Meta Information
ID:5-fu-calcipotriol
Name:5-Fluorouracil + Calcipotriol (Topical)
Schema Version:2.4_uniform_evidence_2026_06_18
Created
2026-07-02T15:09:16Z
Model
phase-c-combo-claude-opus-4.8
Provenance Note
Compounded topical field therapy for actinic keratosis (nonHealthspan). Minimal systemic absorption; interactions are local/photobiologic.
Interactions
Target id:
/lifestyle/sun-exposure
Target name:
Sun / UV exposure
Severity:
moderate
Interaction type:
adverse
Nature:
conditional
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Both 5-FU and the treated skin become markedly photosensitive during the short treatment course, increasing burning and inflammation on sun exposure.
Actionable advice:
Minimise sun on treated areas and use broad-spectrum sunscreen during and for ~2 weeks after the course.
Validation status:
validated_via_class_inference
Evidence tier:
tier_c
Evidence basis:
class_inference_summary
Evidence anchors:
Exact phrase from label:
Topical 5-fluorouracil combined with calcipotriol is used off-label for field treatment of actinic keratoses; localized inflammation is expected.
Label source:
StatPearls / dermatology field-therapy monograph
Action type:
separate
Target id:
/intervention/tretinoin
Target name:
Topical retinoids / exfoliants
Severity:
moderate
Interaction type:
adverse
Nature:
relative
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Concurrent topical retinoids, AHAs or other exfoliants compound irritation and barrier disruption on skin already inflamed by 5-FU/calcipotriol.
Actionable advice:
Pause other active topicals on the treated area until the reaction resolves.
Validation status:
validated_via_class_inference
Evidence tier:
tier_c
Evidence basis:
class_inference_summary
Evidence anchors:
Exact phrase from label:
Topical 5-fluorouracil combined with calcipotriol is used off-label for field treatment of actinic keratoses; localized inflammation is expected.
Label source:
StatPearls / dermatology field-therapy monograph
Action type:
separate
Target id:
/condition/pregnancy
Target name:
Pregnancy
Severity:
major
Interaction type:
contraindication
Nature:
absolute
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
5-Fluorouracil is teratogenic; topical use over actinic-keratosis fields is generally avoided in pregnancy.
Actionable advice:
This should not be used during pregnancy or when planning pregnancy; alternatives are worth discussing with a clinician.
Validation status:
validated_via_class_inference
Evidence tier:
tier_c
Evidence basis:
class_inference_summary
Evidence anchors:
Exact phrase from label:
Topical 5-fluorouracil combined with calcipotriol is used off-label for field treatment of actinic keratoses; localized inflammation is expected.
Label source:
StatPearls / dermatology field-therapy monograph
Action type:
avoid
Target id:
/biomarker/calcium
Target name:
Serum calcium (high-dose/large-area calcipotriol)
Severity:
minor
Interaction type:
monitoring
Nature:
conditional
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Very large-area or prolonged calcipotriol use can rarely raise serum calcium; standard actinic-keratosis field courses are low-risk.
Actionable advice:
No routine action for standard courses; avoid treating very large body-surface areas without clinician guidance.
Validation status:
validated_via_class_inference
Evidence tier:
tier_c
Evidence basis:
class_inference_summary
Evidence anchors:
Exact phrase from label:
Topical 5-fluorouracil combined with calcipotriol is used off-label for field treatment of actinic keratoses; localized inflammation is expected.
Label source:
StatPearls / dermatology field-therapy monograph
Action type:
monitor