Intervention Data
Meta Information
ID:5-fu-calcipotriol
Name:5-FU and Calcipotriol
Schema Version:1.5
Alternate Names
- 5-Fluorouracil and Calcipotriol
- Topical Senolytic Combination
Intervention Type
synergistic_therapy
Expected Cost Mean
Low Cost:
100
High Cost:
300
Cost Type:
procedure
Description:
Cost for a single course of compounded prescription cream; not covered by insurance.
Summary
A combination topical therapy (5-fluorouracil plus the vitamin D analog calcipotriol) used as a field treatment for actinic keratoses, sun-induced precancerous skin lesions. Calcipotriol induces the alarmin TSLP, priming a CD4+ T-cell immune response that, with 5-FU, clears precancerous keratinocytes; randomized-trial evidence supports efficacy for actinic keratosis. Its relevance to skin healthspan is as a precancer field therapy that may also improve the appearance of photoaged skin.
Purpose
Topical senolytic therapy to clear aged cells from the skin.
Card Summary
A topical combination therapy that acts as a senolytic, selectively destroying senescent (aged) cells in the skin to improve skin health and appearance.
Drug Class
Drugs In Class
Empty Array
Impact
Score:
3.5
Justification:
A targeted topical senolytic for skin with no proven systemic healthspan benefits.
Evidence
Grade:
B
Score:
6.5
Justification:
A single human RCT demonstrated effective clearance of senescent cells in treated skin.
Safety
Score:
6.2
Justification:
Causes significant, expected local inflammation and skin reactions; requires medical supervision.
Flags
- Causes significant skin irritation, redness, and peeling as part of its mechanism of action.
- Systemic healthspan or longevity benefits beyond skin are currently speculative and unproven.
- Should not be used by pregnant women or on open wounds.
Verdict
A proven and effective immunotherapy for actinic-keratosis with the added potential to reverse signs of photoaging.
Created
2026-04-26T15:56:21.021016Z
Model
Gemini 3.1 Pro (High)
Delivery
Route:
topical_skin
Scope:
- local
Is Skin Health
True
Indication
Focus:
healthspan
Description:
This is a combination topical therapy that acts as a potent senolytic, an agent that selectively destroys senescent (aged) cells. 5-Fluorouracil (5-FU), a chemotherapy drug, induces cell death in sene...
Typical Protocol
- Apply a topical cream containing 0.005% calcipotriol and 5% 5-fluorouracil twice daily for 2-4 days.
Non Healthspan
False