Meta Information

ID:topical-niacinamide

Name:Topical Niacinamide

Schema Version:2.4_uniform_evidence_2026_06_18

Created

2026-07-02T07:35:59Z

Model

phase-b-topical-claude-opus-4.8

Interactions

Target id:

/class/exfoliating-acids

Target name:

Exfoliating acids / retinoids

Severity:

minor

Interaction type:

synergistic

Nature:

relative

Temporal spacing:

Hours before target:

0

Hours after target:

0

Description:

Niacinamide is soothing and compatible with most actives, helping buffer irritation from acids and retinoids.

Actionable advice:

Layer freely; niacinamide supports the skin barrier.

Validation status:

validated_via_class_inference

Evidence tier:

tier_c

Evidence basis:

class_inference_summary

Evidence anchors:

Source url:

Established mechanism / dermatologic practice (no single primary source quoted)

Exact phrase from label:

Niacinamide is barrier-supporting and broadly compatible. Dermatologic practice.

Label source:

Class inference

Action type:

informational_none