Meta Information
ID:prebiotic-supplements
Name:Prebiotic Supplements
Schema Version:2.4_uniform_evidence_2026_06_18
Created
2026-07-02T07:04:56Z
Model
phase-b-newfiles-claude-opus-4.8
Interactions
Target id:
/class/acid-dependent-absorption-drugs
Target name:
Oral medications (absorption)
Severity:
minor
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
2
Description:
Fermentable prebiotic fibers can bind or alter the gut environment and modestly affect absorption of some oral drugs.
Actionable advice:
Other oral medications and large fiber doses are best separated by ~2 hours.
Validation status:
validated_via_class_inference
Evidence tier:
tier_c
Evidence basis:
class_inference_summary
Evidence anchors:
Source url:
Established mechanism / class pharmacology (no single primary source quoted)
Exact phrase from label:
Prebiotic fibers can affect gut transit/absorption; low-magnitude, mechanistic.
Label source:
Class inference
Action type:
separate
Target id:
/condition/sibo
Target name:
Small intestinal bacterial overgrowth (SIBO) / IBS
Severity:
minor
Interaction type:
adverse
Nature:
conditional
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Fermentable prebiotics can worsen bloating and symptoms in SIBO or sensitive IBS.
Actionable advice:
Introduce slowly; reduce or avoid if bloating worsens.
Validation status:
validated_via_class_inference
Evidence tier:
tier_c
Evidence basis:
class_inference_summary
Evidence anchors:
Source url:
Established mechanism / class pharmacology (no single primary source quoted)
Exact phrase from label:
Fermentable substrates increase gas in SIBO/IBS; practical tolerance issue.
Label source:
Class inference
Action type:
informational_none