Meta Information

ID:nano-hydroxyapatite

Name:Nano-Hydroxyapatite

Schema Version:2.4_uniform_evidence_2026_06_18

Created

2026-07-02T07:04:56Z

Model

phase-b-newfiles-claude-opus-4.8

Interactions

Target id:

/intervention/levothyroxine

Target name:

Levothyroxine (if ingested in quantity)

Severity:

minor

Interaction type:

diminishing

Nature:

temporal

Temporal spacing:

Hours before target:

4

Hours after target:

4

Description:

Nano-hydroxyapatite is a calcium-phosphate mineral used mainly in toothpaste (local); if meaningfully ingested, its calcium could bind levothyroxine.

Actionable advice:

Primarily a topical dental agent; if taken orally in quantity, separate from levothyroxine by 4 hours.

Validation status:

validated_via_class_inference

Evidence tier:

tier_c

Evidence basis:

class_inference_summary

Evidence anchors:

Source url:

Established mechanism / class pharmacology (no single primary source quoted)

Exact phrase from label:

Calcium-containing minerals chelate levothyroxine; relevant only with meaningful oral intake (product is mainly topical/dental). Mechanistic.

Label source:

Class inference

Action type:

separate