Energy & Heart449

Arterial health, metabolic efficiency, and cardiorespiratory fitness (VO2 Max).

Supplements

Efficacy: High  |  Grade: A

Aged Garlic Extract

AGE, Kyolic Garlic Extract

Supports cardiovascular health by improving blood pressure, cholesterol levels, and slowing arterial calcification.

Efficacy: High  |  Grade: A

Akkermansia Muciniphila

A. muciniphila, Akkermansia

Improves metabolic efficiency by supporting healthy blood sugar levels and body composition, benefiting cardiovascular health.

Efficacy: High  |  Grade: A

Acetyl-L-Carnitine

ALCAR, ALC

Supports cellular energy production by transporting fats into mitochondria, benefiting heart muscle and overall metabolic efficiency.

Efficacy: High  |  Grade: A

Alpha-Lipoic Acid

ALA, Thioctic acid

Supports cellular energy production and improves insulin sensitivity, which is crucial for metabolic health.

Efficacy: High  |  Grade: A

B Complex Vitamins

B Vitamins, Vitamin B Complex

B-complex vitamins are essential for converting food into cellular energy and help maintain healthy homocysteine levels.

Efficacy: High  |  Grade: A

Berberine

Berberine HCL

Activates a key metabolic enzyme, helping to regulate blood sugar, cholesterol, and support overall cardiovascular health.

Efficacy: High  |  Grade: A

Beta-Alanine

β-Alanine, 3-aminopropanoic acid

Boosts muscular endurance during high-intensity exercise, allowing for improved training capacity and fitness gains.

Efficacy: High  |  Grade: A

Betaine (TMG)

Trimethylglycine, TMG, Glycine Betaine

Lowers homocysteine levels to support arterial health and aids liver function by reducing fat accumulation.

Efficacy: High  |  Grade: A

Caffeine

1,3,7-trimethylxanthine, Methyltheobromine

Boosts metabolic rate and enhances physical performance, contributing to better cardiorespiratory fitness and energy levels.

Efficacy: High  |  Grade: A

Cinnamon Extract

Cinnamomum verum, Cinnamomum cassia, Ceylon Cinnamon, Cassia Cinnamon

Supports healthy blood sugar regulation and metabolic efficiency, which are crucial for cardiovascular and energetic health.

Efficacy: High  |  Grade: A

Cocoa Flavanols

Cacao Flavanols, Flavan-3-ols

Supports cardiovascular health by improving blood flow, blood pressure, and arterial flexibility via nitric oxide production.

Efficacy: High  |  Grade: A

Coenzyme Q10

Ubiquinone, Ubidecarenone, CoQ10

Supports cellular energy production, particularly in the heart, and promotes healthy blood vessel function.

Efficacy: High  |  Grade: A

Copper

Cupric, Copper Gluconate, Copper Bisglycinate, Copper Sulfate

Essential for mitochondrial energy production, iron metabolism, and maintaining the integrity of blood vessels.

Efficacy: High  |  Grade: A

Liposomal CoQ10

Liposomal Coenzyme Q10, Liposomal Ubiquinone, Liposomal Ubiquinol

Supports cellular energy production for heart muscle function and helps maintain healthy cardiovascular performance.

Efficacy: High  |  Grade: A

Cordyceps

Cordyceps militaris, Cordyceps sinensis, Caterpillar fungus

Enhances exercise performance and cellular energy production by improving the body's oxygen utilization.

Efficacy: High  |  Grade: A

Folate (Vitamin B9)

Folic Acid, L-Methylfolate, L-5-MTHF, Vitamin B9

Supports cardiovascular health by helping to regulate homocysteine levels, a key factor in arterial wellness.

Efficacy: High  |  Grade: A

Garlic Extract

Aged Garlic Extract, Allicin supplements

Supports healthy blood pressure and cholesterol levels, promoting flexible arteries and robust cardiovascular function.

Efficacy: High  |  Grade: A

Green Tea Extract

GTE, Camellia sinensis extract, EGCG

Supports cardiovascular health by improving blood flow and cholesterol levels, while also boosting metabolic rate.

Efficacy: High  |  Grade: A

Hibiscus Extract

Roselle extract, Hibiscus sabdariffa extract

Supports healthy blood pressure and cholesterol levels, promoting overall cardiovascular system health.

Efficacy: High  |  Grade: A

Inositol

Myo-inositol, D-chiro-inositol, Vitamin B8

Improves insulin sensitivity and supports healthy blood sugar levels, promoting overall metabolic health.

Efficacy: High  |  Grade: A

Iodine

Potassium Iodide, Lugol's Solution

Essential for producing thyroid hormones, which regulate the body's metabolic rate and overall energy levels.

Efficacy: High  |  Grade: A

Iron Bisglycinate

Ferrous Bisglycinate, Chelated Iron

Essential for oxygen transport and cellular energy, directly combating fatigue and supporting physical stamina.

Efficacy: High  |  Grade: A

Iron Fumarate

Ferrous Fumarate

Essential for producing hemoglobin, which transports oxygen for cellular energy, reducing fatigue and supporting cardiovascular performance.

Efficacy: High  |  Grade: A

Iron Gluconate

Ferrous Gluconate

Supports oxygen transport and cellular energy production, combating fatigue and improving physical endurance.

Efficacy: High  |  Grade: A

Iron

Ferrous Sulfate, Ferrous Gluconate, Iron Bisglycinate, Ferritin

Supports oxygen transport for cellular energy production, enhancing physical stamina and cardiovascular efficiency.

Efficacy: High  |  Grade: A

Iron Sulfate

Ferrous Sulfate

Boosts oxygen transport and cellular energy production, which is crucial for stamina and cardiovascular function.

Efficacy: High  |  Grade: A

L-Carnitine

Acetyl-L-Carnitine, ALCAR, Propionyl-L-Carnitine, L-Carnitine L-Tartrate

Supports heart muscle function and cellular energy production by helping convert fat into usable fuel.

Efficacy: High  |  Grade: A

L-Methylfolate

5-MTHF, Levomefolic acid, Metafolin, Deplin

Supports cardiovascular health by helping to regulate homocysteine levels, a key factor in arterial wellness.

Efficacy: High  |  Grade: A

Low-Dose Aspirin

Baby Aspirin, Acetylsalicylic Acid (low dose)

Reduces platelet aggregation, supporting clear blood flow and protecting against cardiovascular events like heart attack and stroke.

Efficacy: High  |  Grade: A

Lycopene

psi-psi-carotene

Supports healthy blood flow and protects arteries from oxidative damage, contributing to long-term cardiovascular wellness.

Efficacy: High  |  Grade: A

Magnesium Chloride

MgCl2, Magnesium oil

Supports cellular energy production and helps maintain healthy blood pressure and normal heart rhythm.

Efficacy: High  |  Grade: A

Magnesium Citrate

Magnesium

Supports cellular energy production and helps maintain healthy blood pressure and normal heart rhythm.

Efficacy: High  |  Grade: A

Liposomal Magnesium

Liposome-encapsulated Magnesium

Supports cellular energy production and helps maintain healthy blood pressure and normal heart rhythm.

Efficacy: High  |  Grade: A

Magnesium

Magnesium Citrate, Magnesium Glycinate, Magnesium L-Threonate, Magnesium Oxide

Supports cellular energy production and helps maintain healthy blood pressure and heart rhythm.

Efficacy: High  |  Grade: A

Myo-inositol

Inositol, Vitamin B8, cis-1,2,3,5-trans-4,6-cyclohexanehexol

Improves insulin sensitivity and supports healthy blood sugar and lipid levels, promoting metabolic efficiency.

Efficacy: High  |  Grade: A

Liposomal NMN

Liposomal Nicotinamide Mononucleotide

Boosts cellular energy production and supports healthy vascular function by raising essential NAD+ levels.

Efficacy: High  |  Grade: A

Liposomal Nicotinamide Riboside

Liposomal NR

Boosts cellular NAD+ levels, supporting energy production, metabolic efficiency, and cardiovascular health.

Efficacy: High  |  Grade: A

Omega-7 Fatty Acids

Palmitoleic Acid, C16:1n7

Supports healthy cholesterol and triglyceride levels while reducing systemic inflammation for better cardiovascular health.

Efficacy: High  |  Grade: A

Plant Sterols/Stanols

Phytosterols, Phytostanols

Effectively lowers LDL cholesterol by blocking its absorption, which helps maintain clear arteries and cardiovascular health.

Efficacy: High  |  Grade: A

Psyllium Husk

Ispaghula

Lowers LDL cholesterol and improves blood sugar control, supporting long-term cardiovascular and metabolic health.

Efficacy: High  |  Grade: A

Liposomal Quercetin

Liposome-encapsulated quercetin

Supports cardiovascular health by promoting healthy blood pressure, blood vessel function, and protecting against oxidative stress.

Efficacy: High  |  Grade: A

Red Yeast Rice

RYR, Monascus purpureus, Hong Qu

Supports cardiovascular health by helping to maintain healthy cholesterol levels and promoting clear arteries.

Efficacy: High  |  Grade: A

Resveratrol

trans-Resveratrol, 3,5,4'-trihydroxy-trans-stilbene

Supports cardiovascular health by improving blood vessel function and enhancing cellular energy production.

Efficacy: High  |  Grade: A

Retatrutide

LY3437943

Dramatically improves metabolic health by promoting significant weight loss, reducing liver fat, and improving blood sugar levels.

Efficacy: High  |  Grade: A

SGLT2 Inhibitors

Gliflozins

Significantly protects heart function and improves metabolic health by lowering blood sugar and blood pressure.

Efficacy: High  |  Grade: A

SS-31

Elamipretide, Bendavia, MTP-131

Enhances mitochondrial function to boost cellular energy production, supporting heart health and improving physical stamina.

Efficacy: High  |  Grade: A

Statins

HMG-CoA reductase inhibitors

Lowers LDL cholesterol and reduces inflammation in arteries, supporting long-term cardiovascular and circulatory system health.

Efficacy: High  |  Grade: A

Sustained Release Niacin

SR Niacin, Slow-Release Niacin

Effectively improves cholesterol profiles by lowering triglycerides and raising HDL, supporting long-term arterial and heart health.

Efficacy: High  |  Grade: A

Taurine

2-aminoethanesulfonic acid, L-Taurine

Supports heart muscle function, helps maintain healthy blood pressure, and improves cellular energy production.

Efficacy: High  |  Grade: A

Ubiquinol

Reduced Coenzyme Q10, Reduced CoQ10

Powers cellular energy production, especially in the heart, and supports healthy cardiovascular function.

Efficacy: High  |  Grade: A

Urolithin A

UA

Improves cellular energy production by renewing mitochondria, which supports muscle endurance and cardiovascular health.

Efficacy: High  |  Grade: A

Vitamin B12

Cobalamin, Methylcobalamin, Cyanocobalamin, Adenosylcobalamin, Hydroxocobalamin

Essential for red blood cell production and converting food into cellular energy, supporting cardiovascular health.

Efficacy: High  |  Grade: A

Vitamin B2

Riboflavin, Vitamin G

Essential for converting food into cellular energy and helps maintain healthy homocysteine levels for cardiovascular support.

Efficacy: High  |  Grade: A

Vitamin K2

Menaquinone, MK-4, MK-7

Helps direct calcium away from arteries, promoting flexible blood vessels and supporting cardiovascular health.

Efficacy: High  |  Grade: B

17-Alpha-Estradiol

17α-estradiol, alfatradiol

Improves glucose metabolism and reduces systemic inflammation, supporting overall metabolic and cardiovascular health with age.

Efficacy: High  |  Grade: B

AICAR

Acadesine, 5-Aminoimidazole-4-carboxamide ribonucleotide

Activates cellular energy pathways to improve metabolic efficiency and endurance, mimicking effects of exercise.

Efficacy: Medium  |  Grade: A

Choline

Alpha-GPC, CDP-Choline, Citicoline, Choline Bitartrate, Phosphatidylcholine

Supports liver health by aiding fat metabolism and helps maintain healthy homocysteine levels for cardiovascular wellness.

Efficacy: Medium  |  Grade: A

Chromium Picolinate

Chromium(III) picolinate

Supports healthy insulin function and blood sugar regulation, which is crucial for metabolic efficiency and cardiovascular health.

Efficacy: Medium  |  Grade: A

Chromium Polynicotinate

Chromium Niacinate, Chromium Nicotinate

Supports healthy blood sugar regulation and metabolic efficiency, which are foundational for cardiovascular health.

Efficacy: Medium  |  Grade: A

Chromium

Chromium Picolinate, Chromium Polynicotinate, Chromium Chloride

Supports healthy blood sugar and insulin function, which is foundational for metabolic energy and cardiovascular wellness.

Efficacy: Medium  |  Grade: A

Creatine Monohydrate

Creatine

Enhances cellular energy recycling, improving capacity for high-intensity exercise and overall metabolic efficiency.

Efficacy: Medium  |  Grade: A

Curcumin

Turmeric, Diferuloylmethane, Meriva, Longvida, BCM-95, Theracurmin

Supports flexible arteries and healthy blood flow by reducing systemic inflammation and oxidative stress.

Efficacy: Medium  |  Grade: A

Egcg

Epigallocatechin gallate, Green Tea Extract

Supports cardiovascular health by improving blood vessel function and promoting healthy metabolic activity.

Efficacy: Medium  |  Grade: A

Enclomiphene

Enclomiphene Citrate, Androxal

Restores testosterone levels, which can improve body composition, metabolic health, and overall energy.

Efficacy: Medium  |  Grade: A

Fenugreek Extract

Trigonella foenum-graecum, Methi

Supports healthy blood sugar and cholesterol profiles, which are key for metabolic and cardiovascular health.

Efficacy: Medium  |  Grade: A

Ginger

Zingiber officinale

Supports metabolic health by helping to maintain healthy blood sugar and cholesterol levels.

Efficacy: High  |  Grade: B

Klotho

alpha-Klotho, α-Klotho

Protects blood vessels from stiffening and supports healthy metabolic function, crucial for cardiovascular endurance.

Efficacy: Medium  |  Grade: A

Magnesium Glycinate

Magnesium Bisglycinate

Supports healthy blood pressure and heart rhythm, while also being essential for cellular energy production.

Efficacy: High  |  Grade: B

Magnesium Malate

Supports cellular energy production and cardiovascular function by aiding in ATP synthesis and maintaining healthy heart rhythm.

Efficacy: High  |  Grade: B

Magnesium Taurate

Mg Taurate

Supports healthy blood pressure and heart rhythm, contributing to overall cardiovascular efficiency and function.

Efficacy: High  |  Grade: B

Methylene Blue

MB, Methylthioninium chloride

Enhances mitochondrial function to boost cellular energy production and supports healthy circulation.

Efficacy: High  |  Grade: B

MOTS-c

Mitochondrial-derived peptide

Enhances cellular energy production and improves insulin sensitivity, supporting overall metabolic and cardiovascular health.

Efficacy: Medium  |  Grade: A

Multivitamin (Women)

Women's Multi, MVM for Women

Supports cellular energy production and cardiovascular function by ensuring adequate levels of essential B vitamins and minerals.

Efficacy: High  |  Grade: B

Liposomal NAD+

Liposomal Nicotinamide Adenine Dinucleotide

Boosts cellular energy production by supporting mitochondrial function, essential for metabolic and cardiovascular health.

Efficacy: High  |  Grade: B

NAD+ (IV Therapy)

Nicotinamide Adenine Dinucleotide IV, IV NAD+ Therapy

Supports fundamental cellular energy production and metabolic efficiency, which are critical for cardiovascular function.

Efficacy: High  |  Grade: B

NMN

Nicotinamide Mononucleotide

Supports cellular energy production and metabolic efficiency, which may enhance physical endurance and cardiovascular health.

Efficacy: High  |  Grade: B

Nicotinamide Riboside

NR, Niagen

Boosts the essential coenzyme NAD+, supporting cellular energy production and healthy cardiovascular function.

Efficacy: Medium  |  Grade: A

Panax Ginseng

Asian Ginseng, Korean Ginseng, Ren Shen

Supports sustained energy levels and metabolic balance by helping to reduce fatigue and regulate blood sugar.

Efficacy: Medium  |  Grade: A

Phytoestrogens: Soy Isoflavones

Isoflavones, Genistein, Daidzein, Glycitein

Supports cardiovascular health by improving cholesterol profiles and promoting flexible, healthy blood vessels.

Efficacy: High  |  Grade: B

Pyrroloquinoline Quinone (PQQ)

PQQ

Enhances cellular energy by promoting the growth and efficiency of mitochondria, the powerhouses of your cells.

Efficacy: Medium  |  Grade: A

Prebiotic Supplements

Prebiotics, Fermentable Fiber, Inulin, FOS, GOS

Supports healthy blood sugar and cholesterol levels by nourishing beneficial gut bacteria, contributing to metabolic efficiency.

Efficacy: Medium  |  Grade: A

Protein Powder

Whey Protein, Casein Protein, Plant-Based Protein, Collagen Peptides

Supports metabolic efficiency by aiding in the maintenance of lean muscle mass, which influences glucose uptake.

Efficacy: Medium  |  Grade: A

Quercetin

Quercetin Dihydrate, Sophoretin

Supports cardiovascular health by promoting healthy blood pressure, flexible arteries, and efficient cellular energy production.

Efficacy: High  |  Grade: B

Liposomal Resveratrol

Liposomal Trans-Resveratrol

Supports cardiovascular health by improving blood vessel function and enhancing cellular energy metabolism.

Efficacy: Medium  |  Grade: A

Tart Cherry Extract

Montmorency Cherry, Sour Cherry, Prunus cerasus

Supports cardiovascular health by helping to maintain healthy blood pressure and blood flow.

Efficacy: Medium  |  Grade: A

Vitamin B6

Pyridoxine, Pyridoxal 5'-Phosphate, P-5-P

Helps regulate homocysteine levels, a key factor for maintaining healthy arteries and blood flow.

Efficacy: Medium  |  Grade: A

Vitamin B7

Biotin, Vitamin H

Plays a crucial role in converting carbohydrates, fats, and proteins into usable energy for cellular function.

Efficacy: Medium  |  Grade: B

Ashwagandha

Withania somnifera, Indian ginseng, Winter cherry

Enhances cardiorespiratory fitness by improving VO2 max and supports overall endurance during physical activity.

Efficacy: Medium  |  Grade: B

Astaxanthin

asta

Supports cardiovascular health by improving blood flow and protecting blood lipids from oxidative damage.

Efficacy: Medium  |  Grade: B

Astragalus

Huang Qi, Milk-vetch root

Promotes healthy cardiovascular function and helps protect blood vessels from age-related oxidative stress.

Efficacy: Medium  |  Grade: B

Benfotiamine

S-benzoylthiamine O-monophosphate

Supports efficient cellular energy production and helps protect blood vessels from damage caused by excess sugar.

Efficacy: Medium  |  Grade: B

Bilberry Extract

Vaccinium myrtillus extract, European Blueberry extract

Supports flexible arteries and healthy blood flow by protecting blood vessel linings from oxidative stress.

Efficacy: Medium  |  Grade: B

Bitter Melon

Momordica charantia, Bitter Gourd, Karela

Supports healthy blood sugar levels and improves the body's response to insulin, aiding metabolic efficiency.

Efficacy: Medium  |  Grade: B

Butyrate Supplements

Sodium Butyrate, Calcium Butyrate, Magnesium Butyrate, Tributyrin, Butyric Acid

Supports metabolic health by improving insulin sensitivity and providing an alternative cellular energy source.

Efficacy: Medium  |  Grade: B

Butyrate

Sodium Butyrate, Butanoic Acid

Supports metabolic health by improving insulin sensitivity and contributing to healthy blood pressure and cholesterol levels.

Efficacy: Medium  |  Grade: B

Liposomal Calcium AKG

Liposomal Ca-AKG, Liposomal Alpha-Ketoglutarate

Supports cellular energy production by providing a key molecule for metabolic processes, enhancing overall vitality.

Efficacy: Medium  |  Grade: B

Calcium Alpha-Ketoglutarate

Ca-AKG, CaAKG

Supports cellular energy production as a key part of the Krebs cycle and may promote vascular health.

Efficacy: Medium  |  Grade: B

Capsaicin

Chili Pepper Extract, 8-methyl-N-vanillyl-6-nonenamide

Supports metabolic efficiency by modestly increasing energy expenditure and promotes healthy blood vessel function.

Efficacy: Medium  |  Grade: B

Carnosine

L-carnosine, beta-alanyl-L-histidine

Supports high-intensity exercise performance and protects blood vessels from age-related stiffening due to glycation.

Efficacy: Medium  |  Grade: B

Centella Asiatica (Cica)

Cica, Gotu Kola, Brahmi, Asiatic Pennywort

Improves circulation and strengthens blood vessel walls, supporting overall cardiovascular and microvascular health.

Efficacy: Medium  |  Grade: B

Cissus Quadrangularis

Veldt Grape, Devil's Backbone, Hadjod

Aids in weight management and supports healthy blood sugar and lipid levels.

Efficacy: Medium  |  Grade: B

CJC-1295

CJC-1295 with DAC, Modified GRF (1-29) with DAC

May improve body composition by reducing visceral fat and supports healthy metabolic function.

Efficacy: Medium  |  Grade: B

CNM-Au8

Gold Nanocrystals, Gold Nanocatalyst Suspension

Enhances cellular energy metabolism by improving the NAD+/NADH ratio, supporting the fundamental energy needs of cells.

Efficacy: Medium  |  Grade: B

Digestive Enzymes

Pancreatic Enzymes, Protease, Amylase, Lipase, Betaine HCl

Enhances nutrient absorption from food, which supports overall energy levels and metabolic efficiency.

Efficacy: Medium  |  Grade: B

Eleuthero (Siberian Ginseng)

Siberian Ginseng, Eleutherococcus senticosus

Enhances physical stamina and endurance by improving the body's use of oxygen during exercise.

Efficacy: Medium  |  Grade: B

Fisetin

Smoketree extract, 3,3',4',7-tetrahydroxyflavone

Supports cardiovascular health by reducing oxidative stress and inflammation in blood vessels and improving metabolic markers.

Efficacy: Medium  |  Grade: B

FOXO4-DRI

FOXO4-Peptide Based Inhibitor, FOXO4-PBI

Supports cardiovascular health and physical stamina by clearing dysfunctional cells that accumulate with age.

Efficacy: Medium  |  Grade: B

Ginkgo Biloba

Maidenhair Tree, Ginkgo Folium, EGb 761

Supports cardiovascular health by improving blood flow and circulation, especially to peripheral tissues.

Efficacy: Medium  |  Grade: B

Glucosamine

Glucosamine Sulfate, Glucosamine Hydrochloride, N-Acetyl Glucosamine

May support cardiovascular health by reducing systemic inflammation, a key factor in maintaining healthy arteries.

Efficacy: Medium  |  Grade: B

Liposomal Glutathione

L-Glutathione (Liposomal), GSH (Liposomal)

Supports cellular energy production and protects blood vessels by reducing systemic oxidative stress.

Efficacy: Medium  |  Grade: B

Glutathione

L-Glutathione, GSH, Liposomal GSH

Supports cellular energy production and protects blood vessels from oxidative stress, promoting cardiovascular health.

Efficacy: Medium  |  Grade: B

Green-Lipped Mussel Extract

GLM, Perna canaliculus extract, Lyprinol

Supports cardiovascular health and circulation due to its unique profile of anti-inflammatory omega-3 fatty acids.

Efficacy: Medium  |  Grade: B

Gymnema Sylvestre

Gurmar, Meshashringi, Australian Cowplant, Periploca of the woods

Supports healthy blood sugar regulation and metabolic efficiency, which are foundational for long-term cardiovascular health.

Efficacy: Medium  |  Grade: B

Holy Basil (Tulsi)

Tulsi, Ocimum tenuiflorum, Ocimum sanctum

Aids in maintaining healthy blood sugar and lipid levels, supporting overall metabolic and cardiovascular function.

Efficacy: Medium  |  Grade: B

IGF-1 LR3

Insulin-like Growth Factor 1 Long R3

Supports heart muscle function and improves the body's utilization of glucose for cellular energy.

Efficacy: Medium  |  Grade: B

Ipamorelin

NNC 26-0161

Aids in reducing body fat by promoting its use for energy, which supports overall metabolic health.

Efficacy: Medium  |  Grade: B

L-Ergothioneine

Ergothioneine, ET, EGT

Protects heart and blood vessel cells from oxidative stress, supporting cardiovascular health and cellular energy.

Efficacy: Medium  |  Grade: B

Liposomal Calcium AKG

Liposomal Ca-AKG, Liposomal Alpha-Ketoglutarate Calcium Salt

Serves as a crucial molecule in the Krebs cycle for cellular energy production.

Efficacy: Medium  |  Grade: B

Maca Root

Lepidium meyenii, Peruvian Ginseng

May enhance physical endurance and subjective energy levels, supporting an active lifestyle and exercise performance.

Efficacy: Medium  |  Grade: B

Mastic Gum

Chios Mastic, Pistacia lentiscus

Supports healthy cholesterol and blood sugar levels, contributing to better metabolic and cardiovascular function.

Efficacy: Medium  |  Grade: B

Medicinal Mushrooms (Beta-Glucans)

Beta-Glucans, Mushroom Polysaccharides

Supports healthy cholesterol levels and may enhance oxygen utilization for better physical stamina and endurance.

Efficacy: Medium  |  Grade: B

Melatonin

SR Melatonin, Low-Dose Melatonin, Physiological-Dose Melatonin

Supports cardiovascular health by acting as a potent antioxidant and helping to regulate nocturnal blood pressure.

Efficacy: Medium  |  Grade: B

Milk Thistle (Silymarin)

Silybum marianum, Silymarin, Silibinin

Aids in maintaining healthy blood sugar and cholesterol levels, supporting overall metabolic and cardiovascular function.

Efficacy: Medium  |  Grade: B

Myostatin Inhibitors

GDF-8 Inhibitors, Activin Receptor Type IIB Blockers

Improves metabolic health by increasing muscle, which serves as a primary site for glucose disposal.

Efficacy: Medium  |  Grade: B

Phenylpiracetam

Phenotropil, Carphedon, Fonturacetam

Increases physical endurance and tolerance to environmental stressors like cold and fatigue.

Efficacy: Medium  |  Grade: B

Partially Hydrolyzed Guar Gum

PHGG, Sunfiber

Helps maintain healthy blood sugar and cholesterol levels, supporting overall metabolic and cardiovascular function.

Efficacy: Medium  |  Grade: B

Postbiotic Supplements

Postbiotics, Metabolite Supplements, Paraprobiotics

Contributes to metabolic efficiency and helps maintain healthy cholesterol and blood sugar levels already in normal range.

Efficacy: Medium  |  Grade: B

Procyanidin C1

PCC1

Supports flexible arteries and healthy blood flow by promoting nitric oxide production and reducing oxidative stress.

Efficacy: Medium  |  Grade: B

Pterostilbene

Dimethylresveratrol, 3,5-dimethoxy-4'-hydroxystilbene

Supports healthy cholesterol levels and blood pressure, contributing to overall cardiovascular wellness.

Efficacy: Medium  |  Grade: B

Rhodiola Rosea

Golden Root, Arctic Root, Roseroot

Reduces feelings of fatigue and improves physical endurance by supporting cellular energy metabolism.

Efficacy: Medium  |  Grade: B

Saffron Extract

Crocus sativus, Safranal, Crocin

Supports healthy blood pressure and lipid profiles, contributing to overall cardiovascular wellness.

Efficacy: Medium  |  Grade: B

Saffron

Crocus sativus

Supports healthy blood vessel function and may help maintain balanced blood sugar and cholesterol levels.

Efficacy: Medium  |  Grade: B

Schisandra

Schisandra chinensis, Five-Flavor Berry, Wu Wei Zi

Enhances physical endurance and stamina by supporting cellular energy production under stress.

Efficacy: Medium  |  Grade: B

Selenium

Selenomethionine, Selenocysteine, Sodium Selenite

Supports cardiovascular health by reducing oxidative stress and is essential for normal thyroid-driven metabolism.

Efficacy: Medium  |  Grade: B

Sermorelin

Geref, GHRH (1-29)

Improves body composition by reducing visceral fat, which supports metabolic and cardiovascular health.

Efficacy: Medium  |  Grade: B

Shilajit

Mumie, Mineral Pitch, Fulvic Acid

Enhances mitochondrial function to improve cellular energy production and exercise endurance.

Efficacy: Medium  |  Grade: B

Spermidine

N-(3-aminopropyl)butane-1,4-diamine

Supports cardiovascular health and cellular energy by promoting the cleanup and renewal of aging heart cells.

Efficacy: Medium  |  Grade: B

Sulbutiamine

Arcalion, Enerion, Bisibutiamine

Helps reduce feelings of fatigue and weakness by supporting the body's core energy production pathways.

Efficacy: Medium  |  Grade: B

Sulforaphane

SFN, Glucoraphanin, Broccoli Sprout Extract

Supports cardiovascular health by reducing oxidative stress and promoting healthy blood vessel function.

Efficacy: Medium  |  Grade: B

Sustained Release Melatonin

Time-Release Melatonin, Extended-Release Melatonin, Prolonged-Release Melatonin

Supports cardiovascular health by helping to regulate nocturnal blood pressure and providing antioxidant protection to blood vessels.

Efficacy: Medium  |  Grade: B

Sustained Release Vitamin C

Time-Release Vitamin C, Extended-Release Ascorbic Acid

Supports blood vessel flexibility and protects against oxidative stress, promoting healthy circulation and cardiovascular function.

Efficacy: Medium  |  Grade: B

TB-500

Thymosin Beta-4

Supports heart tissue repair and promotes the growth of new blood vessels, aiding cardiovascular recovery.

Efficacy: Medium  |  Grade: B

Tongkat Ali

Eurycoma longifolia, Malaysian Ginseng, Longjack

Enhances vitality and physical performance by supporting healthy hormone levels and reducing fatigue.

Efficacy: Medium  |  Grade: B

Trehalose

Mycose, Tremalose

Supports metabolic health by improving insulin sensitivity and aiding the cellular clearance of arterial plaques.

Efficacy: Medium  |  Grade: B

Vitamin B5

Pantothenic Acid

Essential for converting food into cellular energy and may help maintain healthy cholesterol and triglyceride levels.

Efficacy: Medium  |  Grade: B

Liposomal Vitamin C

Liposomal Ascorbic Acid, L-Ascorbic Acid (Liposomal)

Supports blood vessel integrity through collagen synthesis and protects cells from oxidative stress.

Efficacy: Medium  |  Grade: B

Vitamin E

Tocopherols, Tocotrienols, Alpha-tocopherol

Helps protect cardiovascular cells and LDL cholesterol from oxidative stress, supporting overall blood vessel health.

Efficacy: Low  |  Grade: B

Boron

Boric Acid, Sodium Borate

May support arterial health by reducing inflammation and influencing lipid metabolism.

Efficacy: Low  |  Grade: B

Chamomile Extract

Matricaria recutita, Chamaemelum nobile, Apigenin

Supports healthy blood sugar levels and cardiovascular function through its antioxidant properties.

Efficacy: Low  |  Grade: B

Elderberry

Sambucus nigra, Elder

Its high antioxidant content helps protect blood vessels from oxidative stress, supporting cardiovascular health.

Efficacy: Medium  |  Grade: C

Liposomal Fisetin

Liposomal 3,3',4',7-tetrahydroxyflavone

Helps reduce cellular stress and inflammation, which supports the long-term health of blood vessels.

Efficacy: Low  |  Grade: B

GABA

Gamma-Aminobutyric Acid

May help maintain healthy blood pressure levels, contributing to overall cardiovascular wellness.

Efficacy: Low  |  Grade: B

L-Theanine

Theanine, gamma-glutamylethylamide

Supports cardiovascular health by helping to manage blood pressure responses during stressful situations.

Efficacy: Low  |  Grade: B

Lutein

Zeaxanthin

Supports cardiovascular health by protecting blood vessels from oxidative stress and reducing inflammation.

Efficacy: Low  |  Grade: B

MSM (Methylsulfonylmethane)

Dimethyl sulfone, DMSO2

Reduces exercise-induced muscle soreness and oxidative stress, supporting faster recovery and consistent physical performance.

Efficacy: Low  |  Grade: B

Multivitamin (Men)

Men's Multi, MVM

Supports fundamental cellular energy production by providing B vitamins and minerals essential for metabolic processes.

Efficacy: Low  |  Grade: B

Peppermint Oil

Mentha piperita oil

May enhance exercise performance and respiratory function, contributing to better cardiorespiratory fitness.

Efficacy: Low  |  Grade: B

Probiotics

Beneficial Bacteria, Live Cultures

May support cardiovascular health by helping to maintain healthy cholesterol levels and blood pressure.

Efficacy: Low  |  Grade: B

Zinc Gluconate

Zincum Gluconicum

Supports cellular antioxidant defenses and plays a role in healthy glucose metabolism.

Efficacy: Low  |  Grade: B

Zinc

Zinc Picolinate, Zinc Gluconate, Zinc Citrate, Zinc Orotate

Acts as an antioxidant, helping to protect blood vessel linings from oxidative stress and inflammation.

Efficacy: Low  |  Grade: C

3-Hydroxyanthranilic Acid

3-HAA

Contributes to the body's production of NAD+, a key molecule for cellular energy and metabolism.

Efficacy: Low  |  Grade: C

Liposomal Apigenin

Bioavailable Apigenin, Apigenin Phytosome

May support healthy blood vessel function and cellular energy by inhibiting the enzyme CD38.

Efficacy: Low  |  Grade: C

BPC-157

Body Protection Compound 157, Bepecin

Supports the formation of new blood vessels, which can improve blood flow and aid tissue repair.

Efficacy: Low  |  Grade: C

Bromelain

Pineapple Extract, Ananase

May support healthy circulation by helping to break down certain proteins that can impede blood flow.

Efficacy: Low  |  Grade: C

Citicoline

CDP-Choline, Cytidine Diphosphate-Choline

Supports cellular energy production by contributing to the health of mitochondria, the powerhouses of our cells.

Efficacy: Low  |  Grade: C

Epitalon

Epithalon, Epithalamin, Ala-Glu-Asp-Gly

May support cardiovascular function and metabolic health in older individuals by regulating endocrine and antioxidant systems.

Efficacy: Low  |  Grade: C

Glycine

2-Aminoacetic acid

Contributes to glutathione production, a master antioxidant that protects cells and supports metabolic health.

Efficacy: Low  |  Grade: C

L-Glutamine

Glutamine

Supports cellular energy, particularly for immune and intestinal cells during periods of high stress.

Efficacy: Low  |  Grade: C

Lemon Balm

Melissa officinalis

Contributes to metabolic health by supporting the maintenance of healthy blood sugar and lipid levels.

Efficacy: Low  |  Grade: C

Lion's Mane Mushroom

Hericium erinaceus, Yamabushitake, Monkey Head Mushroom

Animal studies suggest it may help support healthy lipid metabolism and blood sugar levels.

Efficacy: Low  |  Grade: C

Liposomal Melatonin

Encapsulated Melatonin, Liposome-Entrapped Melatonin

Protects cellular powerhouses (mitochondria) from oxidative stress, supporting overall metabolic health.

Efficacy: Low  |  Grade: C

Piperine

Black Pepper Extract, Bioperine

Supports healthy metabolism and may assist in maintaining normal cholesterol levels by improving nutrient uptake.

Efficacy: Low  |  Grade: C

Piracetam

Nootropil, Lucetam, 2-oxo-1-pyrrolidine acetamide

May improve microcirculation and red blood cell flexibility, supporting oxygen delivery to the brain and tissues.

Efficacy: Low  |  Grade: C

Reishi Mushroom

Ganoderma lucidum, Lingzhi, Mushroom of Immortality

May offer mild support for blood sugar regulation and cardiovascular health, though human evidence is inconsistent.

Efficacy: Low  |  Grade: C

Orthosilicic acid

OSA, Choline-stabilized orthosilicic acid (ch-OSA), Silica

Contributes to the structural integrity and elasticity of arterial walls by supporting connective tissue formation.

Efficacy: Low  |  Grade: C

Uridine Monophosphate

UMP, Uridine

Provides essential building blocks that support cellular energy production and mitochondrial function.

Medications

Efficacy: High  |  Grade: A

Acarbose

Precose, Glucobay

Reduces post-meal glucose spikes, supporting metabolic health and protecting long-term cardiovascular function.

Efficacy: High  |  Grade: A

ACE Inhibitors

Angiotensin-Converting Enzyme Inhibitors

Lowers blood pressure and reduces heart strain, supporting long-term cardiovascular health and arterial function.

Efficacy: High  |  Grade: A

Aliskiren

Tekturna, Rasilez

Lowers blood pressure by relaxing blood vessels, reducing strain on the heart and supporting long-term cardiovascular health.

Efficacy: High  |  Grade: A

Amlodipine

Norvasc, Katerzia, Amvaz

Lowers blood pressure by relaxing blood vessels, reducing heart workload and supporting long-term arterial health.

Efficacy: High  |  Grade: A

Angiotensin Receptor Blockers

ARBs

Lowers blood pressure and reduces strain on the heart, supporting long-term arterial health and cardiovascular function.

Efficacy: High  |  Grade: A

Atorvastatin

Lipitor

Significantly lowers LDL cholesterol, reducing arterial plaque buildup and supporting long-term cardiovascular and circulatory health.

Efficacy: High  |  Grade: A

Bempedoic Acid

Nexletol, Nilemdo

Lowers LDL cholesterol, a key factor in maintaining clear arteries and supporting long-term cardiovascular health.

Efficacy: High  |  Grade: A

Bexagliflozin

Brenzavvy

Supports cardiovascular health by improving blood sugar control, lowering blood pressure, and reducing stress on the heart.

Efficacy: High  |  Grade: A

Bile Acid Sequestrants

Bile Acid Resins

Effectively lowers LDL cholesterol, a primary driver of atherosclerosis, thereby supporting long-term arterial and heart health.

Efficacy: High  |  Grade: A

Canagliflozin

Invokana

Strongly protects heart and kidney function, modestly lowers blood pressure, and improves metabolic efficiency.

Efficacy: High  |  Grade: A

Daily Low-Dose Tadalafil

Cialis (daily), PDE5 inhibitor

Improves blood flow and arterial health by enhancing endothelial function, which supports overall cardiovascular efficiency.

Efficacy: High  |  Grade: A

Dapagliflozin

Farxiga

Significantly reduces risk of heart failure and protects kidney function, supporting overall cardiovascular and metabolic health.

Efficacy: High  |  Grade: A

Empagliflozin

Jardiance

Significantly reduces cardiovascular risk and improves heart function by enhancing metabolic efficiency and lowering blood pressure.

Efficacy: High  |  Grade: A

Ertugliflozin

Steglatro

Reduces cardiovascular risk and improves heart function by lowering blood pressure and metabolic stress on the heart.

Efficacy: High  |  Grade: A

Erythropoietin

EPO, Epoetin alfa

Boosts oxygen delivery to tissues, significantly enhancing endurance, aerobic capacity, and overall energy levels.

Efficacy: High  |  Grade: A

Estradiol Cypionate

Depo-Estradiol

Supports cardiovascular health by improving cholesterol profiles and promoting flexible, healthy blood vessels.

Efficacy: High  |  Grade: A

Estradiol Valerate

EV, Delestrogen

Supports cardiovascular health by improving cholesterol levels and promoting flexible, healthy blood vessels.

Efficacy: High  |  Grade: A

Estradiol

E2, 17β-estradiol, Oestradiol

Supports cardiovascular health by improving cholesterol levels and maintaining flexible, healthy blood vessels.

Efficacy: High  |  Grade: A

Ezetimibe

Zetia

Lowers LDL cholesterol by reducing its absorption, which helps maintain clear arteries and supports cardiovascular health.

Efficacy: High  |  Grade: A

Fibrates

Fenofibrate, Gemfibrozil, Bezafibrate, Ciprofibrate

Effectively lowers triglycerides and improves the overall lipid profile, supporting long-term arterial health and metabolic function.

Efficacy: High  |  Grade: A

Fluvastatin

Lescol, Lescol XL

Reduces 'bad' cholesterol and arterial inflammation, supporting long-term cardiovascular health and healthy blood flow.

Efficacy: High  |  Grade: A

GLP-1 Receptor Agonists

Incretin Mimetics, GLP-1 RAs

Improves metabolic efficiency, supports weight management, and reduces major cardiovascular events for better heart health.

Efficacy: High  |  Grade: A

Icosapent Ethyl

Vascepa, purified EPA

Significantly lowers triglycerides and reduces cardiovascular events, promoting long-term heart and arterial health.

Efficacy: High  |  Grade: A

Inclisiran

Leqvio

Dramatically lowers LDL cholesterol, promoting clear arteries and supporting long-term cardiovascular system health.

Efficacy: High  |  Grade: A

Lisinopril

Prinivil, Zestril

Lowers blood pressure and reduces cardiac workload, supporting long-term arterial and heart health.

Efficacy: High  |  Grade: A

Lovastatin

Mevacor, Altoprev

Significantly lowers LDL cholesterol, which helps maintain clear arteries and supports long-term cardiovascular health.

Efficacy: High  |  Grade: A

Low-Dose Colchicine

Colcrys, Mitigare, Gloperba

Reduces inflammation in arteries, which helps stabilize plaque and lower the risk of cardiovascular events.

Efficacy: High  |  Grade: A

Menopausal HRT

Hormone Replacement Therapy, MHT, Menopausal Hormone Therapy

Supports cardiovascular health by improving cholesterol levels and blood vessel function, especially when started early in menopause.

Efficacy: High  |  Grade: A

Metformin

Glucophage, Fortamet, Glumetza

Enhances metabolic efficiency by improving insulin sensitivity and supports cardiovascular health by protecting blood vessels.

Efficacy: High  |  Grade: A

Nebivolol

Bystolic, Brevibloc

Supports cardiovascular health by lowering blood pressure, improving blood flow, and reducing cardiac workload.

Efficacy: High  |  Grade: A

Niacin (Vitamin B3)

Nicotinic Acid, Vitamin B3

Effectively improves cholesterol profiles by raising 'good' HDL and lowering triglycerides, supporting arterial health.

Efficacy: High  |  Grade: A

Omega-3 Fatty Acids

Fish Oil, EPA, DHA, Marine Oils, Omega-3 Softgel, Omega-3 Supplement

Supports cardiovascular health by maintaining healthy triglyceride levels, blood pressure, and promoting flexible arteries.

Efficacy: High  |  Grade: A

PCSK9 Inhibitors

Proprotein Convertase Subtilisin/Kexin type 9 Inhibitors

Dramatically lowers LDL cholesterol, reducing plaque buildup in arteries and supporting long-term cardiovascular health.

Efficacy: High  |  Grade: A

PDE5 Inhibitors

Phosphodiesterase-5 Inhibitors, Tadalafil, Sildenafil, Vardenafil, Avanafil

Improves blood flow and endothelial function, supporting cardiovascular health and reducing cardiac workload.

Efficacy: High  |  Grade: A

Pitavastatin

Livalo, Zypitamag

Significantly lowers LDL cholesterol, which helps maintain clear arteries and supports long-term cardiovascular health.

Efficacy: High  |  Grade: A

Potassium Chloride

KCl, Potassium salt

Supports healthy blood pressure by balancing sodium levels and is essential for maintaining a regular heartbeat.

Efficacy: High  |  Grade: A

Potassium Citrate

K-Citrate, Urocit-K

Supports healthy blood pressure levels, which is crucial for long-term cardiovascular and arterial health.

Efficacy: High  |  Grade: A

Pravastatin

Pravachol

Lowers harmful cholesterol and reduces arterial inflammation, significantly supporting long-term cardiovascular and metabolic health.

Efficacy: High  |  Grade: A

Propranolol

Inderal, InnoPran XL

Reduces blood pressure and cardiac workload, supporting long-term cardiovascular health in managing hypertension or heart conditions.

Efficacy: High  |  Grade: A

Rosuvastatin

Crestor

Significantly lowers LDL cholesterol, reducing arterial plaque buildup and supporting long-term cardiovascular system health.

Efficacy: High  |  Grade: A

Semaglutide

Ozempic, Wegovy, Rybelsus

Significantly improves metabolic health and reduces cardiovascular risk by promoting weight loss and better blood sugar control.

Efficacy: High  |  Grade: A

Simvastatin

Zocor

Significantly lowers 'bad' LDL cholesterol, reducing arterial plaque buildup and supporting long-term cardiovascular system health.

Efficacy: High  |  Grade: A

Telmisartan

Micardis

Lowers blood pressure and improves metabolic health, supporting overall cardiovascular function and arterial well-being.

Efficacy: High  |  Grade: A

Tesamorelin

Egrifta

Reduces harmful visceral belly fat and improves metabolic markers, supporting long-term cardiovascular and metabolic health.

Efficacy: High  |  Grade: A

Vitamin B1 (Thiamine)

Thiamin

Thiamine is essential for converting food into cellular energy, supporting heart muscle function and overall metabolic efficiency.

Efficacy: High  |  Grade: A

Tirzepatide

Mounjaro, Zepbound

Significantly improves metabolic efficiency, supports weight loss, and reduces key risk factors for cardiovascular disease.

Efficacy: High  |  Grade: B

mTOR Inhibitors

Rapalogs, Mechanistic Target of Rapamycin Inhibitors

Protects against age-related decline in heart function and improves overall metabolic efficiency.

Efficacy: Medium  |  Grade: A

Raloxifene (SERMs)

Evista

Helps maintain a healthier cardiovascular profile by lowering LDL ('bad') cholesterol levels.

Efficacy: High  |  Grade: B

Rapamycin

Sirolimus

Supports cardiovascular health by improving metabolic function and reducing age-related changes in heart structure.

Efficacy: Medium  |  Grade: A

Testosterone Replacement Therapy

TRT, Testosterone Therapy

Improves energy levels and metabolic function by increasing lean mass and reducing body fat.

Efficacy: Medium  |  Grade: A

Testosterone

TRT, Testosterone Replacement Therapy

Supports red blood cell production and metabolic health, which can enhance energy levels and physical capacity.

Efficacy: Medium  |  Grade: A

Vitamin C

Ascorbic Acid, L-Ascorbic Acid

Supports blood vessel flexibility and protects against oxidative stress, contributing to overall cardiovascular health.

Efficacy: Medium  |  Grade: B

Dasatinib

Sprycel

Helps improve vascular function and reduce arterial stiffness by clearing aged, dysfunctional cells from tissues.

Efficacy: Medium  |  Grade: B

Everolimus

Afinitor, Zortress, RAD001

Supports metabolic health and may protect against age-related changes in heart function by modulating cellular nutrient sensing.

Efficacy: Medium  |  Grade: B

NAC

N-Acetylcysteine, N-acetyl-L-cysteine

Supports cardiovascular health by reducing oxidative stress and improving blood vessel function.

Efficacy: Medium  |  Grade: B

Oxytocin

OT, Love Hormone

Supports cardiovascular health by promoting healthy blood pressure and may aid in regulating metabolism and energy balance.

Efficacy: Low  |  Grade: A

Selective Estrogen Receptor Modulators

SERMs

May help maintain healthy cholesterol levels, which supports long-term cardiovascular function.

Efficacy: Medium  |  Grade: B

Testosterone Therapy (Women) (Topical)

Low-dose Testosterone for Women, Female Androgen Therapy

May enhance energy levels and support a healthier body composition by increasing lean muscle mass.

Efficacy: Medium  |  Grade: B

Vitamin D3

Cholecalciferol (D3), Ergocalciferol (D2), Calcifediol, Calcitriol

Contributes to healthy blood vessel function and plays a role in regulating blood pressure.

Efficacy: Low  |  Grade: B

Dual Orexin Receptor Antagonists

DORAs, Lemborexant, Suvorexant, Daridorexant

By improving sleep quality, it may indirectly support metabolic health and cardiovascular function.

Topical Agents

Dietary Practices

Efficacy: High  |  Grade: A

Alternate-Day Fasting (ADF)

ADF, Every-Other-Day Fasting

Improves metabolic markers like insulin sensitivity and cholesterol, supporting long-term cardiovascular and metabolic health.

Efficacy: High  |  Grade: A

Anti-Inflammatory Diet

Mediterranean Diet, DASH Diet, MIND Diet

Reduces systemic inflammation, supporting arterial health, healthy blood pressure, and efficient metabolic function.

Efficacy: High  |  Grade: A

Avoiding Processed Foods

Minimally Processed Diet, Whole Foods Diet

Improves metabolic health and reduces key risk factors for heart disease like blood pressure and cholesterol.

Efficacy: High  |  Grade: A

Beetroot Juice

Beet Juice, Beetroot Extract

Enhances exercise performance and supports healthy blood pressure by improving blood flow and oxygen use.

Efficacy: High  |  Grade: A

The Blue Zones Diet

Longevity Diet, Blue Zone Eating Pattern

Promotes cardiovascular health and metabolic efficiency through high fiber, healthy fats, and plant-based nutrients.

Efficacy: High  |  Grade: A

Calorie Restriction Diet

CR, Caloric Restriction

Improves metabolic efficiency, supports healthy blood pressure, and promotes long-term cardiovascular health.

Efficacy: High  |  Grade: A

Calorie Restriction Without Malnutrition

CR, Dietary Restriction, Nutritional Restriction

Improves metabolic efficiency, lowers blood pressure, and supports overall cardiovascular health by reducing key risk factors.

Efficacy: High  |  Grade: A

Cruciferous Vegetables

Brassicas, Cole crops

Supports cardiovascular health by promoting flexible arteries and protecting against oxidative stress.

Efficacy: High  |  Grade: A

DASH Diet

Dietary Approaches to Stop Hypertension

Significantly lowers blood pressure and improves cholesterol, directly supporting long-term cardiovascular and arterial health.

Efficacy: High  |  Grade: A

Dietary Nitrate

Beetroot Juice, Leafy Greens, NO3-

Enhances exercise efficiency and supports healthy blood pressure by improving blood flow throughout the body.

Efficacy: High  |  Grade: A

Fasting-Mimicking Diet (FMD)

FMD, Prolon Diet

Improves key metabolic markers like blood pressure, cholesterol, and fasting glucose for better cardiovascular health.

Efficacy: High  |  Grade: A

5:2 Diet

The Fast Diet, Intermittent Fasting (5:2)

Improves insulin sensitivity and key cardiovascular markers like blood pressure and cholesterol for better metabolic health.

Efficacy: High  |  Grade: A

Flaxseed

Linseed, Ground Flaxseed

Supports cardiovascular health by helping to lower blood pressure and manage cholesterol levels.

Efficacy: High  |  Grade: A

Flexitarian Diet

Semi-vegetarianism, Flexible vegetarianism

Promotes cardiovascular health by improving cholesterol, blood pressure, and metabolic markers through increased plant-based food intake.

Efficacy: High  |  Grade: A

Hibiscus Tea

Roselle Tea, Sour Tea, Karkadeh

Supports healthy blood pressure and cholesterol levels, which are crucial for long-term cardiovascular function.

Efficacy: High  |  Grade: A

High-Fiber Diet

Fiber-rich eating, Plant-forward diet

Lowers cholesterol and improves blood sugar control, supporting arterial health and stable metabolic energy.

Efficacy: High  |  Grade: A

5:2 Intermittent Fasting

5-2 method, The Fast Diet

Improves metabolic flexibility and insulin sensitivity, supporting cardiovascular health and stable energy levels.

Efficacy: High  |  Grade: A

Intermittent Fasting

IF, Periodic Fasting

Improves metabolic flexibility and insulin sensitivity, supporting stable energy levels and cardiovascular health markers.

Efficacy: High  |  Grade: A

Ketogenic Diet

Keto, Keto Diet

Improves metabolic efficiency by lowering blood sugar and triglycerides, which supports long-term cardiovascular health.

Efficacy: High  |  Grade: A

Low-Carb Diet

Very Low-Carbohydrate Ketogenic Diet (VLCKD), Keto Diet

Improves metabolic markers like blood sugar and triglycerides, supporting stable energy and cardiovascular health.

Efficacy: High  |  Grade: A

Mediterranean Diet

MedDiet

Strongly supports cardiovascular health by improving cholesterol, blood pressure, and blood vessel function.

Efficacy: High  |  Grade: A

MIND Diet

Mediterranean-DASH Intervention for Neurodegenerative Delay

Strongly supports cardiovascular health by improving blood pressure, cholesterol, and reducing systemic inflammation.

Efficacy: High  |  Grade: A

Nordic Diet

New Nordic Diet, NND

Supports cardiovascular health by improving blood pressure, cholesterol levels, and reducing systemic inflammation.

Efficacy: High  |  Grade: A

The Okinawa Diet

Okinawan Longevity Diet, Traditional Okinawan Diet

Promotes excellent cardiovascular health and metabolic efficiency due to its low saturated fat and high nutrient density.

Efficacy: High  |  Grade: A

One Meal A Day

OMAD, 23:1 Intermittent Fasting

Improves insulin sensitivity and metabolic flexibility, which are crucial for efficient energy use and cardiovascular health.

Efficacy: High  |  Grade: A

Ovo-Lacto Vegetarian Diet

Vegetarian Diet

Significantly improves cardiovascular health by lowering cholesterol, blood pressure, and risk of metabolic disease.

Efficacy: High  |  Grade: A

Paleo Diet

Paleolithic Diet, Caveman Diet

Improves metabolic markers like blood sugar control and cholesterol, supporting long-term cardiovascular and arterial health.

Efficacy: High  |  Grade: A

Pescatarian Diet

Pescatarianism, Fish-based diet

Reduces cardiovascular risk by improving cholesterol, blood pressure, and providing anti-inflammatory omega-3 fatty acids.

Efficacy: High  |  Grade: A

Plant-Forward Diet

Plant-Based Diet, Flexitarian Diet, Vegetarian Diet, Vegan Diet

Promotes flexible arteries and efficient metabolism, supporting cardiovascular endurance and long-term heart health.

Efficacy: High  |  Grade: A

Polyphenol-Rich Diet

High-Polyphenol Diet, Colorful Diet, Polyphenol-rich Foods, Phytonutrient-dense foods, Flavonoid-rich foods

Supports cardiovascular health by improving blood flow, blood pressure, and protecting blood vessels from oxidative stress.

Efficacy: High  |  Grade: A

Potassium

K, Potassium Chloride, Potassium Citrate

Helps regulate blood pressure by balancing sodium levels, which is crucial for long-term cardiovascular health.

Efficacy: High  |  Grade: A

Prolonged Fasting (Supervised)

Therapeutic Fasting, Extended Fasting, Water Fasting (Supervised)

Significantly improves metabolic markers like blood sugar, blood pressure, and cholesterol, supporting overall cardiovascular health.

Efficacy: High  |  Grade: A

Protein

Amino Acids, Dietary Protein

Supports a healthy metabolism and provides the essential building blocks for a strong heart muscle.

Efficacy: High  |  Grade: A

Resistant Starch

RS, Undigestable Starch

Improves metabolic health by supporting stable blood sugar levels and enhancing insulin sensitivity.

Efficacy: High  |  Grade: A

Soluble Fiber

Dietary fiber (soluble), Beta-glucans, Psyllium, Inulin, Pectins

Lowers LDL cholesterol and helps stabilize blood sugar levels, supporting long-term cardiovascular and metabolic health.

Efficacy: High  |  Grade: A

Time-Restricted Eating (16:8)

TRE, 16:8 Intermittent Fasting, Leangains Protocol

Improves metabolic flexibility and key markers of cardiovascular health like blood pressure and insulin sensitivity.

Efficacy: High  |  Grade: A

Vegan Diet

Plant-Based Diet, Strict Vegetarianism

Lowers cholesterol and blood pressure, improving arterial health and supporting long-term cardiovascular function.

Efficacy: High  |  Grade: A

Vegetarian Diet

Plant-based diet, Lacto-ovo vegetarianism

Reduces risk factors for heart disease, such as high blood pressure and cholesterol, supporting cardiovascular health.

Efficacy: High  |  Grade: A

Water Fasting

Prolonged Fasting, Extended Fasting

Improves metabolic flexibility, reduces blood pressure, and supports healthy cholesterol levels for better cardiovascular function.

Efficacy: High  |  Grade: A

Whole Food Plant Based

WFPB, Plant-Based Diet

Significantly improves cardiovascular health by lowering cholesterol, improving blood flow, and supporting stable energy levels.

Efficacy: High  |  Grade: B

Blueprint Protocol

Bryan Johnson's Blueprint

Enhances cardiovascular fitness and metabolic efficiency through a structured diet, exercise, and targeted supplementation.

Efficacy: High  |  Grade: B

Branched-Chain Amino AcidRestriction

Low BCAA Diet

Improves insulin sensitivity and metabolic flexibility, which supports long-term cardiovascular and metabolic health.

Efficacy: Medium  |  Grade: A

Inulin (Prebiotic Fiber)

Prebiotic Fiber, Chicory Root Fiber, Fructan

Supports healthy blood sugar and cholesterol levels, contributing to better metabolic and cardiovascular function.

Efficacy: High  |  Grade: B

Methionine Restriction

MR, Low-Methionine Diet

Improves metabolic efficiency, enhances insulin sensitivity, and reduces oxidative stress, supporting long-term cardiovascular health.

Efficacy: Medium  |  Grade: A

Tart Cherry Juice

Montmorency Cherry, Prunus cerasus, Sour Cherry

Supports healthy blood pressure and blood flow while aiding recovery from strenuous physical activity.

Efficacy: Medium  |  Grade: B

Apple Cider Vinegar

ACV

Supports healthy blood sugar regulation after meals and may contribute to favorable cholesterol levels.

Efficacy: Medium  |  Grade: B

Fermented Foods

Probiotic Foods, Live Culture Foods, Gut-Healthy Foods

May support cardiovascular health by helping to maintain healthy blood pressure and cholesterol levels.

Efficacy: Medium  |  Grade: B

Gluten-Free Diet

GF Diet

Restores energy levels by correcting nutrient malabsorption and related anemia in people with celiac disease.

Efficacy: Medium  |  Grade: B

Kefir / Fermented Foods

Probiotic Foods, Cultured Foods

May support cardiovascular health by helping to maintain healthy blood pressure and cholesterol levels.

Efficacy: Medium  |  Grade: C

Autoimmune Protocol Diet

AIP, AIP Diet

Reduces systemic inflammation and improves metabolic health, which supports healthy arteries and stable energy levels.

Efficacy: Medium  |  Grade: C

Freegan Vegan Diet

Freeganism

A plant-based diet, often low in saturated fat, can support healthy cholesterol levels and blood pressure.

Efficacy: Medium  |  Grade: C

Whole30

Whole 30 Diet, 30-Day Elimination Diet

May improve metabolic markers and stabilize energy levels by eliminating processed sugars and refined carbohydrates.

Efficacy: Low  |  Grade: C

Alkaline Water Consumption

May improve blood flow by reducing blood viscosity after intense exercise that causes dehydration.

Efficacy: Low  |  Grade: C

Alkaline Water

Ionized Water, High pH Water

May improve hydration and reduce blood viscosity after exercise, which could support circulatory efficiency.

Efficacy: Medium  |  Grade: D

Carnivore Diet

All-Meat Diet, Zero-Carb Diet

Can improve metabolic markers like insulin sensitivity and promote weight loss by eliminating processed carbohydrates and sugars.

Efficacy: Low  |  Grade: C

Kombucha

Fermented Tea, Tea Fungus

Contains tea-derived antioxidants and B-vitamins that may offer minor support for metabolic health.

Lifestyle Practices

Efficacy: High  |  Grade: A

Running

Jogging, Aerobic Exercise, Cardio

Strengthens the heart, improves blood vessel health, and boosts cellular energy production for enhanced endurance.

Efficacy: High  |  Grade: A

Sauna

Sauna Bathing, Hyperthermic Conditioning, Heat Therapy

Mimics moderate exercise to improve heart function, lower blood pressure, and enhance cardiorespiratory fitness.

Efficacy: High  |  Grade: A

Smoking Cessation

Quitting Smoking, Tobacco Cessation

Dramatically lowers cardiovascular risk, improves blood flow, and enhances oxygen delivery for better physical performance.

Efficacy: High  |  Grade: A

Strength Training

Resistance Training, Weightlifting, Resistance Exercise

Enhances metabolic efficiency by improving insulin sensitivity and glucose control, supporting long-term cardiovascular and energy health.

Efficacy: High  |  Grade: A

Stress Management

Mindfulness, Relaxation Techniques, Cognitive Behavioral Therapy (CBT), Meditation

Reduces the cardiovascular strain of chronic stress, supporting healthy blood pressure and arterial function.

Efficacy: Medium  |  Grade: A

Breathwork

Pranayama, Conscious Connected Breathing, Holotropic Breathwork, Wim Hof Method

Improves heart rate variability and helps regulate blood pressure, supporting overall cardiovascular efficiency.

Efficacy: Medium  |  Grade: A

Daily Flossing

Dental Flossing

Reduces oral inflammation, which helps lower the systemic inflammatory burden linked to poor arterial and heart health.

Efficacy: Medium  |  Grade: A

Deep Breathing Exercises

Diaphragmatic Breathing, Belly Breathing, Mindful Breathing

Promotes cardiovascular health by lowering blood pressure and improving heart rate variability.

Efficacy: Medium  |  Grade: A

Electric Toothbrushing

Powered Toothbrushing

Reduces gum inflammation, which lowers systemic inflammation and protects long-term cardiovascular and arterial health.

Efficacy: Medium  |  Grade: A

Meditation

Mindfulness, Vipassanā, Zazen, Transcendental Meditation

Reduces stress-related high blood pressure and improves heart rate variability, supporting overall cardiovascular resilience.

Efficacy: Medium  |  Grade: A

Mindfulness Meditation

Mindfulness-Based Stress Reduction (MBSR), Vipassana, Concentrative Meditation

Reduces stress-related high blood pressure and improves heart rate variability, supporting long-term cardiovascular resilience.

Efficacy: Medium  |  Grade: A

Regular Dental Cleanings

Prophylaxis, Oral Hygiene Visits, Professional Teeth Cleaning

Reduces systemic inflammation from the gums, a known contributor to arterial and cardiovascular disease.

Efficacy: Medium  |  Grade: A

Relaxation

Meditation, Mindfulness, Yoga, Tai Chi, Deep Breathing, Progressive Muscle Relaxation

Helps lower blood pressure and heart rate, reducing strain on the cardiovascular system over time.

Efficacy: Medium  |  Grade: B

Cold Exposure

Cold Therapy, Cold Water Immersion, Cryotherapy, Ice Bath

Activates brown fat to enhance metabolic rate and may improve insulin sensitivity and circulatory health.

Efficacy: Medium  |  Grade: B

Sexual Activity

Sex, Intercourse, Orgasm

Acts as a form of moderate exercise, supporting cardiovascular health and improving blood flow.

Efficacy: Medium  |  Grade: B

Water Flossing

Oral Irrigator, Water Pik

Reduces gum inflammation, which helps lower the systemic inflammatory burden linked to cardiovascular disease.

Efficacy: Low  |  Grade: B

EFT Tapping

Emotional Freedom Techniques, Tapping

By lowering the physiological stress response, it can contribute to healthier blood pressure and heart rate variability.

Efficacy: Medium  |  Grade: C

Travel

Vacation, Exploration, Novelty Seeking

Increased physical activity from exploring new places can support cardiovascular fitness and overall metabolic health.

Efficacy: Low  |  Grade: C

Mouth Taping

Oral Taping, Sleep Taping

Encourages nasal breathing, increasing nitric oxide uptake to support circulation and efficient oxygen delivery.

Efficacy: Low  |  Grade: C

Temperature Regulating Mattresses

Cooling Mattresses, Smart Beds, Climate Control Sleep Systems

Supports metabolic efficiency and cardiovascular recovery overnight by contributing to higher quality, uninterrupted sleep.

Efficacy: Low  |  Grade: C

Weighted Blankets (Topical)

sensory blankets, gravity blankets

Helps lower heart rate through deep pressure stimulation, supporting a calmer cardiovascular state.

Exercise & Sports

Efficacy: High  |  Grade: A

Australian Rules Football

Aussie Rules, Footy

Improves cardiorespiratory fitness and metabolic efficiency through high-intensity, intermittent running and sprinting.

Efficacy: High  |  Grade: A

Badminton

The fast-paced, interval-like nature of the game significantly boosts cardiorespiratory fitness and improves metabolic health.

Efficacy: High  |  Grade: A

Basketball

Hoops

Boosts cardiorespiratory fitness and metabolic efficiency through its dynamic, high-intensity interval nature.

Efficacy: High  |  Grade: A

Bicycling

Cycling

Strengthens the heart, improves circulation, and enhances cellular energy production for robust cardiovascular fitness.

Efficacy: High  |  Grade: A

BMX

Bicycle Motocross, BMX Racing, Freestyle BMX

Boosts cardiorespiratory fitness and metabolic efficiency through high-intensity, full-body engagement.

Efficacy: High  |  Grade: A

Bodyboarding

Boogie boarding

Provides an intense cardiovascular workout through paddling and kicking, significantly improving heart health and aerobic capacity.

Efficacy: High  |  Grade: A

Boxing

Pugilism, Sweet Science

Boxing provides intense cardiovascular conditioning, improving heart efficiency, metabolic function, and overall endurance.

Efficacy: High  |  Grade: A

Calisthenics

Bodyweight Training, Bodyweight Exercise

Boosts cardiovascular fitness and metabolic efficiency by building functional muscle and improving heart health.

Efficacy: High  |  Grade: A

Canoeing

Kayaking, Paddling

Builds cardiovascular endurance and strengthens the heart, improving metabolic efficiency and overall stamina.

Efficacy: High  |  Grade: A

Cross-Country Skiing

Nordic Skiing, XC Skiing

Dramatically boosts cardiorespiratory fitness (VO2 max) and metabolic efficiency by engaging the entire body.

Efficacy: High  |  Grade: A

Daily Brisk Walking

Brisk Walking, Regular Walking, Moderate-intensity Walking

Strengthens the heart, improves circulation, and enhances metabolic efficiency for sustained daily energy.

Efficacy: High  |  Grade: A

Dodgeball

The fast-paced, stop-and-go nature of the game improves cardiovascular fitness and metabolic efficiency.

Efficacy: High  |  Grade: A

Endurance Training

Aerobic Exercise, Cardio

Boosts cardiorespiratory fitness (VO2 max), enhances metabolic efficiency, and supports long-term arterial health.

Efficacy: High  |  Grade: A

Exercise Snack

Movement Snack, Micro-workouts

Brief, frequent bursts of activity improve blood sugar control and boost cardiorespiratory fitness over time.

Efficacy: High  |  Grade: A

Flag Football

Non-contact Football

Improves cardiorespiratory fitness and metabolic health through intense, interval-based running and sprinting.

Efficacy: High  |  Grade: A

Gymnastics

Artistic Gymnastics, Rhythmic Gymnastics, Calisthenics, Gymnastic Strength Training

Builds exceptional cardiorespiratory fitness and metabolic efficiency through its high-intensity, full-body movements.

Efficacy: High  |  Grade: A

High-Intensity Interval Training

HIIT, Sprint Interval Training

Dramatically improves cardiorespiratory fitness (VO2 max) and enhances cellular energy production within mitochondria.

Efficacy: High  |  Grade: A

Hiking

Trekking, Rucking, Hillwalking

Enhances cardiorespiratory fitness and metabolic efficiency, supporting long-term heart and arterial health.

Efficacy: High  |  Grade: A

High-Intensity Resistance Training (HIRT)

HIRT, Heavy Duty Training, HDT

Boosts metabolic efficiency and cardiovascular fitness through time-efficient, high-effort strength workouts.

Efficacy: High  |  Grade: A

Ice Hockey

Hockey

Improves cardiorespiratory fitness and metabolic efficiency through its high-intensity, interval-based nature.

Efficacy: High  |  Grade: A

Ice Skating

Figure Skating, Speed Skating, Ice Hockey

Builds cardiovascular endurance and improves metabolic efficiency by challenging the heart and circulatory system.

Efficacy: High  |  Grade: A

Indoor Cycling

Stationary Biking, Spinning

Significantly boosts cardiorespiratory fitness, enhances metabolic efficiency, and supports long-term heart and arterial health.

Efficacy: High  |  Grade: A

Isometrics

Isometric Exercise, Static Strength Training

Effectively lowers resting blood pressure and improves arterial health by enhancing blood vessel function.

Efficacy: High  |  Grade: A

Jogging

Running, Aerobic Exercise

Strengthens the heart, improves blood circulation, and boosts cellular energy production for sustained vitality.

Efficacy: High  |  Grade: A

Jump Rope

Skipping Rope, Rope Jumping

Dramatically improves cardiorespiratory fitness (VO2 max) and metabolic efficiency for sustained energy and a healthy heart.

Efficacy: High  |  Grade: A

Kayaking

Paddling, Canoeing

Strengthens the heart and improves cardiorespiratory fitness, enhancing overall metabolic efficiency and endurance.

Efficacy: High  |  Grade: A

Kettlebell Training

KB Training, Girevoy Sport

Boosts cardiorespiratory fitness and metabolic efficiency through dynamic, full-body movements.

Efficacy: High  |  Grade: A

Kickball

Soccer Baseball, Football Rounders

Improves cardiovascular fitness and metabolic efficiency through running, sprinting, and active play.

Efficacy: High  |  Grade: A

Kite Surfing

Kitesurfing, Kiteboarding

Offers a high-intensity cardiovascular workout that significantly improves heart strength, metabolic rate, and cardiorespiratory fitness.

Efficacy: High  |  Grade: A

Marathon Training

Long-Distance Running, Endurance Running Training

Dramatically improves cardiorespiratory fitness, metabolic efficiency, and long-term heart and arterial health.

Efficacy: High  |  Grade: A

Martial Arts

Tai Chi, Judo, Karate, Brazilian Jiu-Jitsu, Kung Fu

Improves cardiovascular fitness and metabolic health through a dynamic combination of aerobic and anaerobic activity.

Efficacy: High  |  Grade: A

Mixed Martial Arts

MMA

Dramatically improves cardiorespiratory fitness and metabolic efficiency through high-intensity, full-body conditioning.

Efficacy: High  |  Grade: A

Mountain Biking

MTB, Off-road Cycling

Dramatically improves cardiorespiratory fitness and metabolic health through its high-intensity, interval-like nature.

Efficacy: High  |  Grade: A

Mountaineering

Alpinism, Mountain Climbing

Builds elite cardiorespiratory fitness and metabolic efficiency through intense, high-altitude endurance training.

Efficacy: High  |  Grade: A

Muay Thai

Thai Boxing, The Art of Eight Limbs

Dramatically improves cardiorespiratory fitness and metabolic efficiency through high-intensity, full-body conditioning.

Efficacy: High  |  Grade: A

Netball

The fast-paced, intermittent nature of the game significantly boosts cardiorespiratory fitness and metabolic health.

Efficacy: High  |  Grade: A

Nordic Walking

Pole Walking, Exerstriding

Engages the whole body to significantly boost cardiovascular fitness, metabolic health, and overall energy levels.

Efficacy: High  |  Grade: A

Padel

Padel tennis

Improves cardiorespiratory fitness and metabolic health through its high-intensity, interval-based nature, supporting heart function.

Efficacy: High  |  Grade: A

Pickleball

Improves cardiovascular fitness and metabolic health through sustained, moderate-intensity aerobic activity.

Efficacy: High  |  Grade: A

Plyometrics

Jump Training, Plyos, Reactive Strength Training

Improves cardiorespiratory fitness and metabolic efficiency by challenging the heart with high-intensity, explosive movements.

Efficacy: High  |  Grade: A

Race Walking

Power Walking

Significantly boosts cardiorespiratory fitness (VO2 max), improves metabolic efficiency, and supports overall cardiovascular health.

Efficacy: High  |  Grade: A

Rebounding

Mini-trampoline exercise, Cellercising

Effectively boosts cardiorespiratory fitness and oxygen uptake, supporting efficient cellular energy and heart health.

Efficacy: High  |  Grade: A

Regular Aerobic Exercise

Cardio, Endurance Training, Aerobics

Boosts cardiorespiratory fitness (VO2 max), enhances metabolic efficiency, and supports long-term arterial health.

Efficacy: High  |  Grade: A

Resistance Training

Strength Training, Weightlifting

Improves metabolic efficiency by enhancing insulin sensitivity and supports healthy blood pressure and lipid profiles.

Efficacy: High  |  Grade: A

Road Cycling

Cycling, Bicycling

Dramatically improves cardiovascular fitness, heart efficiency, and metabolic health for enhanced endurance and cellular energy.

Efficacy: High  |  Grade: A

Rowing

Ergometer, Crew, Sculling

Rowing significantly boosts cardiorespiratory fitness (VO2 max) and enhances metabolic efficiency for sustained energy production.

Efficacy: High  |  Grade: A

Rucking

Weighted Walking, Backpack Training

Builds cardiovascular endurance and improves heart efficiency by adding a load to steady-state walking.

Efficacy: High  |  Grade: A

Rugby

Rugby Union, Rugby League

The mix of sprinting and sustained running provides elite-level conditioning for cardiorespiratory fitness and metabolic health.

Efficacy: High  |  Grade: A

Skiing

Downhill Skiing, Alpine Skiing, Cross-Country Skiing, Nordic Skiing

Provides an excellent cardiovascular workout, improving heart efficiency, endurance, and overall metabolic health.

Efficacy: High  |  Grade: A

Snowboarding

Snowboard

Improves cardiovascular fitness and metabolic efficiency through sustained, variable-intensity exertion at altitude.

Efficacy: High  |  Grade: A

Snowshoeing

Winter hiking, Snow-shoeing

Boosts cardiovascular fitness and metabolic efficiency by providing a challenging, low-impact aerobic workout in a cold environment.

Efficacy: High  |  Grade: A

Soccer (Football)

Football

Improves cardiovascular fitness, lowers blood pressure, and enhances metabolic health through its mix of running and sprinting.

Efficacy: High  |  Grade: A

Sprinting

High-Intensity Interval Training (HIIT), Sprint Interval Training (SIT)

Dramatically improves cardiorespiratory fitness (VO2 max) and enhances cellular energy production within mitochondria.

Efficacy: High  |  Grade: A

Stand-Up Paddleboarding

SUP, Paddleboarding

Provides a robust cardiovascular workout, improving heart health, endurance, and overall metabolic efficiency.

Efficacy: High  |  Grade: A

Structured Interval Training

HIIT, High-Intensity Interval Training, SIT

Dramatically improves cardiorespiratory fitness (VO2 max) and enhances cellular energy production for better metabolic health.

Efficacy: High  |  Grade: A

Surfing

Wave riding

Builds exceptional cardiovascular fitness and endurance through a dynamic mix of paddling and wave riding.

Efficacy: High  |  Grade: A

Swimming

Aquatic Exercise

Swimming strengthens the heart, improves circulation, and boosts aerobic capacity for sustained energy.

Efficacy: High  |  Grade: A

Tennis

Racket Sports

Enhances cardiorespiratory fitness and metabolic efficiency through its high-intensity, interval-based nature.

Efficacy: High  |  Grade: A

Track and Field

Athletics

Dramatically improves cardiorespiratory fitness, metabolic efficiency, and overall heart health through varied intensity training.

Efficacy: High  |  Grade: A

Trail Running

Off-road running, Mountain running

Significantly boosts cardiorespiratory fitness and metabolic efficiency by challenging the heart and lungs on varied terrain.

Efficacy: High  |  Grade: A

Ultimate Frisbee

Ultimate

The mix of sprinting and jogging provides high-intensity interval training, boosting VO2 max and cardiovascular health.

Efficacy: High  |  Grade: A

Volleyball

Beach Volleyball

Improves cardiorespiratory fitness and metabolic health through intense, intermittent bursts of activity.

Efficacy: High  |  Grade: A

Walking Golf

Golf (walking), Carry golf

Provides sustained, moderate-intensity aerobic exercise which improves heart health, circulation, and metabolic fitness.

Efficacy: High  |  Grade: A

Water Polo

Polo

Dramatically improves cardiorespiratory fitness and metabolic efficiency through high-intensity, full-body aquatic exercise.

Efficacy: High  |  Grade: A

Weight-Bearing Exercise

Resistance Training, Strength Training, Impact Exercise

Strengthens the heart, improves metabolic efficiency, and enhances cardiorespiratory fitness for sustained energy.

Efficacy: High  |  Grade: A

Weighted Vest Walking

Rucking, Loaded Carries

Increases cardiovascular demand and metabolic rate, improving heart efficiency and overall cardiorespiratory fitness.

Efficacy: High  |  Grade: A

Zone 2 Cardio Training

Aerobic Base Training, Low-Intensity Steady-State (LISS) Cardio

Builds a strong aerobic base by improving mitochondrial function, heart efficiency, and metabolic flexibility.

Efficacy: High  |  Grade: A

Zone 2 Exercise

Aerobic Base Training, Endurance Training, Low-Intensity Steady-State (LISS) Cardio, LISS

Improves mitochondrial efficiency for cellular energy, enhancing heart function and overall cardiorespiratory fitness.

Efficacy: Medium  |  Grade: A

Blood Flow Restriction Training

Kaatsu Training, Occlusion Training

Enhances blood vessel function and can improve cardiorespiratory fitness even with low-intensity aerobic exercise.

Efficacy: High  |  Grade: B

Brazilian Jiu-Jitsu

BJJ

Improves cardiorespiratory fitness and metabolic efficiency through intense, interval-based sparring sessions.

Efficacy: High  |  Grade: B

Parkour

Freerunning, Art du Déplacement

Builds exceptional cardiorespiratory fitness and metabolic efficiency through dynamic, full-body, high-intensity movements.

Efficacy: Medium  |  Grade: A

Qigong

Chi Kung, Chi Gung

Qigong can lower blood pressure and improve heart function through gentle, mindful movements and controlled breathing.

Efficacy: High  |  Grade: B

Skateboarding

Skating, Street Skating, Vert Skating

Provides a vigorous cardiovascular workout that improves endurance, heart health, and metabolic efficiency.

Efficacy: Medium  |  Grade: A

Softball

Slow-pitch Softball, Fast-pitch Softball

Improves cardiovascular fitness and metabolic health through short bursts of running, throwing, and swinging.

Efficacy: Medium  |  Grade: A

Table Tennis

Ping-Pong

Enhances cardiorespiratory fitness and metabolic efficiency through its fast-paced, aerobic nature.

Efficacy: Medium  |  Grade: A

Tai Chi

Taijiquan

Improves cardiovascular efficiency and metabolic health through low-impact movement, supporting healthy blood pressure levels.

Efficacy: Medium  |  Grade: A

Treadmill Desk Walking

Walking Desk, Under-Desk Treadmill

Combats sedentarism by improving blood sugar control, blood pressure, and daily energy expenditure.

Efficacy: High  |  Grade: B

Wakeboarding

Waterskiing

Provides a high-intensity cardiovascular workout that improves heart function, circulation, and overall metabolic health.

Efficacy: Medium  |  Grade: A

Yoga

Hatha Yoga, Vinyasa Yoga, Ashtanga Yoga, Pranayama

Yoga improves cardiovascular health by lowering blood pressure and enhancing metabolic efficiency for sustained energy.

Efficacy: Medium  |  Grade: B

Baseball

Softball, America's Pastime

Intermittent sprinting and fielding improves cardiorespiratory fitness and supports overall metabolic health.

Efficacy: Medium  |  Grade: B

Bouldering / Rock Climbing

Climbing

Challenges the cardiovascular system in short, intense bursts, improving overall metabolic health and endurance.

Efficacy: Medium  |  Grade: B

Disc Golf

Frisbee Golf, Frolf

Provides sustained, low-impact cardiovascular exercise by walking the course, supporting heart health and metabolic efficiency.

Efficacy: Medium  |  Grade: B

Downhill Skiing

Alpine Skiing

Improves cardiovascular fitness and metabolic efficiency through intermittent, high-intensity exertion in a cold environment.

Efficacy: Medium  |  Grade: B

Rock Climbing

Bouldering, Sport Climbing, Trad Climbing

Improves cardiovascular fitness and metabolic efficiency through sustained, interval-like exertion during climbing sessions.

Efficacy: Medium  |  Grade: B

Squash

Racquetball, Racket Sports

Supports healthy blood pressure and arterial function with its rich potassium and antioxidant content.

Efficacy: Medium  |  Grade: C

Animal Flow

Quadrupedal Movement Training, Ground-Based Movement

Improves cardiovascular conditioning and metabolic efficiency through dynamic, full-body, ground-based movement sequences.

Efficacy: Low  |  Grade: B

Flexibility Training / Stretching

Stretching, Mobility Work, Range of Motion Training

Certain practices like yoga can help lower resting heart rate and blood pressure, supporting overall cardiovascular health.

Efficacy: Medium  |  Grade: C

Hackeysack

Footbag

Improves cardiorespiratory fitness and metabolic health through sustained, moderate-intensity aerobic activity.

Efficacy: Low  |  Grade: B

Pilates

Contrology

Improves muscular endurance and circulation, contributing to better overall metabolic efficiency and heart health.

Efficacy: Low  |  Grade: C

Cricket

Supplies significant amounts of iron and vitamin B12, which are essential for energy production and oxygen transport.

Devices

Efficacy: High  |  Grade: A

At-Home Blood Pressure Monitor

Home BP Monitor, Sphygmomanometer

Empowers proactive management of blood pressure, a key factor for maintaining long-term arterial and heart health.

Efficacy: High  |  Grade: A

At-Home Metabolic Analyzer

Breathalyzer for Metabolism, Respiratory Exchange Ratio (RER) Device, Metabolic Breath Tester

Reveals if you're burning fats or carbs, helping personalize nutrition and exercise for better metabolic efficiency.

Efficacy: High  |  Grade: A

Continuous Ambulatory ECG (Topical)

Holter Monitor, Ambulatory ECG Monitoring, AECG

Detects hidden heart rhythm and blood flow issues, enabling early intervention to maintain long-term cardiovascular health.

Efficacy: High  |  Grade: A

Continuous Glucose Monitor (CGM)

CGM, Continuous Glucose Monitoring

Provides real-time feedback to stabilize blood sugar, which supports metabolic efficiency and protects arterial health.

Efficacy: High  |  Grade: A

Continuous Ketone Monitor

CKM

Provides real-time data to optimize metabolic flexibility, supporting stable energy and cardiovascular health markers.

Efficacy: High  |  Grade: A

HRV and Recovery Tracker

Wearable Recovery Monitor, HRV Biofeedback Device

Guides training intensity based on physiological readiness, optimizing cardiovascular fitness and preventing overtraining.

Efficacy: Medium  |  Grade: A

Continuous Pulse Oximeter (Topical)

Wearable SpO2 Monitor, Continuous Oxygen Saturation Monitor

Provides data on heart rate and oxygen levels, helping to optimize cardiorespiratory fitness and recovery.

Efficacy: High  |  Grade: B

Thyroid Red Light Therapy (Topical)

Thyroid Photobiomodulation, Thyroid PBM, Low-Level Laser Therapy for Thyroid

Improves thyroid hormone production, which is critical for regulating metabolic rate and maintaining energy levels.

Efficacy: Medium  |  Grade: B

Bioelectrical Impedance Scale

BIA Scale, Smart Scale, Body Composition Scale

Tracks body composition metrics like visceral fat, motivating lifestyle changes for better metabolic and cardiovascular health.

Efficacy: Medium  |  Grade: B

Gait and Balance Accelerometer

Wearable Gait Sensor, Inertial Measurement Unit (IMU) for Balance

Encourages safer, more consistent physical activity, which in turn supports overall cardiovascular health and metabolic function.

Efficacy: Medium  |  Grade: B

Sleep Staging Tracker

EEG Sleep Tracker, Polysomnography (PSG) At-Home, Sleep Stage Monitor

Helps optimize sleep patterns to support overnight cardiovascular recovery and improve metabolic health.

Efficacy: Medium  |  Grade: B

Vagus Nerve Stimulation

transcutaneous Vagus Nerve Stimulation, tVNS, auricular Vagus Nerve Stimulation, taVNS

Improves heart rate variability and reduces inflammation, supporting overall cardiovascular health and resilience.

Procedures

Efficacy: High  |  Grade: A

Sauna Therapy

Heat Therapy, Hyperthermic Conditioning, Sauna Bathing

Improves cardiovascular function, lowers blood pressure, and enhances blood flow, with effects similar to moderate exercise.

Efficacy: Medium  |  Grade: A

Biofeedback Therapy

Neurofeedback, EMG Biofeedback, Thermal Biofeedback, HRV Biofeedback

Helps regulate blood pressure and improve heart rate variability, supporting overall cardiovascular health and efficiency.

Efficacy: Medium  |  Grade: A

Cognitive Behavioral Therapy

CBT

Reduces stress-related physiological strain on the heart and vascular system, supporting long-term cardiovascular health.

Efficacy: Medium  |  Grade: A

Hyperbaric Oxygen Therapy

HBOT

Enhances oxygen delivery to tissues, supporting heart function and improving cellular energy production.

Efficacy: High  |  Grade: B

SIRT6 Gene Therapy

SIRT6 Overexpression Therapy

Improves metabolic efficiency, glucose control, and protects the heart and blood vessels from age-related dysfunction.

Efficacy: Medium  |  Grade: B

Blood Donation (Therapeutic Phlebotomy)

Phlebotomy, Venesection

Regular donation helps manage iron levels, which can reduce oxidative stress and support healthy blood vessel function.

Efficacy: Medium  |  Grade: B

Exosome Therapy

Extracellular Vesicle (EV) Therapy

Supports cardiac tissue repair and reduces inflammation, potentially improving long-term heart function.

Efficacy: Medium  |  Grade: B

Fecal Microbiota Transplant

FMT, Stool Transplant, Bacteriotherapy

May improve metabolic efficiency and insulin sensitivity by altering gut microbe composition and their byproducts.

Efficacy: Medium  |  Grade: B

Floatation Therapy

Float Tank, Sensory Deprivation Tank, REST, Restricted Environmental Stimulation Therapy

Reduces stress-induced high blood pressure and heart rate, promoting cardiovascular relaxation and long-term heart health.

Efficacy: Medium  |  Grade: B

Follistatin Gene Therapy

FST Gene Therapy

Enhances muscle mass, which improves metabolic efficiency and glucose utilization, supporting overall energy levels.

Efficacy: Medium  |  Grade: B

Infrared Light Therapy

Red Light Therapy, RLT, Photobiomodulation, PBM, Low-Level Laser Therapy, LLLT

Boosts cellular energy production within mitochondria and supports healthy circulation by promoting nitric oxide release.

Efficacy: Medium  |  Grade: B

LED Red Light Therapy

Photobiomodulation, PBM, Low-Level Laser Therapy, LLLT

Enhances cellular energy production and supports muscle performance and post-exercise recovery.

Efficacy: Medium  |  Grade: B

Mesenchymal Stem Cell (MSC) Therapy

MSCs, Mesenchymal Stromal Cells, Stem Cell Therapy

Supports cardiovascular repair and reduces inflammation, potentially improving heart function and blood vessel health.

Efficacy: Medium  |  Grade: B

Muse Cell Therapy

Multilineage-differentiating Stress Enduring cells

Supports cardiovascular repair by homing to damaged areas, potentially improving heart function and reducing inflammation.

Efficacy: Medium  |  Grade: B

White Noise / Sound Therapy

Pink Noise, Brown Noise, Acoustic Stimulation, Sound Masking

Helps regulate heart rate and blood pressure by calming the nervous system and reducing stress.

Efficacy: Medium  |  Grade: B

Therapeutic Plasma Exchange (TPE)

Plasmapheresis, Plasma Exchange, Plasma Dilution

May improve arterial health by removing inflammatory factors and certain harmful lipids from the blood.

Efficacy: Low  |  Grade: B

Acupuncture

Traditional Chinese Medicine (TCM) Needling

May help regulate blood pressure and improve local circulation by influencing the autonomic nervous system.

Efficacy: Low  |  Grade: B

Light Therapy Glasses

Light Visor, Wearable Light Therapy, SAD Glasses

Can boost daytime energy levels and alertness by helping to regulate the body's internal clock.

Efficacy: Low  |  Grade: B

Vibration Therapy

Whole Body Vibration, WBV

Supports improved circulation and may enhance the flexibility of blood vessels.

Protocols

Synergistic Therapy

Efficacy: High  |  Grade: A

B-Complex Vitamins

B Vitamins, Vitamin B Complex

B-vitamins are essential for converting food into cellular energy and help maintain healthy homocysteine levels.

Efficacy: High  |  Grade: A

Liposomal Vitamin D3/K2

Liposomal D3/K2, Vitamin D3 + K2 (Liposomal)

Directs calcium away from arteries, supporting cardiovascular flexibility and long-term heart health.

Efficacy: High  |  Grade: A

Vitamin D3 and K2 with Calcium

Vitamin D3, Vitamin K2, and Calcium

Promotes cardiovascular health by directing calcium to bones, helping to maintain flexible and clear arteries.

Efficacy: High  |  Grade: A

Myo-Inositol and D-Chiro-Inositol

MI/DCI, Inositol combination

Enhances insulin sensitivity, promoting stable blood sugar levels and supporting healthy metabolic function.

Efficacy: Medium  |  Grade: A

Caffeine and L-Theanine

Caffeine Theanine Stack, Smart Caffeine

Improves physical performance and subjective energy levels, with L-theanine mitigating caffeine-induced jitters.

Efficacy: High  |  Grade: B

Dasatinib and Quercetin

D+Q, Senolytics

Helps clear aged cells from blood vessels, supporting flexible arteries and healthy cardiovascular function.

Efficacy: High  |  Grade: B

GlyNAC

Glycine + N-Acetylcysteine, Glycine and NAC

Restores cellular antioxidant levels, supporting mitochondrial energy production and healthy cardiovascular function.

Efficacy: Medium  |  Grade: B

Curcumin and Piperine

Turmeric and Black Pepper Extract, Bioavailable Curcumin

Supports healthy blood vessel function and helps maintain balanced cholesterol levels.

Efficacy: Low  |  Grade: B

Glucosamine and Chondroitin

Glucosamine Sulfate, Chondroitin Sulfate

May support cardiovascular health by reducing systemic inflammation, a factor linked to arterial well-being.