier:
tier_b
Evidence basis:
pubmed_abstract_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
Dietary factors impairing Mg2+ up-take include high doses of other minerals, partly fermentable fibres (e.g., hemicellulose), non-fermentable fibres (e.g., cellulose, lignin), phytate and oxalate, whereas proteins, medium-chain-triglycerides, and low- or indigestible carbohydrates (e.g., resistant starch, oligosaccharides, inulin, mannitol and lactulose) enhance Mg2+ uptake.
Label source:
PubMed: Current nutrition and food science (2017)
Source url:
Exact phrase from label:
In general, it has been shown that dietary fiber may bind metallic cations in both in vitro and in vivo studies. However, there clearly are many unresolved questions on the effects of high-fiber diets on mineral availability.
Label source:
PubMed: Critical reviews in food science and nutrition (1991)
Source url:
Exact phrase from label:
Because dietary fibers and some associated substances, such as phytate, have in vitro mineral-binding capacities, they have been thought to impair absorption of minerals such as calcium, iron and zinc, although magnesium absorption seems to be less affected.
Label source:
PubMed: The Journal of nutrition (2003)
Action type:
separate
Target id:
/dietary/calcium-rich-foods
Target name:
Calcium-Rich Foods (e.g., Dairy)
Severity:
minor
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
2
Description:
Consuming very large amounts of calcium from food at the same time as a magnesium supplement can lead to competition for absorption.
Actionable advice:
Magnesium supplements are generally best not taken with a very large, dairy-heavy meal.
Validation status:
validated_via_pubmed
Evidence tier:
tier_b
Evidence basis:
pubmed_abstract_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
We tested the hypothesis that increased intakes of calcium and phosphate lower magnesium solubility in the intestinal lumen, causing a decreased magnesium absorption.
Label source:
PubMed: The Journal of nutrition (1992)
Source url:
Exact phrase from label:
The ratio of calcium-to-magnesium intake (Ca:Mg) may be important for bone due to their competitive absorption.
Label source:
PubMed: The Journal of nutrition (2023)
Source url:
Exact phrase from label:
Intestinal interactions between Mg and calcium or phosphate have been demonstrated in both humans and animals. The nature of these interactions cannot be readily explained by data currently available.
Label source:
PubMed: The Journal of nutrition (1991)
Action type:
avoid
Target id:
/intervention/vitamin-b6
Target name:
Vitamin B6 (Pyridoxine)
Severity:
minor
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Vitamin B6 is thought to enhance the transport of magnesium into cells, potentially improving its effectiveness.
Actionable advice:
Consider taking magnesium and vitamin B6 together.
Validation status:
validated_via_pubmed
Evidence tier:
tier_b
Evidence basis:
pubmed_abstract_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
Following vitamin B6 administration, the mean plasma and RBC magnesium levels were significantly elevated, with a doubling of RBC levels after four weeks of therapy. These results support the postulate that vitamin B6 plays a fundamental role in the active transport of minerals across cell membranes.
Label source:
PubMed: Annals of clinical and laboratory science (1981)
Source url:
Exact phrase from label:
Dietary supplementation with PN.HCl produces alterations in tissue magnesium levels in the rat and these alterations are modulated by dietary magnesium and PN.HCl supplementation.
Label source:
PubMed: International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition (1989)
Source url:
Exact phrase from label:
The Mg lactate + vitamin B6 association interferes specifically with the cationic conductance components with regard to individual components.
Label source:
PubMed: Magnesium research (1998)
Action type:
informational_none
Target id:
/class/calcium-channel-blockers
Target name:
Calcium Channel Blockers
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Magnesium can relax blood vessels, and when taken with calcium channel blockers, there is a theoretical additive effect that could lead to low blood pressure.
Actionable advice:
It is a good idea to check blood pressure, especially when starting or increasing magnesium doses.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
Inhaled magnesium sulphate as a smooth muscle relaxant (natural calcium antagonist) can cause both bronchodilator and consequently vasodilator effects (via a direct effect on alveolar arterioles in well-ventilated areas) in the respiratory tract.
Label source:
PubMed: Evaluation of the efficacy and safety of inhaled magnesium sulphate in combination with standard treatment in patients with moderate or severe COVID-19: A structured summary of a study protocol for a randomised controlled trial. (PMID 33461602)
Action type:
monitor
Target id:
/biomarker/rbc-magnesium
Target name:
RBC Magnesium Blood Test
Severity:
minor
Interaction type:
assay_interference
Nature:
temporal
Temporal spacing:
Hours before target:
12
Hours after target:
0
Description:
Taking a magnesium supplement shortly before a blood draw can cause a temporary spike that may not reflect long-term intracellular status.
Actionable advice:
A magnesium supplement is generally best not taken on the morning of a blood test for the most accurate reading.
Validation status:
validated_via_pubmed
Evidence tier:
tier_b
Evidence basis:
pubmed_abstract_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
The results of this study showed that only the erythrocyte intracellular ionized Mg2+ (RBC [Mg2+]i), a representative Mg2+ pool, could effectively represent abnormal body Mg2+ metabolisms in various conditions, including dietary Mg2+ adjustments, aging and metabolic syndrome.
Label source:
PubMed: Biological & pharmaceutical bulletin (2019)
Source url:
Exact phrase from label:
Available data analysis suggests that serum/plasma magnesium concentration, red blood cell (RBC) concentration and urinary magnesium excretion responded to dietary manipulation.
Label source:
PubMed: Magnesium research (2011)
Source url:
Exact phrase from label:
Efflux of ErMg is controlled through membranous sodium-dependent and sodium-independent pathways and through genetic and neurohormonal regulations. Variations in the total or ionized ErMg do not necessarily mean that similar changes should exist in the magnesium pool.
Label source:
PubMed: Magnesium research (1995)
Action type:
monitor
Target id:
/dietary/hot-foods-beverages
Target name:
Hot Foods or Beverages
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Liposomal magnesium relies on a heat-sensitive phospholipid bilayer to protect and deliver its payload. Stirring it into a hot beverage (coffee, tea, soup) can melt or rupture the liposomes, destroying the enhanced-absorption advantage that is the entire point of the liposomal form.
Actionable advice:
Liposomal magnesium should not be added to hot drinks or food. It should be taken with cool or room-temperature liquid to keep the liposomes intact.
Validation status:
validated_via_class_inference
Evidence tier:
tier_c
Evidence basis:
class_inference_summary
Evidence anchors:
Source url:
Mechanism / liposome thermal stability
Exact phrase from label:
Phospholipid liposomal delivery systems are thermally labile and lose bilayer integrity when exposed to hot liquids, negating the absorption advantage of the liposomal format.
Label source:
Mechanistic inference
Action type:
avoid
Derived From
magnesium
Provenance Note
Interactions duplicated from 'magnesium'. Liposomal formulation; same interactions.