Appearance & Youth364

Structural proteins (collagen/elastin), oral/periodontal health, hair preservation, and halting dermal 'inflammaging'.

Supplements

Efficacy: High  |  Grade: A

Alpha Hydroxy Acids (AHAs)

AHAs, Fruit Acids

Promotes skin cell turnover and boosts collagen production, reducing fine lines and improving skin texture.

Efficacy: High  |  Grade: A

Astaxanthin

asta

Protects skin from UV damage and oxidative stress, improving hydration, elasticity, and overall skin tone.

Efficacy: High  |  Grade: A

Bakuchiol

Psoralea corylifolia extract, Babchi oil

Promotes collagen production and reduces fine lines, functioning similarly to retinol but with better skin tolerability.

Efficacy: High  |  Grade: A

Centella Asiatica (Cica)

Cica, Gotu Kola, Brahmi, Asiatic Pennywort

Enhances collagen production and circulation in the skin, improving firmness and aiding in wound healing.

Efficacy: High  |  Grade: A

Ceramides

Phytoceramides

Replenishes essential skin lipids to improve hydration, strengthen the skin barrier, and reduce visible signs of aging.

Efficacy: High  |  Grade: A

Collagen Peptides

Hydrolyzed Collagen

Improves skin hydration and elasticity, helping to reduce the appearance of fine lines and wrinkles.

Efficacy: High  |  Grade: A

Nano-Hydroxyapatite

n-HA, nHAp

Rebuilds and strengthens tooth enamel, reducing sensitivity and enhancing the brightness of your smile.

Efficacy: High  |  Grade: A

Orthosilicic acid

OSA, Choline-stabilized orthosilicic acid (ch-OSA), Silica

Promotes collagen production, which helps maintain skin elasticity and strengthens hair and nails.

Efficacy: High  |  Grade: A

Sustained Release Vitamin C

Time-Release Vitamin C, Extended-Release Ascorbic Acid

Crucial for collagen production to maintain skin elasticity and protects skin cells from oxidative damage.

Efficacy: High  |  Grade: A

Vitamin A

Retinol, Retinal, Retinoic Acid, Carotenoids

Promotes skin cell renewal and collagen production, helping to maintain smoother and more youthful-looking skin.

Efficacy: High  |  Grade: A

Liposomal Vitamin C

Liposomal Ascorbic Acid, L-Ascorbic Acid (Liposomal)

Promotes collagen production for skin elasticity and firmness, while also protecting skin from oxidative damage.

Efficacy: High  |  Grade: A

Xylitol

Birch Sugar

Significantly improves oral health by inhibiting cavity-causing bacteria and reducing plaque formation.

Efficacy: Medium  |  Grade: A

B Complex Vitamins

B Vitamins, Vitamin B Complex

Supports healthy cell turnover and protein synthesis, contributing to strong hair, nails, and a resilient skin barrier.

Efficacy: Medium  |  Grade: A

Beta Hydroxy Acids (BHAs)

Salicylic Acid

Exfoliates skin and clears pores to improve texture, reduce blemishes, and calm dermal inflammation.

Efficacy: Medium  |  Grade: A

Calcium Citrate

Calcium

Contributes to maintaining strong teeth and jawbone density, supporting long-term oral health and facial structure.

Efficacy: High  |  Grade: B

Carnosine

L-carnosine, beta-alanyl-L-histidine

Helps maintain skin elasticity by protecting collagen from sugar-induced damage, a key driver of wrinkles.

Efficacy: High  |  Grade: B

Fisetin

Smoketree extract, 3,3',4',7-tetrahydroxyflavone

As a potent senolytic, it helps clear aged 'zombie' cells, reducing skin inflammaging and protecting against damage.

Efficacy: High  |  Grade: B

FOXO4-DRI

FOXO4-Peptide Based Inhibitor, FOXO4-PBI

Promotes a more youthful appearance by restoring hair growth and improving tissue quality in animal studies.

Efficacy: Medium  |  Grade: A

Green Tea Oral Rinse

Catechin Mouthwash, Matcha Rinse

Reduces harmful oral bacteria, helping to prevent cavities, gum inflammation, and bad breath.

Efficacy: Medium  |  Grade: A

Hyaluronic Acid

HA, Hyaluronan, Sodium Hyaluronate

Promotes skin hydration from within, helping to reduce fine lines and maintain a supple complexion.

Efficacy: Medium  |  Grade: A

Iodine

Potassium Iodide, Lugol's Solution

Contributes to the health and maintenance of skin, hair, and nails through metabolic regulation.

Efficacy: Medium  |  Grade: A

Lutein

Zeaxanthin

Protects skin from light-induced damage, improving hydration, elasticity, and overall skin tone.

Efficacy: Medium  |  Grade: A

Lycopene

psi-psi-carotene

Acts as an internal antioxidant to help protect skin from UV damage and premature aging.

Efficacy: Medium  |  Grade: A

Myo-inositol

Inositol, Vitamin B8, cis-1,2,3,5-trans-4,6-cyclohexanehexol

Helps balance hormones that can contribute to clearer skin and reduced unwanted hair growth.

Efficacy: High  |  Grade: B

Myostatin Inhibitors

GDF-8 Inhibitors, Activin Receptor Type IIB Blockers

Promotes a leaner, more toned physique by significantly increasing muscle mass and potentially reducing body fat.

Efficacy: High  |  Grade: B

Procyanidin C1

PCC1

Acts as a senolytic to clear aged cells, which may help rejuvenate skin and support hair growth.

Efficacy: Medium  |  Grade: A

Vitamin B2

Riboflavin, Vitamin G

Supports tissue repair and is essential for maintaining healthy skin, hair, and mucous membranes.

Efficacy: Medium  |  Grade: A

Zinc Gluconate

Zincum Gluconicum

Supports collagen production and wound healing, promoting clear skin and healthy hair growth.

Efficacy: Medium  |  Grade: A

Zinc Picolinate

Zinc (Picolinate)

Promotes skin health and wound healing by supporting collagen production and reducing inflammation.

Efficacy: Medium  |  Grade: B

Benfotiamine

S-benzoylthiamine O-monophosphate

Helps protect skin collagen from sugar-related damage, supporting skin structure and elasticity over time.

Efficacy: Medium  |  Grade: B

Bilberry Extract

Vaccinium myrtillus extract, European Blueberry extract

Helps protect skin from environmental stressors, supporting collagen integrity and a more youthful appearance.

Efficacy: Medium  |  Grade: B

Boswellia Serrata

Indian Frankincense, Salai Guggal

Helps combat skin 'inflammaging' and may protect structural proteins for improved skin firmness.

Efficacy: Medium  |  Grade: B

Liposomal Calcium AKG

Liposomal Ca-AKG, Liposomal Alpha-Ketoglutarate

Promotes collagen production for skin structure and may help reduce age-related inflammation for healthier hair.

Efficacy: Medium  |  Grade: B

Calcium Alpha-Ketoglutarate

Ca-AKG, CaAKG

Supports collagen synthesis for skin structure and has been shown in animal models to preserve hair health.

Efficacy: Medium  |  Grade: B

Carnosine Eye Drops

N-acetylcarnosine eye drops, NAC eye drops, Can-C

Helps protect the eye's lens proteins from damage and clouding, supporting clear vision with age.

Efficacy: Medium  |  Grade: B

CJC-1295

CJC-1295 with DAC, Modified GRF (1-29) with DAC

Supports skin elasticity and hydration by stimulating the production of collagen, a key structural protein.

Efficacy: Medium  |  Grade: B

Coenzyme Q10

Ubiquinone, Ubidecarenone, CoQ10

Functions as an antioxidant in skin cells, helping protect against damage that contributes to visible aging.

Efficacy: Medium  |  Grade: B

Copper

Cupric, Copper Gluconate, Copper Bisglycinate, Copper Sulfate

Aids in the production of collagen and elastin for skin structure and melanin for hair pigmentation.

Efficacy: Medium  |  Grade: B

Liposomal CoQ10

Liposomal Coenzyme Q10, Liposomal Ubiquinone, Liposomal Ubiquinol

Acts as an antioxidant to protect skin cells from damage and supports cellular energy for repair.

Efficacy: Medium  |  Grade: B

DHEA

Dehydroepiandrosterone

Improves skin hydration, thickness, and tone in older adults by supporting structural protein production.

Efficacy: Medium  |  Grade: B

Egcg

Epigallocatechin gallate, Green Tea Extract

Helps protect skin from environmental stressors like UV radiation, reducing signs of premature aging.

Efficacy: Medium  |  Grade: B

Eggshell Membrane

NEM, Natural Eggshell Membrane

Provides collagen and hyaluronic acid to help maintain skin elasticity, hydration, and a youthful appearance.

Efficacy: Medium  |  Grade: B

Liposomal Glutathione

L-Glutathione (Liposomal), GSH (Liposomal)

Helps protect skin from oxidative damage, supporting skin elasticity and a more even tone.

Efficacy: Medium  |  Grade: B

Glutathione

L-Glutathione, GSH, Liposomal GSH

Helps protect skin from oxidative damage, supporting skin elasticity and promoting a more even skin tone.

Efficacy: Medium  |  Grade: B

Glycine

2-Aminoacetic acid

Supports the body's natural collagen synthesis, promoting skin elasticity and structural integrity.

Efficacy: Medium  |  Grade: B

Green Tea Extract

GTE, Camellia sinensis extract, EGCG

Helps protect skin from UV damage and reduces inflammation, supporting skin elasticity and a youthful appearance.

Efficacy: Medium  |  Grade: B

Iron Bisglycinate

Ferrous Bisglycinate, Chelated Iron

Promotes healthy hair growth and strong nails by addressing deficiencies that can cause shedding and brittleness.

Efficacy: Medium  |  Grade: B

Iron Fumarate

Ferrous Fumarate

Helps prevent hair loss, brittle nails, and pale skin that can result from iron deficiency.

Efficacy: Medium  |  Grade: B

Iron Gluconate

Ferrous Gluconate

Promotes healthy hair growth and nail strength, and helps maintain vibrant skin tone by preventing deficiency.

Efficacy: Medium  |  Grade: B

Iron

Ferrous Sulfate, Ferrous Gluconate, Iron Bisglycinate, Ferritin

Contributes to healthy hair growth and nail strength, often reversing deficiency-related thinning and brittleness.

Efficacy: Medium  |  Grade: B

Iron Sulfate

Ferrous Sulfate

Helps prevent hair thinning and brittle nails that can result from iron deficiency.

Efficacy: Medium  |  Grade: B

L-Lysine

Lysine

Contributes to skin elasticity and firmness as a fundamental building block for collagen protein.

Efficacy: Medium  |  Grade: B

Liposomal Calcium AKG

Liposomal Ca-AKG, Liposomal Alpha-Ketoglutarate Calcium Salt

Promotes collagen production for skin structure and has been shown to compress morbidity in animal models.

Efficacy: Medium  |  Grade: B

Magnesium Glycinate

Magnesium Bisglycinate

Provides a core building block for collagen, which is essential for skin elasticity and structural integrity.

Efficacy: Medium  |  Grade: B

Mastic Gum

Chios Mastic, Pistacia lentiscus

Supports oral health by reducing plaque-forming bacteria and promoting fresh breath and healthy gums.

Efficacy: Medium  |  Grade: B

Meso-Zeaxanthin

MZ

Helps protect skin from light-induced damage and oxidative stress, supporting skin tone and elasticity.

Efficacy: Medium  |  Grade: B

Milk Thistle (Silymarin)

Silybum marianum, Silymarin, Silibinin

Provides antioxidant protection for the skin, helping to shield it from environmental stressors like UV damage.

Efficacy: Medium  |  Grade: B

MSM (Methylsulfonylmethane)

Dimethyl sulfone, DMSO2

Provides essential sulfur for collagen and keratin production, supporting skin elasticity, hair strength, and nail health.

Efficacy: Medium  |  Grade: B

Omega-7 Fatty Acids

Palmitoleic Acid, C16:1n7

Promotes skin hydration and elasticity, helping to soothe dryness and maintain a healthy skin barrier.

Efficacy: Medium  |  Grade: B

Phytoestrogens: Soy Isoflavones

Isoflavones, Genistein, Daidzein, Glycitein

Promotes skin elasticity and hydration, helping to reduce fine wrinkles in aging skin.

Efficacy: Medium  |  Grade: B

Postbiotic Supplements

Postbiotics, Metabolite Supplements, Paraprobiotics

Supports skin health and appearance by reducing gut-related inflammation and strengthening the gut-skin axis.

Efficacy: Medium  |  Grade: B

Probiotics

Beneficial Bacteria, Live Cultures

Supports skin health by reducing inflammation via the gut-skin axis and promotes a healthy oral microbiome.

Efficacy: Medium  |  Grade: B

Protein Powder

Whey Protein, Casein Protein, Plant-Based Protein, Collagen Peptides

Supplies the essential building blocks for collagen and keratin, supporting skin elasticity and strong hair and nails.

Efficacy: Medium  |  Grade: B

Liposomal Resveratrol

Liposomal Trans-Resveratrol

Helps protect skin from oxidative stress, supporting collagen integrity and a more youthful appearance.

Efficacy: Medium  |  Grade: B

Resveratrol

trans-Resveratrol, 3,5,4'-trihydroxy-trans-stilbene

Acts as a potent antioxidant, helping to protect skin cells from environmental and oxidative stress.

Efficacy: Medium  |  Grade: B

Selenium

Selenomethionine, Selenocysteine, Sodium Selenite

Acts as an antioxidant to protect skin from environmental damage and supports healthy hair follicle function.

Efficacy: Medium  |  Grade: B

Sulforaphane

SFN, Glucoraphanin, Broccoli Sprout Extract

Helps protect skin cells from environmental stressors like UV radiation, supporting a youthful appearance.

Efficacy: Medium  |  Grade: B

Sustained Release DHEA

Time-Release DHEA, Extended-Release DHEA, Micronized Sustained Release DHEA

Improves skin hydration and thickness, contributing to a healthier and more youthful skin appearance.

Efficacy: Medium  |  Grade: B

Sustained Release Niacin

SR Niacin, Slow-Release Niacin

Supports skin health and barrier function by providing a key building block for cellular repair and energy.

Efficacy: Medium  |  Grade: B

TB-500

Thymosin Beta-4

Promotes skin repair and wound healing and may stimulate the activity of hair follicle stem cells.

Efficacy: Medium  |  Grade: B

Ubiquinol

Reduced Coenzyme Q10, Reduced CoQ10

Functions as an antioxidant in the skin, helping to protect against environmental stressors and maintain smoothness.

Efficacy: Medium  |  Grade: B

Vitamin B5

Pantothenic Acid

Promotes skin hydration and repair, supporting a healthy skin barrier and contributing to smoother-looking skin.

Efficacy: Medium  |  Grade: B

Vitamin B7

Biotin, Vitamin H

Supports the production of keratin, a key protein for maintaining the health and strength of hair and nails.

Efficacy: Medium  |  Grade: B

Vitamin E

Tocopherols, Tocotrienols, Alpha-tocopherol

Helps protect skin cells from UV radiation and environmental oxidative damage, supporting dermal health.

Efficacy: Medium  |  Grade: B

Zeaxanthin

Meso-zeaxanthin

Protects skin from light-induced damage, improving its hydration, elasticity, and overall tone.

Efficacy: Medium  |  Grade: B

Zinc

Zinc Picolinate, Zinc Gluconate, Zinc Citrate, Zinc Orotate

Supports skin health by aiding in collagen production, wound healing, and protecting against oxidative damage.

Efficacy: Medium  |  Grade: C

Astragalus

Huang Qi, Milk-vetch root

Supports cellular health by activating telomerase, an enzyme that helps maintain chromosome integrity during cell division.

Efficacy: Low  |  Grade: B

Bromelain

Pineapple Extract, Ananase

Helps reduce swelling and bruising from minor injuries or procedures, supporting faster tissue recovery.

Efficacy: Low  |  Grade: B

Cocoa Flavanols

Cacao Flavanols, Flavan-3-ols

Improves skin elasticity and hydration by boosting dermal blood flow and providing antioxidant protection.

Efficacy: Low  |  Grade: B

Curcumin

Turmeric, Diferuloylmethane, Meriva, Longvida, BCM-95, Theracurmin

Helps combat skin 'inflammaging' by reducing systemic oxidative stress, supporting a more even complexion.

Efficacy: Medium  |  Grade: C

Epitalon

Epithalon, Epithalamin, Ala-Glu-Asp-Gly

May support skin health and appearance by protecting cellular longevity through its proposed effects on telomeres.

Efficacy: Medium  |  Grade: C

Liposomal Fisetin

Liposomal 3,3',4',7-tetrahydroxyflavone

Protects skin from environmental stressors and helps clear aged cells, supporting skin health and appearance.

Efficacy: Low  |  Grade: B

Glucosamine

Glucosamine Sulfate, Glucosamine Hydrochloride, N-Acetyl Glucosamine

Promotes skin hydration and may reduce fine lines by providing building blocks for hyaluronic acid production.

Efficacy: Low  |  Grade: B

Inositol

Myo-inositol, D-chiro-inositol, Vitamin B8

May improve skin clarity and reduce unwanted hair growth by addressing underlying hormonal imbalances.

Efficacy: Medium  |  Grade: C

Ipamorelin

NNC 26-0161

Supports the body's production of collagen, which can help maintain skin firmness and elasticity.

Efficacy: Low  |  Grade: B

Lavender

Lavandula angustifolia, Silexan

Soothes skin irritation and supports wound healing due to its anti-inflammatory and antimicrobial properties.

Efficacy: Low  |  Grade: B

Lemon Balm

Melissa officinalis

Helps protect skin from environmental stressors and viral triggers due to its potent antioxidant compounds.

Efficacy: Low  |  Grade: B

Monolaurin

Glycerol Monolaurate, GML, Lauricidin

Promotes skin clarity and oral health by reducing the burden of problematic bacteria and fungi.

Efficacy: Low  |  Grade: B

Multivitamin (Men)

Men's Multi, MVM

Provides antioxidants and nutrients like Vitamin C and Zinc that support collagen production and overall skin health.

Efficacy: Medium  |  Grade: C

Quercetin

Quercetin Dihydrate, Sophoretin

May help protect skin from environmental stressors and assist in clearing aged cells, combating premature skin aging.

Efficacy: Medium  |  Grade: C

Sermorelin

Geref, GHRH (1-29)

Supports skin health by promoting collagen production, which may improve skin thickness and elasticity.

Efficacy: Low  |  Grade: B

Spermidine

N-(3-aminopropyl)butane-1,4-diamine

Encourages hair follicle growth and supports skin cell renewal for a more youthful appearance.

Efficacy: Low  |  Grade: B

Strontium

Strontium Citrate, Strontium Ranelate

Can improve oral health by reducing tooth sensitivity when used topically in specialized toothpastes.

Efficacy: Low  |  Grade: B

Teriparatide

Forteo

Supports oral health by promoting bone regeneration in the jaw, which can help secure dental implants.

Efficacy: Low  |  Grade: B

Vitamin B12

Cobalamin, Methylcobalamin, Cyanocobalamin, Adenosylcobalamin, Hydroxocobalamin

Contributes to healthy cell regeneration, which is important for maintaining vibrant skin, hair, and nails.

Efficacy: Medium  |  Grade: C

Vitamin K2

Menaquinone, MK-4, MK-7

Supports dental health by strengthening dentin and may help maintain skin elasticity by preventing tissue calcification.

Efficacy: Low  |  Grade: C

17-Alpha-Estradiol

17α-estradiol, alfatradiol

May protect skin cells from oxidative damage, potentially supporting dermal health without systemic hormonal effects.

Efficacy: Low  |  Grade: C

Akkermansia Muciniphila

A. muciniphila, Akkermansia

May promote skin health by reducing the systemic inflammation ('inflammaging') that contributes to premature aging.

Efficacy: Low  |  Grade: C

Alpha-Lipoic Acid

ALA, Thioctic acid

Acts as a potent antioxidant to help protect skin structures from environmental and oxidative damage.

Efficacy: Low  |  Grade: C

Liposomal Apigenin

Bioavailable Apigenin, Apigenin Phytosome

Helps protect skin cells from oxidative stress, a key factor in premature skin aging.

Efficacy: Low  |  Grade: C

Apigenin

May protect skin from environmental stressors and reduce inflammation associated with skin aging.

Efficacy: Low  |  Grade: C

Ashwagandha

Withania somnifera, Indian ginseng, Winter cherry

May protect skin from oxidative stress and reduce stress-related hair loss through its adaptogenic properties.

Efficacy: Low  |  Grade: C

Beta-Alanine

β-Alanine, 3-aminopropanoic acid

May help protect skin proteins from damage by reducing the formation of advanced glycation end-products (AGEs).

Efficacy: Low  |  Grade: C

Bitter Melon

Momordica charantia, Bitter Gourd, Karela

Provides antioxidants that help protect cells from oxidative stress, a contributing factor in skin aging.

Efficacy: Low  |  Grade: C

Boron

Boric Acid, Sodium Borate

Contributes to skin health and wound healing by supporting collagen production and antioxidant defenses.

Efficacy: Low  |  Grade: C

Boswellia

Indian Frankincense, Boswellia serrata

May help maintain skin elasticity and reduce signs of aging by combating chronic low-grade inflammation.

Efficacy: Low  |  Grade: C

BPC-157

Body Protection Compound 157, Bepecin

Aids in general wound healing processes, which may contribute to improved skin repair and recovery.

Efficacy: Low  |  Grade: C

Caffeine

1,3,7-trimethylxanthine, Methyltheobromine

Provides antioxidant compounds, particularly from coffee or tea, which may help protect skin from oxidative stress.

Efficacy: Low  |  Grade: C

Capsaicin

Chili Pepper Extract, 8-methyl-N-vanillyl-6-nonenamide

May promote hair growth and offer antioxidant benefits that help protect skin from cellular stress.

Efficacy: Low  |  Grade: C

CBD

Cannabidiol

Topical application may help calm skin inflammation and reduce redness, contributing to a healthier skin appearance.

Efficacy: Low  |  Grade: C

Chamomile Extract

Matricaria recutita, Chamaemelum nobile, Apigenin

Helps calm skin and combat 'inflammaging' through its systemic anti-inflammatory and antioxidant effects.

Efficacy: Low  |  Grade: C

Chondroitin Sulfate

Chondroitin

Contributes to skin hydration and structure as a key component of the dermal matrix.

Efficacy: Low  |  Grade: C

Chromium Picolinate

Chromium(III) picolinate

By helping manage blood sugar, it may reduce the formation of compounds that damage skin proteins like collagen.

Efficacy: Low  |  Grade: C

Chromium Polynicotinate

Chromium Niacinate, Chromium Nicotinate

Contributes to healthier skin aging by supporting stable blood sugar, which can help reduce glycation.

Efficacy: Low  |  Grade: C

Cinnamon Extract

Cinnamomum verum, Cinnamomum cassia, Ceylon Cinnamon, Cassia Cinnamon

May support skin health by promoting collagen synthesis and providing antioxidant protection against skin aging.

Efficacy: Low  |  Grade: C

Digestive Enzymes

Pancreatic Enzymes, Protease, Amylase, Lipase, Betaine HCl

Improves absorption of nutrients like amino acids and minerals needed for healthy skin, hair, and nails.

Efficacy: Low  |  Grade: C

Echinacea

Purple Coneflower

Contains anti-inflammatory compounds that may help soothe skin and support dermal health against irritants.

Efficacy: Low  |  Grade: C

Elderberry

Sambucus nigra, Elder

Provides antioxidants that help protect skin from environmental stressors which contribute to premature aging.

Efficacy: Low  |  Grade: C

Enclomiphene

Enclomiphene Citrate, Androxal

Supports a leaner body composition and may contribute to skin health through normalized hormone levels.

Efficacy: Low  |  Grade: C

Folate (Vitamin B9)

Folic Acid, L-Methylfolate, L-5-MTHF, Vitamin B9

Aids in DNA synthesis and repair, which is fundamental for the healthy turnover of skin and hair cells.

Efficacy: Low  |  Grade: C

Ginger

Zingiber officinale

Its antioxidant properties may help protect skin from cellular stress associated with aging.

Efficacy: Low  |  Grade: C

Green-Lipped Mussel Extract

GLM, Perna canaliculus extract, Lyprinol

May support skin health by providing anti-inflammatory compounds that help counter dermal 'inflammaging'.

Efficacy: Low  |  Grade: C

Gymnema Sylvestre

Gurmar, Meshashringi, Australian Cowplant, Periploca of the woods

By supporting healthy blood sugar, it may help reduce the formation of compounds that damage skin proteins.

Efficacy: Low  |  Grade: C

Hibiscus Extract

Roselle extract, Hibiscus sabdariffa extract

Offers antioxidants that help protect skin integrity from environmental stressors and oxidative damage.

Efficacy: Low  |  Grade: C

Holy Basil (Tulsi)

Tulsi, Ocimum tenuiflorum, Ocimum sanctum

Its antioxidant properties help protect cells from damage, potentially reducing inflammation associated with skin aging.

Efficacy: Low  |  Grade: C

IGF-1 LR3

Insulin-like Growth Factor 1 Long R3

May support skin cell regeneration and collagen synthesis, contributing to improved skin quality.

Efficacy: Low  |  Grade: C

Klotho

alpha-Klotho, α-Klotho

May help protect skin cells from oxidative stress, a primary driver of visible signs of aging.

Efficacy: Low  |  Grade: C

L-Ergothioneine

Ergothioneine, ET, EGT

Protects skin cells from environmental and oxidative stress, helping to preserve skin structure and appearance.

Efficacy: Low  |  Grade: C

L-Methylfolate

5-MTHF, Levomefolic acid, Metafolin, Deplin

Contributes to cellular repair and regeneration, which is essential for maintaining healthy skin and hair.

Efficacy: Low  |  Grade: C

Lion's Mane Mushroom

Hericium erinaceus, Yamabushitake, Monkey Head Mushroom

Provides antioxidant compounds that may help protect skin cells from oxidative stress and support wound healing.

Efficacy: Low  |  Grade: C

Low Dose Naltrexone (LDN)

LDN

May help manage certain inflammatory skin conditions by reducing systemic inflammation, contributing to healthier skin appearance.

Efficacy: Low  |  Grade: C

Maca Root

Lepidium meyenii, Peruvian Ginseng

May offer antioxidant protection to skin cells, potentially helping to mitigate environmental stressors like UV exposure.

Efficacy: Low  |  Grade: C

Magnesium

Magnesium Citrate, Magnesium Glycinate, Magnesium L-Threonate, Magnesium Oxide

Supports fundamental cellular processes like DNA repair, which helps protect against premature cellular aging.

Efficacy: Low  |  Grade: C

Medicinal Mushrooms (Beta-Glucans)

Beta-Glucans, Mushroom Polysaccharides

Provides antioxidants that may help protect skin integrity from environmental stressors and oxidative damage.

Efficacy: Low  |  Grade: C

Liposomal Melatonin

Encapsulated Melatonin, Liposome-Entrapped Melatonin

Provides systemic antioxidant protection that may help reduce cellular damage contributing to skin aging.

Efficacy: Low  |  Grade: C

Methylene Blue

MB, Methylthioninium chloride

Functions as an antioxidant in skin cells, potentially supporting collagen and elastin for skin firmness.

Efficacy: Low  |  Grade: C

Melatonin

SR Melatonin, Low-Dose Melatonin, Physiological-Dose Melatonin

Acts as a powerful antioxidant, helping protect skin cells from oxidative stress and supporting overnight repair processes.

Efficacy: Low  |  Grade: C

Multivitamin (Women)

Women's Multi, MVM for Women

Provides key nutrients like Vitamin C and Biotin that support collagen production for skin and hair health.

Efficacy: Low  |  Grade: C

Liposomal NAD+

Liposomal Nicotinamide Adenine Dinucleotide

Provides cellular energy and supports DNA repair, which may help skin cells combat age-related stressors.

Efficacy: Low  |  Grade: C

NAD+ (IV Therapy)

Nicotinamide Adenine Dinucleotide IV, IV NAD+ Therapy

Supports cellular energy and repair processes in skin cells, which may help counter age-related changes.

Efficacy: Low  |  Grade: C

Liposomal NMN

Liposomal Nicotinamide Mononucleotide

Supports cellular DNA repair, which may help maintain skin health and resilience against environmental stressors.

Efficacy: Low  |  Grade: C

NMN

Nicotinamide Mononucleotide

Supports cellular repair mechanisms that may help maintain skin health and combat age-related dermal changes.

Efficacy: Low  |  Grade: C

Panax Ginseng

Asian Ginseng, Korean Ginseng, Ren Shen

Provides antioxidant compounds that may help protect skin cells from environmental stressors and oxidative damage.

Efficacy: Low  |  Grade: C

Peppermint Oil

Mentha piperita oil

May support scalp health and hair growth, and its antimicrobial properties contribute to oral hygiene.

Efficacy: Low  |  Grade: C

Piperine

Black Pepper Extract, Bioperine

Offers antioxidant properties that help protect skin cells from the oxidative stress that contributes to aging.

Efficacy: Low  |  Grade: C

Prebiotic Supplements

Prebiotics, Fermentable Fiber, Inulin, FOS, GOS

Supports skin health by helping to reduce systemic inflammation that originates from an imbalanced gut.

Efficacy: Low  |  Grade: C

Pterostilbene

Dimethylresveratrol, 3,5-dimethoxy-4'-hydroxystilbene

Acts as a potent antioxidant, helping to protect skin cells from environmental stressors.

Efficacy: Low  |  Grade: C

Liposomal Quercetin

Liposome-encapsulated quercetin

Its antioxidant properties may help protect skin from environmental stressors that contribute to premature aging.

Efficacy: Low  |  Grade: C

Saffron Extract

Crocus sativus, Safranal, Crocin

Helps protect skin from oxidative stress with its antioxidant properties, supporting a youthful appearance.

Efficacy: Low  |  Grade: C

Saffron

Crocus sativus

Helps protect skin from oxidative stress, a key factor in premature dermal aging.

Efficacy: Low  |  Grade: C

Schisandra

Schisandra chinensis, Five-Flavor Berry, Wu Wei Zi

Provides antioxidant protection that may help shield skin from environmental stressors and aging.

Efficacy: Low  |  Grade: C

SGLT2 Inhibitors

Gliflozins

Promotes modest weight loss and may help protect skin collagen by reducing excess blood sugar.

Efficacy: Low  |  Grade: C

SS-31

Elamipretide, Bendavia, MTP-131

Theoretically protects skin cells from oxidative damage by improving mitochondrial health, potentially mitigating visible signs of aging.

Efficacy: Low  |  Grade: C

Sustained Release Melatonin

Time-Release Melatonin, Extended-Release Melatonin, Prolonged-Release Melatonin

Contributes to skin health by providing systemic antioxidant protection and supporting the skin's overnight repair processes.

Efficacy: Low  |  Grade: C

Trehalose

Mycose, Tremalose

Helps protect skin cells from dehydration and other environmental stressors, supporting cellular health and resilience.

Efficacy: Low  |  Grade: C

Urolithin A

UA

Theoretically supports skin cell health by improving mitochondrial function and reducing inflammation linked to skin aging.

Efficacy: Low  |  Grade: C

Vitamin B6

Pyridoxine, Pyridoxal 5'-Phosphate, P-5-P

Contributes to skin health by supporting the metabolism of proteins necessary for tissue repair.

Medications

Efficacy: High  |  Grade: A

Vitamin C

Ascorbic Acid, L-Ascorbic Acid

Promotes collagen production for skin elasticity and firmness, while also supporting healthy gums and oral tissues.

Efficacy: Medium  |  Grade: A

Estradiol

E2, 17β-estradiol, Oestradiol

Helps maintain skin elasticity and hydration by supporting collagen production for a smoother appearance.

Efficacy: Medium  |  Grade: A

Fibrates

Fenofibrate, Gemfibrozil, Bezafibrate, Ciprofibrate

Slows the progression of diabetic retinopathy, a leading cause of vision loss, thereby helping preserve eyesight.

Efficacy: Medium  |  Grade: A

Tesamorelin

Egrifta

Effectively reduces excess abdominal fat, leading to a leaner midsection and improved body composition.

Efficacy: Medium  |  Grade: A

Testosterone Replacement Therapy

TRT, Testosterone Therapy

Improves body composition by increasing muscle and reducing fat, contributing to a more youthful physique.

Efficacy: Medium  |  Grade: A

Testosterone

TRT, Testosterone Replacement Therapy

Promotes a leaner body composition by increasing muscle and reducing fat, and supports male hair patterns.

Efficacy: Medium  |  Grade: A

Tranexamic Acid

TXA, Lysteda, Cyklokapron

Helps reduce skin hyperpigmentation, such as melasma, by inhibiting pathways that stimulate excess melanin production.

Efficacy: Medium  |  Grade: B

Dasatinib

Sprycel

Promotes skin health and may combat age-related hair loss by clearing senescent cells from the dermis.

Efficacy: Low  |  Grade: A

Ertugliflozin

Steglatro

Promotes modest weight loss by helping the body excrete excess sugar, contributing to a healthier body composition.

Efficacy: Medium  |  Grade: B

Estradiol Cypionate

Depo-Estradiol

Helps maintain skin elasticity and hydration by supporting collagen production, reducing fine lines and dryness.

Efficacy: Medium  |  Grade: B

Estradiol Valerate

EV, Delestrogen

Promotes skin elasticity and hydration by supporting the production of collagen and other structural proteins.

Efficacy: Medium  |  Grade: B

Menopausal HRT

Hormone Replacement Therapy, MHT, Menopausal Hormone Therapy

Helps maintain skin collagen, thickness, and hydration, reducing the acceleration of skin aging after menopause.

Efficacy: Medium  |  Grade: B

mTOR Inhibitors

Rapalogs, Mechanistic Target of Rapamycin Inhibitors

Promotes cellular cleanup and renewal in the skin, helping to maintain its structure and youthful appearance.

Efficacy: Medium  |  Grade: B

Omega-3 Fatty Acids

Fish Oil, EPA, DHA, Marine Oils, Omega-3 Softgel, Omega-3 Supplement

Supports skin hydration and elasticity by strengthening the skin barrier and reducing underlying 'inflammaging'.

Efficacy: Medium  |  Grade: B

Rapamycin

Sirolimus

Supports skin health and appearance by reducing inflammation and promoting cellular repair and collagen production.

Efficacy: Medium  |  Grade: C

Acarbose

Precose, Glucobay

Lowers blood sugar spikes, which helps reduce the formation of compounds that damage skin collagen and elastin.

Efficacy: Medium  |  Grade: C

Bexagliflozin

Brenzavvy

Helps protect skin's structural proteins by lowering blood sugar and reducing the formation of aging compounds.

Efficacy: Low  |  Grade: B

Denosumab

Prolia, Xgeva

May help preserve jawbone density, providing a stronger foundation for long-term oral health and tooth stability.

Efficacy: Medium  |  Grade: C

NAC

N-Acetylcysteine, N-acetyl-L-cysteine

Helps protect skin cells from oxidative stress, a key factor in premature skin aging.

Efficacy: Low  |  Grade: B

Proton Pump Inhibitors

PPIs

Helps protect tooth enamel from the erosive effects of chronic stomach acid reflux.

Efficacy: Low  |  Grade: B

Vitamin D3

Cholecalciferol (D3), Ergocalciferol (D2), Calcifediol, Calcitriol

Supports jaw bone density for better oral health and contributes to skin cell repair processes.

Efficacy: Low  |  Grade: C

Angiotensin Receptor Blockers

ARBs

May help protect skin's structural proteins by blocking pathways that contribute to inflammation and collagen breakdown.

Efficacy: Low  |  Grade: C

Canagliflozin

Invokana

Contributes to modest weight loss and may reduce skin aging by lowering advanced glycation end-products.

Efficacy: Low  |  Grade: C

Dapagliflozin

Farxiga

May support skin health by reducing the formation of advanced glycation end-products (AGEs) linked to aging.

Efficacy: Low  |  Grade: C

Everolimus

Afinitor, Zortress, RAD001

May support skin cell health by promoting cellular renewal and cleanup processes, reducing signs of aging.

Efficacy: Low  |  Grade: C

Icosapent Ethyl

Vascepa, purified EPA

Supports skin health by helping to manage inflammation and maintain cellular membrane integrity.

Efficacy: Low  |  Grade: C

Low-Dose Colchicine

Colcrys, Mitigare, Gloperba

May help counter 'inflammaging' in the skin by reducing systemic inflammation, a key driver of aging.

Efficacy: Low  |  Grade: C

Metformin

Glucophage, Fortamet, Glumetza

May help combat skin 'inflammaging' by improving systemic metabolic health and reducing cellular stress.

Efficacy: Low  |  Grade: C

Niacin (Vitamin B3)

Nicotinic Acid, Vitamin B3

Contributes to skin cell health and energy metabolism, supporting the maintenance of a healthy skin barrier.

Efficacy: Low  |  Grade: C

Oxytocin

OT, Love Hormone

May support skin repair and wound healing through its anti-inflammatory and cell-regenerating properties.

Efficacy: Low  |  Grade: C

Progesterone

P4, Bioidentical Progesterone, Prometrium

May contribute to skin hydration and elasticity, potentially reducing the appearance of wrinkles.

Efficacy: Low  |  Grade: C

Telmisartan

Micardis

May help counter skin 'inflammaging' by reducing systemic inflammation, potentially supporting dermal health.

Efficacy: Low  |  Grade: C

Testosterone Therapy (Women) (Topical)

Low-dose Testosterone for Women, Female Androgen Therapy

May support skin health and contributes to a leaner physique by improving body composition.

Topical Agents

Efficacy: High  |  Grade: A

Azelaic Acid (Topical)

Azelex, Finacea, Skinoren

Reduces skin inflammation and hyperpigmentation, promoting a clearer and more even-toned complexion.

Efficacy: High  |  Grade: A

Bakuchiol Serum

Bakuchiol

Stimulates collagen production to reduce fine lines and improve skin firmness, similar to retinol but gentler.

Efficacy: High  |  Grade: A

Copper Peptides (Topical)

GHK-Cu, Glycyl-L-Histidyl-L-Lysine

Stimulates collagen and elastin production, improving skin firmness, reducing fine lines, and supporting hair growth.

Efficacy: High  |  Grade: A

Ferulic Acid (Topical)

4-hydroxy-3-methoxycinnamic acid

Protects skin from UV damage and oxidative stress, helping to maintain skin structure and tone.

Efficacy: High  |  Grade: A

Glycolic Acid (Topical)

Alpha Hydroxy Acid, AHA

Promotes skin cell turnover and stimulates collagen production, leading to smoother texture and reduced fine lines.

Efficacy: High  |  Grade: A

Hyaluronic Acid (Topical)

HA, Hyaluronan

Deeply hydrates the skin to reduce the appearance of fine lines and support a firm, plump texture.

Efficacy: High  |  Grade: A

Vitamin C Serum

L-Ascorbic Acid Serum, Ascorbic Acid Topical

Promotes collagen production for firmer skin and provides antioxidant protection against environmental damage and photoaging.

Efficacy: High  |  Grade: A

Natural Moisturizing Factors (Topical)

NMFs

Maintains skin hydration and elasticity, reducing fine lines and supporting a healthy, resilient skin barrier.

Efficacy: High  |  Grade: A

Niacinamide Serum

Vitamin B3 topical, Nicotinamide topical

Strengthens the skin's barrier, reduces inflammation, and improves skin tone for a more youthful appearance.

Efficacy: High  |  Grade: A

Retinol (OTC) (Topical)

Vitamin A (topical), Retinyl palmitate (topical), Retinaldehyde (topical)

Promotes skin cell turnover and boosts collagen production, which helps to reduce fine lines and wrinkles.

Efficacy: High  |  Grade: A

Tazarotene (Topical)

Tazorac, Arazlo, Fabior, Avage

Stimulates collagen production and normalizes skin cell turnover, effectively reducing fine lines and sun damage.

Efficacy: High  |  Grade: A

Niacinamide (Topical)

Nicotinamide, Vitamin B3 (Topical)

Improves skin elasticity and barrier function while reducing redness and evening out skin tone.

Efficacy: High  |  Grade: A

Zinc (Topical)

Zinc Oxide, Zinc Pyrithione, Zinc Sulfate

Protects skin from UV-induced aging, supports collagen repair, and helps manage inflammatory skin conditions like acne.

Efficacy: High  |  Grade: A

Tretinoin (Topical)

Retin-A, All-trans retinoic acid

Promotes skin renewal by stimulating collagen production, reducing fine lines, and improving overall skin texture.

Efficacy: High  |  Grade: A

Vitamin C (Topical)

Vitamin C Serum, L-Ascorbic Acid Serum, Ascorbic Acid Serum, L-Ascorbic Acid, Topical Ascorbate, Ascorbic Acid Topical

Protects skin from sun damage and pollution while promoting collagen to improve firmness and reduce wrinkles.

Efficacy: Medium  |  Grade: A

Estradiol (Topical)

Topical Estrogen, E2 Cream

Helps maintain skin elasticity and hydration by supporting collagen production, reducing skin aging after menopause.

Efficacy: High  |  Grade: B

Ghk-Cu (Topical)

Copper Peptide, GHK-Copper

Stimulates collagen and elastin, improving skin firmness and supporting hair follicle health.

Efficacy: High  |  Grade: B

Glucoside Cleanser

Decyl Glucoside, Coco-Glucoside, Lauryl Glucoside, Alkyl Polyglucoside Cleanser, Gentle Surfactant Cleanser

Promotes skin elasticity and reduces the appearance of wrinkles by breaking down sugar-damaged collagen.

Efficacy: Medium  |  Grade: A

Salicylic Acid (Topical)

Beta Hydroxy Acid, BHA

Promotes clear skin by exfoliating within pores and reducing inflammation, leading to a smoother, more even complexion.

Efficacy: Medium  |  Grade: A

Ceramides (Topical)

Ceramide creams, Dermal ceramides

Strengthens the skin's natural barrier, locking in moisture to improve hydration and reduce visible signs of aging.

Efficacy: Medium  |  Grade: A

Argireline / Matrixyl (Topical)

Acetyl Hexapeptide-3, Acetyl Hexapeptide-8, Palmitoyl Pentapeptide-4, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7

Supports the skin's structural proteins like collagen, helping to improve firmness and reduce the appearance of wrinkles.

Efficacy: Medium  |  Grade: A

Tranexamic Acid (Topical)

TXA Topical

Effectively reduces skin hyperpigmentation and redness, promoting a more even and clear complexion.

Efficacy: Medium  |  Grade: B

KPV (Topical)

Lys-Pro-Val, Alpha-Melanocyte Stimulating Hormone Fragment

Reduces skin inflammation and supports wound healing, promoting a clearer and more even complexion.

Efficacy: Medium  |  Grade: B

PhytoCeramides (Topical)

Plant-derived Ceramides, Glycosphingolipids

Replenishes essential skin lipids to improve hydration, smoothness, and the skin's natural protective barrier.

Efficacy: Medium  |  Grade: B

Rapamycin (Topical)

Sirolimus (Topical)

Reduces signs of skin aging by inhibiting cellular senescence and promoting collagen production in the skin.

Efficacy: Medium  |  Grade: B

Squalene Cleanser

Squalane Cleanser

Helps maintain the skin's natural moisture barrier and provides antioxidant support, promoting hydrated and resilient skin.

Efficacy: Medium  |  Grade: B

CoQ10 (Topical)

Ubiquinone (Topical), Ubidecarenone (Topical)

Acts as a powerful antioxidant in the skin, helping to reduce fine lines and protect against environmental stressors.

Dietary Practices

Efficacy: High  |  Grade: A

Protein

Amino Acids, Dietary Protein

Serves as the raw material for collagen and keratin, supporting skin elasticity and hair strength.

Efficacy: High  |  Grade: B

Blueprint Protocol

Bryan Johnson's Blueprint

Aims to improve skin elasticity, reduce wrinkles, and preserve hair through targeted therapies and nutrition.

Efficacy: Medium  |  Grade: A

Gluten-Free Diet

GF Diet

Resolves specific inflammatory skin conditions, like dermatitis herpetiformis, directly linked to gluten intolerance.

Efficacy: Medium  |  Grade: B

Anti-Inflammatory Diet

Mediterranean Diet, DASH Diet, MIND Diet

Reduces systemic 'inflammaging,' helping to protect skin proteins like collagen for a more youthful appearance.

Efficacy: Medium  |  Grade: B

Avoiding Processed Foods

Minimally Processed Diet, Whole Foods Diet

Reduces skin aging by limiting sugar that damages collagen and supports better oral health.

Efficacy: Medium  |  Grade: B

The Blue Zones Diet

Longevity Diet, Blue Zone Eating Pattern

Combats skin 'inflammaging' and supports structural proteins with a high intake of dietary antioxidants.

Efficacy: Medium  |  Grade: B

Cruciferous Vegetables

Brassicas, Cole crops

Helps protect skin from environmental stressors and provides Vitamin C for healthy collagen production.

Efficacy: Medium  |  Grade: B

Fermented Foods

Probiotic Foods, Live Culture Foods, Gut-Healthy Foods

Helps reduce systemic inflammation, a key driver of skin aging, and supports overall skin health.

Efficacy: Medium  |  Grade: B

Flaxseed

Linseed, Ground Flaxseed

Supports skin hydration and smoothness by providing essential fatty acids and reducing inflammation.

Efficacy: Medium  |  Grade: B

Flexitarian Diet

Semi-vegetarianism, Flexible vegetarianism

Provides antioxidants and vitamins that protect skin from damage and support collagen for a healthier appearance.

Efficacy: Medium  |  Grade: B

Hibiscus Tea

Roselle Tea, Sour Tea, Karkadeh

Rich in antioxidants and Vitamin C, which help protect skin from oxidative damage and support collagen.

Efficacy: Medium  |  Grade: B

Mediterranean Diet

MedDiet

Protects skin from oxidative stress with antioxidants and healthy fats, promoting a more youthful appearance.

Efficacy: Medium  |  Grade: B

Nordic Diet

New Nordic Diet, NND

Provides antioxidants and healthy fats that help protect skin from oxidative stress and support its structure.

Efficacy: Medium  |  Grade: B

The Okinawa Diet

Okinawan Longevity Diet, Traditional Okinawan Diet

Rich in antioxidants that protect skin from oxidative stress, helping to reduce signs of premature aging.

Efficacy: Medium  |  Grade: B

One Meal A Day

OMAD, 23:1 Intermittent Fasting

Stimulates autophagy, a cellular recycling process that helps clear out damaged components and supports cellular rejuvenation.

Efficacy: Medium  |  Grade: B

Ovo-Lacto Vegetarian Diet

Vegetarian Diet

Helps protect skin from oxidative stress with a high intake of vitamins and antioxidants from plants.

Efficacy: Medium  |  Grade: B

Pescatarian Diet

Pescatarianism, Fish-based diet

Supports skin hydration with omega-3s and protects against cellular damage with abundant plant-based antioxidants.

Efficacy: Medium  |  Grade: B

Plant-Forward Diet

Plant-Based Diet, Flexitarian Diet, Vegetarian Diet, Vegan Diet

Delivers antioxidants that protect skin from damage and support collagen health for a youthful appearance.

Efficacy: Medium  |  Grade: B

Polyphenol-Rich Diet

High-Polyphenol Diet, Colorful Diet, Polyphenol-rich Foods, Phytonutrient-dense foods, Flavonoid-rich foods

Helps protect skin from environmental stressors like UV damage, thereby preserving collagen and reducing 'inflammaging'.

Efficacy: Medium  |  Grade: B

Vegan Diet

Plant-Based Diet, Strict Vegetarianism

Provides abundant antioxidants that protect skin from oxidative stress, helping to maintain a youthful appearance.

Efficacy: Medium  |  Grade: B

Vegetarian Diet

Plant-based diet, Lacto-ovo vegetarianism

Provides abundant antioxidants and vitamins that help protect skin from oxidative damage and support collagen production.

Efficacy: Medium  |  Grade: B

Whole Food Plant Based

WFPB, Plant-Based Diet

Protects skin from aging by providing antioxidants that combat oxidative stress and nutrients for collagen production.

Efficacy: Medium  |  Grade: C

Autoimmune Protocol Diet

AIP, AIP Diet

Reduces skin inflammation and provides key nutrients, potentially improving inflammatory skin conditions and overall skin health.

Efficacy: Medium  |  Grade: C

Calorie Restriction Diet

CR, Caloric Restriction

Helps reduce cellular stress and inflammation, which are key drivers of skin aging.

Efficacy: Medium  |  Grade: C

Carnivore Diet

All-Meat Diet, Zero-Carb Diet

Supports skin health by providing ample protein and reducing advanced glycation end-products (AGEs) from sugar.

Efficacy: Medium  |  Grade: C

5:2 Intermittent Fasting

5-2 method, The Fast Diet

Promotes cellular cleanup (autophagy), which helps reduce inflammation and maintain healthier skin function.

Efficacy: Medium  |  Grade: C

Intermittent Fasting

IF, Periodic Fasting

Promotes cellular repair and cleanup (autophagy), which may help maintain skin integrity and slow aging.

Efficacy: Medium  |  Grade: C

Low-Carb Diet

Very Low-Carbohydrate Ketogenic Diet (VLCKD), Keto Diet

Reduces sugar intake, which helps limit the formation of compounds that can damage skin collagen and elastin.

Efficacy: Low  |  Grade: B

MIND Diet

Mediterranean-DASH Intervention for Neurodegenerative Delay

Provides antioxidants and healthy fats that help protect skin from oxidative stress and inflammation.

Efficacy: Medium  |  Grade: C

Paleo Diet

Paleolithic Diet, Caveman Diet

Reduces intake of processed sugars that can damage skin collagen, promoting a more youthful appearance.

Efficacy: Medium  |  Grade: C

Prolonged Fasting (Supervised)

Therapeutic Fasting, Extended Fasting, Water Fasting (Supervised)

Stimulates cellular cleanup processes that can help clear damaged components and reduce low-grade skin inflammation.

Efficacy: Medium  |  Grade: C

Time-Restricted Eating (16:8)

TRE, 16:8 Intermittent Fasting, Leangains Protocol

Promotes cellular renewal and may reduce systemic inflammation, supporting healthier skin aging from within.

Efficacy: Medium  |  Grade: C

Whole30

Whole 30 Diet, 30-Day Elimination Diet

May improve skin clarity by removing common dietary triggers for inflammation like sugar and dairy.

Efficacy: Low  |  Grade: C

Alternate-Day Fasting (ADF)

ADF, Every-Other-Day Fasting

Promotes cellular renewal processes, which may help clear out damaged components and support tissue maintenance.

Efficacy: Low  |  Grade: C

Apple Cider Vinegar

ACV

May support weight management efforts by promoting feelings of fullness, contributing to a healthy body composition.

Efficacy: Low  |  Grade: C

Branched-Chain Amino AcidRestriction

Low BCAA Diet

May help reduce cellular 'inflammaging' by modulating the mTOR nutrient-sensing pathway, a key regulator of aging.

Efficacy: Low  |  Grade: C

Calorie Restriction Without Malnutrition

CR, Dietary Restriction, Nutritional Restriction

May slow aspects of skin aging by reducing systemic inflammation, a key driver of dermal decline.

Efficacy: Low  |  Grade: C

Colostrum

Bovine Colostrum

Provides growth factors that may support skin cell regeneration and promote tissue repair.

Efficacy: Low  |  Grade: C

DASH Diet

Dietary Approaches to Stop Hypertension

Rich in antioxidants from fruits and vegetables that help protect skin from oxidative stress.

Efficacy: Low  |  Grade: C

Fasting-Mimicking Diet (FMD)

FMD, Prolon Diet

Supports cellular cleanup processes that may help reduce systemic inflammation linked to skin aging.

Efficacy: Low  |  Grade: C

5:2 Diet

The Fast Diet, Intermittent Fasting (5:2)

Encourages cellular repair and cleanup processes, which may help combat aspects of age-related cellular damage.

Efficacy: Low  |  Grade: C

High-Fiber Diet

Fiber-rich eating, Plant-forward diet

Supports skin health by reducing systemic inflammation and promoting a healthy gut-skin axis.

Efficacy: Low  |  Grade: C

Inulin (Prebiotic Fiber)

Prebiotic Fiber, Chicory Root Fiber, Fructan

Supports skin health indirectly by promoting a healthy gut microbiome and reducing systemic inflammation.

Efficacy: Low  |  Grade: C

Kefir / Fermented Foods

Probiotic Foods, Cultured Foods

Supports skin health by reducing systemic inflammation through its positive effects on the gut microbiome.

Efficacy: Low  |  Grade: C

Ketogenic Diet

Keto, Keto Diet

May support skin health by reducing sugar-driven inflammation and the formation of advanced glycation end-products (AGEs).

Efficacy: Low  |  Grade: C

Kombucha

Fermented Tea, Tea Fungus

Offers antioxidants from its tea base which can help protect skin cells from oxidative stress.

Efficacy: Low  |  Grade: C

Methionine Restriction

MR, Low-Methionine Diet

May help combat skin 'inflammaging' by reducing systemic oxidative stress and promoting antioxidant pathways.

Efficacy: Low  |  Grade: C

Soluble Fiber

Dietary fiber (soluble), Beta-glucans, Psyllium, Inulin, Pectins

Supports the gut-skin axis, which may help reduce systemic inflammation linked to skin health.

Efficacy: Low  |  Grade: C

Tart Cherry Juice

Montmorency Cherry, Prunus cerasus, Sour Cherry

Provides potent antioxidants that may help protect skin from cellular stress and inflammation.

Efficacy: Low  |  Grade: C

Water Fasting

Prolonged Fasting, Extended Fasting

Stimulates cellular recycling processes that may help clear damaged components and support skin cell health.

Lifestyle Practices

Efficacy: High  |  Grade: A

Daily Flossing

Dental Flossing

Directly maintains gum health and prevents tooth loss, preserving a healthy smile and oral hygiene.

Efficacy: High  |  Grade: A

Electric Toothbrushing

Powered Toothbrushing

Effectively removes stains and plaque, leading to whiter teeth and healthier gums for a youthful smile.

Efficacy: High  |  Grade: A

Regular Dental Cleanings

Prophylaxis, Oral Hygiene Visits, Professional Teeth Cleaning

Directly maintains tooth brightness and gum health, preserving a youthful smile and preventing tooth loss.

Efficacy: High  |  Grade: A

Smoking Cessation

Quitting Smoking, Tobacco Cessation

Improves skin circulation and collagen production, reducing premature wrinkles and improving oral health.

Efficacy: High  |  Grade: A

Sunglasses

UV-blocking eyewear, Shades

Protects the delicate skin around the eyes from UV damage, reducing the formation of wrinkles and crow's feet.

Efficacy: High  |  Grade: A

Broad-Spectrum Sunscreen (Topical)

Sunblock, Sunscreen

Protects skin collagen from UV degradation, significantly reducing the formation of wrinkles and sun spots.

Efficacy: High  |  Grade: A

Water Flossing

Oral Irrigator, Water Pik

Effectively removes plaque and reduces gingivitis, leading to healthier gums and a brighter, more youthful smile.

Efficacy: Medium  |  Grade: B

Oil Pulling

Gandusha, Kavala Graha

Reduces plaque, gingivitis, and odor-causing bacteria, supporting overall oral hygiene and health.

Efficacy: Medium  |  Grade: B

Relaxation

Meditation, Mindfulness, Yoga, Tai Chi, Deep Breathing, Progressive Muscle Relaxation

Lowers cortisol, a stress hormone known to break down skin collagen and accelerate dermal aging.

Efficacy: Medium  |  Grade: B

Strength Training

Resistance Training, Weightlifting, Resistance Exercise

Improves body composition and posture for a more youthful physique and enhances circulation for healthier skin.

Efficacy: Medium  |  Grade: B

Stress Management

Mindfulness, Relaxation Techniques, Cognitive Behavioral Therapy (CBT), Meditation

Reduces stress-induced collagen breakdown and inflammation, helping to preserve skin elasticity and hair health.

Efficacy: Medium  |  Grade: B

Tongue Scraping

Jihwa Prakshalana

Directly improves oral hygiene by removing bacteria and debris, leading to fresher breath and a healthier mouth.

Efficacy: Low  |  Grade: B

Meditation

Mindfulness, Vipassanā, Zazen, Transcendental Meditation

Helps mitigate the effects of chronic stress on cellular aging and skin inflammation.

Efficacy: Medium  |  Grade: C

Mouth Taping

Oral Taping, Sleep Taping

Reduces dry mouth during sleep, which helps maintain a healthy oral microbiome and prevent dental issues.

Efficacy: Low  |  Grade: C

Blue Light Blocking Glasses

Blue Blockers, Amber Glasses, Sleep Glasses

May offer minor protection against skin photoaging from screen exposure and supports overnight skin repair.

Efficacy: Low  |  Grade: C

Breathwork

Pranayama, Conscious Connected Breathing, Holotropic Breathwork, Wim Hof Method

May help mitigate the aging effects of chronic stress on the skin by lowering cortisol levels.

Efficacy: Low  |  Grade: C

Mindfulness Meditation

Mindfulness-Based Stress Reduction (MBSR), Vipassana, Concentrative Meditation

Helps counter the effects of chronic stress on the skin by reducing systemic inflammation and cortisol.

Efficacy: Low  |  Grade: C

Running

Jogging, Aerobic Exercise, Cardio

Improves circulation to the skin, which helps deliver vital oxygen and nutrients for cellular health.

Efficacy: Low  |  Grade: C

Sauna

Sauna Bathing, Hyperthermic Conditioning, Heat Therapy

Improves skin health and hydration by increasing blood flow and promoting cellular repair mechanisms.

Efficacy: Low  |  Grade: C

Sexual Activity

Sex, Intercourse, Orgasm

Supports healthy hormone balance and circulation, which contributes to skin health and vitality.

Exercise & Sports

Efficacy: Medium  |  Grade: B

Calisthenics

Bodyweight Training, Bodyweight Exercise

Improves body composition and posture, contributing to a more toned and vital physical appearance.

Efficacy: Medium  |  Grade: B

Kettlebell Training

KB Training, Girevoy Sport

Improves body composition by building lean muscle and reducing fat, contributing to a vital appearance.

Efficacy: Medium  |  Grade: B

Resistance Training

Strength Training, Weightlifting

Improves body composition by increasing lean muscle mass, which contributes to a more youthful physique.

Efficacy: Medium  |  Grade: B

Squash

Racquetball, Racket Sports

Provides vitamin C for collagen production and antioxidants like beta-carotene to help protect skin from damage.

Efficacy: Low  |  Grade: B

Endurance Training

Aerobic Exercise, Cardio

Improves skin circulation and reduces systemic inflammation, which helps preserve a youthful dermal appearance.

Efficacy: Low  |  Grade: B

Regular Aerobic Exercise

Cardio, Endurance Training, Aerobics

Improves skin circulation and nutrient delivery, which can help counter age-related dermal inflammation.

Efficacy: Low  |  Grade: B

Rock Climbing

Bouldering, Sport Climbing, Trad Climbing

Promotes a lean, toned physique by building functional muscle and reducing overall body fat percentage.

Efficacy: Low  |  Grade: B

Weight-Bearing Exercise

Resistance Training, Strength Training, Impact Exercise

Improves skin circulation and may reduce inflammation, contributing to a healthier and more youthful skin appearance.

Efficacy: Low  |  Grade: C

Badminton

Enhances circulation, delivering more oxygen and nutrients to the skin for improved cellular health and vitality.

Efficacy: Low  |  Grade: C

Basketball

Hoops

Improves skin health through enhanced circulation and helps maintain a lean, toned physique.

Efficacy: Low  |  Grade: C

Bicycling

Cycling

Improves blood flow to the skin and helps manage body composition, contributing to a healthier appearance.

Efficacy: Low  |  Grade: C

Blood Flow Restriction Training

Kaatsu Training, Occlusion Training

Stimulates a systemic release of growth hormone, which can support the integrity of structural proteins like collagen.

Efficacy: Low  |  Grade: C

Daily Brisk Walking

Brisk Walking, Regular Walking, Moderate-intensity Walking

Improves skin circulation for a healthier complexion and helps reduce systemic inflammation linked to aging.

Efficacy: Low  |  Grade: C

Flexibility Training / Stretching

Stretching, Mobility Work, Range of Motion Training

Promotes better posture and circulation, contributing to a more vital and aligned physical appearance.

Efficacy: Low  |  Grade: C

High-Intensity Interval Training

HIIT, Sprint Interval Training

Enhances circulation for healthier skin and stimulates cellular processes that help combat age-related inflammation.

Efficacy: Low  |  Grade: C

High-Intensity Resistance Training (HIRT)

HIRT, Heavy Duty Training, HDT

Improves body composition and hormonal balance, which contributes to a more youthful physical appearance.

Efficacy: Low  |  Grade: C

Indoor Cycling

Stationary Biking, Spinning

Improves circulation to the skin, which delivers vital nutrients and may help reduce systemic inflammation.

Efficacy: Low  |  Grade: C

Jogging

Running, Aerobic Exercise

Improves skin circulation for a healthier appearance by delivering more oxygen and vital nutrients to cells.

Efficacy: Low  |  Grade: C

Jump Rope

Skipping Rope, Rope Jumping

Improves skin health and vitality by boosting circulation and delivering more nutrients to dermal layers.

Efficacy: Low  |  Grade: C

Nordic Walking

Pole Walking, Exerstriding

Contributes to a more youthful appearance by improving posture, promoting healthy circulation, and aiding weight management.

Efficacy: Low  |  Grade: C

Pilates

Contrology

Improves posture and muscle tone, contributing to a more aligned and graceful physical appearance.

Efficacy: Low  |  Grade: C

Qigong

Chi Kung, Chi Gung

By reducing systemic inflammation and stress, qigong may help preserve skin health and slow premature aging.

Efficacy: Low  |  Grade: C

Race Walking

Power Walking

Improves skin circulation and reduces systemic inflammation, which can contribute to healthier-looking skin over time.

Efficacy: Low  |  Grade: C

Road Cycling

Cycling, Bicycling

Enhances blood flow to the skin, delivering nutrients and helping to combat systemic 'inflammaging'.

Efficacy: Low  |  Grade: C

Rowing

Ergometer, Crew, Sculling

Enhances skin health by improving circulation and helps maintain a toned physique through full-body conditioning.

Efficacy: Low  |  Grade: C

Rucking

Weighted Walking, Backpack Training

Improves posture and body composition by building functional strength in the back, core, and legs.

Efficacy: Low  |  Grade: C

Sprinting

High-Intensity Interval Training (HIIT), Sprint Interval Training (SIT)

Enhances circulation and growth hormone release, which can contribute to healthier and more resilient skin.

Efficacy: Low  |  Grade: C

Structured Interval Training

HIIT, High-Intensity Interval Training, SIT

Improves circulation and cellular energy, which helps maintain skin vitality and combat age-related cellular decline.

Efficacy: Low  |  Grade: C

Swimming

Aquatic Exercise

Improves circulation to the skin and tones muscles, contributing to a healthy, vibrant appearance.

Efficacy: Low  |  Grade: C

Track and Field

Athletics

Contributes to a youthful appearance by improving body composition and enhancing circulation to the skin.

Efficacy: Low  |  Grade: C

Wakeboarding

Waterskiing

Promotes lean muscle mass and a toned physique through its full-body resistance training effects.

Efficacy: Low  |  Grade: C

Yoga

Hatha Yoga, Vinyasa Yoga, Ashtanga Yoga, Pranayama

May support skin health and vitality by reducing the aging effects of chronic stress.

Efficacy: Low  |  Grade: C

Zone 2 Cardio Training

Aerobic Base Training, Low-Intensity Steady-State (LISS) Cardio

Improves circulation for better nutrient delivery to the skin and helps reduce systemic 'inflammaging'.

Efficacy: Low  |  Grade: C

Zone 2 Exercise

Aerobic Base Training, Endurance Training, Low-Intensity Steady-State (LISS) Cardio, LISS

Boosts circulation to the skin, delivering more oxygen and nutrients which may help counter 'inflammaging'.

Devices

Procedures

Efficacy: High  |  Grade: A

Chemical Peels

Chemexfoliation, Dermal Peeling

Stimulates collagen production and resurfaces the skin to reduce wrinkles, sun damage, and uneven skin tone.

Efficacy: High  |  Grade: A

High-Intensity Focused Ultrasound (HIFU)

HIFU

Stimulates deep-layer collagen and elastin production, resulting in visibly firmer, tighter, and more youthful-looking skin.

Efficacy: High  |  Grade: A

Hyperbaric Oxygen Therapy

HBOT

Promotes collagen synthesis and can reverse key cellular markers of aging, supporting skin vitality.

Efficacy: High  |  Grade: A

Infrared Light Therapy

Red Light Therapy, RLT, Photobiomodulation, PBM, Low-Level Laser Therapy, LLLT

Stimulates fibroblast cells to increase collagen production, improving skin elasticity and reducing fine lines.

Efficacy: High  |  Grade: A

Intense Pulsed Light

IPL, Photofacial, BBL, BroadBand Light

Reduces signs of sun damage like age spots and redness while stimulating collagen for firmer, smoother skin.

Efficacy: High  |  Grade: A

Laser Skin Resurfacing

Ablative Laser, Non-Ablative Laser, Fractional Laser, CO2 Laser, Erbium Laser

Stimulates new collagen production, reducing wrinkles and improving skin texture for a more youthful appearance.

Efficacy: High  |  Grade: A

LED Red Light Therapy

Photobiomodulation, PBM, Low-Level Laser Therapy, LLLT

Stimulates collagen production to improve skin elasticity and reduce wrinkles, and may also support hair growth.

Efficacy: High  |  Grade: A

Microneedling

Collagen Induction Therapy, Percutaneous Collagen Induction

Stimulates new collagen and elastin production, improving skin texture, firmness, and reducing fine lines and scars.

Efficacy: High  |  Grade: A

Polynucleotides

PN, PDRN, Polydeoxyribonucleotide

Stimulates collagen and elastin production, improving skin hydration, elasticity, and overall dermal health.

Efficacy: High  |  Grade: A

Radiofrequency (RF) Microneedling

RF Microneedling, Fractional Radiofrequency Microneedling

Stimulates new collagen and elastin production, improving skin firmness, texture, and reducing fine lines and wrinkles.

Efficacy: High  |  Grade: A

Poly-L-lactic Acid (Sculptra)

Sculptra

Stimulates your body's own collagen production to restore skin structure, reducing wrinkles and creating a youthful appearance.

Efficacy: High  |  Grade: B

Exosome Therapy

Extracellular Vesicle (EV) Therapy

Promotes skin cell regeneration and collagen production, improving skin texture and youthful appearance.

Efficacy: Medium  |  Grade: A

Photodynamic Therapy

PDT

Reduces signs of sun damage and stimulates collagen, improving skin texture and youthful appearance.

Efficacy: Medium  |  Grade: B

Mesenchymal Stem Cell (MSC) Therapy

MSCs, Mesenchymal Stromal Cells, Stem Cell Therapy

Stimulates collagen production and tissue repair, helping to improve skin elasticity and promote a youthful appearance.

Efficacy: Medium  |  Grade: B

Muse Cell Therapy

Multilineage-differentiating Stress Enduring cells

Supports skin regeneration by replenishing key cells, potentially improving skin structure and reducing chronic inflammation.

Efficacy: Medium  |  Grade: B

Platelet-Rich Plasma (PRP) Therapy

PRP, Autologous Conditioned Plasma

Promotes skin rejuvenation by stimulating collagen and can encourage new hair growth in areas of thinning.

Efficacy: Low  |  Grade: B

SIRT6 Gene Therapy

SIRT6 Overexpression Therapy

Enhances DNA repair and combats chronic inflammation, which helps protect skin from accelerated aging.

Efficacy: Low  |  Grade: C

Acupuncture

Traditional Chinese Medicine (TCM) Needling

May improve facial circulation and stimulate collagen, potentially enhancing skin tone and texture over time.

Efficacy: Low  |  Grade: C

Cognitive Behavioral Therapy

CBT

May reduce the impact of chronic stress and poor sleep on skin health and inflammation.

Efficacy: Low  |  Grade: C

Dermaplaning

Dermal Blading, Skin Blading

Physically exfoliates dead skin cells and removes fine hair, revealing a smoother, brighter complexion and enhancing product penetration.

Efficacy: Low  |  Grade: C

Floatation Therapy

Float Tank, Sensory Deprivation Tank, REST, Restricted Environmental Stimulation Therapy

Helps mitigate the aging effects of chronic stress on the skin by promoting deep relaxation.

Efficacy: Low  |  Grade: C

Follistatin Gene Therapy

FST Gene Therapy

Contributes to a more youthful physique by increasing muscle mass and may have theoretical anti-fibrotic skin benefits.

Efficacy: Low  |  Grade: C

Neti Pot

Nasal Irrigation, Saline Rinse, Jala Neti

Promotes nasal breathing, which can help prevent dry mouth and support better long-term oral health.

Efficacy: Low  |  Grade: C

Sauna Therapy

Heat Therapy, Hyperthermic Conditioning, Sauna Bathing

Enhances skin health by increasing blood flow, promoting hydration, and helping to clear pores through perspiration.

Efficacy: Low  |  Grade: C

Therapeutic Plasma Exchange (TPE)

Plasmapheresis, Plasma Exchange, Plasma Dilution

Theoretically reduces systemic 'inflammaging,' a key driver of accelerated skin and tissue aging.

Protocols

Synergistic Therapy

Efficacy: High  |  Grade: A

5-FU and Calcipotriol (Topical)

5-Fluorouracil and Calcipotriol, Topical Senolytic Combination

Effectively treats precancerous skin lesions (actinic keratosis), reducing a key marker of sun damage and aging.

Efficacy: Medium  |  Grade: B

B-Complex Vitamins

B Vitamins, Vitamin B Complex

Promotes healthy cell turnover for vibrant skin and contributes to the strength of hair and nails.

Efficacy: Medium  |  Grade: B

Myo-Inositol and D-Chiro-Inositol

MI/DCI, Inositol combination

Helps regulate hormones that can influence skin clarity and reduce unwanted hair growth.

Efficacy: Medium  |  Grade: B

Zinc Carnosine

Polaprezinc, L-carnosine zinc complex, PepZin GI

Supports mucosal tissue healing, which may benefit oral health and contribute to skin repair processes.

Efficacy: Low  |  Grade: B

Vitamin D3 and K2 with Calcium

Vitamin D3, Vitamin K2, and Calcium

Helps maintain facial bone structure and supports dental health by promoting strong bones and teeth.

Efficacy: Medium  |  Grade: C

Dasatinib and Quercetin

D+Q, Senolytics

Targets aged 'zombie' cells in the skin, which may help reduce skin inflammation and support structure.

Efficacy: Low  |  Grade: B

Glucosamine and Chondroitin

Glucosamine Sulfate, Chondroitin Sulfate

Provides building blocks for hyaluronic acid, helping to support skin hydration and structural integrity.

Efficacy: Low  |  Grade: C

Curcumin and Piperine

Turmeric and Black Pepper Extract, Bioavailable Curcumin

Combats skin 'inflammaging' and cellular damage through its potent antioxidant activity.

Efficacy: Low  |  Grade: C

Liposomal Vitamin D3/K2

Liposomal D3/K2, Vitamin D3 + K2 (Liposomal)

Supports dental health and may help maintain skin elasticity by preventing soft tissue calcification.

Efficacy: Low  |  Grade: C

GlyNAC

Glycine + N-Acetylcysteine, Glycine and NAC

May support skin health by providing a key collagen building block and reducing oxidative stress.