Sleep & Resilience338

Sleep architecture, Autonomic Nervous System (HRV, vagal tone), and Endocrine health.

Supplements

Efficacy: High  |  Grade: A

Ashwagandha

Withania somnifera, Indian ginseng, Winter cherry

Reduces stress and anxiety by lowering cortisol levels, leading to improved sleep quality and resilience.

Efficacy: High  |  Grade: A

Enclomiphene

Enclomiphene Citrate, Androxal

Directly supports endocrine health by restoring the body's natural signaling for testosterone production.

Efficacy: High  |  Grade: A

Glycine

2-Aminoacetic acid

Improves subjective sleep quality and helps you fall asleep faster by lowering core body temperature.

Efficacy: High  |  Grade: A

Lavender

Lavandula angustifolia, Silexan

Promotes relaxation and improves sleep quality by calming the nervous system for more restorative rest.

Efficacy: High  |  Grade: A

Lemon Balm

Melissa officinalis

Promotes restful sleep and reduces anxiety by calming the nervous system and easing stress.

Efficacy: High  |  Grade: A

Magnesium Chloride

MgCl2, Magnesium oil

Calms the nervous system by regulating key neurotransmitters to promote deeper, more restorative sleep.

Efficacy: High  |  Grade: A

Magnesium Glycinate

Magnesium Bisglycinate

Promotes deeper, more restorative sleep by calming the nervous system and regulating sleep-related neurotransmitters.

Efficacy: High  |  Grade: A

Liposomal Magnesium

Liposome-encapsulated Magnesium

Promotes nervous system relaxation and supports healthy sleep by regulating key neurotransmitters.

Efficacy: High  |  Grade: A

Magnesium

Magnesium Citrate, Magnesium Glycinate, Magnesium L-Threonate, Magnesium Oxide

Promotes relaxation and helps regulate neurotransmitters for deeper, more restorative sleep and better stress management.

Efficacy: High  |  Grade: A

Liposomal Melatonin

Encapsulated Melatonin, Liposome-Entrapped Melatonin

Regulates the natural sleep-wake cycle, promoting restorative sleep and supporting hormonal balance.

Efficacy: High  |  Grade: A

Melatonin

SR Melatonin, Low-Dose Melatonin, Physiological-Dose Melatonin

Helps regulate the natural sleep-wake cycle, improving sleep architecture and supporting hormonal and nervous system balance.

Efficacy: High  |  Grade: A

Myo-inositol

Inositol, Vitamin B8, cis-1,2,3,5-trans-4,6-cyclohexanehexol

Promotes hormonal balance by improving the body's response to insulin, which is crucial for endocrine health.

Efficacy: High  |  Grade: A

Psilocybin Therapy

Psychedelic-Assisted Therapy, Magic Mushrooms

Can help re-regulate the nervous system's stress response, improving psychological resilience and associated sleep quality.

Efficacy: High  |  Grade: A

Rhodiola Rosea

Golden Root, Arctic Root, Roseroot

Helps the body adapt to stress by modulating cortisol levels, which enhances overall resilience.

Efficacy: High  |  Grade: A

Selenium

Selenomethionine, Selenocysteine, Sodium Selenite

Crucial for producing and regulating thyroid hormones, which govern metabolism, energy, and stress response.

Efficacy: High  |  Grade: A

Sustained Release Melatonin

Time-Release Melatonin, Extended-Release Melatonin, Prolonged-Release Melatonin

Mimics the body's natural release to improve sleep quality and help you stay asleep through the night.

Efficacy: High  |  Grade: B

Liposomal Apigenin

Bioavailable Apigenin, Apigenin Phytosome

Encourages relaxation and improves sleep quality by calming the nervous system without causing significant morning grogginess.

Efficacy: High  |  Grade: B

CBD

Cannabidiol

Promotes relaxation and can improve sleep quality by addressing underlying factors like anxiety and physical discomfort.

Efficacy: Medium  |  Grade: A

Chamomile Extract

Matricaria recutita, Chamaemelum nobile, Apigenin

Promotes relaxation and improves sleep quality by gently calming the nervous system.

Efficacy: Medium  |  Grade: A

DHEA

Dehydroepiandrosterone

Helps restore youthful levels of key precursor hormones that naturally decline with age, supporting endocrine balance.

Efficacy: High  |  Grade: B

Liposomal GABA

Liposomal Gamma-Aminobutyric Acid

Helps reduce the time to fall asleep and supports deeper sleep quality by calming the nervous system.

Efficacy: High  |  Grade: B

GABA

Gamma-Aminobutyric Acid

Helps quiet the mind to shorten the time it takes to fall asleep and improve overall sleep quality.

Efficacy: Medium  |  Grade: A

Inositol

Myo-inositol, D-chiro-inositol, Vitamin B8

Promotes hormonal balance, particularly in conditions like PCOS, and supports healthy thyroid function.

Efficacy: Medium  |  Grade: A

Iodine

Potassium Iodide, Lugol's Solution

Supports endocrine health via the thyroid, helping to regulate systems that influence sleep and stress.

Efficacy: Medium  |  Grade: A

Iron Fumarate

Ferrous Fumarate

Helps alleviate Restless Legs Syndrome, a common cause of sleep disruption that is often linked to low iron.

Efficacy: Medium  |  Grade: A

Iron Gluconate

Ferrous Gluconate

Helps alleviate Restless Legs Syndrome, a common cause of sleep disruption, in individuals with low iron.

Efficacy: Medium  |  Grade: A

L-Theanine

Theanine, gamma-glutamylethylamide

Helps manage the body's stress response and improves sleep quality by promoting relaxation.

Efficacy: Medium  |  Grade: A

L-Tyrosine

Tyrosine

Enhances resilience to stress by providing the building blocks for crucial neurotransmitters like dopamine and norepinephrine.

Efficacy: High  |  Grade: B

Maca Root

Lepidium meyenii, Peruvian Ginseng

Acts as an adaptogen to help balance hormones and improve the body's resilience to stress.

Efficacy: High  |  Grade: B

Magnesium Citrate

Magnesium

Promotes relaxation and helps regulate neurotransmitters involved in achieving deep, restorative sleep.

Efficacy: High  |  Grade: B

Magnesium Taurate

Mg Taurate

Encourages restful sleep and nervous system balance by promoting a state of calm and relaxation.

Efficacy: Medium  |  Grade: A

Phytoestrogens: Soy Isoflavones

Isoflavones, Genistein, Daidzein, Glycitein

Can reduce the frequency and severity of menopausal hot flashes, leading to improved sleep quality.

Efficacy: Medium  |  Grade: A

Retatrutide

LY3437943

Improves sleep quality by addressing weight-related issues like sleep apnea and enhancing overall metabolic health.

Efficacy: Medium  |  Grade: A

Saffron Extract

Crocus sativus, Safranal, Crocin

Promotes restorative sleep by improving sleep quality and duration without causing next-day grogginess.

Efficacy: Medium  |  Grade: A

Saffron

Crocus sativus

Promotes better sleep quality and duration, helping you wake up feeling more refreshed and rested.

Efficacy: Medium  |  Grade: A

Saint John's Wort

Hypericum perforatum, Klamath weed

Promotes deeper, more restorative sleep, particularly in those experiencing mood-related sleep disturbances.

Efficacy: High  |  Grade: B

Schisandra

Schisandra chinensis, Five-Flavor Berry, Wu Wei Zi

Helps the body adapt to stress by balancing cortisol and promoting a calm nervous system.

Efficacy: High  |  Grade: B

Sermorelin

Geref, GHRH (1-29)

Enhances sleep quality by promoting deeper, more restorative slow-wave sleep for improved nightly recovery.

Efficacy: High  |  Grade: B

Tongkat Ali

Eurycoma longifolia, Malaysian Ginseng, Longjack

Helps the body manage stress by modulating cortisol and supporting healthy endocrine function.

Efficacy: High  |  Grade: B

Valerian Root

Valeriana officinalis, Garden Heliotrope

Improves sleep quality and reduces the time it takes to fall asleep, supporting restorative sleep cycles.

Efficacy: Medium  |  Grade: B

Apigenin

Promotes relaxation and improves sleep quality by calming the nervous system without causing significant drowsiness.

Efficacy: Medium  |  Grade: B

B Complex Vitamins

B Vitamins, Vitamin B Complex

Contributes to the production of melatonin for healthy sleep cycles and supports adrenal function for better stress resilience.

Efficacy: Medium  |  Grade: B

Bacopa Monnieri

Brahmi, Water Hyssop, Herb of Grace

Functions as an adaptogen, helping to reduce cortisol levels and improve the body's resilience to stress.

Efficacy: Medium  |  Grade: B

Boron

Boric Acid, Sodium Borate

Supports healthy endocrine function by influencing the metabolism of key hormones like testosterone and estrogen.

Efficacy: Medium  |  Grade: B

Cannabis

Marijuana, THC, CBD, Cannabinoids

Can aid in falling asleep faster and may reduce stress, contributing to better nervous system regulation.

Efficacy: Medium  |  Grade: B

Centella Asiatica (Cica)

Cica, Gotu Kola, Brahmi, Asiatic Pennywort

Helps calm the nervous system and reduce anxiety, which can contribute to improved sleep quality.

Efficacy: Medium  |  Grade: B

CJC-1295

CJC-1295 with DAC, Modified GRF (1-29) with DAC

May enhance deep sleep quality by augmenting the body's natural nighttime release of growth hormone.

Efficacy: Medium  |  Grade: B

Collagen Peptides

Hydrolyzed Collagen

The amino acid glycine helps improve sleep quality and may reduce daytime fatigue.

Efficacy: Medium  |  Grade: B

Eleuthero (Siberian Ginseng)

Siberian Ginseng, Eleutherococcus senticosus

Functions as an adaptogen, helping the body better cope with and recover from daily stressors.

Efficacy: Medium  |  Grade: B

Fenugreek Extract

Trigonella foenum-graecum, Methi

Contributes to endocrine health by supporting hormonal balance, particularly testosterone levels in men.

Efficacy: Medium  |  Grade: B

Holy Basil (Tulsi)

Tulsi, Ocimum tenuiflorum, Ocimum sanctum

Helps the body adapt to stress and promotes a calm, balanced mood by regulating cortisol levels.

Efficacy: Medium  |  Grade: B

Ipamorelin

NNC 26-0161

May improve sleep quality by enhancing the deep, restorative stages of the natural sleep cycle.

Efficacy: Medium  |  Grade: B

Iron Bisglycinate

Ferrous Bisglycinate, Chelated Iron

Can improve sleep quality by helping resolve conditions like restless legs syndrome linked to low iron.

Efficacy: Medium  |  Grade: B

Iron

Ferrous Sulfate, Ferrous Gluconate, Iron Bisglycinate, Ferritin

Can improve sleep quality by addressing iron-related restless legs syndrome and supporting neurotransmitter regulation.

Efficacy: Medium  |  Grade: B

L-Lysine

Lysine

May help regulate the body's stress response, contributing to a calmer state and improved resilience.

Efficacy: Medium  |  Grade: B

Lithium Orotate

Microdose Lithium, Elemental Lithium

Helps regulate the body's internal clock, potentially leading to more stable sleep-wake cycles.

Efficacy: Medium  |  Grade: B

LSD

Lysergic acid diethylamide, Acid

May improve emotional resilience by helping to regulate the body's chronic stress response systems.

Efficacy: Medium  |  Grade: B

Magnesium Malate

Promotes relaxation and supports a healthy sleep cycle by helping to regulate calming neurotransmitters in the brain.

Efficacy: Medium  |  Grade: B

Mucuna Pruriens

Velvet Bean, Cowhage

Helps the body manage stress by modulating cortisol levels and may improve overall sleep quality.

Efficacy: Medium  |  Grade: B

Nicotinamide Riboside

NR, Niagen

Helps regulate the body's internal clock by supporting NAD+ pathways essential for circadian rhythm.

Efficacy: Medium  |  Grade: B

Passionflower

Passiflora incarnata, maypop

Helps calm the nervous system to reduce anxiety and improve overall sleep quality.

Efficacy: Medium  |  Grade: B

Phosphatidylserine

PS

Helps regulate the body's stress response by blunting cortisol, which can promote relaxation and better sleep.

Efficacy: Medium  |  Grade: B

Prebiotic Supplements

Prebiotics, Fermentable Fiber, Inulin, FOS, GOS

Promotes more restorative sleep and helps manage the body's stress response by nurturing the gut microbiome.

Efficacy: Medium  |  Grade: B

Pregnenolone

P5, 3β-hydroxypregn-5-en-20-one

Promotes deep, restorative sleep and helps balance the endocrine system's response to stress.

Efficacy: Medium  |  Grade: B

Probiotics

Beneficial Bacteria, Live Cultures

Promotes restorative sleep and stress resilience by supporting the gut's connection to the nervous system.

Efficacy: Medium  |  Grade: B

Liposomal Quercetin

Liposome-encapsulated quercetin

Acts as a senolytic to help clear aged cells, reducing inflammation and supporting overall systemic resilience.

Efficacy: Medium  |  Grade: B

Reishi Mushroom

Ganoderma lucidum, Lingzhi, Mushroom of Immortality

Promotes relaxation and can improve sleep quality, helping the body better adapt to mental and physical stress.

Efficacy: Medium  |  Grade: B

Semax

N-Acetyl Semax, N-Acetyl Semax Amidate

Helps regulate the body's stress response system, promoting mental resilience and endocrine balance.

Efficacy: Medium  |  Grade: B

Shilajit

Mumie, Mineral Pitch, Fulvic Acid

Functions as an adaptogen to help regulate the endocrine system, including supporting healthy testosterone levels.

Efficacy: Medium  |  Grade: B

Sustained Release DHEA

Time-Release DHEA, Extended-Release DHEA, Micronized Sustained Release DHEA

Helps maintain endocrine balance by restoring a key precursor hormone, supporting the body's stress response system.

Efficacy: Medium  |  Grade: B

Sustained Release Pregnenolone

Pregnenolone SR, Time-Release Pregnenolone

Promotes restorative deep sleep and helps regulate the body's response to stress by supporting endocrine balance.

Efficacy: Medium  |  Grade: B

Tart Cherry Extract

Montmorency Cherry, Sour Cherry, Prunus cerasus

Contains natural melatonin which can help increase sleep time and improve overall sleep quality.

Efficacy: Medium  |  Grade: B

Vitamin B6

Pyridoxine, Pyridoxal 5'-Phosphate, P-5-P

Aids in the production of serotonin and melatonin, hormones essential for regulating healthy sleep cycles.

Efficacy: Medium  |  Grade: B

Zinc Gluconate

Zincum Gluconicum

Aids in regulating the nervous system and supports the production of melatonin for improved sleep quality.

Efficacy: Medium  |  Grade: B

Zinc Picolinate

Zinc (Picolinate)

Contributes to improved sleep quality and supports key endocrine hormones involved in stress resilience.

Efficacy: Low  |  Grade: B

Creatine Monohydrate

Creatine

Helps mitigate the decline in cognitive performance that can result from sleep deprivation.

Efficacy: Medium  |  Grade: C

Epitalon

Epithalon, Epithalamin, Ala-Glu-Asp-Gly

Helps normalize circadian rhythms and melatonin production, leading to improved sleep quality and endocrine system balance.

Efficacy: Low  |  Grade: B

Iron Sulfate

Ferrous Sulfate

May improve sleep quality by helping to alleviate restless legs syndrome associated with iron deficiency.

Efficacy: Low  |  Grade: B

Lutein

Zeaxanthin

May improve sleep quality by filtering blue light, which helps regulate the natural sleep-wake cycle.

Efficacy: Medium  |  Grade: C

Magnesium L-threonate

Magtein

May promote relaxation and support better sleep quality by helping to regulate calming neurotransmitter systems.

Efficacy: Medium  |  Grade: C

Medicinal Mushrooms (Beta-Glucans)

Beta-Glucans, Mushroom Polysaccharides

Functions as an adaptogen, helping the body manage stress and promoting more restorative sleep cycles.

Efficacy: Medium  |  Grade: C

NAD+ (IV Therapy)

Nicotinamide Adenine Dinucleotide IV, IV NAD+ Therapy

Plays a key role in regulating the body's internal clock, which is foundational for sleep cycles.

Efficacy: Low  |  Grade: B

NMN

Nicotinamide Mononucleotide

May help regulate the body's internal clock, potentially improving sleep quality and reducing daytime drowsiness.

Efficacy: Low  |  Grade: B

Panax Ginseng

Asian Ginseng, Korean Ginseng, Ren Shen

Functions as an adaptogen, helping the body better manage stress and supporting endocrine system balance.

Efficacy: Low  |  Grade: B

Pyrroloquinoline Quinone (PQQ)

PQQ

May improve sleep quality and duration by helping to reduce physiological stress markers like cortisol.

Efficacy: Low  |  Grade: B

SAM-e

S-adenosylmethionine, Ademetionine

Contributes to emotional resilience and mood stability, which can indirectly support healthier sleep patterns.

Efficacy: Medium  |  Grade: C

Uridine Monophosphate

UMP, Uridine

May enhance deep sleep phases, contributing to more restorative and restful sleep cycles.

Efficacy: Low  |  Grade: B

Zeaxanthin

Meso-zeaxanthin

May improve sleep quality by filtering high-energy blue light that can disrupt circadian rhythms.

Efficacy: Low  |  Grade: B

Zinc

Zinc Picolinate, Zinc Gluconate, Zinc Citrate, Zinc Orotate

Plays a role in regulating neurotransmitters involved in the sleep-wake cycle, potentially improving sleep quality.

Efficacy: Low  |  Grade: C

Acetyl-L-Carnitine

ALCAR, ALC

May improve resilience by reducing mental and physical fatigue, which can indirectly support better daily energy patterns.

Efficacy: Low  |  Grade: C

Astragalus

Huang Qi, Milk-vetch root

Acts as an adaptogen, helping the body build resilience and adapt more effectively to daily stressors.

Efficacy: Low  |  Grade: C

Butyrate Supplements

Sodium Butyrate, Calcium Butyrate, Magnesium Butyrate, Tributyrin, Butyric Acid

May contribute to better sleep and stress resilience by promoting a healthy gut-brain connection.

Efficacy: Low  |  Grade: C

Butyrate

Sodium Butyrate, Butanoic Acid

Promotes resilience to stress and may support sleep by reducing systemic inflammation via the gut-brain axis.

Efficacy: Low  |  Grade: C

Calcium Alpha-Ketoglutarate

Ca-AKG, CaAKG

May improve resilience by reducing systemic inflammation, a key driver of age-related decline.

Efficacy: Low  |  Grade: C

Cordyceps

Cordyceps militaris, Cordyceps sinensis, Caterpillar fungus

Functions as an adaptogen, helping the body better manage physiological stress and maintain balance.

Efficacy: Low  |  Grade: C

Digestive Enzymes

Pancreatic Enzymes, Protease, Amylase, Lipase, Betaine HCl

May improve sleep quality by reducing digestive discomfort, such as bloating and gas, before bedtime.

Efficacy: Low  |  Grade: C

Echinacea

Purple Coneflower

May help reduce feelings of anxiety, contributing to a greater sense of calm and resilience.

Efficacy: Low  |  Grade: C

Ginkgo Biloba

Maidenhair Tree, Ginkgo Folium, EGb 761

May help reduce stress and anxiety, which can contribute to improved sleep quality and resilience.

Efficacy: Low  |  Grade: C

Liposomal Glutathione

L-Glutathione (Liposomal), GSH (Liposomal)

May support the body's natural restorative processes during sleep by combating oxidative stress.

Efficacy: Low  |  Grade: C

Glutathione

L-Glutathione, GSH, Liposomal GSH

Supports the body's natural detoxification and cellular repair processes that are active during sleep.

Efficacy: Low  |  Grade: C

Klotho

alpha-Klotho, α-Klotho

Contributes to systemic resilience by regulating key metabolic pathways involved in the stress response.

Efficacy: Low  |  Grade: C

L-Methylfolate

5-MTHF, Levomefolic acid, Metafolin, Deplin

May support healthy sleep cycles by aiding in the synthesis of neurotransmitters that regulate mood and rest.

Efficacy: Low  |  Grade: C

Lion's Mane Mushroom

Hericium erinaceus, Yamabushitake, Monkey Head Mushroom

May help reduce feelings of anxiety and depression, which can contribute to improved sleep quality.

Efficacy: Low  |  Grade: C

Microdosing Lithium

Lithium Orotate Microdose, Low-Dose Lithium

May help stabilize the body's internal clock, contributing to more consistent sleep and mood.

Efficacy: Low  |  Grade: C

Low Dose Naltrexone (LDN)

LDN

May improve sleep quality for some individuals by reducing chronic pain and inflammation that can disrupt rest.

Efficacy: Low  |  Grade: C

Meso-Zeaxanthin

MZ

May improve sleep quality by filtering blue light and reducing digital eye strain and fatigue.

Efficacy: Low  |  Grade: C

MOTS-c

Mitochondrial-derived peptide

Contributes to endocrine stability by improving the body's regulation of metabolic hormones like insulin.

Efficacy: Low  |  Grade: C

Multivitamin (Men)

Men's Multi, MVM

Helps prevent deficiencies in nutrients like magnesium, which can play a role in sleep and stress regulation.

Efficacy: Low  |  Grade: C

Multivitamin (Women)

Women's Multi, MVM for Women

Provides foundational minerals like magnesium that support nervous system regulation, which may contribute to better sleep.

Efficacy: Low  |  Grade: C

Liposomal NAD+

Liposomal Nicotinamide Adenine Dinucleotide

May help regulate the body's internal clock, which is fundamental for healthy sleep-wake cycles.

Efficacy: Low  |  Grade: C

Liposomal NMN

Liposomal Nicotinamide Mononucleotide

May help regulate the body's internal clock, potentially contributing to more consistent sleep-wake cycles.

Efficacy: Low  |  Grade: C

Liposomal Nicotinamide Riboside

Liposomal NR

May help regulate the cellular processes that govern circadian rhythms, which are foundational to sleep.

Efficacy: Low  |  Grade: C

Protein Powder

Whey Protein, Casein Protein, Plant-Based Protein, Collagen Peptides

May support restorative sleep by providing a slow-release source of amino acids for overnight muscle repair.

Efficacy: Low  |  Grade: C

Sustained Release Vitamin C

Time-Release Vitamin C, Extended-Release Ascorbic Acid

Supports adrenal gland function, which helps the body manufacture hormones to manage and respond to stress.

Efficacy: Low  |  Grade: C

Taurine

2-aminoethanesulfonic acid, L-Taurine

Promotes relaxation and may improve sleep quality by helping to calm the central nervous system.

Efficacy: Low  |  Grade: C

Thymosin Alpha-1

Zadaxin, Thymalfasin, TA1

May support the body's resilience to stress by helping to balance immune system and endocrine signals.

Efficacy: Low  |  Grade: C

Vitamin B12

Cobalamin, Methylcobalamin, Cyanocobalamin, Adenosylcobalamin, Hydroxocobalamin

May play a role in regulating the sleep-wake cycle by influencing the body's melatonin production.

Efficacy: Low  |  Grade: C

Vitamin B5

Pantothenic Acid

Supports adrenal gland function, aiding in the production of hormones that help manage the body's stress response.

Efficacy: Low  |  Grade: C

Liposomal Vitamin C

Liposomal Ascorbic Acid, L-Ascorbic Acid (Liposomal)

Supports adrenal gland function, which helps the body modulate its response to physical and emotional stress.

Medications

Efficacy: High  |  Grade: A

Clomiphene Citrate

Clomid, Serophene

Directly supports the endocrine system by stimulating the body's own production of key hormones like testosterone.

Efficacy: High  |  Grade: A

Dual Orexin Receptor Antagonists

DORAs, Lemborexant, Suvorexant, Daridorexant

Directly targets the brain's wakefulness system to improve the ability to fall and stay asleep.

Efficacy: High  |  Grade: A

Estradiol Cypionate

Depo-Estradiol

Alleviates menopausal symptoms like hot flashes and night sweats, leading to significantly improved sleep quality.

Efficacy: High  |  Grade: A

Estradiol Valerate

EV, Delestrogen

Improves sleep quality and reduces disruptive menopausal symptoms like hot flashes by restoring hormonal balance.

Efficacy: High  |  Grade: A

Estradiol

E2, 17β-estradiol, Oestradiol

Improves sleep quality by reducing night sweats and hot flashes, supporting a more restful state.

Efficacy: High  |  Grade: A

Human Chorionic Gonadotropin

hCG

Directly supports endocrine health by stimulating natural hormone production, which is foundational for vitality and resilience.

Efficacy: High  |  Grade: A

Menopausal HRT

Hormone Replacement Therapy, MHT, Menopausal Hormone Therapy

Dramatically improves sleep quality by reducing night sweats and hot flashes, supporting mood and endocrine balance.

Efficacy: High  |  Grade: A

Oxytocin

OT, Love Hormone

Helps buffer the body's stress response and promotes relaxation, which can improve sleep quality and resilience.

Efficacy: High  |  Grade: A

Progesterone

P4, Bioidentical Progesterone, Prometrium

Promotes deeper, more restorative sleep and supports nervous system balance by enhancing calming neurotransmitter activity.

Efficacy: High  |  Grade: A

Proton Pump Inhibitors

PPIs

Effectively manages nighttime acid reflux, leading to fewer sleep disturbances and more restorative rest.

Efficacy: High  |  Grade: A

Ramelteon

Rozerem

Promotes natural sleep onset by regulating the body's internal clock, improving sleep architecture without causing dependency.

Efficacy: High  |  Grade: A

Trazodone

Desyrel, Oleptro

Effectively improves sleep quality by increasing deep sleep duration and reducing nighttime awakenings without suppressing REM.

Efficacy: Medium  |  Grade: A

Propranolol

Inderal, InnoPran XL

Blunts the body's physiological stress response, helping to regulate the autonomic nervous system and build resilience.

Efficacy: Medium  |  Grade: A

Semaglutide

Ozempic, Wegovy, Rybelsus

Improves sleep quality and can reduce sleep apnea symptoms by promoting significant weight loss and metabolic health.

Efficacy: Medium  |  Grade: A

Tirzepatide

Mounjaro, Zepbound

Improves sleep quality by reducing the severity of obesity-related sleep apnea, supporting restorative processes.

Efficacy: Low  |  Grade: A

Daily Low-Dose Tadalafil

Cialis (daily), PDE5 inhibitor

Can improve sleep quality for those with BPH by reducing nighttime urination, leading to less disrupted rest.

Efficacy: Medium  |  Grade: B

GLP-1 Receptor Agonists

Incretin Mimetics, GLP-1 RAs

Promotes better sleep quality by aiding weight loss and improving conditions like sleep apnea.

Efficacy: Medium  |  Grade: B

Lithium Carbonate

Lithium, Lithium Orotate

Helps regulate the body's internal clock and promotes mood stability, contributing to overall stress resilience.

Efficacy: Medium  |  Grade: B

Selective Estrogen Receptor Modulators

SERMs

Can help regulate key hormonal pathways, supporting endocrine balance in specific contexts.

Efficacy: Medium  |  Grade: B

Telmisartan

Micardis

Supports better sleep and stress resilience by helping to regulate blood pressure and the autonomic nervous system.

Efficacy: Medium  |  Grade: B

Tesamorelin

Egrifta

May enhance deep, slow-wave sleep, which is crucial for nightly restoration and hormonal balance.

Efficacy: Medium  |  Grade: B

Testosterone

TRT, Testosterone Replacement Therapy

Can improve sleep quality in deficient individuals by helping to restore normal endocrine and hormonal balance.

Efficacy: Medium  |  Grade: B

Vitamin D3

Cholecalciferol (D3), Ergocalciferol (D2), Calcifediol, Calcitriol

Associated with improved sleep quality by influencing brain areas that regulate healthy sleep cycles.

Efficacy: Low  |  Grade: B

Canagliflozin

Invokana

Can improve sleep quality by reducing nighttime urination associated with high blood sugar levels.

Efficacy: Low  |  Grade: B

Galanthamine

Razadyne, Nivalin, Lycoremine

May enhance REM sleep and increase the potential for lucid dreaming by modulating brain activity during sleep.

Efficacy: Low  |  Grade: B

Testosterone Replacement Therapy

TRT, Testosterone Therapy

May improve sleep quality for some, but can also worsen sleep apnea in susceptible individuals.

Efficacy: Low  |  Grade: C

Acarbose

Precose, Glucobay

Promotes stable blood sugar levels, which can contribute to more consistent energy and better sleep patterns.

Efficacy: Low  |  Grade: C

Dasatinib

Sprycel

May enhance overall resilience by reducing the body's systemic inflammatory load from senescent cells.

Efficacy: Low  |  Grade: C

Metformin

Glucophage, Fortamet, Glumetza

Supports endocrine health by stabilizing blood sugar levels, which can contribute to overall systemic resilience.

Efficacy: Low  |  Grade: C

NAC

N-Acetylcysteine, N-acetyl-L-cysteine

May support sleep quality by reducing inflammation and oxidative stress associated with certain conditions.

Efficacy: Low  |  Grade: C

Omega-3 Fatty Acids

Fish Oil, EPA, DHA, Marine Oils, Omega-3 Softgel, Omega-3 Supplement

May contribute to better sleep quality by supporting the regulation of sleep-related hormones and calming the nervous system.

Efficacy: Low  |  Grade: C

Potassium Chloride

KCl, Potassium salt

Contributes to electrolyte balance, which can help prevent nighttime muscle cramps that may disrupt sleep.

Efficacy: Low  |  Grade: C

Rapamycin

Sirolimus

May enhance resilience to stress by modulating systemic inflammation and supporting cellular housekeeping processes.

Efficacy: Low  |  Grade: C

Testosterone Therapy (Women) (Topical)

Low-dose Testosterone for Women, Female Androgen Therapy

Contributes to overall hormonal balance, which may indirectly support better sleep quality and stress resilience.

Efficacy: Low  |  Grade: C

Vitamin B1 (Thiamine)

Thiamin

Supports nervous system health, which may indirectly contribute to stable sleep patterns and stress response regulation.

Efficacy: Low  |  Grade: C

Vitamin C

Ascorbic Acid, L-Ascorbic Acid

May help regulate the body's stress response system, which can indirectly support more restful sleep patterns.

Topical Agents

Dietary Practices

Efficacy: High  |  Grade: B

Blueprint Protocol

Bryan Johnson's Blueprint

Optimizes sleep quality and autonomic nervous system balance through strict routines and environmental controls.

Efficacy: Medium  |  Grade: A

Tart Cherry Juice

Montmorency Cherry, Prunus cerasus, Sour Cherry

Naturally contains melatonin, which can help improve sleep duration and overall sleep quality.

Efficacy: Medium  |  Grade: B

Anti-Inflammatory Diet

Mediterranean Diet, DASH Diet, MIND Diet

Helps regulate the body's stress response systems, promoting more restorative sleep and hormonal balance.

Efficacy: Medium  |  Grade: B

Avoiding Processed Foods

Minimally Processed Diet, Whole Foods Diet

Promotes stable blood sugar and hormone levels, which contributes to deeper and more restorative sleep.

Efficacy: Medium  |  Grade: B

The Blue Zones Diet

Longevity Diet, Blue Zone Eating Pattern

Promotes stable blood sugar and provides key minerals that support relaxation and better sleep quality.

Efficacy: Medium  |  Grade: B

Calorie Restriction Diet

CR, Caloric Restriction

Can improve sleep quality and helps regulate key hormones for better stress resilience.

Efficacy: Medium  |  Grade: B

Calorie Restriction Without Malnutrition

CR, Dietary Restriction, Nutritional Restriction

Helps regulate key hormones and reduces systemic stress, which can contribute to more restorative sleep patterns.

Efficacy: Medium  |  Grade: B

Fermented Foods

Probiotic Foods, Live Culture Foods, Gut-Healthy Foods

Promotes relaxation and better sleep quality by influencing mood-regulating neurotransmitters via the gut-brain axis.

Efficacy: Medium  |  Grade: B

5:2 Intermittent Fasting

5-2 method, The Fast Diet

Supports hormonal balance and cellular stress resilience, which can contribute to more restorative sleep cycles.

Efficacy: Medium  |  Grade: B

Intermittent Fasting

IF, Periodic Fasting

Helps regulate key hormones and align circadian rhythms, which can improve sleep quality and stress resilience.

Efficacy: Medium  |  Grade: B

Low-FODMAP Diet

Low Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols Diet

Promotes more restful sleep by minimizing nighttime digestive distress that can cause awakenings and discomfort.

Efficacy: Medium  |  Grade: B

Mediterranean Diet

MedDiet

Provides nutrients like magnesium and tryptophan that support better sleep quality and nervous system regulation.

Efficacy: Medium  |  Grade: B

Methionine Restriction

MR, Low-Methionine Diet

Modulates key endocrine pathways like IGF-1, which supports cellular stress resilience and hormonal balance.

Efficacy: Medium  |  Grade: B

One Meal A Day

OMAD, 23:1 Intermittent Fasting

Helps regulate the body's internal clock (circadian rhythm) by creating a distinct daily fasting-feeding cycle.

Efficacy: Medium  |  Grade: B

Plant-Forward Diet

Plant-Based Diet, Flexitarian Diet, Vegetarian Diet, Vegan Diet

Supports a balanced nervous system and hormonal health, creating a foundation for restorative sleep.

Efficacy: Medium  |  Grade: B

Prolonged Fasting (Supervised)

Therapeutic Fasting, Extended Fasting, Water Fasting (Supervised)

Helps reset key hormone systems like insulin and improves markers of autonomic nervous system balance.

Efficacy: Medium  |  Grade: B

Protein

Amino Acids, Dietary Protein

Supplies amino acids like tryptophan and glycine, which support the production of sleep-regulating hormones.

Efficacy: Medium  |  Grade: B

Time-Restricted Eating (16:8)

TRE, 16:8 Intermittent Fasting, Leangains Protocol

Helps align your body's internal clocks, potentially leading to deeper, more restorative sleep.

Efficacy: Medium  |  Grade: B

Whole Food Plant Based

WFPB, Plant-Based Diet

Promotes restorative sleep and stress resilience through improved metabolic health and key sleep-supporting nutrients.

Efficacy: Medium  |  Grade: C

Branched-Chain Amino AcidRestriction

Low BCAA Diet

Helps support the natural production of the sleep hormone melatonin by reducing brain transport competition.

Efficacy: Medium  |  Grade: C

Fasting-Mimicking Diet (FMD)

FMD, Prolon Diet

Helps regulate key hormones and reduce systemic inflammation, which supports the body's stress response system.

Efficacy: Low  |  Grade: B

High-Fiber Diet

Fiber-rich eating, Plant-forward diet

May promote deeper, more restorative sleep by preventing large blood sugar fluctuations throughout the night.

Efficacy: Medium  |  Grade: C

Whole30

Whole 30 Diet, 30-Day Elimination Diet

Can improve sleep quality by stabilizing blood sugar and removing common sleep disruptors like alcohol.

Efficacy: Low  |  Grade: C

Autoimmune Protocol Diet

AIP, AIP Diet

May support more restful sleep by calming systemic inflammation and promoting a balanced stress response system.

Efficacy: Low  |  Grade: C

Alternate-Day Fasting (ADF)

ADF, Every-Other-Day Fasting

Can improve key endocrine markers like insulin, which contributes to overall metabolic and hormonal balance.

Efficacy: Low  |  Grade: C

Cruciferous Vegetables

Brassicas, Cole crops

Contributes to endocrine balance through compounds that support healthy hormone metabolism.

Efficacy: Low  |  Grade: C

5:2 Diet

The Fast Diet, Intermittent Fasting (5:2)

May help regulate circadian rhythms and improve stress resilience, though individual responses to fasting can vary.

Efficacy: Low  |  Grade: C

Flexitarian Diet

Semi-vegetarianism, Flexible vegetarianism

Contributes to stable blood sugar and provides key nutrients, which can indirectly support better sleep quality.

Efficacy: Low  |  Grade: C

Gluten-Free Diet

GF Diet

May improve sleep quality by alleviating the gastrointestinal discomfort that can disrupt rest in sensitive individuals.

Efficacy: Low  |  Grade: C

Inulin (Prebiotic Fiber)

Prebiotic Fiber, Chicory Root Fiber, Fructan

May promote more restorative sleep, particularly by helping the body better manage the effects of stress.

Efficacy: Low  |  Grade: C

Kefir / Fermented Foods

Probiotic Foods, Cultured Foods

May support relaxation and sleep quality through its influence on the gut-brain axis and key neurotransmitters.

Efficacy: Low  |  Grade: C

Ketogenic Diet

Keto, Keto Diet

May promote deeper, more restorative slow-wave sleep by altering brain energy metabolism and neurotransmitter activity.

Efficacy: Low  |  Grade: C

Pescatarian Diet

Pescatarianism, Fish-based diet

May improve sleep quality through nutrients like omega-3s and vitamin D involved in sleep regulation.

Efficacy: Low  |  Grade: C

Polyphenol-Rich Diet

High-Polyphenol Diet, Colorful Diet, Polyphenol-rich Foods, Phytonutrient-dense foods, Flavonoid-rich foods

May indirectly support stress resilience and sleep quality through broad anti-inflammatory and antioxidant effects.

Efficacy: Low  |  Grade: C

Potassium

K, Potassium Chloride, Potassium Citrate

May support uninterrupted sleep by helping to prevent nighttime muscle cramps and regulating nerve signals.

Efficacy: Low  |  Grade: C

Resistant Starch

RS, Undigestable Starch

Contributes to a balanced stress response and may improve sleep quality by nurturing the gut-brain connection.

Efficacy: Low  |  Grade: C

Vegetarian Diet

Plant-based diet, Lacto-ovo vegetarianism

May promote better sleep quality through high intake of magnesium and complex carbohydrates, supporting relaxation.

Efficacy: Low  |  Grade: C

Water Fasting

Prolonged Fasting, Extended Fasting

May help reset circadian rhythms and improve autonomic nervous system balance for more restorative sleep.

Lifestyle Practices

Efficacy: High  |  Grade: A

Blue Light Blocking Glasses

Blue Blockers, Amber Glasses, Sleep Glasses

Helps regulate the natural sleep-wake cycle by allowing for normal melatonin production in the evening.

Efficacy: High  |  Grade: A

Breathwork

Pranayama, Conscious Connected Breathing, Holotropic Breathwork, Wim Hof Method

Calms the nervous system to facilitate faster sleep onset and improves resilience to daily stressors.

Efficacy: High  |  Grade: A

Deep Breathing Exercises

Diaphragmatic Breathing, Belly Breathing, Mindful Breathing

Calms the nervous system to promote faster sleep onset and improve overall sleep quality.

Efficacy: High  |  Grade: A

Meditation

Mindfulness, Vipassanā, Zazen, Transcendental Meditation

Calms the nervous system and lowers stress hormones, leading to improved sleep quality and resilience.

Efficacy: High  |  Grade: A

Mindfulness Meditation

Mindfulness-Based Stress Reduction (MBSR), Vipassana, Concentrative Meditation

Calms the nervous system to improve sleep quality and regulates stress hormones for enhanced daily resilience.

Efficacy: High  |  Grade: A

Relaxation

Meditation, Mindfulness, Yoga, Tai Chi, Deep Breathing, Progressive Muscle Relaxation

Calms the nervous system to improve sleep quality and regulate the body's response to stress.

Efficacy: High  |  Grade: A

Running

Jogging, Aerobic Exercise, Cardio

Promotes deeper, more restorative sleep and helps regulate the body's stress response systems.

Efficacy: High  |  Grade: A

Stress Management

Mindfulness, Relaxation Techniques, Cognitive Behavioral Therapy (CBT), Meditation

Calms the nervous system to improve sleep quality and duration, and enhances resilience to daily stressors.

Efficacy: High  |  Grade: A

Temperature Regulating Mattresses

Cooling Mattresses, Smart Beds, Climate Control Sleep Systems

Promotes deeper, more restorative sleep by helping the body reach and maintain its optimal temperature for rest.

Efficacy: High  |  Grade: B

Cold Exposure

Cold Therapy, Cold Water Immersion, Cryotherapy, Ice Bath

Builds resilience to stress by training the nervous system and can improve autonomic balance over time.

Efficacy: Medium  |  Grade: A

EFT Tapping

Emotional Freedom Techniques, Tapping

Reduces stress hormones like cortisol and calms the nervous system, promoting better sleep and emotional resilience.

Efficacy: High  |  Grade: B

Sexual Activity

Sex, Intercourse, Orgasm

Reduces stress hormones and releases compounds like oxytocin, promoting relaxation and better sleep quality.

Efficacy: Medium  |  Grade: A

Smoking Cessation

Quitting Smoking, Tobacco Cessation

Eliminating nicotine's stimulant effects leads to deeper, more restorative sleep and a calmer nervous system.

Efficacy: Medium  |  Grade: A

Strength Training

Resistance Training, Weightlifting, Resistance Exercise

Improves overall sleep quality, helps you fall asleep faster, and can reduce nighttime awakenings.

Efficacy: High  |  Grade: B

Travel

Vacation, Exploration, Novelty Seeking

Taking a break from daily routines can significantly reduce stress, lower cortisol, and improve nervous system balance.

Efficacy: Medium  |  Grade: B

Mouth Taping

Oral Taping, Sleep Taping

Promotes nasal breathing to reduce snoring and improve sleep architecture for more restorative rest.

Efficacy: Medium  |  Grade: B

Sauna

Sauna Bathing, Hyperthermic Conditioning, Heat Therapy

Promotes deeper, more restorative sleep by helping to regulate the body's core temperature and calm the nervous system.

Efficacy: Medium  |  Grade: B

Weighted Blankets (Topical)

sensory blankets, gravity blankets

Promotes relaxation by calming the nervous system, leading to deeper and more restorative sleep.

Efficacy: Low  |  Grade: C

Electric Toothbrushing

Powered Toothbrushing

Helps prevent painful dental issues that can disrupt sleep quality and overall systemic health.

Efficacy: Low  |  Grade: C

Sunglasses

UV-blocking eyewear, Shades

May help regulate the body's internal clock by reducing bright light exposure in the late afternoon and evening.

Exercise & Sports

Efficacy: High  |  Grade: A

Endurance Training

Aerobic Exercise, Cardio

Enhances deep sleep quality, helps regulate the nervous system, and improves the body's response to stress.

Efficacy: High  |  Grade: A

Qigong

Chi Kung, Chi Gung

By calming the nervous system, qigong effectively reduces stress and significantly improves overall sleep quality.

Efficacy: High  |  Grade: A

Regular Aerobic Exercise

Cardio, Endurance Training, Aerobics

Promotes deeper, more restorative sleep and helps regulate the body's stress response systems.

Efficacy: High  |  Grade: A

Yoga

Hatha Yoga, Vinyasa Yoga, Ashtanga Yoga, Pranayama

Promotes deeper, more restorative sleep by calming the nervous system and building resilience to stress.

Efficacy: Medium  |  Grade: A

Basketball

Hoops

Promotes deeper sleep and better stress regulation through vigorous physical activity and social engagement.

Efficacy: Medium  |  Grade: A

Bicycling

Cycling

Helps regulate sleep cycles and reduces stress hormones, leading to more restorative sleep and better resilience.

Efficacy: Medium  |  Grade: A

Calisthenics

Bodyweight Training, Bodyweight Exercise

Promotes deeper, more restorative sleep and helps regulate stress hormones for improved daily resilience.

Efficacy: Medium  |  Grade: A

Cross-Country Skiing

Nordic Skiing, XC Skiing

Promotes deeper, more restorative sleep and improves nervous system regulation through vigorous outdoor activity.

Efficacy: Medium  |  Grade: A

Daily Brisk Walking

Brisk Walking, Regular Walking, Moderate-intensity Walking

Promotes deeper, more restorative sleep and helps regulate the body's response to daily stress.

Efficacy: Medium  |  Grade: A

Hiking

Trekking, Rucking, Hillwalking

Improves sleep quality and stress resilience by regulating circadian rhythms and reducing cortisol levels.

Efficacy: Medium  |  Grade: A

High-Intensity Resistance Training (HIRT)

HIRT, Heavy Duty Training, HDT

Promotes deeper, more restorative sleep and helps regulate the body's stress response systems.

Efficacy: Medium  |  Grade: A

Ice Skating

Figure Skating, Speed Skating, Ice Hockey

Promotes deeper sleep and helps regulate the nervous system's response to daily stressors.

Efficacy: Medium  |  Grade: A

Indoor Cycling

Stationary Biking, Spinning

Promotes deeper, more restorative sleep and helps regulate the nervous system for better stress resilience.

Efficacy: Medium  |  Grade: A

Jogging

Running, Aerobic Exercise

Promotes deeper, more restorative sleep and helps balance the nervous system for improved stress resilience.

Efficacy: Medium  |  Grade: A

Jump Rope

Skipping Rope, Rope Jumping

Promotes deeper, more restorative sleep and helps regulate the body's stress-response systems through vigorous activity.

Efficacy: Medium  |  Grade: A

Kayaking

Paddling, Canoeing

Helps regulate sleep cycles and reduce stress through physical exertion and time spent in nature.

Efficacy: Medium  |  Grade: A

Kickball

Soccer Baseball, Football Rounders

Promotes better sleep quality and stress resilience through physical activity and positive social interaction.

Efficacy: Medium  |  Grade: A

Marathon Training

Long-Distance Running, Endurance Running Training

Promotes deeper, more restorative sleep and enhances the body's ability to manage and recover from stress.

Efficacy: Medium  |  Grade: A

Padel

Padel tennis

Promotes better sleep quality and stress reduction through vigorous physical activity and its inherent social engagement.

Efficacy: Medium  |  Grade: A

Pickleball

Promotes better sleep quality and stress reduction through regular physical activity and social engagement.

Efficacy: Medium  |  Grade: A

Race Walking

Power Walking

Promotes deeper, more restorative sleep and helps regulate the body's stress response system for improved resilience.

Efficacy: Medium  |  Grade: A

Resistance Training

Strength Training, Weightlifting

Enhances deep sleep quality and helps regulate the body's stress response systems for better resilience.

Efficacy: Medium  |  Grade: A

Road Cycling

Cycling, Bicycling

Regular cycling can improve sleep quality and helps regulate the autonomic nervous system for better stress resilience.

Efficacy: Medium  |  Grade: A

Rowing

Ergometer, Crew, Sculling

Regular sessions can improve deep sleep quality and help regulate the body's stress response systems.

Efficacy: Medium  |  Grade: A

Skiing

Downhill Skiing, Alpine Skiing, Cross-Country Skiing, Nordic Skiing

Promotes deeper, more restorative sleep through vigorous physical exertion and natural light exposure during the day.

Efficacy: Medium  |  Grade: A

Snowboarding

Snowboard

Promotes deeper, more restorative sleep through vigorous physical exertion and exposure to natural daylight.

Efficacy: Medium  |  Grade: A

Snowshoeing

Winter hiking, Snow-shoeing

Promotes deeper sleep and stress resilience through vigorous physical activity and exposure to natural daylight.

Efficacy: Medium  |  Grade: A

Softball

Slow-pitch Softball, Fast-pitch Softball

Promotes better sleep quality and stress resilience through regular physical activity and social engagement.

Efficacy: Medium  |  Grade: A

Stand-Up Paddleboarding

SUP, Paddleboarding

Reduces stress and regulates circadian rhythms through exercise and nature exposure, promoting deeper, more restorative sleep.

Efficacy: Medium  |  Grade: A

Swimming

Aquatic Exercise

Regular swimming can deepen sleep quality and regulate stress hormones for improved daily resilience.

Efficacy: Medium  |  Grade: A

Tai Chi

Taijiquan

Calms the nervous system and reduces stress hormones, leading to improved sleep quality and resilience.

Efficacy: Medium  |  Grade: A

Track and Field

Athletics

Promotes deeper, more restorative sleep and helps regulate the body's response to daily stress.

Efficacy: Medium  |  Grade: A

Trail Running

Off-road running, Mountain running

Promotes deeper, more restorative sleep and enhances stress resilience through vigorous exercise in a natural environment.

Efficacy: Medium  |  Grade: A

Walking Golf

Golf (walking), Carry golf

Promotes better sleep and stress resilience through several hours of outdoor activity and social engagement.

Efficacy: Medium  |  Grade: A

Water Polo

Polo

Promotes deeper, more restorative sleep and improves stress resilience through vigorous physical exertion.

Efficacy: Medium  |  Grade: A

Weight-Bearing Exercise

Resistance Training, Strength Training, Impact Exercise

Helps regulate stress hormones and improves sleep quality, contributing to better overall resilience and recovery.

Efficacy: Medium  |  Grade: A

Zone 2 Cardio Training

Aerobic Base Training, Low-Intensity Steady-State (LISS) Cardio

Improves deep sleep quality and helps balance the autonomic nervous system for better stress resilience.

Efficacy: Medium  |  Grade: A

Zone 2 Exercise

Aerobic Base Training, Endurance Training, Low-Intensity Steady-State (LISS) Cardio, LISS

Helps regulate the autonomic nervous system and circadian rhythms, promoting deeper and more restorative sleep.

Efficacy: Medium  |  Grade: B

Australian Rules Football

Aussie Rules, Footy

Promotes deeper sleep and helps regulate the body's stress response systems through vigorous physical exertion.

Efficacy: Medium  |  Grade: B

Badminton

Regular play helps regulate stress hormones and can lead to deeper, more restorative sleep patterns.

Efficacy: Medium  |  Grade: B

BMX

Bicycle Motocross, BMX Racing, Freestyle BMX

Promotes deeper sleep and enhances stress resilience by providing a powerful physical outlet for the body.

Efficacy: Medium  |  Grade: B

Bodyboarding

Boogie boarding

Combines vigorous physical exertion with natural light exposure to help regulate circadian rhythms and improve sleep quality.

Efficacy: Medium  |  Grade: B

Bouldering / Rock Climbing

Climbing

Combines intense physical effort with mindful focus to help regulate the nervous system and reduce stress.

Efficacy: Medium  |  Grade: B

Boxing

Pugilism, Sweet Science

Intense training sessions help regulate stress hormones and improve nervous system balance, promoting deeper, restorative sleep.

Efficacy: Medium  |  Grade: B

Canoeing

Kayaking, Paddling

Promotes deeper sleep and stress resilience by combining physical exertion with the calming effects of nature.

Efficacy: Medium  |  Grade: B

Disc Golf

Frisbee Golf, Frolf

Reduces stress and supports the nervous system through moderate exercise and time spent in natural environments.

Efficacy: Medium  |  Grade: B

Dodgeball

Promotes deeper sleep through vigorous physical exertion and can help regulate stress hormones.

Efficacy: Medium  |  Grade: B

Downhill Skiing

Alpine Skiing

Reduces stress and can improve sleep quality through vigorous physical activity and time spent in nature.

Efficacy: Medium  |  Grade: B

Flag Football

Non-contact Football

Promotes better sleep quality and stress resilience through vigorous physical activity and social team engagement.

Efficacy: Medium  |  Grade: B

Flexibility Training / Stretching

Stretching, Mobility Work, Range of Motion Training

Reduces muscle tension and calms the nervous system, which can lead to falling asleep faster and better sleep quality.

Efficacy: Medium  |  Grade: B

Gymnastics

Artistic Gymnastics, Rhythmic Gymnastics, Calisthenics, Gymnastic Strength Training

Regular, intense practice can improve deep sleep quality and builds nervous system resilience to physical stress.

Efficacy: Medium  |  Grade: B

High-Intensity Interval Training

HIIT, Sprint Interval Training

Can deepen sleep quality and improve nervous system regulation, enhancing the body's stress resilience.

Efficacy: Medium  |  Grade: B

Ice Hockey

Hockey

Promotes deeper sleep and stress resilience through vigorous physical activity and team camaraderie.

Efficacy: Medium  |  Grade: B

Kettlebell Training

KB Training, Girevoy Sport

Promotes deeper sleep and enhances stress resilience by regulating the nervous and endocrine systems.

Efficacy: Medium  |  Grade: B

Kite Surfing

Kitesurfing, Kiteboarding

The intense physical exertion and mental focus helps regulate the nervous system, improving stress resilience and sleep quality.

Efficacy: Medium  |  Grade: B

Martial Arts

Tai Chi, Judo, Karate, Brazilian Jiu-Jitsu, Kung Fu

Reduces stress and improves sleep quality by regulating the nervous system through controlled breathing and exercise.

Efficacy: Medium  |  Grade: B

Mixed Martial Arts

MMA

Promotes significant stress adaptation and resilience, which can improve autonomic nervous system regulation.

Efficacy: Medium  |  Grade: B

Mountain Biking

MTB, Off-road Cycling

Reduces stress and can improve sleep quality through vigorous exercise and exposure to natural environments.

Efficacy: Medium  |  Grade: B

Mountaineering

Alpinism, Mountain Climbing

Trains the body's stress response systems, building profound physiological and mental resilience to challenges.

Efficacy: Medium  |  Grade: B

Muay Thai

Thai Boxing, The Art of Eight Limbs

Promotes deeper sleep and enhances stress resilience by providing an intense physical outlet for stress.

Efficacy: Medium  |  Grade: B

Netball

Team-based exercise helps regulate stress hormones and promotes better sleep quality through physical exertion.

Efficacy: Medium  |  Grade: B

Nordic Walking

Pole Walking, Exerstriding

Promotes deeper, more restorative sleep and helps balance the nervous system for better stress resilience.

Efficacy: Medium  |  Grade: B

Parkour

Freerunning, Art du Déplacement

Promotes deeper sleep and builds stress resilience by combining intense physical exertion with mindful risk management.

Efficacy: Medium  |  Grade: B

Pilates

Contrology

Reduces stress and promotes relaxation, which can lead to improved sleep quality and nervous system balance.

Efficacy: Medium  |  Grade: B

Rebounding

Mini-trampoline exercise, Cellercising

Promotes better sleep quality and stress resilience by regulating the nervous system through rhythmic exercise.

Efficacy: Medium  |  Grade: B

Rock Climbing

Bouldering, Sport Climbing, Trad Climbing

Promotes deeper sleep and stress reduction through intense physical exertion and the mindful focus required.

Efficacy: Medium  |  Grade: B

Rucking

Weighted Walking, Backpack Training

Promotes deeper, more restorative sleep and helps balance the nervous system through consistent physical activity.

Efficacy: Medium  |  Grade: B

Rugby

Rugby Union, Rugby League

Vigorous physical training helps regulate the nervous system, which can lead to deeper sleep and improved stress resilience.

Efficacy: Medium  |  Grade: B

Skateboarding

Skating, Street Skating, Vert Skating

Promotes stress reduction and better sleep quality through intense physical exertion and mental focus.

Efficacy: Medium  |  Grade: B

Soccer (Football)

Football

Promotes deeper sleep and helps regulate stress hormones through vigorous physical activity and social engagement.

Efficacy: Medium  |  Grade: B

Sprinting

High-Intensity Interval Training (HIIT), Sprint Interval Training (SIT)

Promotes deeper sleep and optimizes key hormones like insulin and growth hormone for better stress resilience.

Efficacy: Medium  |  Grade: B

Structured Interval Training

HIIT, High-Intensity Interval Training, SIT

Promotes deeper sleep and helps regulate the nervous system for improved stress resilience and hormonal balance.

Efficacy: Medium  |  Grade: B

Surfing

Wave riding

Promotes deeper sleep and stress resilience through vigorous exercise and mindful immersion in a natural environment.

Efficacy: Medium  |  Grade: B

Tennis

Racket Sports

Promotes deeper, more restorative sleep and helps regulate the body's response to stress.

Efficacy: Medium  |  Grade: B

Ultimate Frisbee

Ultimate

Vigorous team play can deepen sleep quality, while the social engagement helps build resilience to stress.

Efficacy: Medium  |  Grade: B

Volleyball

Beach Volleyball

Promotes better sleep and stress resilience through vigorous exercise and social team interaction.

Efficacy: Medium  |  Grade: B

Wakeboarding

Waterskiing

Vigorous physical exertion combined with mental focus can help regulate stress hormones and improve sleep quality.

Efficacy: Low  |  Grade: B

Baseball

Softball, America's Pastime

Regular physical activity and the social aspect of teamwork can help regulate stress and improve sleep.

Efficacy: Low  |  Grade: B

Blood Flow Restriction Training

Kaatsu Training, Occlusion Training

Promotes a robust hormonal response, including growth hormone, which is crucial for nightly tissue repair.

Efficacy: Medium  |  Grade: C

Brazilian Jiu-Jitsu

BJJ

Improves stress resilience through controlled exposure to high-pressure situations and promotes deeper, more restorative sleep.

Efficacy: Low  |  Grade: B

Plyometrics

Jump Training, Plyos, Reactive Strength Training

Regular training improves the body's ability to manage stress, which can contribute to more restorative sleep.

Efficacy: Low  |  Grade: B

Table Tennis

Ping-Pong

Can improve sleep quality and reduce stress as a form of moderate, engaging physical activity.

Efficacy: Low  |  Grade: B

Treadmill Desk Walking

Walking Desk, Under-Desk Treadmill

Contributes to total daily activity, which helps regulate circadian rhythms and can improve sleep quality.

Efficacy: Low  |  Grade: C

Animal Flow

Quadrupedal Movement Training, Ground-Based Movement

Promotes better sleep and stress resilience as a result of consistent, mindful physical activity.

Efficacy: Low  |  Grade: C

Exercise Snack

Movement Snack, Micro-workouts

Spreading activity throughout the day can help regulate energy levels and may contribute to better sleep quality.

Efficacy: Low  |  Grade: C

Hackeysack

Footbag

Can reduce stress through playful physical activity, which supports a more balanced nervous system.

Efficacy: Low  |  Grade: C

Isometrics

Isometric Exercise, Static Strength Training

Can contribute to better sleep quality and stress resilience as part of a regular exercise routine.

Efficacy: Low  |  Grade: C

Slacklining

Balance training, Proprioceptive training

Promotes a state of mindful focus, which can help regulate the nervous system and reduce stress.

Efficacy: Low  |  Grade: C

Weighted Vest Walking

Rucking, Loaded Carries

Promotes deeper sleep and better stress regulation by increasing the intensity of moderate physical activity.

Devices

Efficacy: High  |  Grade: A

Continuous Pulse Oximeter (Topical)

Wearable SpO2 Monitor, Continuous Oxygen Saturation Monitor

Monitors blood oxygen overnight, revealing sleep disturbances that impact sleep quality and nervous system balance.

Efficacy: High  |  Grade: A

HRV and Recovery Tracker

Wearable Recovery Monitor, HRV Biofeedback Device

Directly measures sleep quality and autonomic nervous system recovery, promoting resilience and hormonal balance.

Efficacy: High  |  Grade: A

Sleep Staging Tracker

EEG Sleep Tracker, Polysomnography (PSG) At-Home, Sleep Stage Monitor

Provides direct feedback on sleep architecture and nervous system recovery, enabling targeted improvements to sleep quality.

Efficacy: Medium  |  Grade: A

Continuous Ambulatory ECG (Topical)

Holter Monitor, Ambulatory ECG Monitoring, AECG

Assesses nighttime heart rhythms and nervous system balance, revealing issues that can disrupt restorative sleep quality.

Efficacy: High  |  Grade: B

Thyroid Red Light Therapy (Topical)

Thyroid Photobiomodulation, Thyroid PBM, Low-Level Laser Therapy for Thyroid

Directly supports the thyroid, a key endocrine gland, helping to balance hormones that regulate metabolism.

Efficacy: High  |  Grade: B

Vagus Nerve Stimulation

transcutaneous Vagus Nerve Stimulation, tVNS, auricular Vagus Nerve Stimulation, taVNS

Activates the parasympathetic nervous system, helping to regulate the stress response and improve overall sleep quality.

Efficacy: Medium  |  Grade: B

At-Home Blood Pressure Monitor

Home BP Monitor, Sphygmomanometer

Provides insights into how your sleep quality and nervous system regulation are impacting your cardiovascular health.

Efficacy: Medium  |  Grade: B

Continuous Glucose Monitor (CGM)

CGM, Continuous Glucose Monitoring

Reveals how meals affect overnight blood sugar, helping to prevent fluctuations that can disrupt restorative sleep.

Efficacy: Low  |  Grade: C

At-Home Metabolic Analyzer

Breathalyzer for Metabolism, Respiratory Exchange Ratio (RER) Device, Metabolic Breath Tester

Promotes stable overnight blood sugar by informing dietary choices, which can lead to less disrupted sleep.

Efficacy: Low  |  Grade: C

Continuous Ketone Monitor

CKM

Aids in maintaining stable metabolic energy, which can contribute to more consistent and restful sleep patterns.

Efficacy: Low  |  Grade: C

Gait and Balance Accelerometer

Wearable Gait Sensor, Inertial Measurement Unit (IMU) for Balance

By promoting regular physical activity, it can indirectly contribute to better sleep quality and nervous system regulation.

Procedures

Efficacy: High  |  Grade: A

Acupuncture

Traditional Chinese Medicine (TCM) Needling

Promotes relaxation and regulates the nervous system, leading to improved sleep quality and duration.

Efficacy: High  |  Grade: A

Biofeedback Therapy

Neurofeedback, EMG Biofeedback, Thermal Biofeedback, HRV Biofeedback

Promotes nervous system balance by reducing stress responses, leading to improved sleep quality and greater resilience.

Efficacy: High  |  Grade: A

Cognitive Behavioral Therapy

CBT

Resets sleep-related behaviors and thoughts to promote restorative sleep architecture and calm the nervous system.

Efficacy: High  |  Grade: A

Light Therapy Glasses

Light Visor, Wearable Light Therapy, SAD Glasses

Helps regulate the sleep-wake cycle, making it easier to fall asleep at night and wake refreshed.

Efficacy: High  |  Grade: A

MDMA Therapy

3,4-Methylenedioxymethamphetamine-Assisted Therapy, MDMA-Assisted Psychotherapy

Helps re-regulate the nervous system and restore natural sleep cycles by resolving underlying psychological trauma.

Efficacy: High  |  Grade: A

SAD Lamp

Light Therapy Box, Bright Light Therapy

Helps synchronize the body's internal clock, promoting consistent sleep patterns and hormonal balance.

Efficacy: High  |  Grade: A

White Noise / Sound Therapy

Pink Noise, Brown Noise, Acoustic Stimulation, Sound Masking

Promotes deeper, more restorative sleep and calms the nervous system by masking noise and encouraging relaxation.

Efficacy: High  |  Grade: B

Floatation Therapy

Float Tank, Sensory Deprivation Tank, REST, Restricted Environmental Stimulation Therapy

Calms the nervous system and lowers stress hormones, leading to improved sleep quality and enhanced stress resilience.

Efficacy: Medium  |  Grade: B

Neti Pot

Nasal Irrigation, Saline Rinse, Jala Neti

Clears nasal passages to promote easier breathing, which can reduce snoring and improve overall sleep quality.

Efficacy: Medium  |  Grade: B

Sauna Therapy

Heat Therapy, Hyperthermic Conditioning, Sauna Bathing

Promotes deeper, more restorative sleep and helps the body better manage stress by balancing the nervous system.

Efficacy: Medium  |  Grade: B

Transcranial Electrical Stimulation

tES, tDCS, tACS, tRNS

Can enhance deep sleep quality and help regulate the nervous system's response to stress.

Efficacy: Medium  |  Grade: B

Transcranial magnetic stimulation

TMS, rTMS

Helps regulate brain activity associated with mood, which can lead to improved sleep quality and stress resilience.

Efficacy: Low  |  Grade: C

Fecal Microbiota Transplant

FMT, Stool Transplant, Bacteriotherapy

May help regulate sleep cycles by restoring gut microbes that influence key sleep-related hormones.

Efficacy: Low  |  Grade: C

Hyperbaric Oxygen Therapy

HBOT

May help regulate the nervous system and reduce inflammation, potentially contributing to more restorative sleep.

Efficacy: Low  |  Grade: C

Infrared Light Therapy

Red Light Therapy, RLT, Photobiomodulation, PBM, Low-Level Laser Therapy, LLLT

May support the body's natural sleep cycle and improve rest by reducing systemic pain and inflammation.

Efficacy: Low  |  Grade: C

LED Red Light Therapy

Photobiomodulation, PBM, Low-Level Laser Therapy, LLLT

May support the body's natural sleep cycle without disrupting melatonin production like blue light.

Efficacy: Low  |  Grade: C

Vibration Therapy

Whole Body Vibration, WBV

May promote relaxation and help modulate the body's response to stress.

Protocols

Synergistic Therapy