Meta Information
ID:vitamin-b7
Name:Vitamin B7 (Biotin)
Schema Version:2.4_uniform_evidence_2026_06_18
Created
2026-07-02T07:03:07Z
Model
phase-b-newfiles-claude-opus-4.8
Interactions
Target id:
/biomarker/thyroid-panel
Target name:
Lab tests using biotin-streptavidin assays (thyroid, troponin, hormones)
Severity:
major
Interaction type:
assay_interference
Nature:
relative
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
High-dose biotin interferes with many common lab immunoassays, producing falsely high or low results (thyroid hormones, troponin, hormones, vitamin D).
Actionable advice:
High-dose biotin should be stopped several days before blood tests, and the lab should be told about its use; FDA has linked biotin interference to a missed heart attack.
Validation status:
validated_via_clinical_guidance
Evidence tier:
tier_b
Evidence basis:
clinical_guidance_verbatim
Evidence anchors:
Exact phrase from label:
Very high intakes of biotin may interfere with diagnostic assays that use biotin-streptavidin technology and are commonly used to measure levels of hormones (such as thyroid hormone) and other analytes such as 25-hydroxyvitamin D, producing falsely normal or abnormal results.
Label source:
NIH ODS fact sheet
Action type:
separate
Target id:
/class/anticonvulsants
Target name:
Anticonvulsants (carbamazepine, phenytoin, phenobarbital)
Severity:
minor
Interaction type:
diminishing
Nature:
relative
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Long-term anticonvulsant therapy lowers biotin status by increasing its breakdown and impairing absorption.
Actionable advice:
If on long-term anticonvulsants, biotin supplementation may be reasonable - discuss with your prescriber.
Validation status:
validated_via_clinical_guidance
Evidence tier:
tier_b
Evidence basis:
clinical_guidance_verbatim
Evidence anchors:
Exact phrase from label:
anticonvulsant treatment for at least 1 year was associated with significantly lower serum biotin levels than in control group patients.
Label source:
NIH ODS fact sheet
Action type:
monitor