Gut & Immunity394

Microbiome diversity, gut-lining integrity, and immune system modulation.

Supplements

Efficacy: High  |  Grade: A

Akkermansia Muciniphila

A. muciniphila, Akkermansia

Strengthens the gut lining and supports a balanced immune response by reinforcing the intestinal mucus layer.

Efficacy: High  |  Grade: A

Boswellia Serrata

Indian Frankincense, Salai Guggal

Soothes the gut lining and helps modulate the immune system, particularly in inflammatory conditions.

Efficacy: High  |  Grade: A

Butyrate Supplements

Sodium Butyrate, Calcium Butyrate, Magnesium Butyrate, Tributyrin, Butyric Acid

Nourishes colon cells to strengthen the gut lining and supports a balanced immune response.

Efficacy: High  |  Grade: A

Butyrate

Sodium Butyrate, Butanoic Acid

Nourishes colon cells, strengthens the gut lining, and helps modulate the immune system for balanced function.

Efficacy: High  |  Grade: A

Digestive Enzymes

Pancreatic Enzymes, Protease, Amylase, Lipase, Betaine HCl

Promotes complete food breakdown, reducing bloating and supporting a healthy gut lining and microbiome balance.

Efficacy: High  |  Grade: A

Ginger

Zingiber officinale

Promotes digestive comfort and motility, soothes the gut lining, and supports a healthy immune response.

Efficacy: High  |  Grade: A

L-Glutamine

Glutamine

Provides essential fuel for gut lining cells, supporting intestinal integrity and immune system function.

Efficacy: High  |  Grade: A

Medicinal Mushrooms (Beta-Glucans)

Beta-Glucans, Mushroom Polysaccharides

Modulates the immune system for a balanced response and acts as a prebiotic to nourish beneficial gut bacteria.

Efficacy: High  |  Grade: A

Milk Thistle (Silymarin)

Silybum marianum, Silymarin, Silibinin

Strongly supports liver health and detoxification, which is essential for processing nutrients and maintaining immune balance.

Efficacy: High  |  Grade: A

Peppermint Oil

Mentha piperita oil

Relaxes intestinal muscles to effectively soothe digestive discomfort, bloating, and symptoms associated with IBS.

Efficacy: High  |  Grade: A

Partially Hydrolyzed Guar Gum

PHGG, Sunfiber

Nourishes beneficial gut bacteria, supporting a diverse microbiome and strengthening the protective gut lining.

Efficacy: High  |  Grade: A

Piperine

Black Pepper Extract, Bioperine

Significantly enhances the absorption of nutrients and beneficial compounds from food and supplements, supporting overall gut function.

Efficacy: High  |  Grade: A

Postbiotic Supplements

Postbiotics, Metabolite Supplements, Paraprobiotics

Postbiotics directly nourish gut lining cells, strengthen the intestinal barrier, and help balance the immune system.

Efficacy: High  |  Grade: A

Prebiotic Supplements

Prebiotics, Fermentable Fiber, Inulin, FOS, GOS

Directly nourishes beneficial gut bacteria, strengthening the gut lining and supporting a balanced immune system.

Efficacy: High  |  Grade: A

Probiotics

Beneficial Bacteria, Live Cultures

Directly enhances gut microbiome diversity, strengthens the gut lining, and helps regulate immune system responses.

Efficacy: High  |  Grade: A

Psyllium Husk

Ispaghula

Acts as a prebiotic to nourish beneficial gut bacteria and promotes regularity, supporting a healthy microbiome.

Efficacy: High  |  Grade: A

Liposomal Quercetin

Liposome-encapsulated quercetin

Modulates the immune system and supports gut barrier function, helping to maintain a balanced immune response.

Efficacy: High  |  Grade: A

Quercetin

Quercetin Dihydrate, Sophoretin

Helps regulate the immune system, stabilizes mast cells for seasonal allergy relief, and supports gut health.

Efficacy: High  |  Grade: A

Saccharomyces boulardii

S. boulardii, Florastor

Supports a balanced gut microbiome and strengthens the intestinal lining, enhancing overall immune function.

Efficacy: High  |  Grade: A

Selenium

Selenomethionine, Selenocysteine, Sodium Selenite

Essential for a robust immune response and helps regulate inflammation throughout the body and gut.

Efficacy: High  |  Grade: A

Sustained Release Vitamin C

Time-Release Vitamin C, Extended-Release Ascorbic Acid

Enhances immune cell function and antioxidant defenses, helping to maintain resilience against common illnesses.

Efficacy: High  |  Grade: A

Thymosin Alpha-1

Zadaxin, Thymalfasin, TA1

Enhances immune system readiness and balance by promoting the maturation and function of key immune cells.

Efficacy: High  |  Grade: A

Vitamin A

Retinol, Retinal, Retinoic Acid, Carotenoids

Crucial for maintaining a healthy gut lining and supports the proper development and function of immune cells.

Efficacy: High  |  Grade: A

Liposomal Vitamin C

Liposomal Ascorbic Acid, L-Ascorbic Acid (Liposomal)

Enhances the function of various immune cells and strengthens the body's natural defense systems.

Efficacy: High  |  Grade: A

Zinc Gluconate

Zincum Gluconicum

Crucial for immune cell function and helps maintain a strong, healthy gut-lining integrity.

Efficacy: High  |  Grade: A

Zinc Picolinate

Zinc (Picolinate)

Critically supports immune cell function for a robust defense and helps maintain gut lining integrity.

Efficacy: High  |  Grade: A

Zinc

Zinc Picolinate, Zinc Gluconate, Zinc Citrate, Zinc Orotate

Crucial for developing and activating immune cells, and helps maintain the integrity of the gut lining.

Efficacy: High  |  Grade: B

Astragalus

Huang Qi, Milk-vetch root

Supports a balanced immune system response and enhances the activity of key protective immune cells.

Efficacy: Medium  |  Grade: A

Boswellia

Indian Frankincense, Boswellia serrata

Soothes the gut lining and modulates the immune response, helping to manage inflammatory bowel conditions.

Efficacy: High  |  Grade: B

BPC-157

Body Protection Compound 157, Bepecin

Promotes the integrity of the gut lining and helps repair damage from inflammation or ulcers.

Efficacy: Medium  |  Grade: A

D-Mannose

Mannose

Helps prevent certain harmful bacteria from adhering to the urinary tract lining, supporting immune system defense.

Efficacy: High  |  Grade: B

Glutathione

L-Glutathione, GSH, Liposomal GSH

Plays a crucial role in immune cell function, helping to balance immune responses and protect gut lining.

Efficacy: Medium  |  Grade: A

Iron Sulfate

Ferrous Sulfate

Crucial for the proper development and function of immune cells, supporting a robust immune response.

Efficacy: Medium  |  Grade: A

L-Lysine

Lysine

Helps the immune system manage certain viral infections, particularly the herpes simplex virus.

Efficacy: Medium  |  Grade: A

Low-Dose Aspirin

Baby Aspirin, Acetylsalicylic Acid (low dose)

Modulates inflammatory pathways, which has been shown to significantly reduce the risk of developing certain cancers.

Efficacy: High  |  Grade: B

Low Dose Naltrexone (LDN)

LDN

Modulates the immune system and reduces inflammation, showing promise for improving gut lining integrity in autoimmune conditions.

Efficacy: High  |  Grade: B

Mastic Gum

Chios Mastic, Pistacia lentiscus

Promotes a healthy gut environment by balancing microbes and soothing the digestive tract lining.

Efficacy: Medium  |  Grade: A

Multivitamin (Men)

Men's Multi, MVM

Supplies essential vitamins and minerals like Zinc, Vitamin C, and D that are foundational for immune health.

Efficacy: Medium  |  Grade: A

Multivitamin (Women)

Women's Multi, MVM for Women

Supports a healthy immune system by providing essential vitamins and minerals like Zinc, Vitamin C, and D.

Efficacy: Medium  |  Grade: A

Panax Ginseng

Asian Ginseng, Korean Ginseng, Ren Shen

Strengthens the immune system's ability to respond effectively, potentially reducing the frequency of common illnesses.

Efficacy: Medium  |  Grade: A

SAM-e

S-adenosylmethionine, Ademetionine

Supports liver health and detoxification by increasing levels of the master antioxidant glutathione.

Efficacy: Medium  |  Grade: A

Type II Collagen

Undenatured Type II Collagen, UC-II, Hydrolyzed Type II Collagen

Helps regulate the immune response to protect joint cartilage from degradation and inflammation.

Efficacy: Medium  |  Grade: A

Vitamin B6

Pyridoxine, Pyridoxal 5'-Phosphate, P-5-P

Is essential for a robust immune response, supporting the production and activity of immune cells.

Efficacy: Medium  |  Grade: B

17-Alpha-Estradiol

17α-estradiol, alfatradiol

Helps to lower the chronic, low-grade inflammation associated with aging, supporting a balanced immune response.

Efficacy: Medium  |  Grade: B

3-Hydroxyanthranilic Acid

3-HAA

Acts as a signaling molecule that helps regulate immune cell activity and resolve inflammation.

Efficacy: Medium  |  Grade: B

Aged Garlic Extract

AGE, Kyolic Garlic Extract

Enhances immune cell function, which may help reduce the severity and duration of common colds.

Efficacy: Medium  |  Grade: B

Apigenin

Helps balance the immune system and calm inflammation throughout the body, including the gut.

Efficacy: Medium  |  Grade: B

B Complex Vitamins

B Vitamins, Vitamin B Complex

Essential for the production and function of immune cells, supporting a robust and effective immune system response.

Efficacy: Medium  |  Grade: B

Berberine

Berberine HCL

Modulates the gut microbiome by selectively favoring beneficial bacteria, which supports gut lining integrity and reduces inflammation.

Efficacy: Medium  |  Grade: B

Bilberry Extract

Vaccinium myrtillus extract, European Blueberry extract

Nourishes beneficial gut bacteria, which helps strengthen the gut lining and support a balanced immune response.

Efficacy: Medium  |  Grade: B

Boron

Boric Acid, Sodium Borate

Helps modulate the immune system by reducing key systemic inflammatory markers.

Efficacy: Medium  |  Grade: B

Bromelain

Pineapple Extract, Ananase

Aids in protein digestion and helps modulate the immune system, supporting a calm and healthy gut.

Efficacy: Medium  |  Grade: B

Calcium Alpha-Ketoglutarate

Ca-AKG, CaAKG

Helps modulate the immune system to combat 'inflammaging' and serves as a fuel source for gut cells.

Efficacy: Medium  |  Grade: B

Cannabis

Marijuana, THC, CBD, Cannabinoids

Helps modulate the immune system and may reduce gut inflammation, supporting a calm and healthy digestive tract.

Efficacy: Medium  |  Grade: B

Carnosine

L-carnosine, beta-alanyl-L-histidine

Helps maintain the integrity of the gut lining, with strong evidence for its zinc-chelated form.

Efficacy: Medium  |  Grade: B

Chamomile Extract

Matricaria recutita, Chamaemelum nobile, Apigenin

Soothes the digestive system and supports a balanced immune response with its anti-inflammatory properties.

Efficacy: Medium  |  Grade: B

Cinnamon Extract

Cinnamomum verum, Cinnamomum cassia, Ceylon Cinnamon, Cassia Cinnamon

Possesses anti-inflammatory and antimicrobial properties that help support a healthy gut microbiome and immune response.

Efficacy: Medium  |  Grade: B

Cocoa Flavanols

Cacao Flavanols, Flavan-3-ols

Acts as a prebiotic to support a healthy gut microbiome by selectively feeding beneficial bacteria.

Efficacy: Medium  |  Grade: B

Copper

Cupric, Copper Gluconate, Copper Bisglycinate, Copper Sulfate

Supports the development and function of key immune cells, contributing to a healthy immune response.

Efficacy: Medium  |  Grade: B

Cordyceps

Cordyceps militaris, Cordyceps sinensis, Caterpillar fungus

Helps balance the immune system by modulating key immune cells and reducing excessive inflammation.

Efficacy: Medium  |  Grade: B

Curcumin

Turmeric, Diferuloylmethane, Meriva, Longvida, BCM-95, Theracurmin

Helps balance the immune system's inflammatory response and supports a healthy gut lining and microbiome.

Efficacy: Medium  |  Grade: B

Echinacea

Purple Coneflower

Supports a responsive immune system, potentially reducing the duration and severity of upper respiratory infections.

Efficacy: Medium  |  Grade: B

Egcg

Epigallocatechin gallate, Green Tea Extract

Encourages a balanced gut microbiome and helps modulate the body's immune and inflammatory responses.

Efficacy: Medium  |  Grade: B

Elderberry

Sambucus nigra, Elder

Supports a resilient immune system and may reduce the duration and severity of common respiratory illnesses.

Efficacy: Medium  |  Grade: B

Eleuthero (Siberian Ginseng)

Siberian Ginseng, Eleutherococcus senticosus

Supports immune system function, potentially reducing the frequency and severity of common viral infections.

Efficacy: Medium  |  Grade: B

Fenugreek Extract

Trigonella foenum-graecum, Methi

Provides soluble fiber that acts as a prebiotic to nourish beneficial gut bacteria and support digestion.

Efficacy: Medium  |  Grade: B

Folate (Vitamin B9)

Folic Acid, L-Methylfolate, L-5-MTHF, Vitamin B9

Plays a fundamental role in the creation of new immune cells, supporting a robust immune response.

Efficacy: Medium  |  Grade: B

Garlic Extract

Aged Garlic Extract, Allicin supplements

Supports a balanced gut microbiome and enhances the function of key immune cells.

Efficacy: Medium  |  Grade: B

Liposomal Glutathione

L-Glutathione (Liposomal), GSH (Liposomal)

Enhances the function of key immune cells and helps protect the gut lining from damage.

Efficacy: Medium  |  Grade: B

Green-Lipped Mussel Extract

GLM, Perna canaliculus extract, Lyprinol

Helps modulate the immune system towards a less inflammatory state and may support gut lining integrity.

Efficacy: Medium  |  Grade: B

Green Tea Extract

GTE, Camellia sinensis extract, EGCG

Promotes a healthy gut microbiome by encouraging beneficial bacteria, which in turn supports a balanced immune system.

Efficacy: Medium  |  Grade: B

Holy Basil (Tulsi)

Tulsi, Ocimum tenuiflorum, Ocimum sanctum

Supports a balanced immune system response and helps protect against various environmental and microbial stressors.

Efficacy: Medium  |  Grade: B

Iron Bisglycinate

Ferrous Bisglycinate, Chelated Iron

Required for the healthy development and function of immune cells, supporting the body's natural defense systems.

Efficacy: Medium  |  Grade: B

Iron Fumarate

Ferrous Fumarate

Required for the proper development and function of immune cells, helping to maintain a robust immune response.

Efficacy: Medium  |  Grade: B

Iron Gluconate

Ferrous Gluconate

Crucial for the proper development and function of immune cells, helping to maintain a robust immune response.

Efficacy: Medium  |  Grade: B

Iron

Ferrous Sulfate, Ferrous Gluconate, Iron Bisglycinate, Ferritin

Supports robust immune cell function, while its delivery system is gentler on the gut than traditional iron.

Efficacy: Medium  |  Grade: B

Klotho

alpha-Klotho, α-Klotho

Helps modulate the immune system by reducing chronic inflammation, a key factor in age-related decline.

Efficacy: Medium  |  Grade: B

Lion's Mane Mushroom

Hericium erinaceus, Yamabushitake, Monkey Head Mushroom

Acts as a prebiotic to support a healthy gut microbiome and helps modulate the immune system.

Efficacy: Medium  |  Grade: B

Liposomal Calcium AKG

Liposomal Ca-AKG, Liposomal Alpha-Ketoglutarate Calcium Salt

Provides fuel for gut lining cells and immune cells, supporting overall gut integrity.

Efficacy: Medium  |  Grade: B

Lycopene

psi-psi-carotene

Supports immune cell function and may help modulate gut inflammation, contributing to a balanced immune response.

Efficacy: Low  |  Grade: A

Magnesium Citrate

Magnesium

Aids in maintaining regular bowel movements by drawing water into the intestines, supporting digestive comfort.

Efficacy: Medium  |  Grade: B

Liposomal Melatonin

Encapsulated Melatonin, Liposome-Entrapped Melatonin

Supports gut lining integrity and modulates local immune responses, acting as a powerful antioxidant.

Efficacy: Medium  |  Grade: B

Melatonin

SR Melatonin, Low-Dose Melatonin, Physiological-Dose Melatonin

Supports gut lining integrity and helps modulate immune function through its local antioxidant and anti-inflammatory properties.

Efficacy: Medium  |  Grade: B

Monolaurin

Glycerol Monolaurate, GML, Lauricidin

Supports a balanced gut microbiome and a healthy immune response by disrupting unwanted microbes.

Efficacy: Medium  |  Grade: B

MSM (Methylsulfonylmethane)

Dimethyl sulfone, DMSO2

Helps modulate the immune system by reducing inflammation and has been shown to alleviate seasonal allergy symptoms.

Efficacy: Medium  |  Grade: B

Omega-7 Fatty Acids

Palmitoleic Acid, C16:1n7

Helps reduce gut inflammation and supports the integrity of the intestinal lining for a healthier gut.

Efficacy: Medium  |  Grade: B

Protein Powder

Whey Protein, Casein Protein, Plant-Based Protein, Collagen Peptides

Provides key amino acids like glutamine that help maintain gut-lining integrity and fuel immune cells.

Efficacy: Medium  |  Grade: B

Pterostilbene

Dimethylresveratrol, 3,5-dimethoxy-4'-hydroxystilbene

Helps modulate the gut microbiome, supporting a healthy balance of beneficial bacteria.

Efficacy: Medium  |  Grade: B

Reishi Mushroom

Ganoderma lucidum, Lingzhi, Mushroom of Immortality

Modulates immune system activity and may support a healthy gut microbiome through its unique polysaccharides.

Efficacy: Medium  |  Grade: B

Liposomal Resveratrol

Liposomal Trans-Resveratrol

Promotes a healthy gut microbiome and helps modulate the immune system through its anti-inflammatory properties.

Efficacy: Medium  |  Grade: B

Resveratrol

trans-Resveratrol, 3,5,4'-trihydroxy-trans-stilbene

Helps modulate the gut microbiome, supporting a healthy gut lining and a balanced immune response.

Efficacy: Medium  |  Grade: B

Schisandra

Schisandra chinensis, Five-Flavor Berry, Wu Wei Zi

Promotes liver health and detoxification, which is foundational for a healthy immune response.

Efficacy: Medium  |  Grade: B

SGLT2 Inhibitors

Gliflozins

Helps calm systemic inflammation, a key factor in healthy aging, and supports a balanced immune response.

Efficacy: Medium  |  Grade: B

Spermidine

N-(3-aminopropyl)butane-1,4-diamine

Helps maintain a healthy gut lining and supports a balanced, resilient immune system response.

Efficacy: Medium  |  Grade: B

Statins

HMG-CoA reductase inhibitors

Possesses anti-inflammatory properties that help modulate the immune system and reduce systemic inflammation linked to aging.

Efficacy: Medium  |  Grade: B

Sulforaphane

SFN, Glucoraphanin, Broccoli Sprout Extract

Supports a healthy gut environment and balanced immune response by reducing inflammation and unwanted microbes.

Efficacy: Medium  |  Grade: B

Sustained Release Melatonin

Time-Release Melatonin, Extended-Release Melatonin, Prolonged-Release Melatonin

Helps regulate immune function and protects the gut lining, supporting the body's natural overnight repair processes.

Efficacy: Medium  |  Grade: B

Sustained Release Niacin

SR Niacin, Slow-Release Niacin

Helps maintain the integrity of the gut lining and supports balanced immune responses within the gut.

Efficacy: Medium  |  Grade: B

Taurine

2-aminoethanesulfonic acid, L-Taurine

Essential for fat digestion via bile salts and helps reduce inflammation to support gut and immune health.

Efficacy: Medium  |  Grade: B

TB-500

Thymosin Beta-4

Helps regulate the immune system and reduces inflammation, supporting the integrity of the gut lining.

Efficacy: Medium  |  Grade: B

Vitamin B12

Cobalamin, Methylcobalamin, Cyanocobalamin, Adenosylcobalamin, Hydroxocobalamin

Required for the production of new immune cells, supporting a healthy and responsive immune system.

Efficacy: Medium  |  Grade: B

Vitamin E

Tocopherols, Tocotrienols, Alpha-tocopherol

Supports a healthy immune system, particularly by enhancing the function of immune cells in older adults.

Efficacy: Medium  |  Grade: B

Xylitol

Birch Sugar

Acts as a prebiotic to support beneficial gut bacteria and helps inhibit the growth of certain pathogens.

Efficacy: Low  |  Grade: B

Ashwagandha

Withania somnifera, Indian ginseng, Winter cherry

Supports immune function by modulating the activity of key immune cells and reducing systemic inflammation.

Efficacy: Low  |  Grade: B

Astaxanthin

asta

Helps modulate the immune system and reduces systemic inflammation for improved overall resilience.

Efficacy: Low  |  Grade: B

Caffeine

1,3,7-trimethylxanthine, Methyltheobromine

Can positively influence gut microbiome composition, often through polyphenol-rich sources like coffee and tea.

Efficacy: Low  |  Grade: B

Liposomal Calcium AKG

Liposomal Ca-AKG, Liposomal Alpha-Ketoglutarate

Acts as a fuel source for cells in the gut lining, which supports intestinal wall integrity.

Efficacy: Low  |  Grade: B

Capsaicin

Chili Pepper Extract, 8-methyl-N-vanillyl-6-nonenamide

May support a healthy gut lining and favorably modulate the gut microbiome at low dietary doses.

Efficacy: Medium  |  Grade: C

CBD

Cannabidiol

Exerts anti-inflammatory effects that may help regulate the immune system and support a healthy gut lining.

Efficacy: Low  |  Grade: B

Chondroitin Sulfate

Chondroitin

Helps to modulate the body's inflammatory response, which is a key factor in joint health.

Efficacy: Medium  |  Grade: C

Epitalon

Epithalon, Epithalamin, Ala-Glu-Asp-Gly

Shows potential to support immune system function by helping to normalize key immune parameters with age.

Efficacy: Medium  |  Grade: C

Liposomal Fisetin

Liposomal 3,3',4',7-tetrahydroxyflavone

Helps manage inflammation and clear aged immune cells, supporting a balanced immune system response.

Efficacy: Medium  |  Grade: C

Fisetin

Smoketree extract, 3,3',4',7-tetrahydroxyflavone

Helps modulate the immune system and may reduce inflammation within the gut lining, supporting gut integrity.

Efficacy: Medium  |  Grade: C

FOXO4-DRI

FOXO4-Peptide Based Inhibitor, FOXO4-PBI

May help rejuvenate the immune system by clearing senescent immune cells and reducing chronic inflammation.

Efficacy: Low  |  Grade: B

L-Methylfolate

5-MTHF, Levomefolic acid, Metafolin, Deplin

Contributes to the production of new immune cells, a fundamental component of a healthy immune response.

Efficacy: Low  |  Grade: B

Magnesium

Magnesium Citrate, Magnesium Glycinate, Magnesium L-Threonate, Magnesium Oxide

Contributes to a balanced immune response and helps regulate systemic inflammation for overall wellness.

Efficacy: Low  |  Grade: B

Phytoestrogens: Soy Isoflavones

Isoflavones, Genistein, Daidzein, Glycitein

Interacts with the gut microbiome, which is essential for activating its beneficial compounds in the body.

Efficacy: Low  |  Grade: B

Plant Sterols/Stanols

Phytosterols, Phytostanols

May help modulate immune system activity and reduce markers of inflammation within the body.

Efficacy: Medium  |  Grade: C

Urolithin A

UA

May support a healthy gut lining and help modulate the immune system through its anti-inflammatory properties.

Efficacy: Low  |  Grade: B

Vitamin B2

Riboflavin, Vitamin G

Helps maintain the integrity of the gut lining and supports normal immune cell function.

Efficacy: Low  |  Grade: C

AICAR

Acadesine, 5-Aminoimidazole-4-carboxamide ribonucleotide

Theoretically supports gut lining integrity and helps modulate inflammation through its metabolic actions.

Efficacy: Low  |  Grade: C

Liposomal Apigenin

Bioavailable Apigenin, Apigenin Phytosome

Helps modulate the immune system and reduce inflammation, which can support a healthy gut environment.

Efficacy: Low  |  Grade: C

Bitter Melon

Momordica charantia, Bitter Gourd, Karela

Contains compounds that may help modulate immune responses and support a balanced gut environment.

Efficacy: Low  |  Grade: C

Centella Asiatica (Cica)

Cica, Gotu Kola, Brahmi, Asiatic Pennywort

May help protect the stomach lining and reduce inflammation, contributing to overall gut comfort.

Efficacy: Low  |  Grade: C

Ceramides

Phytoceramides

May support the integrity of the gut lining and help modulate the local gut immune environment.

Efficacy: Low  |  Grade: C

Cissus Quadrangularis

Veldt Grape, Devil's Backbone, Hadjod

May help protect the stomach lining and support digestive comfort.

Efficacy: Low  |  Grade: C

Coenzyme Q10

Ubiquinone, Ubidecarenone, CoQ10

Supports energy production in active immune cells and may help modulate the body's inflammatory response.

Efficacy: Low  |  Grade: C

Collagen Peptides

Hydrolyzed Collagen

Provides amino acids that are essential building blocks for maintaining a healthy gut lining.

Efficacy: Low  |  Grade: C

DHEA

Dehydroepiandrosterone

May offer modest support to the immune system by helping to balance the effects of stress hormones.

Efficacy: Low  |  Grade: C

Eggshell Membrane

NEM, Natural Eggshell Membrane

May help soothe gut inflammation and support a balanced immune response through its unique proteins.

Efficacy: Low  |  Grade: C

GABA

Gamma-Aminobutyric Acid

May support a balanced immune response and gut function through its action on the gut-brain axis.

Efficacy: Low  |  Grade: C

Glucosamine

Glucosamine Sulfate, Glucosamine Hydrochloride, N-Acetyl Glucosamine

May contribute to a healthy gut lining by providing building blocks for the protective mucosal layer.

Efficacy: Low  |  Grade: C

Glycine

2-Aminoacetic acid

Exhibits anti-inflammatory properties that may help protect the gut lining and support immune balance.

Efficacy: Low  |  Grade: C

Green Tea Oral Rinse

Catechin Mouthwash, Matcha Rinse

Supports a healthy oral microbiome, which is a key first line of defense for the immune system.

Efficacy: Low  |  Grade: C

Gymnema Sylvestre

Gurmar, Meshashringi, Australian Cowplant, Periploca of the woods

May influence the gut environment by reducing the absorption of dietary sugars from the intestine.

Efficacy: Low  |  Grade: C

Hibiscus Extract

Roselle extract, Hibiscus sabdariffa extract

Contains polyphenols that may help support a healthy gut environment and microbial balance.

Efficacy: Low  |  Grade: C

Ipamorelin

NNC 26-0161

May support digestive function by helping to regulate the natural movement and motility of the gut.

Efficacy: Low  |  Grade: C

L-Ergothioneine

Ergothioneine, ET, EGT

Helps regulate immune responses and protects immune cells from stress, contributing to a balanced immune system.

Efficacy: Low  |  Grade: C

Lemon Balm

Melissa officinalis

Soothes digestive discomfort and supports a balanced immune response through its calming and antioxidant properties.

Efficacy: Low  |  Grade: C

Microdosing Lithium

Lithium Orotate Microdose, Low-Dose Lithium

May help regulate the immune system by gently reducing pro-inflammatory signals throughout the body.

Efficacy: Low  |  Grade: C

Lithium Orotate

Microdose Lithium, Elemental Lithium

Exerts a mild anti-inflammatory effect, which may help modulate the immune system's response over time.

Efficacy: Low  |  Grade: C

Magnesium Chloride

MgCl2, Magnesium oil

Contributes to a balanced immune response and helps regulate systemic inflammation throughout the body.

Efficacy: Low  |  Grade: C

Magnesium Glycinate

Magnesium Bisglycinate

Helps modulate a healthy immune response and supports the gut lining due to its anti-inflammatory properties.

Efficacy: Low  |  Grade: C

Liposomal Magnesium

Liposome-encapsulated Magnesium

Contributes to a balanced inflammatory response and supports the fundamental function of immune cells.

Efficacy: Low  |  Grade: C

MOTS-c

Mitochondrial-derived peptide

Helps regulate inflammatory responses, which can contribute to a more balanced and effective immune system.

Efficacy: Low  |  Grade: C

NAD+ (IV Therapy)

Nicotinamide Adenine Dinucleotide IV, IV NAD+ Therapy

Contributes to the energy supply for immune cells, potentially supporting a balanced immune response.

Efficacy: Low  |  Grade: C

Psilocybin Therapy

Psychedelic-Assisted Therapy, Magic Mushrooms

May reduce stress-related inflammation and support the gut-brain axis, potentially improving immune system regulation.

Efficacy: Low  |  Grade: C

Retatrutide

LY3437943

Helps lower systemic inflammation associated with excess body fat, which supports a more balanced immune response.

Efficacy: Low  |  Grade: C

Rhodiola Rosea

Golden Root, Arctic Root, Roseroot

May help modulate the immune system's response to stress, which can indirectly support gut health.

Efficacy: Low  |  Grade: C

Semax

N-Acetyl Semax, N-Acetyl Semax Amidate

May offer minor support to the immune system through its influence on regulatory peptides.

Efficacy: Low  |  Grade: C

Tart Cherry Extract

Montmorency Cherry, Sour Cherry, Prunus cerasus

Its potent anti-inflammatory effects help to support a balanced and healthy immune response.

Efficacy: Low  |  Grade: C

Ubiquinol

Reduced Coenzyme Q10, Reduced CoQ10

Supports the high energy requirements of immune cells and helps protect them from oxidative damage.

Efficacy: Low  |  Grade: C

Uridine Monophosphate

UMP, Uridine

May support the rapidly renewing cells of the gut lining and the immune system.

Efficacy: Low  |  Grade: C

Vitamin B5

Pantothenic Acid

Plays a foundational role in normal immune cell function and contributes to maintaining a healthy gut lining.

Medications

Efficacy: High  |  Grade: A

Everolimus

Afinitor, Zortress, RAD001

Helps rejuvenate the aging immune system, improving its response to challenges like vaccines and infections.

Efficacy: High  |  Grade: A

mTOR Inhibitors

Rapalogs, Mechanistic Target of Rapamycin Inhibitors

Rejuvenates the aging immune system, improving its function and enhancing responses to new challenges.

Efficacy: High  |  Grade: A

NAC

N-Acetylcysteine, N-acetyl-L-cysteine

Significantly boosts immune resilience against infections and helps maintain a healthy gut environment.

Efficacy: High  |  Grade: A

Proton Pump Inhibitors

PPIs

Reduces stomach acid to help heal ulcers and protect the esophageal lining from damage.

Efficacy: High  |  Grade: A

Rapamycin

Sirolimus

Helps rejuvenate the aging immune system, improving its function and reducing chronic low-grade inflammation.

Efficacy: High  |  Grade: A

Vitamin C

Ascorbic Acid, L-Ascorbic Acid

Supports the function of various immune cells, strengthening the body's natural defenses against pathogens.

Efficacy: High  |  Grade: A

Vitamin D3

Cholecalciferol (D3), Ergocalciferol (D2), Calcifediol, Calcitriol

Modulates the immune system for a balanced response and helps maintain a healthy gut lining.

Efficacy: High  |  Grade: B

Acarbose

Precose, Glucobay

Acts as a prebiotic by feeding beneficial gut bacteria, which supports a healthy microbiome and gut lining.

Efficacy: High  |  Grade: B

Dasatinib

Sprycel

Helps rejuvenate the immune system and reduce chronic inflammation by selectively removing dysfunctional senescent cells.

Efficacy: Medium  |  Grade: A

Fluvastatin

Lescol, Lescol XL

Exerts systemic anti-inflammatory effects, helping to modulate the immune system and reduce chronic low-grade inflammation.

Efficacy: Medium  |  Grade: A

GLP-1 Receptor Agonists

Incretin Mimetics, GLP-1 RAs

Reduces systemic inflammation and modulates gut function, which is central to its metabolic benefits.

Efficacy: Medium  |  Grade: A

Low-Dose Colchicine

Colcrys, Mitigare, Gloperba

Helps regulate the innate immune system by dampening key inflammatory pathways linked to chronic conditions.

Efficacy: Medium  |  Grade: A

Pravastatin

Pravachol

Pravastatin helps lower systemic inflammation, which supports a balanced immune response and overall cellular health.

Efficacy: Medium  |  Grade: A

Rosuvastatin

Crestor

Provides a systemic anti-inflammatory effect by lowering key inflammatory markers like C-reactive protein.

Efficacy: Medium  |  Grade: A

Semaglutide

Ozempic, Wegovy, Rybelsus

Reduces systemic inflammation associated with excess weight and directly influences gut function to support metabolic balance.

Efficacy: Medium  |  Grade: A

Simvastatin

Zocor

Exerts a systemic anti-inflammatory effect, helping to calm the immune response and protect blood vessels.

Efficacy: Low  |  Grade: A

Bempedoic Acid

Nexletol, Nilemdo

Helps reduce systemic inflammation, a key factor in many age-related health conditions.

Efficacy: Medium  |  Grade: B

Bile Acid Sequestrants

Bile Acid Resins

Alters the gut environment by binding bile acids, which can favorably shift the microbiome composition.

Efficacy: Medium  |  Grade: B

Dapagliflozin

Farxiga

Helps lower systemic inflammation, a key factor in healthy aging, by improving metabolic control and fluid balance.

Efficacy: Medium  |  Grade: B

Icosapent Ethyl

Vascepa, purified EPA

Helps balance the immune system by reducing inflammation and may support a healthy gut microbiome.

Efficacy: Medium  |  Grade: B

Lovastatin

Mevacor, Altoprev

Helps reduce systemic inflammation, a key factor in healthy aging and immune system balance.

Efficacy: Medium  |  Grade: B

Metformin

Glucophage, Fortamet, Glumetza

Positively modulates the gut microbiome and reduces systemic inflammation, supporting a balanced immune response.

Efficacy: Medium  |  Grade: B

Omega-3 Fatty Acids

Fish Oil, EPA, DHA, Marine Oils, Omega-3 Softgel, Omega-3 Supplement

Modulates the immune system to resolve inflammation and supports a healthy gut microbiome and intestinal lining.

Efficacy: Medium  |  Grade: B

Oxytocin

OT, Love Hormone

Exerts anti-inflammatory effects and supports the gut-brain axis, contributing to a balanced immune response.

Efficacy: Low  |  Grade: B

Atorvastatin

Lipitor

Provides a systemic anti-inflammatory effect beyond cholesterol lowering, which can help modulate the immune response.

Efficacy: Low  |  Grade: B

Fibrates

Fenofibrate, Gemfibrozil, Bezafibrate, Ciprofibrate

Helps reduce markers of systemic inflammation, which plays a key role in modulating the immune system.

Efficacy: Low  |  Grade: B

Menopausal HRT

Hormone Replacement Therapy, MHT, Menopausal Hormone Therapy

May help maintain a favorable gut microbiome composition, which is linked to metabolic and immune health.

Efficacy: Low  |  Grade: B

Pitavastatin

Livalo, Zypitamag

Exhibits anti-inflammatory properties that may help reduce systemic inflammation, a key factor in age-related diseases.

Efficacy: Low  |  Grade: C

Angiotensin Receptor Blockers

ARBs

Exerts mild anti-inflammatory effects which may help modulate the immune system and reduce systemic inflammation.

Efficacy: Low  |  Grade: C

Erythropoietin

EPO, Epoetin alfa

May help regulate inflammation and support the integrity of the gut lining under stressful conditions.

Efficacy: Low  |  Grade: C

Estradiol Cypionate

Depo-Estradiol

May help maintain a favorable gut microbiome composition, which is linked to overall immune function.

Efficacy: Low  |  Grade: C

Estradiol Valerate

EV, Delestrogen

May influence the gut microbiome composition, which plays a role in overall hormone regulation.

Efficacy: Low  |  Grade: C

Estradiol

E2, 17β-estradiol, Oestradiol

May support a healthy gut microbiome and modulate immune responses, contributing to overall systemic balance.

Efficacy: Low  |  Grade: C

Ezetimibe

Zetia

May positively influence the gut microbiome by altering cholesterol and bile acid metabolism in the intestine.

Efficacy: Low  |  Grade: C

Galanthamine

Razadyne, Nivalin, Lycoremine

May help modulate the body's inflammatory response via its influence on the cholinergic nervous system.

Efficacy: Low  |  Grade: C

Niacin (Vitamin B3)

Nicotinic Acid, Vitamin B3

Helps maintain a healthy gut lining and supports balanced immune responses within the digestive system.

Efficacy: Low  |  Grade: C

PCSK9 Inhibitors

Proprotein Convertase Subtilisin/Kexin type 9 Inhibitors

May help reduce systemic inflammation associated with high cholesterol levels, supporting immune balance.

Efficacy: Low  |  Grade: C

Telmisartan

Micardis

May reduce systemic inflammation, which could potentially benefit gut health and immune system balance.

Efficacy: Low  |  Grade: C

Tesamorelin

Egrifta

Helps lower systemic inflammation by reducing inflammatory visceral fat, supporting a balanced immune response.

Efficacy: Low  |  Grade: C

Testosterone

TRT, Testosterone Replacement Therapy

Plays a role in modulating the immune system, though its direct impact on gut health is emerging.

Efficacy: Low  |  Grade: C

Vitamin B1 (Thiamine)

Thiamin

Aids in proper digestion and supports the energy needs of immune cells for a healthy immune response.

Efficacy: Low  |  Grade: C

Tirzepatide

Mounjaro, Zepbound

May reduce systemic inflammation associated with obesity, which can contribute to a healthier gut environment.

Topical Agents

Dietary Practices

Efficacy: High  |  Grade: A

Anti-Inflammatory Diet

Mediterranean Diet, DASH Diet, MIND Diet

Nourishes a healthy gut microbiome and strengthens the gut lining, which helps regulate the immune system.

Efficacy: High  |  Grade: A

Avoiding Processed Foods

Minimally Processed Diet, Whole Foods Diet

Fosters a diverse microbiome and strengthens the gut lining by removing additives that cause gut dysbiosis.

Efficacy: High  |  Grade: A

The Blue Zones Diet

Longevity Diet, Blue Zone Eating Pattern

Nourishes a diverse gut microbiome with high fiber from plants, supporting digestion and immune function.

Efficacy: High  |  Grade: A

Calorie Restriction Without Malnutrition

CR, Dietary Restriction, Nutritional Restriction

Reduces chronic systemic inflammation and helps modulate the immune system, supporting a balanced and resilient internal environment.

Efficacy: High  |  Grade: A

Colostrum

Bovine Colostrum

Strengthens the gut lining and provides immune factors to support a balanced immune response.

Efficacy: High  |  Grade: A

Cruciferous Vegetables

Brassicas, Cole crops

Promotes a diverse microbiome and strengthens the gut lining through its unique fibers and compounds.

Efficacy: High  |  Grade: A

Fermented Foods

Probiotic Foods, Live Culture Foods, Gut-Healthy Foods

Directly enhances gut microbiome diversity, strengthens the gut lining, and helps regulate immune system function.

Efficacy: High  |  Grade: A

Flaxseed

Linseed, Ground Flaxseed

Promotes a healthy gut microbiome and regularity with its rich blend of soluble and insoluble fiber.

Efficacy: High  |  Grade: A

Flexitarian Diet

Semi-vegetarianism, Flexible vegetarianism

Nourishes a diverse gut microbiome with high fiber intake, supporting digestive health and immune system function.

Efficacy: High  |  Grade: A

Gluten-Free Diet

GF Diet

Allows the gut lining to heal and reduces autoimmune inflammation in individuals with celiac disease or sensitivity.

Efficacy: High  |  Grade: A

High-Fiber Diet

Fiber-rich eating, Plant-forward diet

Directly feeds beneficial gut bacteria, enhancing microbiome diversity, gut lining integrity, and immune function.

Efficacy: High  |  Grade: A

Intermittent Fasting

IF, Periodic Fasting

Reduces systemic inflammation and allows for gut lining rest, which supports a healthy immune response.

Efficacy: High  |  Grade: A

Inulin (Prebiotic Fiber)

Prebiotic Fiber, Chicory Root Fiber, Fructan

Acts as a prebiotic to selectively nourish beneficial gut bacteria, supporting microbiome diversity and gut lining health.

Efficacy: High  |  Grade: A

Kefir / Fermented Foods

Probiotic Foods, Cultured Foods

Promotes a diverse microbiome and strengthens the gut lining, supporting a balanced and resilient immune system.

Efficacy: High  |  Grade: A

Low-FODMAP Diet

Low Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols Diet

Significantly reduces digestive symptoms like bloating and discomfort by limiting fermentable carbs, calming an irritated gut.

Efficacy: High  |  Grade: A

Mediterranean Diet

MedDiet

Nourishes a diverse gut microbiome with abundant fiber, which supports digestive health and immune function.

Efficacy: High  |  Grade: A

Nordic Diet

New Nordic Diet, NND

Nourishes a diverse gut microbiome with high fiber from whole grains, fruits, and vegetables.

Efficacy: High  |  Grade: A

The Okinawa Diet

Okinawan Longevity Diet, Traditional Okinawan Diet

Nourishes a diverse gut microbiome with high fiber from vegetables and legumes, supporting robust immune function.

Efficacy: High  |  Grade: A

Ovo-Lacto Vegetarian Diet

Vegetarian Diet

Promotes a diverse and healthy gut microbiome due to high fiber intake from varied plant sources.

Efficacy: High  |  Grade: A

Plant-Forward Diet

Plant-Based Diet, Flexitarian Diet, Vegetarian Diet, Vegan Diet

Nourishes a diverse gut microbiome, strengthening the gut barrier and supporting a balanced immune response.

Efficacy: High  |  Grade: A

Polyphenol-Rich Diet

High-Polyphenol Diet, Colorful Diet, Polyphenol-rich Foods, Phytonutrient-dense foods, Flavonoid-rich foods

Nourishes beneficial gut bacteria, strengthens the gut lining, and helps maintain a balanced immune system response.

Efficacy: High  |  Grade: A

Protein

Amino Acids, Dietary Protein

Provides the fundamental building blocks for immune cells and antibodies, and helps maintain gut lining integrity.

Efficacy: High  |  Grade: A

Resistant Starch

RS, Undigestable Starch

Acts as a prebiotic to nourish beneficial gut bacteria, strengthening the gut lining and supporting immunity.

Efficacy: High  |  Grade: A

Soluble Fiber

Dietary fiber (soluble), Beta-glucans, Psyllium, Inulin, Pectins

Acts as a prebiotic to nourish beneficial gut bacteria, strengthening the gut lining and supporting immune function.

Efficacy: High  |  Grade: A

Vegan Diet

Plant-Based Diet, Strict Vegetarianism

High fiber content nourishes a diverse gut microbiome, supporting gut lining integrity and immune function.

Efficacy: High  |  Grade: A

Vegetarian Diet

Plant-based diet, Lacto-ovo vegetarianism

Promotes a diverse and healthy gut microbiome by providing abundant fiber, which supports immune function.

Efficacy: High  |  Grade: A

Whole Food Plant Based

WFPB, Plant-Based Diet

Nourishes a diverse gut microbiome with high fiber, strengthening the gut lining and supporting immune function.

Efficacy: High  |  Grade: B

Autoimmune Protocol Diet

AIP, AIP Diet

Designed to heal the gut lining and calm the immune system by removing inflammatory food triggers.

Efficacy: High  |  Grade: B

Fasting-Mimicking Diet (FMD)

FMD, Prolon Diet

Promotes immune system rejuvenation by clearing old immune cells and regenerating new, more functional ones.

Efficacy: Medium  |  Grade: A

MIND Diet

Mediterranean-DASH Intervention for Neurodegenerative Delay

Promotes a diverse and healthy gut microbiome through its high content of fiber and polyphenols.

Efficacy: High  |  Grade: B

One Meal A Day

OMAD, 23:1 Intermittent Fasting

Provides a prolonged period of 'gut rest,' allowing for gut lining repair and potentially reducing systemic inflammation.

Efficacy: Medium  |  Grade: A

Pescatarian Diet

Pescatarianism, Fish-based diet

Promotes a diverse gut microbiome with high fiber intake and helps regulate inflammation via omega-3s.

Efficacy: High  |  Grade: B

Prolonged Fasting (Supervised)

Therapeutic Fasting, Extended Fasting, Water Fasting (Supervised)

Triggers a renewal of the immune system by clearing old cells and promoting stem-cell-based regeneration.

Efficacy: High  |  Grade: B

Water Fasting

Prolonged Fasting, Extended Fasting

Reduces gut inflammation and promotes cellular renewal, which helps reset the immune system and microbiome.

Efficacy: High  |  Grade: B

Whole30

Whole 30 Diet, 30-Day Elimination Diet

Acts as a diagnostic tool to identify food sensitivities, reduce gut inflammation, and support gut-lining integrity.

Efficacy: Medium  |  Grade: B

Alternate-Day Fasting (ADF)

ADF, Every-Other-Day Fasting

Allows the digestive system to rest and repair, which can reduce inflammation and support a healthy gut.

Efficacy: Medium  |  Grade: B

Blueprint Protocol

Bryan Johnson's Blueprint

Promotes a diverse gut microbiome and modulates immune response with a fiber-rich, plant-based diet.

Efficacy: Medium  |  Grade: B

Calorie Restriction Diet

CR, Caloric Restriction

Reduces systemic inflammation and can shift the gut microbiome towards a more beneficial composition.

Efficacy: High  |  Grade: C

Carnivore Diet

All-Meat Diet, Zero-Carb Diet

May calm immune responses and improve gut symptoms by acting as an ultimate elimination diet for plant-based triggers.

Efficacy: Medium  |  Grade: B

DASH Diet

Dietary Approaches to Stop Hypertension

Its high fiber content from whole foods nourishes a diverse gut microbiome, supporting digestive health.

Efficacy: Medium  |  Grade: B

5:2 Diet

The Fast Diet, Intermittent Fasting (5:2)

Supports gut health by beneficially altering the microbiome and reducing systemic inflammation for a balanced immune response.

Efficacy: Medium  |  Grade: B

Hibiscus Tea

Roselle Tea, Sour Tea, Karkadeh

Provides polyphenols that may support a healthy gut microbiome and modulate immune system responses.

Efficacy: Medium  |  Grade: B

5:2 Intermittent Fasting

5-2 method, The Fast Diet

Allows the digestive system to rest and may positively reshape the gut microbiome for better immunity.

Efficacy: Medium  |  Grade: B

Ketogenic Diet

Keto, Keto Diet

Can modulate the immune system and reduce systemic inflammation by altering gut bacteria and cellular fuel sources.

Efficacy: Medium  |  Grade: B

Kombucha

Fermented Tea, Tea Fungus

Provides probiotics and beneficial organic acids that support a diverse and healthy gut microbiome.

Efficacy: Medium  |  Grade: B

Methionine Restriction

MR, Low-Methionine Diet

Helps reduce systemic inflammation and favorably alters the gut microbiome, which supports balanced immune function.

Efficacy: Medium  |  Grade: B

Paleo Diet

Paleolithic Diet, Caveman Diet

May reduce gut inflammation by eliminating processed foods and common irritants, supporting a healthier gut lining.

Efficacy: Medium  |  Grade: B

Time-Restricted Eating (16:8)

TRE, 16:8 Intermittent Fasting, Leangains Protocol

Provides a daily rest period for the gut lining to repair and may foster a healthier microbiome.

Efficacy: Medium  |  Grade: C

Freegan Vegan Diet

Freeganism

A high intake of diverse plant fibers from salvaged produce can nourish a healthy gut microbiome.

Efficacy: Low  |  Grade: B

Low-Carb Diet

Very Low-Carbohydrate Ketogenic Diet (VLCKD), Keto Diet

May help lower systemic inflammation, a key factor in modulating a healthy immune response.

Efficacy: Low  |  Grade: B

Tart Cherry Juice

Montmorency Cherry, Prunus cerasus, Sour Cherry

May support a healthy immune response to stress and positively influence gut bacteria composition.

Efficacy: Low  |  Grade: C

Alkaline Water Consumption

May provide temporary relief from acid reflux symptoms by helping to neutralize stomach acid.

Efficacy: Low  |  Grade: C

Alkaline Water

Ionized Water, High pH Water

May offer temporary relief from acid reflux by helping to neutralize pepsin, a key digestive enzyme.

Efficacy: Low  |  Grade: C

Apple Cider Vinegar

ACV

May help balance the gut environment due to its antimicrobial properties and fermented nature.

Efficacy: Low  |  Grade: C

Beetroot Juice

Beet Juice, Beetroot Extract

May support a healthy gut environment through its antioxidant compounds and influence on oral microbiota.

Efficacy: Low  |  Grade: C

Branched-Chain Amino AcidRestriction

Low BCAA Diet

Can favorably alter the gut microbiome, which is linked to better metabolic health and immune balance.

Efficacy: Low  |  Grade: C

Dietary Nitrate

Beetroot Juice, Leafy Greens, NO3-

May support a healthy gut environment by influencing the oral and gut microbiome composition.

Lifestyle Practices

Efficacy: High  |  Grade: A

Stress Management

Mindfulness, Relaxation Techniques, Cognitive Behavioral Therapy (CBT), Meditation

Supports a healthy gut-brain axis, which helps maintain gut lining integrity and a balanced immune system.

Efficacy: Medium  |  Grade: A

Smoking Cessation

Quitting Smoking, Tobacco Cessation

Helps rebalance the gut microbiome, reduces systemic inflammation, and restores proper immune system function.

Efficacy: Medium  |  Grade: A

Broad-Spectrum Sunscreen (Topical)

Sunblock, Sunscreen

Protects the skin's local immune cells from UV damage, helping maintain its defense against pathogens and cancer.

Efficacy: Medium  |  Grade: B

Breathwork

Pranayama, Conscious Connected Breathing, Holotropic Breathwork, Wim Hof Method

Reduces stress-related gut issues and supports immune balance by calming the body's fight-or-flight response.

Efficacy: Medium  |  Grade: B

Cold Exposure

Cold Therapy, Cold Water Immersion, Cryotherapy, Ice Bath

May modulate the immune system by reducing inflammation and potentially increasing certain protective immune cells.

Efficacy: Medium  |  Grade: B

Daily Flossing

Dental Flossing

Helps maintain a healthy oral microbiome, reducing the passage of harmful bacteria into the gut.

Efficacy: Medium  |  Grade: B

Deep Breathing Exercises

Diaphragmatic Breathing, Belly Breathing, Mindful Breathing

Supports gut health and immune function by reducing stress and calming the gut-brain axis.

Efficacy: Medium  |  Grade: B

Electric Toothbrushing

Powered Toothbrushing

Promotes a healthy oral microbiome, reducing the burden on the immune system and gut from pathogenic bacteria.

Efficacy: Medium  |  Grade: B

Meditation

Mindfulness, Vipassanā, Zazen, Transcendental Meditation

Reduces stress-induced inflammation and supports a healthy gut environment through the brain-gut connection.

Efficacy: Medium  |  Grade: B

Mindfulness Meditation

Mindfulness-Based Stress Reduction (MBSR), Vipassana, Concentrative Meditation

Reduces stress-induced inflammation and supports the brain-gut axis, contributing to a healthier immune response.

Efficacy: Medium  |  Grade: B

Regular Dental Cleanings

Prophylaxis, Oral Hygiene Visits, Professional Teeth Cleaning

Supports a healthy gut microbiome by reducing the constant swallowing of inflammatory oral bacteria.

Efficacy: Medium  |  Grade: B

Relaxation

Meditation, Mindfulness, Yoga, Tai Chi, Deep Breathing, Progressive Muscle Relaxation

Soothes the gut-brain axis, which can support a healthy microbiome and a more balanced immune response.

Efficacy: Medium  |  Grade: B

Running

Jogging, Aerobic Exercise, Cardio

Encourages a diverse gut microbiome and helps regulate the immune system to reduce chronic inflammation.

Efficacy: Medium  |  Grade: B

Sauna

Sauna Bathing, Hyperthermic Conditioning, Heat Therapy

Helps regulate the immune system and lowers levels of systemic inflammation, a key driver of aging.

Efficacy: Low  |  Grade: B

Strength Training

Resistance Training, Weightlifting, Resistance Exercise

Positively influences gut microbiome diversity and exerts systemic anti-inflammatory effects that support a balanced immune system.

Efficacy: Medium  |  Grade: C

Water Flossing

Oral Irrigator, Water Pik

Helps manage the oral microbiome, reducing the swallowing of pathogenic bacteria that can disrupt gut health.

Efficacy: Low  |  Grade: C

EFT Tapping

Emotional Freedom Techniques, Tapping

May support the gut-immune axis by mitigating the negative effects of chronic stress on the body.

Efficacy: Low  |  Grade: C

Oil Pulling

Gandusha, Kavala Graha

May reduce harmful oral bacteria, potentially lessening the inflammatory load on the immune system.

Efficacy: Low  |  Grade: C

Sexual Activity

Sex, Intercourse, Orgasm

May support immune function through stress reduction and by boosting certain protective antibodies.

Efficacy: Low  |  Grade: C

Tongue Scraping

Jihwa Prakshalana

Reduces the oral bacterial load, potentially lessening the burden on the gut microbiome and systemic immunity.

Efficacy: Low  |  Grade: C

Weighted Blankets (Topical)

sensory blankets, gravity blankets

By reducing stress and improving sleep, it may indirectly support a healthy gut-brain connection.

Exercise & Sports

Efficacy: Medium  |  Grade: A

Regular Aerobic Exercise

Cardio, Endurance Training, Aerobics

Enhances gut microbiome diversity and helps modulate the immune system to reduce chronic inflammation.

Efficacy: Medium  |  Grade: B

Cricket

Cricket fiber acts as a prebiotic, nourishing beneficial gut bacteria and supporting a healthy immune response.

Efficacy: Medium  |  Grade: B

Daily Brisk Walking

Brisk Walking, Regular Walking, Moderate-intensity Walking

Encourages a diverse gut microbiome and supports a balanced, effective immune system response.

Efficacy: Medium  |  Grade: B

Endurance Training

Aerobic Exercise, Cardio

Promotes a diverse gut microbiome and helps modulate the immune system to reduce chronic inflammation.

Efficacy: Medium  |  Grade: B

Hiking

Trekking, Rucking, Hillwalking

Supports a diverse gut microbiome through moderate physical activity and exposure to natural environments.

Efficacy: Medium  |  Grade: B

Jogging

Running, Aerobic Exercise

Encourages a diverse gut microbiome and helps regulate the immune system to reduce chronic inflammation.

Efficacy: Medium  |  Grade: B

Qigong

Chi Kung, Chi Gung

Qigong helps regulate the immune system by reducing stress-related inflammation, which also supports a healthy gut.

Efficacy: Medium  |  Grade: B

Race Walking

Power Walking

Supports a diverse gut microbiome and helps modulate the immune system, reducing chronic low-grade inflammation.

Efficacy: Medium  |  Grade: B

Road Cycling

Cycling, Bicycling

Positively influences gut microbiome diversity and helps modulate the immune system, reducing chronic low-grade inflammation.

Efficacy: Medium  |  Grade: B

Squash

Racquetball, Racket Sports

Its high fiber content nourishes beneficial gut bacteria, while vitamins A and C support a robust immune system.

Efficacy: Medium  |  Grade: B

Trail Running

Off-road running, Mountain running

Supports a diverse gut microbiome and modulates immune function through consistent physical activity and exposure to nature.

Efficacy: Medium  |  Grade: B

Zone 2 Cardio Training

Aerobic Base Training, Low-Intensity Steady-State (LISS) Cardio

Promotes a healthier gut microbiome and helps regulate the immune system to reduce chronic inflammation.

Efficacy: Medium  |  Grade: B

Zone 2 Exercise

Aerobic Base Training, Endurance Training, Low-Intensity Steady-State (LISS) Cardio, LISS

Encourages a healthier gut microbiome composition and helps modulate the immune system to reduce chronic inflammation.

Efficacy: Low  |  Grade: B

Basketball

Hoops

Supports a diverse gut microbiome and modulates immune function through regular vigorous physical activity.

Efficacy: Low  |  Grade: B

Bicycling

Cycling

Promotes a diverse gut microbiome and helps regulate the immune system to reduce chronic inflammation.

Efficacy: Low  |  Grade: B

Calisthenics

Bodyweight Training, Bodyweight Exercise

Supports a diverse gut microbiome and helps modulate the immune system through regular physical activity.

Efficacy: Low  |  Grade: B

Cross-Country Skiing

Nordic Skiing, XC Skiing

Supports a diverse gut microbiome and helps modulate the immune system through regular, vigorous exercise.

Efficacy: Low  |  Grade: B

Indoor Cycling

Stationary Biking, Spinning

Regular exercise can positively influence gut microbiome diversity and support a balanced immune system response.

Efficacy: Low  |  Grade: B

Jump Rope

Skipping Rope, Rope Jumping

Supports a diverse gut microbiome and helps modulate the immune system for better overall resilience.

Efficacy: Low  |  Grade: B

Kayaking

Paddling, Canoeing

Supports a healthy gut microbiome and immune function through consistent, moderate-intensity physical activity.

Efficacy: Low  |  Grade: B

Kickball

Soccer Baseball, Football Rounders

Supports a healthy gut microbiome and immune function through moderate physical activity and stress reduction.

Efficacy: Low  |  Grade: B

Padel

Padel tennis

Supports a healthy gut microbiome and immune response, which are benefits associated with regular moderate exercise.

Efficacy: Medium  |  Grade: C

Rebounding

Mini-trampoline exercise, Cellercising

The vertical motion is theorized to stimulate lymphatic circulation, which supports immune system function.

Efficacy: Low  |  Grade: B

Resistance Training

Strength Training, Weightlifting

Promotes a healthier gut microbiome composition and exerts systemic anti-inflammatory effects that support immune function.

Efficacy: Low  |  Grade: B

Rowing

Ergometer, Crew, Sculling

Supports a diverse gut microbiome and helps modulate the immune system through regular, moderate-intensity activity.

Efficacy: Low  |  Grade: B

Rugby

Rugby Union, Rugby League

Consistent high-intensity exercise can positively influence gut microbiome diversity and help modulate immune system responses.

Efficacy: Low  |  Grade: B

Snowshoeing

Winter hiking, Snow-shoeing

Supports a healthy gut microbiome and robust immune function through regular, moderate-to-vigorous physical activity.

Efficacy: Low  |  Grade: B

Softball

Slow-pitch Softball, Fast-pitch Softball

Supports a healthy immune system and gut microbiome diversity through consistent, moderate physical activity.

Efficacy: Low  |  Grade: B

Structured Interval Training

HIIT, High-Intensity Interval Training, SIT

Encourages a more diverse gut microbiome, which plays a key role in immune function and overall health.

Efficacy: Low  |  Grade: B

Swimming

Aquatic Exercise

Supports a diverse gut microbiome and helps regulate the immune system through consistent, moderate activity.

Efficacy: Low  |  Grade: B

Tai Chi

Taijiquan

May support a balanced immune system and gut health by reducing chronic stress and inflammation.

Efficacy: Low  |  Grade: B

Track and Field

Athletics

Supports a healthy gut microbiome and robust immune function through regular, moderate physical activity.

Efficacy: Low  |  Grade: B

Water Polo

Polo

Supports a diverse gut microbiome and robust immune function through regular, intense physical activity.

Efficacy: Low  |  Grade: B

Weight-Bearing Exercise

Resistance Training, Strength Training, Impact Exercise

Encourages a diverse gut microbiome and helps regulate the immune system for improved digestive and immune health.

Efficacy: Low  |  Grade: B

Yoga

Hatha Yoga, Vinyasa Yoga, Ashtanga Yoga, Pranayama

Supports gut health and immune function by reducing stress's negative impact on the gut-brain axis.

Efficacy: Low  |  Grade: C

Australian Rules Football

Aussie Rules, Footy

May support a more diverse gut microbiome and modulate immune function through regular vigorous exercise.

Efficacy: Low  |  Grade: C

Badminton

Promotes a healthy immune response and may support gut microbiome diversity through regular physical activity.

Efficacy: Low  |  Grade: C

BMX

Bicycle Motocross, BMX Racing, Freestyle BMX

May support a healthy gut microbiome and balanced immune function through regular vigorous physical activity.

Efficacy: Low  |  Grade: C

Bodyboarding

Boogie boarding

The consistent, moderate-to-high intensity exercise involved supports a healthy and robust immune system response.

Efficacy: Low  |  Grade: C

Bouldering / Rock Climbing

Climbing

As a form of regular, intense exercise, it can contribute to a healthy gut microbiome and immune response.

Efficacy: Low  |  Grade: C

Boxing

Pugilism, Sweet Science

Regular, intense exercise can positively influence gut microbiome diversity and support a more robust immune system.

Efficacy: Low  |  Grade: C

Canoeing

Kayaking, Paddling

Supports a healthy immune system and can positively influence gut microbiome through regular moderate exercise.

Efficacy: Low  |  Grade: C

Disc Golf

Frisbee Golf, Frolf

Supports a healthy immune system and gut through moderate physical activity and exposure to natural environments.

Efficacy: Low  |  Grade: C

Dodgeball

Regular play can support a healthy gut microbiome and balanced immune function through moderate physical stress.

Efficacy: Low  |  Grade: C

Flag Football

Non-contact Football

May support gut microbiome diversity and immune function as a secondary effect of regular vigorous exercise.

Efficacy: Low  |  Grade: C

Flexibility Training / Stretching

Stretching, Mobility Work, Range of Motion Training

Helps manage the stress response, which indirectly supports a healthy gut-brain axis and balanced immune function.

Efficacy: Low  |  Grade: C

Gymnastics

Artistic Gymnastics, Rhythmic Gymnastics, Calisthenics, Gymnastic Strength Training

As a form of intense physical activity, gymnastics may support a healthy immune system and gut microbiome.

Efficacy: Low  |  Grade: C

High-Intensity Interval Training

HIIT, Sprint Interval Training

May positively influence gut microbiome diversity and helps regulate the immune system's inflammatory response.

Efficacy: Low  |  Grade: C

High-Intensity Resistance Training (HIRT)

HIRT, Heavy Duty Training, HDT

May positively influence microbiome diversity and helps modulate the immune system through controlled physical stress.

Efficacy: Low  |  Grade: C

Ice Hockey

Hockey

May support a robust immune response and gut health as a result of regular, intense exercise.

Efficacy: Low  |  Grade: C

Ice Skating

Figure Skating, Speed Skating, Ice Hockey

Regular physical activity can support a healthy gut microbiome and a well-functioning immune system.

Efficacy: Low  |  Grade: C

Kettlebell Training

KB Training, Girevoy Sport

Supports a healthy gut microbiome and immune function through regular, vigorous physical activity.

Efficacy: Low  |  Grade: C

Kite Surfing

Kitesurfing, Kiteboarding

Regular vigorous exercise like this can contribute to a more diverse microbiome and a well-regulated immune system.

Efficacy: Low  |  Grade: C

Marathon Training

Long-Distance Running, Endurance Running Training

May support a more diverse gut microbiome, though intense sessions can be an acute stressor.

Efficacy: Low  |  Grade: C

Martial Arts

Tai Chi, Judo, Karate, Brazilian Jiu-Jitsu, Kung Fu

Supports a healthy immune response through the combined effects of regular exercise and stress management.

Efficacy: Low  |  Grade: C

Mountain Biking

MTB, Off-road Cycling

May positively influence gut microbiome diversity and immune regulation through moderate physical stress.

Efficacy: Low  |  Grade: C

Mountaineering

Alpinism, Mountain Climbing

May support a more robust immune system through adaptation to physical stress and environmental exposure.

Efficacy: Low  |  Grade: C

Muay Thai

Thai Boxing, The Art of Eight Limbs

May support a balanced immune response through the anti-inflammatory effects of regular, intense physical activity.

Efficacy: Low  |  Grade: C

Netball

Consistent, moderate-to-vigorous activity supports a balanced immune system and can positively influence gut health.

Efficacy: Low  |  Grade: C

Nordic Walking

Pole Walking, Exerstriding

Supports a balanced immune system and healthy gut environment through consistent, moderate physical activity.

Efficacy: Low  |  Grade: C

Pickleball

Supports a healthy immune system and gut microbiome as a beneficial form of moderate physical activity.

Efficacy: Low  |  Grade: C

Pilates

Contrology

Supports a healthy immune system and gut function through moderate physical activity and stress reduction.

Efficacy: Low  |  Grade: C

Rock Climbing

Bouldering, Sport Climbing, Trad Climbing

Supports a healthy gut microbiome and immune function as a positive outcome of consistent physical activity.

Efficacy: Low  |  Grade: C

Rucking

Weighted Walking, Backpack Training

Supports a healthy gut microbiome and balanced immune function as a positive side-effect of regular exercise.

Efficacy: Low  |  Grade: C

Skateboarding

Skating, Street Skating, Vert Skating

Supports a healthy immune response and gut microbiome as a secondary benefit of consistent physical activity.

Efficacy: Low  |  Grade: C

Skiing

Downhill Skiing, Alpine Skiing, Cross-Country Skiing, Nordic Skiing

May support a healthy gut microbiome and balanced immune function through moderate physical activity.

Efficacy: Low  |  Grade: C

Snowboarding

Snowboard

Supports a healthy immune system as a beneficial form of moderate-to-vigorous outdoor physical activity.

Efficacy: Low  |  Grade: C

Soccer (Football)

Football

May support a more diverse gut microbiome and help regulate the immune system through regular physical activity.

Efficacy: Low  |  Grade: C

Sprinting

High-Intensity Interval Training (HIIT), Sprint Interval Training (SIT)

May encourage a more diverse gut microbiome and helps train a more resilient immune system over time.

Efficacy: Low  |  Grade: C

Stand-Up Paddleboarding

SUP, Paddleboarding

Supports a healthy gut and immune system by reducing stress and promoting beneficial exercise-induced changes.

Efficacy: Low  |  Grade: C

Surfing

Wave riding

May support immune function through the stress-reducing and anti-inflammatory effects of regular, moderate exercise.

Efficacy: Low  |  Grade: C

Tennis

Racket Sports

Supports a diverse gut microbiome and helps modulate immune function through regular physical activity.

Efficacy: Low  |  Grade: C

Treadmill Desk Walking

Walking Desk, Under-Desk Treadmill

Gentle, consistent movement can aid digestive regularity by stimulating normal gut motility throughout the day.

Efficacy: Low  |  Grade: C

Ultimate Frisbee

Ultimate

Consistent physical activity from playing supports a more diverse gut microbiome and helps regulate immune function.

Efficacy: Low  |  Grade: C

Volleyball

Beach Volleyball

May support a healthy immune system and gut microbiome as a result of regular, vigorous exercise.

Efficacy: Low  |  Grade: C

Wakeboarding

Waterskiing

The intense physical activity may positively influence gut microbiome diversity and support healthy immune function.

Efficacy: Low  |  Grade: C

Walking Golf

Golf (walking), Carry golf

Supports a healthy gut microbiome and immune response through consistent, low-impact physical activity.

Devices

Procedures

Efficacy: High  |  Grade: A

Fecal Microbiota Transplant

FMT, Stool Transplant, Bacteriotherapy

Directly restores microbiome diversity, strengthens the gut barrier, and helps regulate immune system responses.

Efficacy: High  |  Grade: B

Mesenchymal Stem Cell (MSC) Therapy

MSCs, Mesenchymal Stromal Cells, Stem Cell Therapy

Helps regulate the immune system and reduce gut inflammation, supporting a healthy and balanced gut environment.

Efficacy: High  |  Grade: B

Muse Cell Therapy

Multilineage-differentiating Stress Enduring cells

Helps regulate the immune system and reduces systemic inflammation, supporting tissue repair throughout the body.

Efficacy: High  |  Grade: B

Therapeutic Plasma Exchange (TPE)

Plasmapheresis, Plasma Exchange, Plasma Dilution

Modulates the immune system by removing circulating inflammatory proteins and harmful autoantibodies.

Efficacy: Medium  |  Grade: B

Acupuncture

Traditional Chinese Medicine (TCM) Needling

Helps regulate gut motility and reduces nausea, supporting digestive comfort via the gut-brain axis.

Efficacy: Medium  |  Grade: B

Biofeedback Therapy

Neurofeedback, EMG Biofeedback, Thermal Biofeedback, HRV Biofeedback

Helps regulate the gut-brain axis by managing stress, which can improve digestive function and support immunity.

Efficacy: Medium  |  Grade: B

Cognitive Behavioral Therapy

CBT

Calms the gut-brain axis by reducing stress, which can improve digestive symptoms and support immune balance.

Efficacy: Medium  |  Grade: B

Exosome Therapy

Extracellular Vesicle (EV) Therapy

Helps modulate immune responses and reduce systemic inflammation for a more balanced system.

Efficacy: Medium  |  Grade: B

Hyperbaric Oxygen Therapy

HBOT

Helps modulate the immune system and reduces inflammation, supporting the integrity of the gut lining.

Efficacy: Medium  |  Grade: B

Neti Pot

Nasal Irrigation, Saline Rinse, Jala Neti

Helps flush allergens and pathogens from nasal passages, supporting upper respiratory immune function and reducing inflammation.

Efficacy: Medium  |  Grade: B

SIRT6 Gene Therapy

SIRT6 Overexpression Therapy

Reduces systemic inflammation and supports gut barrier integrity, contributing to a balanced immune system.

Efficacy: Low  |  Grade: C

Blood Donation (Therapeutic Phlebotomy)

Phlebotomy, Venesection

May help manage systemic iron levels, which can influence the balance of bacteria within the gut microbiome.

Efficacy: Low  |  Grade: C

Floatation Therapy

Float Tank, Sensory Deprivation Tank, REST, Restricted Environmental Stimulation Therapy

May support gut and immune health indirectly by significantly reducing the negative effects of chronic stress.

Efficacy: Low  |  Grade: C

Light Therapy Glasses

Light Visor, Wearable Light Therapy, SAD Glasses

May support gut and immune health by stabilizing the body's master clock, which influences digestive rhythms.

Efficacy: Low  |  Grade: C

MDMA Therapy

3,4-Methylenedioxymethamphetamine-Assisted Therapy, MDMA-Assisted Psychotherapy

May indirectly support gut and immune health by reducing the chronic stress load associated with trauma.

Efficacy: Low  |  Grade: C

Photodynamic Therapy

PDT

May help selectively reduce harmful gut or oral bacteria, potentially supporting a healthier microbial balance.

Efficacy: Low  |  Grade: C

Sauna Therapy

Heat Therapy, Hyperthermic Conditioning, Sauna Bathing

Helps to lower systemic inflammation and may support a healthy gut lining through cellular stress responses.

Efficacy: Low  |  Grade: C

White Noise / Sound Therapy

Pink Noise, Brown Noise, Acoustic Stimulation, Sound Masking

May support gut health and immune function by reducing chronic stress's negative impact on the body.

Protocols

Synergistic Therapy

Efficacy: High  |  Grade: A

Zinc Carnosine

Polaprezinc, L-carnosine zinc complex, PepZin GI

Promotes the integrity of the stomach and intestinal lining, supporting a healthy and resilient gut barrier.

Efficacy: Medium  |  Grade: A

5-FU and Calcipotriol (Topical)

5-Fluorouracil and Calcipotriol, Topical Senolytic Combination

Promotes a targeted immune response within the skin to effectively clear sun-damaged and precancerous cells.

Efficacy: Medium  |  Grade: A

Liposomal Vitamin D3/K2

Liposomal D3/K2, Vitamin D3 + K2 (Liposomal)

Plays a key role in modulating the immune system, enhancing resilience against common infections.

Efficacy: Medium  |  Grade: A

Vitamin D3 and K2 with Calcium

Vitamin D3, Vitamin K2, and Calcium

Supports a balanced and effective immune system, enhancing resilience against common infections.

Efficacy: Medium  |  Grade: B

B-Complex Vitamins

B Vitamins, Vitamin B Complex

Supports the growth and function of immune cells and helps maintain the integrity of the gut lining.

Efficacy: Medium  |  Grade: B

Curcumin and Piperine

Turmeric and Black Pepper Extract, Bioavailable Curcumin

Helps balance the immune system and supports a healthy gut lining through its anti-inflammatory properties.

Efficacy: Medium  |  Grade: B

Dasatinib and Quercetin

D+Q, Senolytics

Helps clear aged immune cells, potentially rejuvenating immune function and reducing chronic low-grade inflammation.

Efficacy: Medium  |  Grade: B

GlyNAC

Glycine + N-Acetylcysteine, Glycine and NAC

Helps regulate the immune system by reducing systemic inflammation and replenishing a critical cellular antioxidant.

Efficacy: Low  |  Grade: C

Glucosamine and Chondroitin

Glucosamine Sulfate, Chondroitin Sulfate

May contribute to a healthy gut lining by supporting the protective mucus layer in the intestines.