Meta Information
ID:pregnenolone
Name:Pregnenolone
Schema Version:2.4_uniform_evidence_2026_06_18
Created
2026-07-02T06:44:03Z
Model
phase-b-newfiles-claude-opus-4.8
Interactions
Target id:
/class/estrogens
Target name:
Estrogens / estrogen therapy
Severity:
moderate
Interaction type:
adverse
Nature:
relative
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Pregnenolone is an upstream steroid precursor that can raise downstream sex-hormone levels, adding to hormone therapy.
Actionable advice:
This is best used only under supervision by those on hormone therapy, and it is a good idea to monitor hormone levels.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
increased several sex steroid hormone levels: pregnenolone, progesterone, 17alpha-hydroxypregnenolone, androstenedione, androsterone, and etiocholanolone
Label source:
Europe PMC MED/41972586. Pregnenolone supplementation raises downstream sex-steroid pools.
Action type:
monitor
Target id:
/class/androgens
Target name:
Androgens / testosterone therapy
Severity:
moderate
Interaction type:
adverse
Nature:
relative
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Pregnenolone is an upstream steroid precursor that can raise downstream sex-hormone levels, adding to hormone therapy.
Actionable advice:
This is best used only under supervision by those on hormone therapy, and it is a good idea to monitor hormone levels.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
increased several sex steroid hormone levels: pregnenolone, progesterone, 17alpha-hydroxypregnenolone, androstenedione, androsterone, and etiocholanolone
Label source:
Europe PMC MED/41972586. Pregnenolone supplementation raises downstream sex-steroid pools.
Action type:
monitor
Target id:
/condition/hormone-sensitive-cancer
Target name:
Hormone-sensitive cancers (breast, prostate)
Severity:
major
Interaction type:
adverse
Nature:
conditional
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
By raising sex-steroid precursors, pregnenolone could theoretically stimulate hormone-sensitive tumors.
Actionable advice:
Pregnenolone should be avoided with a history of, or high risk for, hormone-sensitive cancer unless directed by an oncologist.
Validation status:
validated_via_class_inference
Evidence tier:
tier_c
Evidence basis:
class_inference_summary
Evidence anchors:
Source url:
Established mechanism / class pharmacology (no single primary source quoted)
Exact phrase from label:
Pregnenolone feeds androgen/estrogen synthesis; precautionary in hormone-sensitive malignancy. Theoretical/mechanistic.
Label source:
Class inference
Action type:
avoid
Target id:
/class/cns-depressants
Target name:
Sedatives / alcohol / CNS depressants
Severity:
moderate
Interaction type:
adverse
Nature:
relative
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Pregnenolone converts to allopregnanolone, a GABA-A positive modulator, which can add to the sedation of alcohol and CNS depressants.
Actionable advice:
Caution is a good idea when combining with alcohol or sedatives; it is worth watching out for excess drowsiness.
Validation status:
validated_via_class_inference
Evidence tier:
tier_c
Evidence basis:
class_inference_summary
Evidence anchors:
Source url:
Established mechanism / class pharmacology (no single primary source quoted)
Exact phrase from label:
Pregnenolone->allopregnanolone is a positive allosteric GABA-A modulator; additive CNS depression with sedatives/alcohol. Mechanistic.
Label source:
Class inference
Action type:
monitor
Target id:
/class/anticonvulsants
Target name:
Anticonvulsants / benzodiazepines
Severity:
minor
Interaction type:
adverse
Nature:
relative
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Neurosteroid GABA-A modulation overlaps antiseizure and benzodiazepine mechanisms; effects on seizure threshold are complex.
Actionable advice:
If you have epilepsy or take benzodiazepines, discuss pregnenolone with your neurologist first.
Validation status:
validated_via_class_inference
Evidence tier:
tier_c
Evidence basis:
class_inference_summary
Evidence anchors:
Source url:
Established mechanism / class pharmacology (no single primary source quoted)
Exact phrase from label:
Neurosteroids modulate GABA-A receptors; overlapping mechanism with anticonvulsants/benzodiazepines, direction context-dependent. Theoretical.
Label source:
Class inference
Action type:
informational_none