Meta Information

ID:topical-peptides

Name:Topical Peptides (Argireline / Matrixyl)

Schema Version:2.4_uniform_evidence_2026_06_18

Created

2026-07-02T07:35:59Z

Model

phase-b-topical-claude-opus-4.8

Interactions

Target id:

/class/exfoliating-acids

Target name:

Low-pH acids (AHAs/BHAs, vitamin C)

Severity:

minor

Interaction type:

diminishing

Nature:

temporal

Temporal spacing:

Hours before target:

0

Hours after target:

0

Description:

Some signal peptides can be destabilized by low-pH acids applied at the same time.

Actionable advice:

Peptides are best applied separately from strong low-pH acids (e.g., peptides at night, acids/vitamin C in the morning).

Validation status:

validated_via_class_inference

Evidence tier:

tier_c

Evidence basis:

class_inference_summary

Evidence anchors:

Source url:

Established mechanism / dermatologic practice (no single primary source quoted)

Exact phrase from label:

Certain peptides are pH-sensitive and may be degraded by co-applied low-pH actives. Dermatologic/formulation practice.

Label source:

Class inference

Action type:

separate