Meta Information
ID:silicon
Name:
Schema Version:2.4_uniform_evidence_2026_06_18
Created
2026-05-21T22:30:00Z
Model
phase-a-upgrade-claude-sonnet-4.6
Interactions
Target id:
/class/antacids
Target name:
Aluminum-Containing Antacids
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Dissolved silicon (as orthosilicic acid or oligomeric silica) at physiologic concentrations reduces oral aluminum absorption in mammals, by sequestering aluminum in the gut. Silicon supplementation may therefore be protective against aluminum loading from antacids.
Actionable advice:
Silicon supplements should not be taken with any aluminum-containing antacids (e.g., Gaviscon, Maalox).
Validation status:
validated_via_pubmed
Evidence tier:
tier_b
Evidence basis:
pubmed_abstract_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
Dissolved Si, at a concentration found in some water supplies (100 mumol/L), reduced the peak plasma 26Al concentration to 15% of the value obtained in the absence of Si.
Label source:
PubMed: Lancet (London, England) (1993)
Source url:
Exact phrase from label:
It has been reported that silicon might have a protective effect for limiting oral aluminum absorption. This review is focused primarily on the potential role of silicon in preventing oral aluminum absorption and retention in mammals.
Label source:
PubMed: Nutrition reviews (2011)
Source url:
Exact phrase from label:
Oligomeric silica reduced the availability of aluminum by 67% (P = 0.01) compared with the control, whereas monomeric silica had no effect (P = 0.40).
Label source:
PubMed: The American journal of clinical nutrition (2000)
Action type:
avoid
Target id:
/condition/renal-impairment
Target name:
Renal Impairment
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
The kidneys are responsible for excreting excess silicon. In cases of significant renal impairment, silicon can accumulate to potentially harmful levels, and the risk of aluminum toxicity from other sources is greatly magnified.
Actionable advice:
Silicon should not be supplemented with significant kidney disease, unless under direct medical supervision.
Validation status:
validated_via_pubmed
Evidence tier:
tier_b
Evidence basis:
pubmed_abstract_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
In 36 patients suffering from chronic renal failure (mean creatinine clearance 26 ml/min), serum silicon levels were significantly increased (mean 0.52 microgram/ml compared with 0.265 microgram/ml in normals; p less than 0.005). Urinary silicon excretion per 24 h was significantly decreased (15.71 mg/24 h compared with 21.4 mg/24 h in normals; p less than 0.001).
Label source:
PubMed: Nephron (1986)
Source url:
Exact phrase from label:
All dialysis groups showed marked elevations in their plasma silicon that correlated with the silicon content of their respective dialysis fluids.
Label source:
PubMed: American journal of kidney diseases : the official journal of the National Kidney Foundation (1992)
Source url:
Exact phrase from label:
Aluminium toxicity in dialysis patients is well described. Aluminium has a close chemical affinity with silicon. Silicon may have a role in protection against aluminium toxicity.
Label source:
PubMed: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (1998)
Action type:
informational_none
Target id:
/class/loop-diuretics
Target name:
Loop Diuretics
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Loop diuretics (e.g., furosemide, bumetanide) increase the urinary excretion of various minerals, including silicon. Long-term use may deplete bodily stores of silicon.
Actionable advice:
If taking loop diuretics long-term, discuss your silicon status with your healthcare provider.
Validation status:
validated_via_fda_label
Evidence tier:
tier_a
Evidence basis:
fda_label_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
Reference ID: 5673142
11 DESCRIPTION
Lasix ONYU (furosemide injection) for subcutaneous use is a loop diuretic.
Label source:
Action type:
informational_none
Target id:
/class/viscous-fibers
Target name:
High-Fiber Foods & Supplements
Severity:
moderate
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
1
Hours after target:
2
Description:
Dietary fibers, particularly gel-forming fibers like psyllium or beta-glucans, can bind to minerals in the gut and reduce the absorption of supplemental silicon.
Actionable advice:
Silicon supplements are best taken at least 1 hour before or 2 hours after high-fiber meals or fiber supplements.
Validation status:
validated_via_pubmed
Evidence tier:
tier_b
Evidence basis:
pubmed_abstract_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
Mean daily balances on the low and high fiber diets repectively, were: calcium +72 and -122 mg; magnesium, +28 and -32 mg; iron, +3.8 and +4.6 mg; silicon, -3.5 and -14.6 mg. Calcium magnesium, and silicon balances were significantly lower on the high than on the low fiber diet (P less than 0.01).
Label source:
PubMed: The American journal of clinical nutrition (1979)
Source url:
Exact phrase from label:
Various kinds of dietary fibre have been reported to be effective in preventing experimental models of atherosclerosis, reducing cholesterol and blood-lipid levels, and binding bile acids in vitro. Exceptionally large amounts of silicon (1000 to 25 000 p.p.m.) were found in fibre products of greatly varying origin and chemical composition which were active in these tests.
Label source:
PubMed: Lancet (London, England) (1977)
Action type:
separate
Target id:
/intervention/bisphosphonates
Target name:
Bisphosphonates
Severity:
moderate
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
2
Description:
Bisphosphonates have very poor and specific absorption requirements. Taking them with any mineral, including silicon, can significantly reduce their uptake and effectiveness.
Actionable advice:
Silicon supplements and bisphosphonate medications should be separated by at least 2 hours.
Validation status:
validated_via_fda_label
Evidence tier:
tier_a
Evidence basis:
fda_label_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
Co-administration of FOSAMAX and calcium, antacids, or oral medications containing multivalent cations will interfere with absorption of FOSAMAX.
Label source:
FDA label: Alendronate (Fosamax)
Action type:
separate
Target id:
/intervention/collagen-peptides
Target name:
Collagen Peptides
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Silicon is a crucial cofactor for the enzyme prolyl hydroxylase, which is essential for collagen cross-linking and stabilization. Co-supplementation provides both the building blocks (peptides) and a key catalyst (silicon) for connective tissue synthesis.
Actionable advice:
Taking silicon and collagen together may enhance benefits for skin, hair, nails, and joint health.
Validation status:
validated_via_pubmed
Evidence tier:
tier_b
Evidence basis:
pubmed_abstract_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
The effect of orthosilicic acid was abolished in the presence of prolyl hydroxylase inhibitors. No change in collagen type 1 mRNA level was seen in treated MG-63 cells.
Label source:
PubMed: Bone (2003)
Source url:
Exact phrase from label:
The activity of partly purified collagen prolyl-hydroxylase in the presence of silatranes was also studied.
Label source:
PubMed: Biokhimiia (Moscow, Russia) (1977)
Source url:
Exact phrase from label:
The presence of the particulates had no direct effect on protein (collagen) synthesis, proline incorporation or prolyl hydroxylase activity; the latter is determined by the degree of hydroxylation.
Label source:
PubMed: Life sciences (1983)
Action type:
informational_none
Target id:
/intervention/vitamin-d
Target name:
Vitamin D
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Silicon contributes to the organic matrix of bone (collagen), while Vitamin D is essential for calcium absorption. Together, they support both the structural framework and mineralization of bone.
Actionable advice:
Adequate Vitamin D levels may help when taking silicon for bone health.
Validation status:
anecdotal
Evidence tier:
tier_d
Evidence basis:
anecdotal_summary
Evidence anchors:
Exact phrase from label:
Including silicon in your diet may boost the benefits of calcium, glucosomine and vitamin D.
Label source:
Anecdotal: Life Extension
Action type:
informational_none
Target id:
/intervention/vitamin-k2
Target name:
Vitamin K2
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Silicon helps build the bone's collagen matrix, while Vitamin K2 activates proteins that direct calcium into that matrix. This combination ensures calcium is deposited correctly for optimal bone density.
Actionable advice:
Consider taking Vitamin K2 alongside silicon as part of a comprehensive bone support strategy.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Exact phrase from label:
Many essential nutrients behave synergistically, for example, vitamin D and vitamin K in the production and activation of osteocalcin
Label source:
Action type:
informational_none
Target id:
/intervention/boron
Target name:
Boron
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Boron and silicon appear to have complementary roles in bone and connective tissue health. Boron influences the metabolism of calcium and magnesium, which complements silicon's role in matrix formation.
Actionable advice:
Consider taking boron as part of a comprehensive bone support protocol that includes silicon.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
It has been reported that boron may be beneficial for optimal calcium metabolism and, thus, optimal bone metabolism.
Label source:
PubMed: Effect of boron supplementation on blood and urinary calcium, magnesium, and phosphorus, and urinary boron in athletic and sedentary women. (PMID 7840072)
Action type:
informational_none