Meta Information
ID:niacinamide-serum
Name:Niacinamide Serum
Schema Version:2.4_uniform_evidence_2026_06_18
Created
2026-07-02T07:35:59Z
Model
phase-b-topical-claude-opus-4.8
Interactions
Target id:
/intervention/vitamin-c-topical
Target name:
Topical vitamin C
Severity:
minor
Interaction type:
adverse
Nature:
relative
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
An old concern that niacinamide plus L-ascorbic acid causes flushing/reduced efficacy is largely debunked for modern formulations.
Actionable advice:
Generally compatible; if you notice flushing, apply at different times.
Validation status:
validated_via_class_inference
Evidence tier:
tier_c
Evidence basis:
class_inference_summary
Evidence anchors:
Source url:
Established mechanism / dermatologic practice (no single primary source quoted)
Exact phrase from label:
The niacinamide + ascorbic acid 'nicotinic acid flushing' concern is largely disproven at room temperature. Dermatologic consensus.
Label source:
Class inference
Action type:
informational_none
Target id:
/class/exfoliating-acids
Target name:
Exfoliating acids / retinoids
Severity:
minor
Interaction type:
synergistic
Nature:
relative
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Niacinamide is soothing and can buffer the irritation from acids and retinoids.
Actionable advice:
Layer niacinamide to help tolerate stronger actives.
Validation status:
validated_via_class_inference
Evidence tier:
tier_c
Evidence basis:
class_inference_summary
Evidence anchors:
Source url:
Established mechanism / dermatologic practice (no single primary source quoted)
Exact phrase from label:
Niacinamide is barrier-supporting and anti-inflammatory; mitigates active-related irritation. Dermatologic practice.
Label source:
Class inference
Action type:
informational_none