Meta Information
ID:nad-liposomal
Name:Liposomal NAD+
Schema Version:2.4_uniform_evidence_2026_06_18
Created
2026-07-02T06:44:03Z
Model
phase-b-newfiles-claude-opus-4.8
Interactions
Target id:
/class/parp-inhibitors
Target name:
PARP inhibitors / DNA-damaging chemotherapy
Severity:
moderate
Interaction type:
diminishing
Nature:
relative
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
NAD+ fuels PARP-mediated DNA repair; raising NAD+ could theoretically support tumor DNA repair and reduce the efficacy of PARP inhibitors or DNA-damaging chemo.
Actionable advice:
Boosting NAD+ is best avoided during PARP-inhibitor or DNA-damaging cancer therapy without oncology guidance.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
NAD+ metabolic reprogramming exerts a core role in colorectal cancer chemoresistance by regulating energy metabolism, DNA repair, and the immune microenvironment.
Label source:
Europe PMC MED/42294340. Supports NAD+ role in DNA-repair-mediated chemoresistance.
Action type:
avoid
Target id:
/intervention/nmn
Target name:
Other NAD+ precursors (NMN, NR)
Severity:
minor
Interaction type:
diminishing
Nature:
relative
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
NMN and NR feed the same NAD+ salvage pathway, so stacking them with NAD+ is redundant rather than additive.
Actionable advice:
One NAD+-raising strategy is generally sufficient; stacking adds cost without clear benefit.
Validation status:
validated_via_class_inference
Evidence tier:
tier_c
Evidence basis:
class_inference_summary
Evidence anchors:
Source url:
Established mechanism / class pharmacology (no single primary source quoted)
Exact phrase from label:
NMN/NR and NAD+ converge on the same salvage pathway; combined use is redundant, not synergistic.
Label source:
Class inference
Action type:
informational_none
Target id:
/condition/active-cancer
Target name:
Active cancer
Severity:
moderate
Interaction type:
adverse
Nature:
conditional
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
NAD+ metabolism is dysregulated in cancer and supports tumor energy and DNA repair; raising NAD+ in active malignancy is of uncertain safety.
Actionable advice:
It is important to talk to an oncologist before using NAD+ or its precursors during active cancer.
Validation status:
validated_via_class_inference
Evidence tier:
tier_c
Evidence basis:
class_inference_summary
Evidence anchors:
Source url:
Established mechanism / class pharmacology (no single primary source quoted)
Exact phrase from label:
NAD+ fuels tumor metabolism/DNA repair; precautionary in active malignancy. Theoretical, no controlled human data.
Label source:
Class inference
Action type:
monitor
Target id:
/dietary/hot-foods-beverages
Target name:
Hot Foods or Beverages
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Liposomal NAD+ relies on a heat-sensitive phospholipid bilayer to protect and deliver its payload. Stirring it into a hot beverage (coffee, tea, soup) can melt or rupture the liposomes, destroying the enhanced-absorption advantage that is the entire point of the liposomal form.
Actionable advice:
Liposomal NAD+ should not be added to hot drinks or food. It should be taken with cool or room-temperature liquid to keep the liposomes intact.
Validation status:
validated_via_class_inference
Evidence tier:
tier_c
Evidence basis:
class_inference_summary
Evidence anchors:
Source url:
Mechanism / liposome thermal stability
Exact phrase from label:
Phospholipid liposomal delivery systems are thermally labile and lose bilayer integrity when exposed to hot liquids, negating the absorption advantage of the liposomal format.
Label source:
Mechanistic inference
Action type:
avoid
Derived From
nad
Provenance Note
Interactions duplicated from 'nad'. Liposomal formulation; same interactions.