Meta Information
ID:uridine-monophosphate
Name:
Schema Version:2.4_uniform_evidence_2026_06_18
Created
2026-05-21T22:30:00Z
Model
phase-a-upgrade-claude-sonnet-4.6
Interactions
Target id:
/class/antiretrovirals
Target name:
Antiretroviral Medications (for HIV)
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Uridine competes with certain thymidine analog antiretroviral drugs (e.g., zidovudine, stavudine) for the same metabolic activation pathway, which could reduce their effectiveness against HIV.
Actionable advice:
Uridine supplements should be strictly avoided while taking thymidine analog antiretroviral medications.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Exact phrase from label:
AZT itself was a potent inhibitor of thymidine phosphorylation... The presence of AZT in the perfusate inhibits the phosphorylation of [3H]thymidine with a 50% inhibitory concentration of 24+/-4 microM.
Label source:
PMC1855461. Supports competition between thymidine-analog antiretrovirals (AZT/zidovudine) and natural pyrimidine-nucleoside phosphorylation; stavudine not separately tested - mechanism on point.
Action type:
avoid
Target id:
/class/chemotherapy-radiation
Target name:
Pyrimidine Analog Chemotherapy
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Uridine can compete with or directly counteract the effects of chemotherapy drugs designed to disrupt pyrimidine metabolism (e.g., 5-Fluorouracil, Capecitabine), potentially reducing their cancer-fighting efficacy.
Actionable advice:
Uridine supplements should be strictly avoided during treatment with pyrimidine analog chemotherapy unless specifically directed by an oncologist.
Validation status:
validated_via_fda_label
Evidence tier:
tier_a
Evidence basis:
fda_label_verbatim
Evidence anchors:
Source url:
Exact phrase from label:
The effect of tamoxifen on metabolism and excretion of other antineoplastic drugs, such as cyclophosphamide and other drugs that require mixed function oxidases for activation, is not known.
Label source:
Action type:
avoid
Target id:
/condition/pregnancy
Target name:
Pregnancy
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
The safety of uridine monophosphate supplementation during pregnancy has not been established, and its effects on fetal development are unknown.
Actionable advice:
This should be strictly avoided during pregnancy.
Validation status:
unvalidatable
Evidence tier:
tier_e
Evidence basis:
unvalidatable
Evidence anchors:
Source url:
Scientific literature support not found
Exact phrase from label:
Label source:
Action type:
avoid
Target id:
/condition/lactation
Target name:
Breastfeeding (Lactation)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
It is unknown if supplemental uridine passes into breast milk or what its effects might be on a nursing infant; therefore, it should be avoided.
Actionable advice:
It should be avoided completely while breastfeeding.
Validation status:
unvalidatable
Evidence tier:
tier_e
Evidence basis:
unvalidatable
Evidence anchors:
Source url:
Scientific literature support not found
Exact phrase from label:
Label source:
Action type:
avoid
Target id:
/class/choline-precursors
Target name:
Choline Precursors (e.g., Alpha-GPC, Citicoline)
Severity:
moderate
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Uridine and choline are both essential precursors for the synthesis of phosphatidylcholine, a critical component of brain cell membranes, leading to enhanced synaptic formation and cognitive benefits.
Actionable advice:
It is best taken together with a choline source like Alpha-GPC or Citicoline to support brain health.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Exact phrase from label:
As uridine and choline work synergistically with DHA to increase phosphatidylcholine formation, there is a compelling rationale to combine these nutrients.
Label source:
Baumel et al. 2021, PMC8139993. Directly supports uridine + choline as co-precursors for phosphatidylcholine.
Action type:
informational_none
Target id:
/intervention/omega-3-dha
Target name:
Omega-3 DHA
Severity:
moderate
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
DHA is the specific fatty acid incorporated into neuronal membranes during phosphatidylcholine synthesis, a process promoted by uridine and choline.
Actionable advice:
It is best taken together with a high-DHA fish oil or algal oil for optimal cognitive benefits.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Exact phrase from label:
As uridine and choline work synergistically with DHA to increase phosphatidylcholine formation, there is a compelling rationale to combine these nutrients.
Label source:
Baumel et al. 2021, PMC8139993. Supports DHA's role alongside uridine/choline in phosphatidylcholine synthesis.
Action type:
informational_none
Target id:
/intervention/folate
Target name:
Folate (Vitamin B9)
Severity:
moderate
Interaction type:
requirement
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Folate is essential for the one-carbon metabolism pathway, which provides methyl groups necessary for the synthesis and recycling of nucleotides like uridine.
Actionable advice:
It is a good idea to maintain adequate folate intake through diet or supplementation for optimal uridine utilization.
Validation status:
unvalidatable
Evidence tier:
tier_e
Evidence basis:
unvalidatable
Evidence anchors:
Source url:
Scientific literature support not found
Exact phrase from label:
Label source:
Action type:
informational_none
Target id:
/biomarker/vitamin-b12
Target name:
Vitamin B12
Severity:
moderate
Interaction type:
requirement
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Vitamin B12 is a critical cofactor in the methylation cycle, which is closely linked to nucleotide synthesis pathways that involve uridine.
Actionable advice:
Sufficient Vitamin B12 levels are best maintained to support the metabolic pathways that utilize uridine.
Validation status:
unvalidatable
Evidence tier:
tier_e
Evidence basis:
unvalidatable
Evidence anchors:
Source url:
Scientific literature support not found
Exact phrase from label:
Label source:
Action type:
monitor
Target id:
/condition/bipolar-disorder
Target name:
Bipolar Disorder
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
While uridine is being researched for bipolar disorder, unsupervised use could potentially alter mood states and interfere with prescribed treatments.
Actionable advice:
This is best used only under the direct supervision of a psychiatrist.
Validation status:
validated_via_primary_literature
Evidence tier:
tier_b
Evidence basis:
primary_literature_verbatim
Evidence anchors:
Exact phrase from label:
This report is an open-label case series of seven depressed adolescents with bipolar disorder treated with uridine for 6 weeks... Uridine was associated with decreased depressive symptoms.
Label source:
Kondo et al. 2011, PMC3080753. Confirms uridine is psychoactively relevant and under investigation in bipolar disorder - supports caution about unsupervised use alongside prescribed treatment.
Action type:
avoid
Target id:
/circadian/sleep
Target name:
Going to Sleep
Severity:
minor
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
1
Hours after target:
null
Description:
Uridine may promote sleep-related processes in the brain, and some users report a relaxing effect, making evening administration potentially beneficial for sleep quality.
Actionable advice:
Consider taking your dose 1 hour before bedtime to potentially enhance sleep quality.
Validation status:
unvalidatable
Evidence tier:
tier_e
Evidence basis:
unvalidatable
Evidence anchors:
Source url:
Scientific literature support not found
Exact phrase from label:
Label source:
Unvalidatable: human evidence that uridine promotes sleep is lacking (only weak animal data); original source was a vendor page.
Action type:
separate
Target id:
/condition/hepatic-impairment
Target name:
Hepatic Impairment
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
The metabolism of uridine may be altered in individuals with liver disease, warranting caution.
Actionable advice:
Consulting a healthcare professional before use may help for those with liver disease.
Validation status:
unvalidatable
Evidence tier:
tier_e
Evidence basis:
unvalidatable
Evidence anchors:
Source url:
Scientific literature support not found
Exact phrase from label:
Label source:
Action type:
informational_none
Target id:
/condition/renal-impairment
Target name:
Renal Impairment
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
The clearance of uridine metabolites may be affected by kidney function, warranting caution in individuals with renal impairment.
Actionable advice:
Consulting a healthcare professional before use may help for those with kidney disease.
Validation status:
unvalidatable
Evidence tier:
tier_e
Evidence basis:
unvalidatable
Evidence anchors:
Source url:
Scientific literature support not found
Exact phrase from label:
Label source:
Action type:
informational_none