Meta Information
ID:ubiquinol
Name:
Schema Version:2.4_uniform_evidence_2026_06_18
Created
2026-05-21T22:30:00Z
Model
phase-a-upgrade-claude-sonnet-4.6
Interactions
Target id:
/dietary/high-fat-meal
Target name:
Meal Containing Fat
Severity:
major
Interaction type:
requirement
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Ubiquinol is a fat-soluble compound, and its absorption from the small intestine is significantly increased when co-ingested with dietary fats which stimulate bile secretion.
Actionable advice:
Ubiquinol should be taken with a meal that contains some fat or oil for optimal absorption.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
It is a fat-soluble molecule that acts as an electron carrier in mitochondria, and as a coenzyme for mitochondrial enzymes.
Label source:
PubMed: Coenzyme Q10 for heart failure. (PMID 35608922)
Action type:
informational_none
Target id:
/dietary/fasting-state
Target name:
Empty Stomach / Fasting
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
As a fat-soluble molecule, Ubiquinol requires dietary fats to be properly absorbed; taking it without food results in very low bioavailability.
Actionable advice:
Ubiquinol should not be taken on an empty stomach, to ensure it is properly absorbed.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Exact phrase from label:
CoQ10 is a hydrophobic (lipophilic) molecule with a high molecular weight; absorption of dietary CoQ10 is slow but is improved in the presence of fatty meals.
Label source:
Primary literature: https://www.ncbi.nlm.nih.gov/books/NBK531491/
Action type:
separate
Target id:
/class/statins
Target name:
Statins
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Statin medications inhibit an enzyme (HMG-CoA reductase) that is required for the body's production of both cholesterol and Coenzyme Q10, leading to lower CoQ10 levels.
Actionable advice:
Consider supplementing with Ubiquinol when taking statins to replenish depleted levels and potentially reduce muscle-related side effects.
Validation status:
validated_via_fda_label
Evidence tier:
tier_a
Evidence basis:
fda_label_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
11 DESCRIPTION
LIPITOR (atorvastatin) is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA)
reductase.
Label source:
Action type:
informational_none
Target id:
/class/chemotherapy-radiation
Target name:
Chemotherapy and Radiation Therapy
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
The strong antioxidant properties of Ubiquinol may interfere with chemotherapy or radiation treatments that rely on generating oxidative stress to destroy cancer cells.
Actionable advice:
Ubiquinol should be avoided during active chemotherapy or radiation therapy unless specifically approved by an oncologist.
Validation status:
validated_via_fda_label
Evidence tier:
tier_a
Evidence basis:
fda_label_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
In the placebo group, one patient with FIGO Stage IB cancer received radiation therapy and the patient with FIGO Stage IVB cancer received chemotherapy and hormonal therapy.
Label source:
Action type:
avoid
Target id:
/class/anticoagulants-antiplatelets
Target name:
Anticoagulants (e.g., Warfarin)
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Ubiquinol is structurally similar to Vitamin K, a key factor in blood clotting, and may theoretically interfere with the action of anticoagulant drugs like warfarin, potentially decreasing their effectiveness.
Actionable advice:
It is important to consult a doctor before taking Ubiquinol while on blood-thinning medication, as dose adjustments and monitoring may be necessary.
Validation status:
validated_via_fda_label
Evidence tier:
tier_a
Evidence basis:
fda_label_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
6 Aluminum Lake
10 mg: Dye-free
12 CLINICAL PHARMACOLOGY
12.1 Mechanism of Action
Warfarin acts by inhibiting the synthesis of vitamin K-dependent clotting factors, which include
Factors II, VII, IX, and X, and the anticoagulant proteins C and S.
Label source:
Action type:
adjust_with_prescriber
Target id:
/procedure/scheduled-surgery
Target name:
Scheduled Surgery
Severity:
moderate
Interaction type:
adverse
Nature:
temporal
Temporal spacing:
Hours before target:
336
Hours after target:
null
Description:
Ubiquinol may affect blood pressure and blood clotting, which could interfere with blood pressure control and increase bleeding risk during and after surgical procedures.
Actionable advice:
Ubiquinol should be discontinued at least two weeks before any scheduled surgery, and it is important to let a surgeon know.
Validation status:
validated_via_clinical_guidance
Evidence tier:
tier_b
Evidence basis:
clinical_guidance_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
CoQ10 (may interact with blood thinners like warfarin and diabetes drug insulin) … CoQ10 (may lower blood sugar levels in diabetics and interact with warfarin)
Label source:
Clinical guidance: OrthoIndy / University of Texas Southwestern — perioperative supplement discontinuation
Action type:
avoid
Target id:
/intervention/pqq
Target name:
PQQ (Pyrroloquinoline quinone)
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
PQQ supports the creation of new mitochondria, while Ubiquinol is a critical component for energy production within existing mitochondria, creating a complementary effect for cellular energy.
Actionable advice:
Consider taking PQQ and Ubiquinol together to comprehensively support mitochondrial health and function.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Exact phrase from label:
CoQ10 is a benzoquinone derivative playing a central role in the mitochondrial respiratory chain through shuttling between three redox forms. CARN (bioactive l-form) is biosynthesized from lysine and methionine and is concentrated in tissues that use fatty acids as their primary source of energy. It is involved in the transport of long-chain fatty acids from the intermembraneous space to the matrix in the mitochondria for generation of metabolic energy.
Label source:
Primary literature: https://pmc.ncbi.nlm.nih.gov/articles/PMC4264162/
Action type:
informational_none
Target id:
/intervention/omega-3-epa-dha
Target name:
Omega-3 Fatty Acids (Fish Oil)
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
As a fat-soluble nutrient, Ubiquinol's absorption is enhanced by the presence of fats, such as those provided by omega-3 supplements.
Actionable advice:
Ubiquinol is best taken at the same time as an omega-3 supplement to improve its absorption.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
CoQ10 and ubiquinol are fat-soluble molecules and are best absorbed with fats or oils, which is why it is good to take them with the largest meal of the day.
Label source:
Primary literature: https://www.consumerlab.com/answers/does-coq10-have-to-be-taken-with-food/water-soluble-coq10/
Action type:
informational_none
Target id:
/condition/pregnancy
Target name:
Pregnancy
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
The safety of high-dose Ubiquinol supplementation during pregnancy has not been well-established, so its use is not recommended out of caution.
Actionable advice:
Ubiquinol supplements are best avoided during pregnancy unless specifically advised by a doctor.
Validation status:
anecdotal
Evidence tier:
tier_d
Evidence basis:
anecdotal_summary
Evidence anchors:
Exact phrase from label:
Healthcare professionals haven't decided if CoQ10 is safe to take during pregnancy or while breastfeeding.
Label source:
Anecdotal: Mayo Clinic
Action type:
avoid
Target id:
/condition/lactation
Target name:
Lactation
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
It is unknown if supplemental Ubiquinol passes into breast milk in significant amounts or what its effects might be on a nursing infant.
Actionable advice:
Ubiquinol supplements are best avoided while breastfeeding due to a lack of safety data.
Validation status:
anecdotal
Evidence tier:
tier_d
Evidence basis:
anecdotal_summary
Evidence anchors:
Exact phrase from label:
It is not known if coenzyme Q10 passes into breast milk.
Label source:
Anecdotal: WebMD
Action type:
avoid
Target id:
/class/antihypertensives
Target name:
Blood Pressure Lowering Medications
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Ubiquinol may have a mild blood pressure-lowering effect, which can add to the effects of antihypertensive medications, potentially increasing the risk of hypotension.
Actionable advice:
It is a good idea to check blood pressure regularly if Ubiquinol is combined with blood pressure medication, and to talk to a doctor.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
Given its favorable safety profile, CoQ10 could be considered as a supportive option in the management of hypertension, particularly for patients seeking non-pharmacological interventions or those with mild elevations in systolic BP.
Label source:
PubMed: Effects of coenzyme Q10 administration on blood pressure and heart rate in adults: A systematic review and meta-analysis of randomized controlled trials. (PMID 40495903)
Action type:
monitor
Target id:
/class/antidiabetic-medications
Target name:
Diabetes Medications (including Insulin)
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Ubiquinol may improve glucose metabolism and lower blood sugar levels, potentially enhancing the effects of diabetes medications and increasing the risk of hypoglycemia.
Actionable advice:
Blood glucose levels are best monitored closely if Ubiquinol is taken with diabetes medication, and consulting a doctor may help.
Validation status:
validated_via_fda_label
Evidence tier:
tier_a
Evidence basis:
fda_label_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
12 CLINICAL PHARMACOLOGY 12.1 Mechanism of Action Metformin is an antihyperglycemic agent which improves glucose tolerance in patients with type 2 diabetes mellitus, lowering both basal and postprandial plasma glucose.
Label source:
Action type:
monitor
Target id:
/intervention/vitamin-e
Target name:
Vitamin E
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Vitamin E and Ubiquinol are both fat-soluble antioxidants that work together to protect cell membranes, and Vitamin E can help recycle Coenzyme Q10 back to its active Ubiquinol form.
Actionable advice:
Taking Vitamin E and Ubiquinol together may provide enhanced antioxidant protection.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
In this model system, possible synergism of the antioxidant action of CoQ10H2 and α-TOH has been shown. Putative mechanisms of bioregeneration of lipophilic antioxidants in LDL particles, including regeneration of α-TOH from the tocopheroxyl radical (α-TO•) with participation of CoQ10H2 and/or ascorbate, are discussed.
Label source:
PubMed: Mechanisms of Antioxidant Protection of Low-Density Lipoprotein Particles Against Free Radical Oxidation. (PMID 40058977)
Action type:
informational_none
Target id:
/intervention/alcar
Target name:
Acetyl-L-Carnitine (ALCAR)
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
L-Carnitine transports fuel (fatty acids) into the mitochondria, while Ubiquinol is essential for converting that fuel into cellular energy (ATP), making them a synergistic pair for energy metabolism.
Actionable advice:
Taking L-Carnitine and Ubiquinol together can support overall mitochondrial energy production.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Exact phrase from label:
CARN is the main carrier of acyl groups across the mitochondrial membrane. This process is of paramount importance for the delivery of free fatty acids released from different tissues, especially adipose tissue, to the mitochondria. These fatty acids will be used for ATP production after β oxidation.
Label source:
Primary literature: https://pmc.ncbi.nlm.nih.gov/articles/PMC7582285/
Action type:
informational_none
Target id:
/circadian/sleep
Target name:
Bedtime / Sleep
Severity:
minor
Interaction type:
adverse
Nature:
temporal
Temporal spacing:
Hours before target:
4
Hours after target:
null
Description:
As Ubiquinol is central to cellular energy production, some individuals may find that taking it close to bedtime can be mildly stimulating and interfere with sleep.
Actionable advice:
If you are sensitive, consider taking your dose earlier in the day, such as with breakfast or lunch.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
Coenzyme Q(10) is a remarkable lipid involved in many cellular processes such as energy production through the mitochondrial respiratory chain (RC), beta-oxidation of fatty acids, and pyrimidine biosynthesis, but it is also one of the main cellular antioxidants.
Label source:
PubMed: Genetic bases and clinical manifestations of coenzyme Q10 (CoQ 10) deficiency. (PMID 25091424)
Action type:
informational_none