Brain & Focus452

Brain structural integrity, glymphatic clearance, and neurotransmitters.

Supplements

Efficacy: High  |  Grade: A

Acetyl-L-Carnitine

ALCAR, ALC

Enhances brain energy metabolism and supports neurotransmitters involved in memory, focus, and mental clarity.

Efficacy: High  |  Grade: A

Alpha-GPC

L-Alpha glycerylphosphorylcholine, Choline alfoscerate

Provides a key building block for acetylcholine, a neurotransmitter essential for memory, learning, and focus.

Efficacy: High  |  Grade: A

B Complex Vitamins

B Vitamins, Vitamin B Complex

Supports the production of key neurotransmitters for mood and focus, while also protecting nerve cells and brain structure.

Efficacy: High  |  Grade: A

Bacopa Monnieri

Brahmi, Water Hyssop, Herb of Grace

Improves memory formation, learning rate, and the speed of visual information processing under stress.

Efficacy: High  |  Grade: A

Caffeine

1,3,7-trimethylxanthine, Methyltheobromine

Enhances alertness and concentration by blocking sleep-promoting signals, and may support long-term brain health.

Efficacy: High  |  Grade: A

Cerebrolysin

FPF-1070

Promotes neuronal repair and synaptic plasticity, supporting cognitive function and recovery from brain injury or stroke.

Efficacy: High  |  Grade: A

Citicoline

CDP-Choline, Cytidine Diphosphate-Choline

Enhances focus and memory by providing essential building blocks for brain cell membranes and key neurotransmitters.

Efficacy: High  |  Grade: A

CNM-Au8

Gold Nanocrystals, Gold Nanocatalyst Suspension

Supports brain cell energy production and protects neurons, which is critical for maintaining long-term neurological health.

Efficacy: High  |  Grade: A

Iodine

Potassium Iodide, Lugol's Solution

Crucial for brain development and supports ongoing cognitive function and mental clarity in adults.

Efficacy: High  |  Grade: A

L-Methylfolate

5-MTHF, Levomefolic acid, Metafolin, Deplin

Supports the production of key neurotransmitters which are essential for mood regulation and cognitive function.

Efficacy: High  |  Grade: A

L-Theanine

Theanine, gamma-glutamylethylamide

Promotes a state of calm alertness and sharpens focus by increasing alpha brain waves.

Efficacy: High  |  Grade: A

Melatonin

SR Melatonin, Low-Dose Melatonin, Physiological-Dose Melatonin

Promotes restorative sleep, which is essential for the brain's nightly waste clearance and long-term cognitive health.

Efficacy: High  |  Grade: A

Phosphatidylserine

PS

Supports brain cell structure, aiding memory, focus, and overall cognitive function, particularly with age.

Efficacy: High  |  Grade: A

Psilocybin Therapy

Psychedelic-Assisted Therapy, Magic Mushrooms

Promotes neural plasticity and new brain connections, potentially improving mood, cognitive flexibility, and focus.

Efficacy: High  |  Grade: A

Saffron Extract

Crocus sativus, Safranal, Crocin

Enhances mood and cognitive function by supporting neurotransmitter balance and protecting brain cells from stress.

Efficacy: High  |  Grade: A

Saffron

Crocus sativus

Enhances mood and cognitive function by supporting key neurotransmitter systems involved in focus and well-being.

Efficacy: High  |  Grade: A

Saint John's Wort

Hypericum perforatum, Klamath weed

Supports a positive mood and emotional well-being by helping to maintain balanced neurotransmitter levels.

Efficacy: High  |  Grade: A

SAM-e

S-adenosylmethionine, Ademetionine

Supports a positive mood and cognitive function by aiding in the production of key brain neurotransmitters.

Efficacy: High  |  Grade: A

Vitamin B12

Cobalamin, Methylcobalamin, Cyanocobalamin, Adenosylcobalamin, Hydroxocobalamin

Crucial for maintaining nerve health and producing neurotransmitters, which supports cognitive function and mental clarity.

Efficacy: High  |  Grade: A

Vitamin B6

Pyridoxine, Pyridoxal 5'-Phosphate, P-5-P

Serves as a crucial building block for neurotransmitters that regulate mood, focus, and cognition.

Efficacy: High  |  Grade: A

Zeaxanthin

Meso-zeaxanthin

Protects the retina from light damage to support sharp vision and also aids cognitive processing speed.

Efficacy: Medium  |  Grade: A

Ashwagandha

Withania somnifera, Indian ginseng, Winter cherry

Supports cognitive functions like memory and attention, promoting mental clarity and information processing speed.

Efficacy: High  |  Grade: B

Centella Asiatica (Cica)

Cica, Gotu Kola, Brahmi, Asiatic Pennywort

Supports cognitive functions like memory and alertness, while protecting brain cells from age-related oxidative stress.

Efficacy: High  |  Grade: B

Choline

Alpha-GPC, CDP-Choline, Citicoline, Choline Bitartrate, Phosphatidylcholine

Serves as a crucial building block for acetylcholine, a neurotransmitter vital for memory, learning, and focus.

Efficacy: Medium  |  Grade: A

Cocoa Flavanols

Cacao Flavanols, Flavan-3-ols

Enhances cognitive function and memory, particularly in older adults, by increasing blood flow to the brain.

Efficacy: High  |  Grade: B

Liposomal Fisetin

Liposomal 3,3',4',7-tetrahydroxyflavone

Supports brain cell health by clearing cellular debris and reducing inflammation, which may aid cognitive function.

Efficacy: High  |  Grade: B

Fisetin

Smoketree extract, 3,3',4',7-tetrahydroxyflavone

Protects brain cells from age-related stress and supports pathways involved in long-term memory and cognitive function.

Efficacy: Medium  |  Grade: A

Folate (Vitamin B9)

Folic Acid, L-Methylfolate, L-5-MTHF, Vitamin B9

Supports neurotransmitter production and may help protect against age-related cognitive decline, especially when levels are low.

Efficacy: High  |  Grade: B

Glutathione

L-Glutathione, GSH, Liposomal GSH

Acts as the brain's master antioxidant, protecting neurons from oxidative damage and supporting long-term cognitive function.

Efficacy: Medium  |  Grade: A

Iron Bisglycinate

Ferrous Bisglycinate, Chelated Iron

Supports neurotransmitter production and brain energy, which helps maintain mental clarity and cognitive function.

Efficacy: Medium  |  Grade: A

Iron Fumarate

Ferrous Fumarate

Supports neurotransmitter synthesis and oxygen delivery to the brain, which is crucial for maintaining mental clarity and focus.

Efficacy: Medium  |  Grade: A

Iron Gluconate

Ferrous Gluconate

Essential for neurotransmitter production, helping to improve mental clarity, focus, and cognitive performance.

Efficacy: Medium  |  Grade: A

Iron

Ferrous Sulfate, Ferrous Gluconate, Iron Bisglycinate, Ferritin

Essential for neurotransmitter synthesis and brain energy, supporting mental clarity, focus, and cognitive function.

Efficacy: Medium  |  Grade: A

Iron Sulfate

Ferrous Sulfate

Supports neurotransmitter synthesis and brain energy metabolism, helping to maintain mental clarity and reduce fatigue.

Efficacy: High  |  Grade: B

Klotho

alpha-Klotho, α-Klotho

Supports cognitive functions like learning and memory and may protect brain cells from age-related decline.

Efficacy: High  |  Grade: B

L-Ergothioneine

Ergothioneine, ET, EGT

Acts as a potent brain antioxidant, helping protect neurons from age-related stress and supporting cognitive function.

Efficacy: Medium  |  Grade: A

L-Tyrosine

Tyrosine

Supports mental performance and focus by replenishing key neurotransmitters depleted during stressful or demanding situations.

Efficacy: High  |  Grade: B

Lithium Orotate

Microdose Lithium, Elemental Lithium

Promotes the growth of new brain cells and protects against age-related cognitive decline.

Efficacy: Medium  |  Grade: A

Low-Dose Aspirin

Baby Aspirin, Acetylsalicylic Acid (low dose)

Helps protect brain tissue by reducing the risk of clot-related strokes and supporting cerebral blood flow.

Efficacy: High  |  Grade: B

LSD

Lysergic acid diethylamide, Acid

Promotes brain plasticity and new neural connections, potentially enhancing cognitive flexibility and long-term brain health.

Efficacy: Medium  |  Grade: A

Lutein

Zeaxanthin

Accumulates in the brain to support cognitive sharpness, processing speed, and long-term neural health.

Efficacy: High  |  Grade: B

Magnesium L-threonate

Magtein

Effectively increases brain magnesium levels, supporting synaptic health for improved memory and cognitive function.

Efficacy: Medium  |  Grade: A

Meso-Zeaxanthin

MZ

Supports cognitive function and enhances visual processing speed by protecting neural tissue from oxidative stress.

Efficacy: High  |  Grade: B

Methylene Blue

MB, Methylthioninium chloride

Supports memory and cognitive function by improving brain cell energy and protecting against protein aggregation.

Efficacy: High  |  Grade: B

Mucuna Pruriens

Velvet Bean, Cowhage

Provides a natural source of L-DOPA, a precursor to dopamine, supporting motivation, focus, and motor control.

Efficacy: Medium  |  Grade: A

Multivitamin (Men)

Men's Multi, MVM

May support cognitive function and memory in older adults by supplying a broad range of essential micronutrients.

Efficacy: Medium  |  Grade: A

Multivitamin (Women)

Women's Multi, MVM for Women

Supports cognitive function and memory, particularly in older adults, by providing key nutrients for brain health.

Efficacy: High  |  Grade: B

Phenylpiracetam

Phenotropil, Carphedon, Fonturacetam

Enhances mental alertness, focus, and memory formation, supporting overall cognitive performance under stress.

Efficacy: High  |  Grade: B

Semax

N-Acetyl Semax, N-Acetyl Semax Amidate

Enhances cognitive functions like memory and attention by supporting brain cell health and growth factors.

Efficacy: High  |  Grade: B

Trehalose

Mycose, Tremalose

Promotes the brain's cellular cleanup process, helping to clear protein buildup associated with neurodegeneration.

Efficacy: High  |  Grade: B

Uridine Monophosphate

UMP, Uridine

Supports the formation of new brain connections, which is crucial for memory and cognitive function.

Efficacy: Medium  |  Grade: A

Vitamin B2

Riboflavin, Vitamin G

Supports brain energy metabolism and may reduce the frequency of migraines by improving mitochondrial function.

Efficacy: Medium  |  Grade: A

Zinc

Zinc Picolinate, Zinc Gluconate, Zinc Citrate, Zinc Orotate

Essential for nerve cell communication, supporting mood regulation and cognitive functions like learning and memory.

Efficacy: Medium  |  Grade: B

17-Alpha-Estradiol

17α-estradiol, alfatradiol

Exhibits neuroprotective properties in animal models by shielding brain cells from inflammation and oxidative stress.

Efficacy: Medium  |  Grade: B

Alpha-Lipoic Acid

ALA, Thioctic acid

Protects nerve tissue from oxidative stress, which may support both peripheral nerve health and cognitive function.

Efficacy: Medium  |  Grade: B

Liposomal Apigenin

Bioavailable Apigenin, Apigenin Phytosome

Promotes a calm and focused state by interacting with brain receptors and protecting neurons from stress.

Efficacy: Medium  |  Grade: B

Apigenin

Supports long-term brain health by protecting neurons from stress and reducing brain inflammation.

Efficacy: Medium  |  Grade: B

Astaxanthin

asta

Helps protect brain cells from oxidative stress, supporting cognitive function and mental clarity with age.

Efficacy: Medium  |  Grade: B

Benfotiamine

S-benzoylthiamine O-monophosphate

Helps protect brain cells from metabolic stress and the accumulation of harmful glycation byproducts.

Efficacy: Medium  |  Grade: B

Betaine (TMG)

Trimethylglycine, TMG, Glycine Betaine

Supports brain health by lowering homocysteine and providing methyl groups for neurotransmitter synthesis.

Efficacy: Medium  |  Grade: B

Bilberry Extract

Vaccinium myrtillus extract, European Blueberry extract

May enhance cognitive function by improving blood flow to the brain and reducing oxidative stress.

Efficacy: Medium  |  Grade: B

Boron

Boric Acid, Sodium Borate

Supports cognitive functions like attention and memory, particularly when dietary intake is low.

Efficacy: Medium  |  Grade: B

Boswellia Serrata

Indian Frankincense, Salai Guggal

Its anti-inflammatory properties may protect brain cells and support cognitive function with age.

Efficacy: Medium  |  Grade: B

Butyrate Supplements

Sodium Butyrate, Calcium Butyrate, Magnesium Butyrate, Tributyrin, Butyric Acid

Supports brain health and mood by influencing the gut-brain axis and promoting neuroprotective factors.

Efficacy: Medium  |  Grade: B

Butyrate

Sodium Butyrate, Butanoic Acid

Supports brain health by protecting neurons and enhancing biological pathways involved in learning and memory formation.

Efficacy: Medium  |  Grade: B

Carnosine

L-carnosine, beta-alanyl-L-histidine

Acts as a neuroprotectant by shielding brain cells from oxidative stress and harmful protein buildup.

Efficacy: Medium  |  Grade: B

CBD

Cannabidiol

May reduce anxiety and offer neuroprotective effects, supporting mental clarity and cognitive resilience against stress.

Efficacy: Medium  |  Grade: B

Coenzyme Q10

Ubiquinone, Ubidecarenone, CoQ10

Supports energy production in brain cells and provides antioxidant protection, aiding long-term cognitive health.

Efficacy: Medium  |  Grade: B

Copper

Cupric, Copper Gluconate, Copper Bisglycinate, Copper Sulfate

Acts as a cofactor for enzymes that synthesize neurotransmitters and maintain protective nerve sheaths.

Efficacy: Medium  |  Grade: B

Liposomal CoQ10

Liposomal Coenzyme Q10, Liposomal Ubiquinone, Liposomal Ubiquinol

Protects brain cells from oxidative stress and supports the high energy demands of neural activity.

Efficacy: Medium  |  Grade: B

Creatine Monohydrate

Creatine

Supports brain energy metabolism, which may enhance cognitive function, especially under mentally demanding conditions.

Efficacy: Medium  |  Grade: B

Curcumin

Turmeric, Diferuloylmethane, Meriva, Longvida, BCM-95, Theracurmin

Protects brain cells from inflammation and oxidative stress, which may support long-term cognitive function.

Efficacy: High  |  Grade: C

Dihexa

N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, PNA-11

Potently promotes the formation of new neural connections, supporting memory, learning, and overall cognitive function.

Efficacy: Medium  |  Grade: B

Egcg

Epigallocatechin gallate, Green Tea Extract

Offers neuroprotective benefits for long-term brain health and may enhance mental clarity and focus.

Efficacy: Medium  |  Grade: B

Enclomiphene

Enclomiphene Citrate, Androxal

May enhance mood, mental clarity, and libido by normalizing testosterone levels in the brain.

Efficacy: Medium  |  Grade: B

GABA

Gamma-Aminobutyric Acid

Promotes a state of calm and relaxation, which can help reduce mental chatter and improve focus.

Efficacy: Medium  |  Grade: B

Ginkgo Biloba

Maidenhair Tree, Ginkgo Folium, EGb 761

Aids cognitive function and mental clarity by enhancing blood flow and antioxidant activity in the brain.

Efficacy: Medium  |  Grade: B

Liposomal Glutathione

L-Glutathione (Liposomal), GSH (Liposomal)

Acts as a primary brain antioxidant, protecting neurons from damage linked to cognitive decline.

Efficacy: Medium  |  Grade: B

Green Tea Extract

GTE, Camellia sinensis extract, EGCG

Enhances focus and mental clarity through its unique combination of L-theanine and caffeine, offering neuroprotective benefits.

Efficacy: Medium  |  Grade: B

Huperzine A

HupA, Qian Ceng Ta

Supports memory and learning by increasing acetylcholine, a key neurotransmitter for cognitive function and focus.

Efficacy: Medium  |  Grade: B

IGF-1 LR3

Insulin-like Growth Factor 1 Long R3

Promotes the growth and survival of neurons, which is important for long-term cognitive function.

Efficacy: Medium  |  Grade: B

Inositol

Myo-inositol, D-chiro-inositol, Vitamin B8

Supports mood regulation and a sense of calm by influencing key brain signaling pathways.

Efficacy: Medium  |  Grade: B

L-Carnitine

Acetyl-L-Carnitine, ALCAR, Propionyl-L-Carnitine, L-Carnitine L-Tartrate

Aids in producing key neurotransmitters for memory and learning while protecting brain cells from age-related stress.

Efficacy: Medium  |  Grade: B

Lemon Balm

Melissa officinalis

Enhances calmness and cognitive performance, particularly during periods of mental stress, by modulating key neurotransmitters.

Efficacy: Medium  |  Grade: B

Lion's Mane Mushroom

Hericium erinaceus, Yamabushitake, Monkey Head Mushroom

Supports nerve growth factor (NGF) production, which helps maintain neurons and enhance cognitive function.

Efficacy: Medium  |  Grade: B

Microdosing Lithium

Lithium Orotate Microdose, Low-Dose Lithium

Supports long-term brain health by protecting neurons and promoting cellular maintenance and cleanup processes.

Efficacy: Medium  |  Grade: B

Low Dose Naltrexone (LDN)

LDN

May reduce neuroinflammation, potentially protecting brain health and supporting mood and cognitive function in certain conditions.

Efficacy: Medium  |  Grade: B

Magnesium Chloride

MgCl2, Magnesium oil

Plays a key role in neurotransmitter function, supporting a calm mood and neuronal health.

Efficacy: Medium  |  Grade: B

Magnesium Citrate

Magnesium

Contributes to a calm nervous system and supports healthy nerve signaling, which is essential for mood and focus.

Efficacy: Medium  |  Grade: B

Magnesium Glycinate

Magnesium Bisglycinate

Promotes a calm, focused mind by supporting healthy neurotransmitter function and nervous system regulation.

Efficacy: Medium  |  Grade: B

Liposomal Magnesium

Liposome-encapsulated Magnesium

Plays a key role in neurotransmitter regulation, which supports mood balance and cognitive function.

Efficacy: Medium  |  Grade: B

Magnesium Taurate

Mg Taurate

Promotes a calm, focused mental state by supporting neurotransmitter balance and protecting brain cells.

Efficacy: Medium  |  Grade: B

Magnesium

Magnesium Citrate, Magnesium Glycinate, Magnesium L-Threonate, Magnesium Oxide

Aids in nerve signal transmission and synaptic plasticity, supporting learning, memory, and a calm mood.

Efficacy: Medium  |  Grade: B

Medicinal Mushrooms (Beta-Glucans)

Beta-Glucans, Mushroom Polysaccharides

Promotes nerve growth factor (NGF) production, which supports cognitive function and long-term brain health.

Efficacy: Medium  |  Grade: B

Liposomal Melatonin

Encapsulated Melatonin, Liposome-Entrapped Melatonin

Acts as a powerful brain antioxidant and supports the nightly clearance of cellular waste.

Efficacy: Medium  |  Grade: B

Myo-inositol

Inositol, Vitamin B8, cis-1,2,3,5-trans-4,6-cyclohexanehexol

Acts as a key messenger molecule in the brain, potentially supporting stable mood and cognitive function.

Efficacy: Medium  |  Grade: B

Liposomal NAD+

Liposomal Nicotinamide Adenine Dinucleotide

Supports brain cell energy and repair processes, which may help maintain cognitive function with age.

Efficacy: Medium  |  Grade: B

NAD+ (IV Therapy)

Nicotinamide Adenine Dinucleotide IV, IV NAD+ Therapy

Aids neuronal energy metabolism and DNA repair, which are essential for maintaining cognitive function with age.

Efficacy: Medium  |  Grade: B

Liposomal NMN

Liposomal Nicotinamide Mononucleotide

Supports brain cell energy metabolism, which may help maintain cognitive function and neural health with age.

Efficacy: Medium  |  Grade: B

Noopept

N-phenylacetyl-L-prolylglycine ethyl ester, GVS-111

Supports memory formation and brain cell health by increasing key neurotrophic factors like BDNF.

Efficacy: Medium  |  Grade: B

Liposomal Nicotinamide Riboside

Liposomal NR

Supports brain cell energy metabolism, which is crucial for neuronal health and long-term cognitive function.

Efficacy: Medium  |  Grade: B

Panax Ginseng

Asian Ginseng, Korean Ginseng, Ren Shen

Enhances mental clarity and working memory, supporting cognitive function during demanding tasks and as we age.

Efficacy: Medium  |  Grade: B

Peppermint Oil

Mentha piperita oil

Its aroma can enhance alertness, improve memory, and reduce mental fatigue for better cognitive performance.

Efficacy: Medium  |  Grade: B

Piperine

Black Pepper Extract, Bioperine

May protect brain cells from stress and supports neurotransmitters involved in mood and cognitive function.

Efficacy: Medium  |  Grade: B

Piracetam

Nootropil, Lucetam, 2-oxo-1-pyrrolidine acetamide

Supports neuronal membrane health and neurotransmitter function, potentially aiding cognitive clarity and memory recall.

Efficacy: Medium  |  Grade: B

Pyrroloquinoline Quinone (PQQ)

PQQ

Protects brain cells from stress and supports cognitive functions like attention and memory by improving neuronal energy.

Efficacy: Medium  |  Grade: B

Prebiotic Supplements

Prebiotics, Fermentable Fiber, Inulin, FOS, GOS

Supports mood and cognitive function by influencing the gut-brain axis and production of beneficial compounds.

Efficacy: Medium  |  Grade: B

Pregnenolone

P5, 3β-hydroxypregn-5-en-20-one

Supports cognitive functions like memory and learning by acting as a key neurosteroid in the brain.

Efficacy: Medium  |  Grade: B

Probiotics

Beneficial Bacteria, Live Cultures

Supports mood and cognitive function by influencing the gut-brain axis and neurotransmitter production.

Efficacy: Medium  |  Grade: B

Pterostilbene

Dimethylresveratrol, 3,5-dimethoxy-4'-hydroxystilbene

Protects brain cells from oxidative stress and may help maintain cognitive function with age.

Efficacy: Medium  |  Grade: B

Liposomal Resveratrol

Liposomal Trans-Resveratrol

Enhances brain health by improving cerebral blood flow and protecting neurons from oxidative stress.

Efficacy: Medium  |  Grade: B

Resveratrol

trans-Resveratrol, 3,5,4'-trihydroxy-trans-stilbene

Enhances blood flow to the brain, which may support memory, focus, and overall cognitive function.

Efficacy: Medium  |  Grade: B

Retatrutide

LY3437943

Supports long-term brain health by improving metabolic markers that are closely linked to cognitive function.

Efficacy: Medium  |  Grade: B

Rhodiola Rosea

Golden Root, Arctic Root, Roseroot

Enhances mental clarity and cognitive performance, especially during periods of stress and fatigue.

Efficacy: Medium  |  Grade: B

Schisandra

Schisandra chinensis, Five-Flavor Berry, Wu Wei Zi

Supports mental performance and cognitive clarity, particularly during periods of high stress.

Efficacy: Medium  |  Grade: B

Selenium

Selenomethionine, Selenocysteine, Sodium Selenite

Protects brain cells from oxidative stress, which helps support long-term cognitive function and mood.

Efficacy: Medium  |  Grade: B

Sermorelin

Geref, GHRH (1-29)

May support cognitive function, particularly memory and executive function, in aging individuals.

Efficacy: Medium  |  Grade: B

SGLT2 Inhibitors

Gliflozins

May support brain health by improving blood flow and providing a more efficient energy source for brain cells.

Efficacy: Medium  |  Grade: B

Orthosilicic acid

OSA, Choline-stabilized orthosilicic acid (ch-OSA), Silica

May help protect the brain by reducing the body's accumulation of aluminum, a potential neurotoxin.

Efficacy: Medium  |  Grade: B

Spermidine

N-(3-aminopropyl)butane-1,4-diamine

Promotes the brain's natural cleanup processes, which may help preserve memory and cognitive function with age.

Efficacy: Medium  |  Grade: B

SS-31

Elamipretide, Bendavia, MTP-131

Supports brain cell health by improving mitochondrial energy and reducing oxidative stress, which may aid cognitive function.

Efficacy: Medium  |  Grade: B

Statins

HMG-CoA reductase inhibitors

By improving blood flow and reducing stroke risk, statins may help protect the brain from vascular-related damage.

Efficacy: Medium  |  Grade: B

Sulbutiamine

Arcalion, Enerion, Bisibutiamine

May improve memory and attention by increasing brain thiamine levels, which supports neurotransmitter function.

Efficacy: Medium  |  Grade: B

Sulforaphane

SFN, Glucoraphanin, Broccoli Sprout Extract

Protects brain cells from stress and inflammation, supporting long-term cognitive function and brain health.

Efficacy: Medium  |  Grade: B

Sustained Release Melatonin

Time-Release Melatonin, Extended-Release Melatonin, Prolonged-Release Melatonin

Provides neuroprotective antioxidant effects and supports the brain's nightly waste clearance system by improving deep sleep.

Efficacy: Medium  |  Grade: B

Sustained Release Niacin

SR Niacin, Slow-Release Niacin

Supports brain cell energy production by serving as a precursor to NAD+, a coenzyme essential for neuronal health.

Efficacy: Medium  |  Grade: B

Sustained Release Pregnenolone

Pregnenolone SR, Time-Release Pregnenolone

Supports cognitive functions like memory and mood by acting as a key neurosteroid in the brain.

Efficacy: Medium  |  Grade: B

Taurine

2-aminoethanesulfonic acid, L-Taurine

Protects brain cells from damage and supports a calm, focused mental state by acting as a neurotransmitter.

Efficacy: Medium  |  Grade: B

TB-500

Thymosin Beta-4

Protects brain cells from damage and supports the formation of new neural connections following injury.

Efficacy: Medium  |  Grade: B

Ubiquinol

Reduced Coenzyme Q10, Reduced CoQ10

Protects brain cells from oxidative stress and supports the high energy demands of cognitive function.

Efficacy: Medium  |  Grade: B

Vitamin A

Retinol, Retinal, Retinoic Acid, Carotenoids

Supports brain cell development and plasticity, which is important for learning and memory functions.

Efficacy: Medium  |  Grade: B

Vitamin E

Tocopherols, Tocotrienols, Alpha-tocopherol

Acts as a primary antioxidant in the brain, helping to protect neuronal membranes from oxidative damage.

Efficacy: Medium  |  Grade: B

Zinc Gluconate

Zincum Gluconicum

Supports neurotransmitter function and brain cell health, which are essential for learning and memory.

Efficacy: Low  |  Grade: B

Beta-Alanine

β-Alanine, 3-aminopropanoic acid

May support cognitive function and reduce mental fatigue, particularly in older adults or under stressful conditions.

Efficacy: Low  |  Grade: B

Boswellia

Indian Frankincense, Boswellia serrata

May support cognitive function by reducing brain inflammation and protecting neurons from oxidative stress.

Efficacy: Low  |  Grade: B

Chromium Picolinate

Chromium(III) picolinate

May support cognitive function and memory by improving the brain's utilization of glucose for energy.

Efficacy: Low  |  Grade: B

Chromium

Chromium Picolinate, Chromium Polynicotinate, Chromium Chloride

Aids in regulating the brain's glucose supply, which may support stable mood and cognitive function.

Efficacy: Low  |  Grade: B

DHEA

Dehydroepiandrosterone

May support a positive mood and sense of well-being by acting as a neurosteroid in the brain.

Efficacy: Medium  |  Grade: C

Liposomal GABA

Liposomal Gamma-Aminobutyric Acid

Promotes a calm and focused mental state by reducing excessive neuronal activity and mental noise.

Efficacy: Low  |  Grade: B

Ginger

Zingiber officinale

Its antioxidant compounds may help protect brain cells from stress and support cognitive function with age.

Efficacy: Low  |  Grade: B

Glycine

2-Aminoacetic acid

Functions as a neurotransmitter that may support memory, attention, and overall cognitive function.

Efficacy: Medium  |  Grade: C

MOTS-c

Mitochondrial-derived peptide

Supports brain cell energy and may protect against age-related cognitive decline by improving mitochondrial function.

Efficacy: Medium  |  Grade: C

NMN

Nicotinamide Mononucleotide

May support brain cell energy and repair, potentially aiding cognitive function as we age.

Efficacy: Medium  |  Grade: C

Nicotinamide Riboside

NR, Niagen

Supports brain cell energy and health by increasing NAD+, a key molecule for neuronal function.

Efficacy: Low  |  Grade: B

Phytoestrogens: Soy Isoflavones

Isoflavones, Genistein, Daidzein, Glycitein

May support cognitive functions like memory and executive processing, particularly during menopausal transitions.

Efficacy: Low  |  Grade: B

Tart Cherry Extract

Montmorency Cherry, Sour Cherry, Prunus cerasus

May protect brain cells from oxidative stress, supporting cognitive function in older adults.

Efficacy: Medium  |  Grade: C

Urolithin A

UA

May support brain cell health by clearing damaged mitochondria, a process crucial for neuronal energy.

Efficacy: Low  |  Grade: B

Valerian Root

Valeriana officinalis, Garden Heliotrope

Promotes a calm and relaxed mental state by modulating key neurotransmitter activity in the brain.

Efficacy: Low  |  Grade: B

Zinc Picolinate

Zinc (Picolinate)

Supports healthy brain function by contributing to neurotransmitter regulation and neuronal communication.

Efficacy: Low  |  Grade: C

3-Hydroxyanthranilic Acid

3-HAA

May offer neuroprotective effects by acting as an antioxidant within the brain's metabolic pathways.

Efficacy: Low  |  Grade: C

Aged Garlic Extract

AGE, Kyolic Garlic Extract

Offers antioxidant properties that may help protect brain cells from age-related oxidative stress.

Efficacy: Low  |  Grade: C

AICAR

Acadesine, 5-Aminoimidazole-4-carboxamide ribonucleotide

May offer neuroprotective effects by improving brain cell energy regulation and waste clearance.

Efficacy: Low  |  Grade: C

Akkermansia Muciniphila

A. muciniphila, Akkermansia

May support brain health by strengthening the gut lining, which helps reduce systemic inflammation.

Efficacy: Low  |  Grade: C

Berberine

Berberine HCL

May offer neuroprotective benefits by reducing inflammation and oxidative stress in the brain, though human evidence is limited.

Efficacy: Low  |  Grade: C

BPC-157

Body Protection Compound 157, Bepecin

May offer protective effects to the nervous system and support recovery from certain types of brain injury.

Efficacy: Low  |  Grade: C

Chamomile Extract

Matricaria recutita, Chamaemelum nobile, Apigenin

May offer neuroprotective benefits and promote a calm mind, potentially reducing anxiety-related distraction.

Efficacy: Low  |  Grade: C

Chromium Polynicotinate

Chromium Niacinate, Chromium Nicotinate

May support brain health by helping to maintain a stable energy supply from glucose metabolism.

Efficacy: Low  |  Grade: C

Cinnamon Extract

Cinnamomum verum, Cinnamomum cassia, Ceylon Cinnamon, Cassia Cinnamon

May offer neuroprotective benefits by reducing inflammation and oxidative stress in the brain.

Efficacy: Low  |  Grade: C

Eleuthero (Siberian Ginseng)

Siberian Ginseng, Eleutherococcus senticosus

May help maintain mental clarity and focus, particularly during periods of physical or mental stress.

Efficacy: Low  |  Grade: C

Garlic Extract

Aged Garlic Extract, Allicin supplements

Provides antioxidant compounds that may help protect brain cells from age-related oxidative stress.

Efficacy: Low  |  Grade: C

Holy Basil (Tulsi)

Tulsi, Ocimum tenuiflorum, Ocimum sanctum

May enhance mental clarity and cognitive function, particularly by reducing the distracting effects of stress.

Efficacy: Low  |  Grade: C

L-Glutamine

Glutamine

Serves as a building block for key brain neurotransmitters essential for normal cognitive function.

Efficacy: Low  |  Grade: C

Lycopene

psi-psi-carotene

As an antioxidant, it may help protect brain cells from oxidative stress, supporting long-term cognitive health.

Efficacy: Low  |  Grade: C

Maca Root

Lepidium meyenii, Peruvian Ginseng

May support mood and reduce feelings of anxiety, which can contribute to better mental clarity.

Efficacy: Low  |  Grade: C

Mastic Gum

Chios Mastic, Pistacia lentiscus

May offer neuroprotective benefits through its antioxidant properties, though human evidence is still emerging.

Efficacy: Low  |  Grade: C

Milk Thistle (Silymarin)

Silybum marianum, Silymarin, Silibinin

Offers antioxidant effects that may help protect brain cells from oxidative stress over the long term.

Efficacy: Low  |  Grade: C

MSM (Methylsulfonylmethane)

Dimethyl sulfone, DMSO2

May provide sulfur for producing key brain antioxidants like glutathione, helping protect brain cells from oxidative stress.

Efficacy: Low  |  Grade: C

Partially Hydrolyzed Guar Gum

PHGG, Sunfiber

Promotes a healthy gut-brain axis, which can contribute to a more stable mood and clearer thinking.

Efficacy: Low  |  Grade: C

Postbiotic Supplements

Postbiotics, Metabolite Supplements, Paraprobiotics

May support brain health by modulating the gut-brain axis and reducing gut-derived inflammatory signals.

Efficacy: Low  |  Grade: C

Protein Powder

Whey Protein, Casein Protein, Plant-Based Protein, Collagen Peptides

Provides amino acids that serve as precursors for key neurotransmitters essential for mood and cognitive function.

Efficacy: Low  |  Grade: C

Liposomal Quercetin

Liposome-encapsulated quercetin

May protect brain cells from oxidative stress and inflammation, which supports long-term brain health.

Efficacy: Low  |  Grade: C

Quercetin

Quercetin Dihydrate, Sophoretin

May help protect brain cells from oxidative stress, a key factor in supporting long-term cognitive health.

Efficacy: Low  |  Grade: C

Shilajit

Mumie, Mineral Pitch, Fulvic Acid

May protect long-term brain health by inhibiting the aggregation of certain cellular proteins.

Efficacy: Low  |  Grade: C

Vitamin B5

Pantothenic Acid

Contributes to the synthesis of acetylcholine, a neurotransmitter important for memory and nervous system function.

Efficacy: Low  |  Grade: C

Vitamin K2

Menaquinone, MK-4, MK-7

May contribute to brain cell health and offer neuroprotective effects against age-related changes.

Medications

Efficacy: High  |  Grade: A

Estradiol

E2, 17β-estradiol, Oestradiol

Promotes brain health by protecting neurons and supporting memory, mood, and overall cognitive function.

Efficacy: High  |  Grade: A

Galanthamine

Razadyne, Nivalin, Lycoremine

Supports memory, learning, and attention by increasing key neurotransmitters involved in cognitive processing.

Efficacy: High  |  Grade: A

Menopausal HRT

Hormone Replacement Therapy, MHT, Menopausal Hormone Therapy

Alleviates menopausal brain fog and may reduce the long-term risk of dementia when initiated near menopause.

Efficacy: High  |  Grade: A

Modafinil

Provigil, Alertec

Promotes wakefulness and enhances cognitive functions like attention, memory, and executive control in certain populations.

Efficacy: High  |  Grade: A

Omega-3 Fatty Acids

Fish Oil, EPA, DHA, Marine Oils, Omega-3 Softgel, Omega-3 Supplement

Supports brain cell structure and communication, which is essential for memory, focus, and cognitive longevity.

Efficacy: High  |  Grade: A

Vitamin B1 (Thiamine)

Thiamin

Supports brain energy metabolism and nerve function, which is crucial for maintaining cognitive clarity and memory.

Efficacy: Medium  |  Grade: A

Amlodipine

Norvasc, Katerzia, Amvaz

Helps protect brain blood vessels by managing blood pressure, reducing risk of stroke and vascular cognitive decline.

Efficacy: Medium  |  Grade: A

Angiotensin Receptor Blockers

ARBs

Protects brain blood vessels by managing blood pressure, which helps reduce the risk of stroke and vascular dementia.

Efficacy: Medium  |  Grade: A

Atorvastatin

Lipitor

Protects the brain's blood vessels by reducing atherosclerosis, which lowers the risk of stroke.

Efficacy: Medium  |  Grade: A

Estradiol Cypionate

Depo-Estradiol

Supports cognitive function and may help protect against age-related cognitive decline by maintaining brain cell health.

Efficacy: Medium  |  Grade: A

Lisinopril

Prinivil, Zestril

Helps protect brain blood vessels from high pressure, reducing risk of stroke and cognitive decline.

Efficacy: High  |  Grade: B

Lithium Carbonate

Lithium, Lithium Orotate

Promotes brain cell resilience and growth, potentially protecting against age-related cognitive decline and supporting mood stability.

Efficacy: Medium  |  Grade: A

Oxytocin

OT, Love Hormone

Promotes social bonding and reduces stress, which supports overall mental well-being and cognitive resilience.

Efficacy: Medium  |  Grade: A

PCSK9 Inhibitors

Proprotein Convertase Subtilisin/Kexin type 9 Inhibitors

Supports brain health by improving blood flow and significantly reducing the risk of stroke.

Efficacy: Medium  |  Grade: A

Pitavastatin

Livalo, Zypitamag

By improving blood flow and reducing stroke risk, it helps protect the brain from vascular-related cognitive decline.

Efficacy: Medium  |  Grade: A

Propranolol

Inderal, InnoPran XL

Helps manage the physical symptoms of performance anxiety and can prevent migraines, promoting focus under pressure.

Efficacy: High  |  Grade: B

Rapamycin

Sirolimus

Promotes cellular cleanup in the brain, which may help preserve cognitive function and memory with age.

Efficacy: Medium  |  Grade: A

Simvastatin

Zocor

Reduces the risk of stroke by improving blood flow, thereby protecting brain tissue from vascular damage.

Efficacy: Medium  |  Grade: A

Vitamin D3

Cholecalciferol (D3), Ergocalciferol (D2), Calcifediol, Calcitriol

Acts as a neuro-steroid, protecting brain cells and supporting mood and long-term cognitive function.

Efficacy: Medium  |  Grade: B

Acarbose

Precose, Glucobay

Helps stabilize blood sugar levels, which may protect against age-related cognitive decline.

Efficacy: Medium  |  Grade: B

ACE Inhibitors

Angiotensin-Converting Enzyme Inhibitors

Helps protect brain health by maintaining healthy blood flow, reducing the risk of vascular-related cognitive decline.

Efficacy: Medium  |  Grade: B

Aliskiren

Tekturna, Rasilez

Helps protect brain health and cognitive function by maintaining healthy blood pressure and cerebral blood flow.

Efficacy: Medium  |  Grade: B

Bexagliflozin

Brenzavvy

May support long-term brain health by improving metabolic function and reducing factors linked to cognitive decline.

Efficacy: Medium  |  Grade: B

Canagliflozin

Invokana

May support long-term brain health by improving blood sugar control and cardiovascular function.

Efficacy: Medium  |  Grade: B

Daily Low-Dose Tadalafil

Cialis (daily), PDE5 inhibitor

May support brain health by improving cerebral blood flow, potentially enhancing cognitive function and neural waste clearance.

Efficacy: Medium  |  Grade: B

Dapagliflozin

Farxiga

May protect brain health by improving blood flow and reducing inflammation, potentially lowering long-term cognitive decline risk.

Efficacy: Medium  |  Grade: B

Dasatinib

Sprycel

May support cognitive health by clearing senescent cells that contribute to chronic neuroinflammation.

Efficacy: Medium  |  Grade: B

Dual Orexin Receptor Antagonists

DORAs, Lemborexant, Suvorexant, Daridorexant

Supports the brain's nightly clearance processes and memory consolidation by enabling more restorative sleep.

Efficacy: Medium  |  Grade: B

Empagliflozin

Jardiance

May support long-term brain health by improving blood vessel function and overall metabolic stability.

Efficacy: Medium  |  Grade: B

Erythropoietin

EPO, Epoetin alfa

Offers neuroprotective effects and may support cognitive functions by protecting brain cells from stress and injury.

Efficacy: Medium  |  Grade: B

Estradiol Valerate

EV, Delestrogen

Helps maintain cognitive function and mood stability by supporting brain cell health and neurotransmitter balance.

Efficacy: Medium  |  Grade: B

Everolimus

Afinitor, Zortress, RAD001

Promotes cellular cleanup processes in the brain, potentially protecting against age-related cognitive decline.

Efficacy: Medium  |  Grade: B

GLP-1 Receptor Agonists

Incretin Mimetics, GLP-1 RAs

May protect brain cells from inflammation and support cognitive function, particularly in metabolic-related decline.

Efficacy: Medium  |  Grade: B

Icosapent Ethyl

Vascepa, purified EPA

Supports brain health by reducing inflammation and may help maintain stable mood and cognitive function.

Efficacy: Medium  |  Grade: B

Lovastatin

Mevacor, Altoprev

Supports brain health by improving blood flow and reducing the risk of vascular events like stroke.

Efficacy: Medium  |  Grade: B

Metformin

Glucophage, Fortamet, Glumetza

May protect against age-related cognitive decline by improving brain insulin sensitivity and reducing inflammation.

Efficacy: Medium  |  Grade: B

mTOR Inhibitors

Rapalogs, Mechanistic Target of Rapamycin Inhibitors

Helps clear cellular waste from the brain, which may protect against age-related cognitive decline.

Efficacy: Medium  |  Grade: B

NAC

N-Acetylcysteine, N-acetyl-L-cysteine

Protects brain cells from oxidative damage and helps regulate key neurotransmitters for mood and focus.

Efficacy: Medium  |  Grade: B

Nebivolol

Bystolic, Brevibloc

Helps protect brain blood vessels by managing blood pressure, supporting long-term cognitive health.

Efficacy: Medium  |  Grade: B

Niacin (Vitamin B3)

Nicotinic Acid, Vitamin B3

Supports brain cell energy and repair by serving as a building block for the essential coenzyme NAD+.

Efficacy: Medium  |  Grade: B

Nicotine (Non-Tobacco)

Nicotine Polacrilex

Enhances alertness, sharpens focus, and may support working memory by acting on key brain receptors.

Efficacy: Medium  |  Grade: B

PDE5 Inhibitors

Phosphodiesterase-5 Inhibitors, Tadalafil, Sildenafil, Vardenafil, Avanafil

May enhance cerebral blood flow, potentially supporting cognitive function and protecting against vascular-related decline.

Efficacy: Medium  |  Grade: B

Progesterone

P4, Bioidentical Progesterone, Prometrium

Offers neuroprotective effects and supports a calm mood, which can aid in maintaining mental clarity.

Efficacy: Medium  |  Grade: B

Ramelteon

Rozerem

Supports brain health and cognitive processes by improving sleep quality and reinforcing the natural sleep-wake cycle.

Efficacy: Medium  |  Grade: B

Rosuvastatin

Crestor

Supports brain health by improving blood flow and reducing the risk of vascular events like strokes.

Efficacy: Medium  |  Grade: B

Semaglutide

Ozempic, Wegovy, Rybelsus

May offer neuroprotective benefits by reducing inflammation and supporting brain health, particularly in metabolic dysfunction.

Efficacy: Medium  |  Grade: B

Telmisartan

Micardis

Protects the brain from vascular damage by managing blood pressure and may offer additional neuroprotective benefits.

Efficacy: Medium  |  Grade: B

Tesamorelin

Egrifta

May support cognitive functions like memory and executive processing, particularly in aging individuals.

Efficacy: Medium  |  Grade: B

Testosterone Replacement Therapy

TRT, Testosterone Therapy

Can improve mood, motivation, and libido, which are key components of cognitive and mental well-being.

Efficacy: Medium  |  Grade: B

Testosterone Therapy (Women) (Topical)

Low-dose Testosterone for Women, Female Androgen Therapy

Can improve mood, mental clarity, and cognitive function, potentially reducing 'brain fog' in some women.

Efficacy: Medium  |  Grade: B

Testosterone

TRT, Testosterone Replacement Therapy

May improve mood, mental energy, and certain aspects of cognitive function like verbal memory and motivation.

Efficacy: Medium  |  Grade: B

Tirzepatide

Mounjaro, Zepbound

May support brain health by improving metabolic function, which is closely linked to long-term cognitive integrity.

Efficacy: Medium  |  Grade: B

Trazodone

Desyrel, Oleptro

Promotes deep sleep, which is essential for the brain's nightly cleanup processes and memory consolidation.

Efficacy: Medium  |  Grade: B

Vitamin C

Ascorbic Acid, L-Ascorbic Acid

Acts as a key antioxidant in the brain and aids in producing neurotransmitters for mood and focus.

Efficacy: Low  |  Grade: B

Pravastatin

Pravachol

By improving blood flow and reducing the risk of stroke, pravastatin helps protect brain tissue from vascular damage.

Efficacy: Low  |  Grade: C

Ertugliflozin

Steglatro

May support long-term brain health by improving the body's overall metabolic state and glucose control.

Efficacy: Low  |  Grade: C

Ezetimibe

Zetia

May support long-term brain health by improving blood flow and reducing the risk of cerebrovascular events.

Efficacy: Low  |  Grade: C

Fibrates

Fenofibrate, Gemfibrozil, Bezafibrate, Ciprofibrate

May offer neuroprotective effects by reducing inflammation in the brain, though human cognitive benefits remain theoretical.

Efficacy: Low  |  Grade: C

Fluvastatin

Lescol, Lescol XL

May support brain health by improving blood vessel function, reducing risk of vascular-related cognitive decline.

Efficacy: Low  |  Grade: C

Inclisiran

Leqvio

May support long-term brain health by improving the vascular integrity of blood vessels supplying the brain.

Efficacy: Low  |  Grade: C

Potassium Chloride

KCl, Potassium salt

Essential for proper nerve signal transmission, which is the foundation for all brain and cognitive functions.

Efficacy: Low  |  Grade: C

Potassium Citrate

K-Citrate, Urocit-K

Contributes to proper nerve signaling by maintaining essential electrolyte balance for brain function.

Topical Agents

Dietary Practices

Efficacy: High  |  Grade: A

Anti-Inflammatory Diet

Mediterranean Diet, DASH Diet, MIND Diet

Combats neuroinflammation, protecting brain cells and supporting cognitive function and long-term brain health.

Efficacy: High  |  Grade: A

Avoiding Processed Foods

Minimally Processed Diet, Whole Foods Diet

Protects against cognitive decline and brain inflammation by providing essential nutrients for optimal brain function.

Efficacy: High  |  Grade: A

The Blue Zones Diet

Longevity Diet, Blue Zone Eating Pattern

Supports long-term cognitive function and protects the brain with a rich supply of antioxidants and polyphenols.

Efficacy: High  |  Grade: A

Mediterranean Diet

MedDiet

Protects brain health and cognitive function, helping to preserve memory and slow age-related mental decline.

Efficacy: High  |  Grade: A

MIND Diet

Mediterranean-DASH Intervention for Neurodegenerative Delay

Specifically designed to protect the brain against age-related cognitive decline and support long-term memory.

Efficacy: High  |  Grade: A

Pescatarian Diet

Pescatarianism, Fish-based diet

Supports cognitive function and may reduce risk of age-related decline through brain-healthy omega-3 fatty acids.

Efficacy: High  |  Grade: A

Polyphenol-Rich Diet

High-Polyphenol Diet, Colorful Diet, Polyphenol-rich Foods, Phytonutrient-dense foods, Flavonoid-rich foods

Protects brain cells from stress and enhances cerebral blood flow, supporting memory and cognitive function with age.

Efficacy: Medium  |  Grade: A

DASH Diet

Dietary Approaches to Stop Hypertension

Promotes healthy blood flow to the brain, which helps protect against age-related cognitive decline.

Efficacy: High  |  Grade: B

Ketogenic Diet

Keto, Keto Diet

Provides the brain with a stable, alternative fuel source, potentially enhancing mental clarity and neuroprotection.

Efficacy: Medium  |  Grade: A

Plant-Forward Diet

Plant-Based Diet, Flexitarian Diet, Vegetarian Diet, Vegan Diet

Provides antioxidants and nutrients that protect brain cells and support cognitive function with age.

Efficacy: Medium  |  Grade: A

Protein

Amino Acids, Dietary Protein

Provides amino acids that are precursors to neurotransmitters critical for mood, focus, and cognitive function.

Efficacy: Medium  |  Grade: A

Whole Food Plant Based

WFPB, Plant-Based Diet

Supports long-term cognitive function and brain health by improving blood flow and reducing oxidative stress.

Efficacy: Medium  |  Grade: B

Alternate-Day Fasting (ADF)

ADF, Every-Other-Day Fasting

May enhance mental clarity and support brain cell health by promoting cellular cleanup and efficient energy use.

Efficacy: Medium  |  Grade: B

Beetroot Juice

Beet Juice, Beetroot Extract

Supports cognitive function and mental stamina by increasing blood flow and oxygen delivery to the brain.

Efficacy: Medium  |  Grade: B

Blueprint Protocol

Bryan Johnson's Blueprint

Supports cognitive function and brain health with targeted nutrients, rigorous exercise, and optimized sleep.

Efficacy: Medium  |  Grade: B

Calorie Restriction Diet

CR, Caloric Restriction

May protect brain cells from age-related stress and support cognitive functions like memory.

Efficacy: Medium  |  Grade: B

Calorie Restriction Without Malnutrition

CR, Dietary Restriction, Nutritional Restriction

Promotes cellular cleanup processes in the brain, potentially protecting against age-related cognitive decline and supporting memory.

Efficacy: Medium  |  Grade: B

Cruciferous Vegetables

Brassicas, Cole crops

Provides neuroprotective compounds that help defend the brain against oxidative stress and inflammation.

Efficacy: Medium  |  Grade: B

Dietary Nitrate

Beetroot Juice, Leafy Greens, NO3-

Supports cognitive function and mental clarity by increasing blood flow and oxygen delivery to the brain.

Efficacy: Medium  |  Grade: B

Fasting-Mimicking Diet (FMD)

FMD, Prolon Diet

Promotes cellular cleanup and may support the generation of new brain cells in animal models.

Efficacy: Medium  |  Grade: B

Fermented Foods

Probiotic Foods, Live Culture Foods, Gut-Healthy Foods

Supports mood and cognitive function through the gut-brain axis by influencing neurotransmitter production.

Efficacy: Medium  |  Grade: B

5:2 Diet

The Fast Diet, Intermittent Fasting (5:2)

May support brain health by promoting cellular cleanup processes and reducing inflammation, potentially aiding long-term cognitive function.

Efficacy: Medium  |  Grade: B

Flaxseed

Linseed, Ground Flaxseed

Provides ALA omega-3s, which are building blocks for brain cells and support cognitive function.

Efficacy: Medium  |  Grade: B

Flexitarian Diet

Semi-vegetarianism, Flexible vegetarianism

Supports cognitive function by providing antioxidants and nutrients that reduce inflammation and protect brain cells.

Efficacy: Medium  |  Grade: B

Gluten-Free Diet

GF Diet

Reduces inflammation-related 'brain fog' and protects neurological function in gluten-sensitive individuals.

Efficacy: Medium  |  Grade: B

High-Fiber Diet

Fiber-rich eating, Plant-forward diet

Supports cognitive function and mood by nourishing the gut-brain axis and stabilizing blood sugar levels.

Efficacy: Medium  |  Grade: B

5:2 Intermittent Fasting

5-2 method, The Fast Diet

May enhance cognitive function and protect brain cells by promoting cellular cleanup and growth factors.

Efficacy: Medium  |  Grade: B

Intermittent Fasting

IF, Periodic Fasting

Supports brain cell health and cleanup processes, which may enhance long-term cognitive function and clarity.

Efficacy: Medium  |  Grade: B

Low-Carb Diet

Very Low-Carbohydrate Ketogenic Diet (VLCKD), Keto Diet

Provides a stable fuel source for the brain, potentially enhancing mental clarity and supporting cognitive function.

Efficacy: Medium  |  Grade: B

Low-FODMAP Diet

Low Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols Diet

Can improve mental clarity and reduce 'brain fog' by easing gut-related inflammation and discomfort.

Efficacy: Medium  |  Grade: B

Nordic Diet

New Nordic Diet, NND

Provides key nutrients like omega-3s and antioxidants that support cognitive function and long-term brain health.

Efficacy: Medium  |  Grade: B

The Okinawa Diet

Okinawan Longevity Diet, Traditional Okinawan Diet

Provides antioxidants and healthy fats that protect brain cells from stress and support long-term cognitive function.

Efficacy: Medium  |  Grade: B

One Meal A Day

OMAD, 23:1 Intermittent Fasting

May enhance mental clarity and support neuron health by promoting cellular cleanup and producing brain-fueling ketones.

Efficacy: Medium  |  Grade: B

Ovo-Lacto Vegetarian Diet

Vegetarian Diet

Supports long-term cognitive health through improved vascular function and high antioxidant intake from plants.

Efficacy: Medium  |  Grade: B

Potassium

K, Potassium Chloride, Potassium Citrate

Supports proper nerve signal transmission, which is essential for maintaining healthy brain and cognitive function.

Efficacy: Medium  |  Grade: B

Prolonged Fasting (Supervised)

Therapeutic Fasting, Extended Fasting, Water Fasting (Supervised)

Promotes cellular cleanup and the creation of key growth factors in the brain, supporting cognitive function.

Efficacy: Medium  |  Grade: B

Resistant Starch

RS, Undigestable Starch

Supports brain health and cognitive function through the gut-brain axis by producing beneficial compounds.

Efficacy: Medium  |  Grade: B

Soluble Fiber

Dietary fiber (soluble), Beta-glucans, Psyllium, Inulin, Pectins

Supports the gut-brain axis by nourishing beneficial bacteria, which helps reduce systemic and neuro-inflammation.

Efficacy: Medium  |  Grade: B

Time-Restricted Eating (16:8)

TRE, 16:8 Intermittent Fasting, Leangains Protocol

May support brain health by promoting cellular cleanup processes and growth factors for neurons.

Efficacy: Medium  |  Grade: B

Vegan Diet

Plant-Based Diet, Strict Vegetarianism

Rich in antioxidants that protect brain cells and improves cerebral blood flow, potentially reducing cognitive decline.

Efficacy: Medium  |  Grade: B

Vegetarian Diet

Plant-based diet, Lacto-ovo vegetarianism

High intake of plant-based antioxidants and polyphenols may protect brain cells and support long-term cognitive function.

Efficacy: Medium  |  Grade: B

Water Fasting

Prolonged Fasting, Extended Fasting

Promotes cellular cleanup processes in the brain and may enhance mental clarity and neuronal support.

Efficacy: Medium  |  Grade: C

Autoimmune Protocol Diet

AIP, AIP Diet

May improve mental clarity and reduce 'brain fog' by calming systemic inflammation via the gut-brain axis.

Efficacy: Medium  |  Grade: C

Branched-Chain Amino AcidRestriction

Low BCAA Diet

May improve the brain's access to precursors for key neurotransmitters like serotonin and dopamine.

Efficacy: Low  |  Grade: B

Inulin (Prebiotic Fiber)

Prebiotic Fiber, Chicory Root Fiber, Fructan

May support mood and cognitive function by nourishing the gut-brain axis and reducing systemic inflammation.

Efficacy: Low  |  Grade: B

Tart Cherry Juice

Montmorency Cherry, Prunus cerasus, Sour Cherry

Its antioxidant compounds may help protect brain cells and support cognitive function in older adults.

Efficacy: Medium  |  Grade: D

Carnivore Diet

All-Meat Diet, Zero-Carb Diet

May enhance mental clarity and reduce 'brain fog' for some by providing a stable, ketone-based energy source.

Efficacy: Low  |  Grade: C

Hibiscus Tea

Roselle Tea, Sour Tea, Karkadeh

Contains antioxidants that may offer a protective effect against oxidative stress in the brain.

Efficacy: Low  |  Grade: C

Kefir / Fermented Foods

Probiotic Foods, Cultured Foods

Supports the gut-brain axis, which may contribute to balanced mood and cognitive function.

Efficacy: Low  |  Grade: C

Paleo Diet

Paleolithic Diet, Caveman Diet

Supports stable energy levels and provides healthy fats, which are important for long-term brain health.

Efficacy: Low  |  Grade: D

Whole30

Whole 30 Diet, 30-Day Elimination Diet

Anecdotally reported to enhance mental clarity by stabilizing blood sugar and removing potential inflammatory foods.

Lifestyle Practices

Efficacy: High  |  Grade: A

Breathwork

Pranayama, Conscious Connected Breathing, Holotropic Breathwork, Wim Hof Method

Directly influences the nervous system to enhance mental clarity, reduce anxiety, and improve sustained focus.

Efficacy: High  |  Grade: A

Meditation

Mindfulness, Vipassanā, Zazen, Transcendental Meditation

Enhances focus, memory, and emotional regulation by promoting positive structural changes in the brain.

Efficacy: High  |  Grade: A

Mindfulness Meditation

Mindfulness-Based Stress Reduction (MBSR), Vipassana, Concentrative Meditation

Enhances focus and attention while promoting structural brain changes that support cognitive function and emotional balance.

Efficacy: High  |  Grade: A

Relaxation

Meditation, Mindfulness, Yoga, Tai Chi, Deep Breathing, Progressive Muscle Relaxation

Reduces stress hormones that can impair cognition, helping to protect brain structure and improve focus.

Efficacy: High  |  Grade: A

Running

Jogging, Aerobic Exercise, Cardio

Boosts brain-derived neurotrophic factor (BDNF), supporting neuron health, memory, and cognitive sharpness.

Efficacy: High  |  Grade: A

Smoking Cessation

Quitting Smoking, Tobacco Cessation

Improves blood flow to the brain, reducing the risk of stroke and preserving long-term cognitive function.

Efficacy: High  |  Grade: A

Stress Management

Mindfulness, Relaxation Techniques, Cognitive Behavioral Therapy (CBT), Meditation

Protects the brain from the damaging effects of stress hormones, supporting memory, focus, and cognitive clarity.

Efficacy: Medium  |  Grade: A

Deep Breathing Exercises

Diaphragmatic Breathing, Belly Breathing, Mindful Breathing

Enhances mental clarity and focus by calming the nervous system and reducing stress.

Efficacy: Medium  |  Grade: A

Strength Training

Resistance Training, Weightlifting, Resistance Exercise

Boosts cognitive function and memory by increasing brain-derived neurotrophic factor (BDNF) and improving cerebral blood flow.

Efficacy: High  |  Grade: B

Travel

Vacation, Exploration, Novelty Seeking

Experiencing new environments and cultures stimulates the brain, enhancing cognitive flexibility and creative problem-solving skills.

Efficacy: Medium  |  Grade: B

Blue Light Blocking Glasses

Blue Blockers, Amber Glasses, Sleep Glasses

May reduce digital eye strain and support brain health by promoting better sleep quality and onset.

Efficacy: Medium  |  Grade: B

Cold Exposure

Cold Therapy, Cold Water Immersion, Cryotherapy, Ice Bath

Triggers a release of norepinephrine, a key neurotransmitter for enhancing focus, mood, and alertness.

Efficacy: Medium  |  Grade: B

Electric Toothbrushing

Powered Toothbrushing

Helps reduce systemic inflammation from the mouth, which may protect against neuroinflammation and cognitive decline.

Efficacy: Medium  |  Grade: B

Regular Dental Cleanings

Prophylaxis, Oral Hygiene Visits, Professional Teeth Cleaning

May reduce neuroinflammation by preventing harmful oral bacteria from entering the bloodstream and reaching the brain.

Efficacy: Medium  |  Grade: B

Sauna

Sauna Bathing, Hyperthermic Conditioning, Heat Therapy

Supports neuron growth and may reduce dementia risk by increasing key brain-protective proteins like BDNF.

Efficacy: Medium  |  Grade: B

Sexual Activity

Sex, Intercourse, Orgasm

Releases neurotransmitters that enhance mood and may support long-term cognitive function and memory.

Efficacy: Medium  |  Grade: B

Temperature Regulating Mattresses

Cooling Mattresses, Smart Beds, Climate Control Sleep Systems

Enhances the brain's nightly cleanup process and memory consolidation by facilitating more consistent, high-quality sleep.

Efficacy: Low  |  Grade: B

EFT Tapping

Emotional Freedom Techniques, Tapping

Helps quiet brain regions associated with fear and anxiety, which can reduce mental clutter and distraction.

Efficacy: Low  |  Grade: C

Daily Flossing

Dental Flossing

May reduce the risk of neuroinflammation by limiting the circulation of harmful bacteria from the mouth.

Efficacy: Low  |  Grade: C

Mouth Taping

Oral Taping, Sleep Taping

May improve sleep quality and oxygenation, supporting the brain's nightly clearance processes and next-day focus.

Efficacy: Low  |  Grade: C

Sunglasses

UV-blocking eyewear, Shades

Reduces squinting and eye strain in bright conditions, which can help prevent fatigue and maintain comfortable focus.

Efficacy: Low  |  Grade: C

Water Flossing

Oral Irrigator, Water Pik

May reduce the systemic spread of specific oral bacteria associated with neuroinflammation and cognitive decline.

Efficacy: Low  |  Grade: C

Weighted Blankets (Topical)

sensory blankets, gravity blankets

May reduce anxiety and improve sleep quality, which supports daytime focus and mental clarity.

Exercise & Sports

Efficacy: High  |  Grade: A

Endurance Training

Aerobic Exercise, Cardio

Increases cerebral blood flow and promotes growth factors that support cognitive function and brain structure.

Efficacy: High  |  Grade: A

Jogging

Running, Aerobic Exercise

Boosts brain-derived neurotrophic factor (BDNF), supporting memory, cognitive function, and long-term brain health.

Efficacy: High  |  Grade: A

Martial Arts

Tai Chi, Judo, Karate, Brazilian Jiu-Jitsu, Kung Fu

Enhances cognitive functions like focus and memory by integrating complex motor skills with mindful awareness.

Efficacy: High  |  Grade: A

Regular Aerobic Exercise

Cardio, Endurance Training, Aerobics

Increases cerebral blood flow and key neurotrophic factors, supporting memory, mood, and cognitive function.

Efficacy: High  |  Grade: A

Table Tennis

Ping-Pong

Boosts cognitive function and sharpens focus by requiring rapid strategic thinking and precise hand-eye coordination.

Efficacy: High  |  Grade: A

Trail Running

Off-road running, Mountain running

Navigating uneven terrain enhances cognitive function and promotes brain health by increasing blood flow and neurotrophic factors.

Efficacy: Medium  |  Grade: A

Bicycling

Cycling

Increases blood flow to the brain, supporting cognitive function, memory, and the growth of new neurons.

Efficacy: High  |  Grade: B

Bouldering / Rock Climbing

Climbing

Enhances cognitive function and mental clarity through its unique combination of physical problem-solving and intense focus.

Efficacy: Medium  |  Grade: A

Calisthenics

Bodyweight Training, Bodyweight Exercise

Enhances cognitive function and mood by increasing blood flow and promoting growth factors in the brain.

Efficacy: Medium  |  Grade: A

Daily Brisk Walking

Brisk Walking, Regular Walking, Moderate-intensity Walking

Boosts blood flow to the brain, supporting cognitive function, memory, and long-term brain health.

Efficacy: High  |  Grade: B

Gymnastics

Artistic Gymnastics, Rhythmic Gymnastics, Calisthenics, Gymnastic Strength Training

The complex movements and spatial awareness required enhance neuroplasticity, improving focus, coordination, and balance.

Efficacy: Medium  |  Grade: A

High-Intensity Interval Training

HIIT, Sprint Interval Training

Boosts key brain-growth factors and increases cerebral blood flow, supporting cognitive function and mental clarity.

Efficacy: Medium  |  Grade: A

Hiking

Trekking, Rucking, Hillwalking

Boosts cognitive function and mood by increasing brain blood flow and promoting mental clarity in nature.

Efficacy: Medium  |  Grade: A

Indoor Cycling

Stationary Biking, Spinning

Increases blood flow to the brain and stimulates key growth factors, supporting cognitive function and mental clarity.

Efficacy: Medium  |  Grade: A

Kickball

Soccer Baseball, Football Rounders

Enhances cognitive function and brain blood flow through strategic play and physical activity.

Efficacy: Medium  |  Grade: A

Marathon Training

Long-Distance Running, Endurance Running Training

Enhances brain blood flow and growth factors, supporting cognitive function, memory, and mood regulation.

Efficacy: Medium  |  Grade: A

Padel

Padel tennis

Enhances cognitive functions like reaction time and strategic planning due to the fast-paced, decision-making demands.

Efficacy: High  |  Grade: B

Parkour

Freerunning, Art du Déplacement

Enhances focus, spatial awareness, and problem-solving skills by combining physical activity with environmental navigation.

Efficacy: Medium  |  Grade: A

Race Walking

Power Walking

Enhances brain blood flow and promotes growth factors, supporting cognitive function and long-term brain health.

Efficacy: Medium  |  Grade: A

Resistance Training

Strength Training, Weightlifting

Stimulates brain-derived growth factors that support cognitive function, memory, and overall brain health.

Efficacy: Medium  |  Grade: A

Road Cycling

Cycling, Bicycling

Increases cerebral blood flow and promotes neurotrophic factors, supporting cognitive function, mood, and brain integrity.

Efficacy: Medium  |  Grade: A

Rowing

Ergometer, Crew, Sculling

Promotes brain health by increasing blood flow and growth factors, supporting cognitive function and mental clarity.

Efficacy: Medium  |  Grade: A

Structured Interval Training

HIIT, High-Intensity Interval Training, SIT

Boosts key brain-growth factors like BDNF, supporting cognitive function and long-term brain health.

Efficacy: Medium  |  Grade: A

Swimming

Aquatic Exercise

Promotes new brain cell growth and enhances blood flow, supporting memory and cognitive function.

Efficacy: Medium  |  Grade: A

Tai Chi

Taijiquan

Enhances cognitive functions like memory and executive control by integrating physical coordination with focused attention.

Efficacy: Medium  |  Grade: A

Track and Field

Athletics

Enhances cognitive function and brain health by boosting circulation and key neural growth factors.

Efficacy: Medium  |  Grade: A

Weight-Bearing Exercise

Resistance Training, Strength Training, Impact Exercise

Promotes the growth of new brain cells and enhances blood flow, supporting cognitive function and mental clarity.

Efficacy: Medium  |  Grade: A

Yoga

Hatha Yoga, Vinyasa Yoga, Ashtanga Yoga, Pranayama

Regular practice enhances focus and cognitive function by promoting structural brain changes and reducing stress.

Efficacy: Medium  |  Grade: A

Zone 2 Cardio Training

Aerobic Base Training, Low-Intensity Steady-State (LISS) Cardio

Increases cerebral blood flow and key growth factors, supporting long-term cognitive health and function.

Efficacy: Medium  |  Grade: A

Zone 2 Exercise

Aerobic Base Training, Endurance Training, Low-Intensity Steady-State (LISS) Cardio, LISS

Increases cerebral blood flow and key growth factors that support neuron health and cognitive function.

Efficacy: Medium  |  Grade: B

Australian Rules Football

Aussie Rules, Footy

Sharpens cognitive functions like decision-making and spatial awareness through complex, fast-paced gameplay.

Efficacy: Medium  |  Grade: B

Badminton

Requires quick strategic thinking and sharp focus, which helps maintain cognitive function and brain plasticity.

Efficacy: Medium  |  Grade: B

Baseball

Softball, America's Pastime

Requires intense focus and quick decision-making, which helps maintain cognitive sharpness and hand-eye coordination.

Efficacy: Medium  |  Grade: B

Basketball

Hoops

Enhances cognitive function, decision-making, and spatial awareness through strategic, fast-paced gameplay.

Efficacy: Medium  |  Grade: B

BMX

Bicycle Motocross, BMX Racing, Freestyle BMX

Enhances focus and cognitive function by combining intense physical exertion with complex motor skill execution.

Efficacy: Medium  |  Grade: B

Bodyboarding

Boogie boarding

Requires intense focus and quick decision-making, while exercise in nature helps reduce stress and improve mood.

Efficacy: Medium  |  Grade: B

Boxing

Pugilism, Sweet Science

The sport's demand for focus, coordination, and quick reactions enhances cognitive function and neural pathways.

Efficacy: Medium  |  Grade: B

Canoeing

Kayaking, Paddling

Enhances cognitive function and mental clarity through increased cerebral blood flow and time spent in nature.

Efficacy: Medium  |  Grade: B

Cross-Country Skiing

Nordic Skiing, XC Skiing

Enhances brain blood flow and promotes neurotrophic factors, supporting cognitive function and mental clarity.

Efficacy: Medium  |  Grade: B

Dodgeball

Requires rapid decision-making and spatial awareness, which helps sharpen reaction time and cognitive processing.

Efficacy: Medium  |  Grade: B

Downhill Skiing

Alpine Skiing

Enhances balance, coordination, and focus by requiring rapid decision-making and complex motor control.

Efficacy: Medium  |  Grade: B

Exercise Snack

Movement Snack, Micro-workouts

Short activity breaks can enhance immediate focus and support long-term brain health by improving cerebral blood flow.

Efficacy: Medium  |  Grade: B

Flag Football

Non-contact Football

Enhances cognitive function and quick decision-making by requiring strategic thinking and spatial awareness.

Efficacy: Medium  |  Grade: B

Flexibility Training / Stretching

Stretching, Mobility Work, Range of Motion Training

Mindful flexibility practices can reduce stress and improve body awareness, which supports cognitive function and mental clarity.

Efficacy: Medium  |  Grade: B

High-Intensity Resistance Training (HIRT)

HIRT, Heavy Duty Training, HDT

Stimulates brain-supporting growth factors and improves blood flow, which can enhance cognitive function.

Efficacy: Medium  |  Grade: B

Ice Hockey

Hockey

Enhances rapid decision-making, focus, and hand-eye coordination through complex, fast-paced gameplay.

Efficacy: Medium  |  Grade: B

Ice Skating

Figure Skating, Speed Skating, Ice Hockey

Enhances coordination, balance, and spatial awareness, which supports cognitive function and brain health.

Efficacy: Medium  |  Grade: B

Jump Rope

Skipping Rope, Rope Jumping

Enhances coordination and cognitive function by stimulating neural pathways and promoting brain-supportive growth factors.

Efficacy: Medium  |  Grade: B

Kayaking

Paddling, Canoeing

Promotes mental clarity and focus through rhythmic movement and exposure to natural water environments.

Efficacy: Medium  |  Grade: B

Kettlebell Training

KB Training, Girevoy Sport

Enhances brain health by improving blood flow and stimulating the growth of new neurons.

Efficacy: Medium  |  Grade: B

Mixed Martial Arts

MMA

Enhances focus and rapid decision-making by requiring complex motor skills and strategy under pressure.

Efficacy: Medium  |  Grade: B

Mountain Biking

MTB, Off-road Cycling

Sharpens focus, reaction time, and spatial awareness by requiring constant adaptation to changing trail conditions.

Efficacy: Medium  |  Grade: B

Mountaineering

Alpinism, Mountain Climbing

Enhances focus and problem-solving skills while promoting brain health through vigorous physical and mental challenges.

Efficacy: Medium  |  Grade: B

Muay Thai

Thai Boxing, The Art of Eight Limbs

Enhances focus and reaction time by requiring complex motor skills and rapid, strategic decision-making.

Efficacy: Medium  |  Grade: B

Netball

Requires rapid decision-making and spatial awareness, which helps maintain cognitive sharpness and executive function.

Efficacy: Medium  |  Grade: B

Nordic Walking

Pole Walking, Exerstriding

Enhances coordination and balance while promoting brain health through increased blood flow and rhythmic movement.

Efficacy: Medium  |  Grade: B

Pickleball

Enhances focus, reaction time, and decision-making by combining physical activity with strategic play.

Efficacy: Medium  |  Grade: B

Pilates

Contrology

Enhances mind-body connection, improving focus, coordination, and body awareness through controlled, precise movements.

Efficacy: Medium  |  Grade: B

Plyometrics

Jump Training, Plyos, Reactive Strength Training

Enhances neuromuscular coordination and reaction time while boosting growth factors that support brain cell health.

Efficacy: Medium  |  Grade: B

Qigong

Chi Kung, Chi Gung

The practice enhances mental clarity and focus by integrating mindful movement with meditative breathing techniques.

Efficacy: Medium  |  Grade: B

Rock Climbing

Bouldering, Sport Climbing, Trad Climbing

Sharpens focus, problem-solving skills, and working memory by combining complex physical movement with strategic planning.

Efficacy: Medium  |  Grade: B

Rucking

Weighted Walking, Backpack Training

Enhances mental clarity and supports brain health by increasing blood flow and promoting neurotrophic factor release.

Efficacy: Medium  |  Grade: B

Skateboarding

Skating, Street Skating, Vert Skating

Enhances focus, coordination, and spatial awareness through the continuous learning of complex motor skills.

Efficacy: Medium  |  Grade: B

Skiing

Downhill Skiing, Alpine Skiing, Cross-Country Skiing, Nordic Skiing

Enhances focus, spatial awareness, and decision-making by combining physical activity with complex motor control.

Efficacy: Medium  |  Grade: B

Slacklining

Balance training, Proprioceptive training

Enhances focus and cognitive function by challenging the brain's balance and spatial awareness systems.

Efficacy: Medium  |  Grade: B

Snowboarding

Snowboard

Enhances focus, balance, and spatial awareness by requiring constant adaptation to changing terrain and conditions.

Efficacy: Medium  |  Grade: B

Snowshoeing

Winter hiking, Snow-shoeing

Enhances cognitive function and mood by combining vigorous aerobic exercise with the restorative effects of nature.

Efficacy: Medium  |  Grade: B

Soccer (Football)

Football

Enhances cognitive functions like decision-making and spatial awareness while boosting brain-protective growth factors.

Efficacy: Medium  |  Grade: B

Softball

Slow-pitch Softball, Fast-pitch Softball

Enhances hand-eye coordination, reaction time, and strategic thinking, supporting overall cognitive function.

Efficacy: Medium  |  Grade: B

Sprinting

High-Intensity Interval Training (HIIT), Sprint Interval Training (SIT)

Boosts key brain-growth factors like BDNF, supporting cognitive function and long-term brain health.

Efficacy: Medium  |  Grade: B

Stand-Up Paddleboarding

SUP, Paddleboarding

Enhances balance and coordination, challenging the brain to improve focus and neuromuscular control.

Efficacy: Medium  |  Grade: B

Surfing

Wave riding

Enhances focus and cognitive agility by requiring constant environmental awareness and quick decision-making.

Efficacy: Medium  |  Grade: B

Tennis

Racket Sports

Sharpens cognitive functions like strategic thinking and reaction time through complex, fast-paced play.

Efficacy: Medium  |  Grade: B

Ultimate Frisbee

Ultimate

The fast-paced, strategic nature of the game enhances quick decision-making, spatial awareness, and sustained focus.

Efficacy: Medium  |  Grade: B

Volleyball

Beach Volleyball

Enhances focus, spatial awareness, and quick decision-making through dynamic, strategic gameplay.

Efficacy: Medium  |  Grade: B

Wakeboarding

Waterskiing

Requires intense concentration and complex motor learning, which can enhance neuroplasticity and cognitive function.

Efficacy: Medium  |  Grade: B

Walking Golf

Golf (walking), Carry golf

Combines physical activity with strategic thinking and focus, supporting cognitive function and mental well-being.

Efficacy: Medium  |  Grade: B

Water Polo

Polo

Enhances cognitive function and brain health through strategic, fast-paced gameplay and increased cerebral blood flow.

Efficacy: Medium  |  Grade: C

Animal Flow

Quadrupedal Movement Training, Ground-Based Movement

Enhances coordination, body awareness, and focus by challenging the brain with complex, novel movement patterns.

Efficacy: Low  |  Grade: B

Blood Flow Restriction Training

Kaatsu Training, Occlusion Training

May support cognitive function by increasing systemic growth factors that are beneficial for brain health.

Efficacy: Medium  |  Grade: C

Brazilian Jiu-Jitsu

BJJ

Enhances focus and problem-solving skills by requiring complex strategic thinking under physical pressure.

Efficacy: Medium  |  Grade: C

Disc Golf

Frisbee Golf, Frolf

Combines physical activity with strategic thinking, which can enhance focus, reduce stress, and support cognitive function.

Efficacy: Medium  |  Grade: C

Hackeysack

Footbag

Enhances focus, proprioception, and motor control by challenging the brain with complex, skillful movements.

Efficacy: Low  |  Grade: B

Isometrics

Isometric Exercise, Static Strength Training

May enhance cognitive function and focus by increasing blood flow and activating key brain regions.

Efficacy: Medium  |  Grade: C

Kite Surfing

Kitesurfing, Kiteboarding

Requires intense, sustained concentration and rapid decision-making, which may enhance focus and support neuroplasticity.

Efficacy: Medium  |  Grade: C

Rebounding

Mini-trampoline exercise, Cellercising

Enhances coordination and balance, while the aerobic activity supports brain blood flow and cognitive function.

Efficacy: Low  |  Grade: B

Rugby

Rugby Union, Rugby League

The strategic, fast-paced nature of the game enhances executive function, focus, and rapid decision-making skills.

Efficacy: Low  |  Grade: B

Treadmill Desk Walking

Walking Desk, Under-Desk Treadmill

Increases blood flow to the brain, which can help maintain alertness and cognitive function during work.

Efficacy: Low  |  Grade: C

Squash

Racquetball, Racket Sports

Supplies antioxidants like lutein and zeaxanthin that help protect brain cells from oxidative stress.

Efficacy: Low  |  Grade: C

Weighted Vest Walking

Rucking, Loaded Carries

Boosts blood flow to the brain and may enhance cognitive function through increased exercise intensity.

Devices

Efficacy: High  |  Grade: A

Gait and Balance Accelerometer

Wearable Gait Sensor, Inertial Measurement Unit (IMU) for Balance

Improves neuromuscular coordination and can serve as an early indicator of cognitive changes, supporting long-term brain health.

Efficacy: High  |  Grade: A

Sleep Staging Tracker

EEG Sleep Tracker, Polysomnography (PSG) At-Home, Sleep Stage Monitor

Tracking sleep stages helps optimize deep sleep for brain detoxification and REM sleep for memory consolidation.

Efficacy: High  |  Grade: A

Vagus Nerve Stimulation

transcutaneous Vagus Nerve Stimulation, tVNS, auricular Vagus Nerve Stimulation, taVNS

Modulates key neurotransmitters and brain networks, which can improve mood, focus, and cognitive resilience.

Efficacy: Medium  |  Grade: A

At-Home Blood Pressure Monitor

Home BP Monitor, Sphygmomanometer

Helps protect brain health by enabling better control of blood pressure, a major risk factor for cognitive decline.

Efficacy: Medium  |  Grade: A

Continuous Ambulatory ECG (Topical)

Holter Monitor, Ambulatory ECG Monitoring, AECG

Identifies irregular heart rhythms that can increase stroke risk, thereby protecting long-term brain structure and function.

Efficacy: High  |  Grade: B

Continuous Ketone Monitor

CKM

Helps maintain a ketogenic state, providing the brain with an efficient fuel for sustained mental clarity.

Efficacy: Medium  |  Grade: A

Continuous Pulse Oximeter (Topical)

Wearable SpO2 Monitor, Continuous Oxygen Saturation Monitor

Identifies nighttime oxygen drops that can impair cognitive function, memory consolidation, and long-term brain health.

Efficacy: Medium  |  Grade: B

Continuous Glucose Monitor (CGM)

CGM, Continuous Glucose Monitoring

Helps prevent glucose swings that can cause brain fog, supporting stable mental clarity and long-term brain health.

Efficacy: Medium  |  Grade: B

HRV and Recovery Tracker

Wearable Recovery Monitor, HRV Biofeedback Device

Provides feedback on nervous system balance, helping to manage stress for improved mental clarity and focus.

Efficacy: Medium  |  Grade: C

Thyroid Red Light Therapy (Topical)

Thyroid Photobiomodulation, Thyroid PBM, Low-Level Laser Therapy for Thyroid

Supports the production of thyroid hormones, which are essential for maintaining mental clarity and focus.

Efficacy: Low  |  Grade: C

At-Home Metabolic Analyzer

Breathalyzer for Metabolism, Respiratory Exchange Ratio (RER) Device, Metabolic Breath Tester

Helps maintain stable energy for the brain by guiding diet choices that improve your metabolic state.

Procedures

Efficacy: High  |  Grade: A

Biofeedback Therapy

Neurofeedback, EMG Biofeedback, Thermal Biofeedback, HRV Biofeedback

Trains brainwave patterns to enhance attention, reduce distractibility, and support sustained mental focus and clarity.

Efficacy: High  |  Grade: A

Cognitive Behavioral Therapy

CBT

Enhances mental clarity and focus by restructuring unhelpful thought patterns and reducing cognitive load from worry.

Efficacy: High  |  Grade: A

Hyperbaric Oxygen Therapy

HBOT

Improves blood flow and oxygen supply to the brain, supporting cognitive function and mental clarity.

Efficacy: High  |  Grade: A

MDMA Therapy

3,4-Methylenedioxymethamphetamine-Assisted Therapy, MDMA-Assisted Psychotherapy

Facilitates trauma processing, which can restore healthy brain function and emotional regulation in individuals with PTSD.

Efficacy: High  |  Grade: A

Transcranial magnetic stimulation

TMS, rTMS

Directly modulates neural circuits to improve mood, cognitive function, and mental clarity by enhancing brain plasticity.

Efficacy: Medium  |  Grade: A

Light Therapy Glasses

Light Visor, Wearable Light Therapy, SAD Glasses

Enhances mood, alertness, and cognitive function by aligning the body's internal clock with the daily cycle.

Efficacy: High  |  Grade: B

Muse Cell Therapy

Multilineage-differentiating Stress Enduring cells

Aids in repairing neural tissue and reducing brain inflammation, which may support long-term cognitive health.

Efficacy: Medium  |  Grade: A

SAD Lamp

Light Therapy Box, Bright Light Therapy

Can improve alertness, mood, and cognitive function, particularly during seasons with less natural light.

Efficacy: Medium  |  Grade: B

Acupuncture

Traditional Chinese Medicine (TCM) Needling

Reduces the frequency and severity of chronic headaches, which can improve daily cognitive function.

Efficacy: Medium  |  Grade: B

Exosome Therapy

Extracellular Vesicle (EV) Therapy

May reduce neuroinflammation and support neural tissue repair, contributing to long-term brain health.

Efficacy: Medium  |  Grade: B

Fecal Microbiota Transplant

FMT, Stool Transplant, Bacteriotherapy

Supports mood and cognitive function by modulating gut-brain communication and reducing systemic inflammation.

Efficacy: Medium  |  Grade: B

Floatation Therapy

Float Tank, Sensory Deprivation Tank, REST, Restricted Environmental Stimulation Therapy

Promotes a state of deep mental relaxation, which can reduce anxiety and improve focus and creativity.

Efficacy: Medium  |  Grade: B

Infrared Light Therapy

Red Light Therapy, RLT, Photobiomodulation, PBM, Low-Level Laser Therapy, LLLT

May enhance brain cell energy metabolism and improve cerebral blood flow, potentially supporting cognitive function.

Efficacy: Medium  |  Grade: B

LED Red Light Therapy

Photobiomodulation, PBM, Low-Level Laser Therapy, LLLT

May support brain cell energy metabolism and circulation, potentially aiding cognitive function and mood.

Efficacy: Medium  |  Grade: B

Sauna Therapy

Heat Therapy, Hyperthermic Conditioning, Sauna Bathing

Supports neuron health and may reduce the risk of cognitive decline by stimulating key brain-growth factors.

Efficacy: Medium  |  Grade: B

SIRT6 Gene Therapy

SIRT6 Overexpression Therapy

Protects brain cells from stress and reduces the chronic neuroinflammation associated with age-related cognitive decline.

Efficacy: Medium  |  Grade: B

White Noise / Sound Therapy

Pink Noise, Brown Noise, Acoustic Stimulation, Sound Masking

May enhance focus and mental clarity by encouraging specific brainwave states associated with attention.

Efficacy: Medium  |  Grade: B

Therapeutic Plasma Exchange (TPE)

Plasmapheresis, Plasma Exchange, Plasma Dilution

Helps clear harmful proteins and reduce systemic inflammation linked to age-related cognitive decline.

Efficacy: Medium  |  Grade: B

Transcranial Electrical Stimulation

tES, tDCS, tACS, tRNS

Modulates brainwave activity to potentially enhance learning, memory, and mental focus.

Efficacy: Medium  |  Grade: C

Mesenchymal Stem Cell (MSC) Therapy

MSCs, Mesenchymal Stromal Cells, Stem Cell Therapy

May reduce neuroinflammation and support neuronal health, offering potential protection against age-related cognitive decline.

Efficacy: Low  |  Grade: B

Vibration Therapy

Whole Body Vibration, WBV

Enhances balance and body awareness by stimulating the neuromuscular system.

Efficacy: Low  |  Grade: C

Blood Donation (Therapeutic Phlebotomy)

Phlebotomy, Venesection

May help reduce excess iron accumulation, potentially lowering long-term risk of some neurodegenerative conditions.

Efficacy: Low  |  Grade: C

Neti Pot

Nasal Irrigation, Saline Rinse, Jala Neti

May improve mental clarity by relieving sinus pressure and congestion-related 'brain fog' for some individuals.

Protocols

Synergistic Therapy

Efficacy: High  |  Grade: A

B-Complex Vitamins

B Vitamins, Vitamin B Complex

Supports the production of key neurotransmitters for mood and focus, and helps protect long-term brain health.

Efficacy: High  |  Grade: A

Caffeine and L-Theanine

Caffeine Theanine Stack, Smart Caffeine

Synergistically enhances focus, attention, and cognitive performance while promoting a state of calm alertness.

Efficacy: Medium  |  Grade: B

Curcumin and Piperine

Turmeric and Black Pepper Extract, Bioavailable Curcumin

Protects brain cells from oxidative stress and supports cognitive function and mood.

Efficacy: Medium  |  Grade: B

Liposomal Vitamin D3/K2

Liposomal D3/K2, Vitamin D3 + K2 (Liposomal)

Supports neuronal health and may protect against age-related cognitive decline by reducing brain inflammation.

Efficacy: Medium  |  Grade: B

GlyNAC

Glycine + N-Acetylcysteine, Glycine and NAC

Supports brain health by replenishing a key antioxidant, which helps protect against age-related cognitive decline.

Efficacy: Medium  |  Grade: B

Myo-Inositol and D-Chiro-Inositol

MI/DCI, Inositol combination

Acts as a key signaling molecule in the brain, potentially supporting mood and cognitive function.

Efficacy: Low  |  Grade: B

Vitamin D3 and K2 with Calcium

Vitamin D3, Vitamin K2, and Calcium

Supports long-term brain health and cognitive function by contributing to neuronal maintenance and protection.

Efficacy: Medium  |  Grade: C

Dasatinib and Quercetin

D+Q, Senolytics

May reduce age-related inflammation in the brain, potentially supporting cognitive function and long-term brain health.